LeishMANIAdb
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Protein kinase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase, putative
Gene product:
protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X5M4_LEIDO
TriTrypDb:
LdBPK_321900.1 , LdCL_320024500 , LDHU3_32.2400
Length:
655

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 15
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 65
NetGPI no yes: 0, no: 65
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X5M4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5M4

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 66
GO:0006793 phosphorus metabolic process 3 66
GO:0006796 phosphate-containing compound metabolic process 4 66
GO:0006807 nitrogen compound metabolic process 2 66
GO:0008152 metabolic process 1 66
GO:0009987 cellular process 1 66
GO:0016310 phosphorylation 5 66
GO:0019538 protein metabolic process 3 66
GO:0036211 protein modification process 4 66
GO:0043170 macromolecule metabolic process 3 66
GO:0043412 macromolecule modification 4 66
GO:0044237 cellular metabolic process 2 66
GO:0044238 primary metabolic process 2 66
GO:0071704 organic substance metabolic process 2 66
GO:1901564 organonitrogen compound metabolic process 3 66
GO:0006996 organelle organization 4 1
GO:0016043 cellular component organization 3 1
GO:0032392 DNA geometric change 7 1
GO:0032508 DNA duplex unwinding 8 1
GO:0051276 chromosome organization 5 1
GO:0071103 DNA conformation change 6 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 66
GO:0003824 catalytic activity 1 66
GO:0004672 protein kinase activity 3 66
GO:0005488 binding 1 66
GO:0005524 ATP binding 5 66
GO:0016301 kinase activity 4 66
GO:0016740 transferase activity 2 66
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 66
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 66
GO:0017076 purine nucleotide binding 4 66
GO:0030554 adenyl nucleotide binding 5 66
GO:0032553 ribonucleotide binding 3 66
GO:0032555 purine ribonucleotide binding 4 66
GO:0032559 adenyl ribonucleotide binding 5 66
GO:0035639 purine ribonucleoside triphosphate binding 4 66
GO:0036094 small molecule binding 2 66
GO:0043167 ion binding 2 66
GO:0043168 anion binding 3 66
GO:0097159 organic cyclic compound binding 2 66
GO:0097367 carbohydrate derivative binding 2 66
GO:0140096 catalytic activity, acting on a protein 2 66
GO:1901265 nucleoside phosphate binding 3 66
GO:1901363 heterocyclic compound binding 2 66
GO:0004674 protein serine/threonine kinase activity 4 39
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 46 50 PF00656 0.608
CLV_C14_Caspase3-7 92 96 PF00656 0.592
CLV_NRD_NRD_1 256 258 PF00675 0.366
CLV_NRD_NRD_1 312 314 PF00675 0.297
CLV_NRD_NRD_1 394 396 PF00675 0.294
CLV_NRD_NRD_1 75 77 PF00675 0.465
CLV_PCSK_FUR_1 581 585 PF00082 0.348
CLV_PCSK_KEX2_1 162 164 PF00082 0.404
CLV_PCSK_KEX2_1 256 258 PF00082 0.416
CLV_PCSK_KEX2_1 312 314 PF00082 0.301
CLV_PCSK_KEX2_1 371 373 PF00082 0.274
CLV_PCSK_KEX2_1 394 396 PF00082 0.276
CLV_PCSK_KEX2_1 456 458 PF00082 0.329
CLV_PCSK_KEX2_1 529 531 PF00082 0.510
CLV_PCSK_KEX2_1 583 585 PF00082 0.340
CLV_PCSK_PC1ET2_1 162 164 PF00082 0.364
CLV_PCSK_PC1ET2_1 371 373 PF00082 0.332
CLV_PCSK_PC1ET2_1 456 458 PF00082 0.306
CLV_PCSK_PC1ET2_1 529 531 PF00082 0.564
CLV_PCSK_PC1ET2_1 583 585 PF00082 0.348
CLV_PCSK_SKI1_1 143 147 PF00082 0.357
CLV_PCSK_SKI1_1 266 270 PF00082 0.347
CLV_PCSK_SKI1_1 287 291 PF00082 0.231
CLV_PCSK_SKI1_1 317 321 PF00082 0.294
CLV_PCSK_SKI1_1 329 333 PF00082 0.289
CLV_PCSK_SKI1_1 443 447 PF00082 0.299
CLV_PCSK_SKI1_1 54 58 PF00082 0.587
CLV_PCSK_SKI1_1 556 560 PF00082 0.286
CLV_PCSK_SKI1_1 583 587 PF00082 0.321
DEG_APCC_DBOX_1 442 450 PF00400 0.268
DEG_APCC_DBOX_1 583 591 PF00400 0.269
DOC_CKS1_1 357 362 PF01111 0.340
DOC_CYCLIN_RxL_1 553 564 PF00134 0.263
DOC_CYCLIN_yCln2_LP_2 357 363 PF00134 0.368
DOC_MAPK_gen_1 317 326 PF00069 0.300
DOC_MAPK_RevD_3 300 313 PF00069 0.316
DOC_PP4_FxxP_1 414 417 PF00568 0.342
DOC_PP4_FxxP_1 504 507 PF00568 0.512
DOC_USP7_MATH_1 203 207 PF00917 0.418
DOC_USP7_MATH_1 609 613 PF00917 0.282
DOC_USP7_MATH_1 624 628 PF00917 0.453
DOC_USP7_MATH_2 396 402 PF00917 0.282
DOC_USP7_UBL2_3 371 375 PF12436 0.252
DOC_USP7_UBL2_3 452 456 PF12436 0.174
DOC_WW_Pin1_4 112 117 PF00397 0.640
DOC_WW_Pin1_4 356 361 PF00397 0.310
DOC_WW_Pin1_4 591 596 PF00397 0.337
DOC_WW_Pin1_4 607 612 PF00397 0.342
LIG_14-3-3_CanoR_1 101 110 PF00244 0.546
LIG_14-3-3_CanoR_1 202 211 PF00244 0.399
LIG_14-3-3_CanoR_1 54 59 PF00244 0.720
LIG_14-3-3_CanoR_1 584 593 PF00244 0.371
LIG_Actin_RPEL_3 306 325 PF02755 0.399
LIG_APCC_ABBA_1 265 270 PF00400 0.174
LIG_APCC_ABBAyCdc20_2 312 318 PF00400 0.292
LIG_BRCT_BRCA1_1 327 331 PF00533 0.334
LIG_BRCT_BRCA1_1 536 540 PF00533 0.622
LIG_BRCT_BRCA1_1 629 633 PF00533 0.341
LIG_BRCT_BRCA1_2 327 333 PF00533 0.313
LIG_EH1_1 297 305 PF00400 0.269
LIG_EH1_1 642 650 PF00400 0.160
LIG_eIF4E_1 298 304 PF01652 0.303
LIG_EVH1_2 617 621 PF00568 0.399
LIG_FHA_1 105 111 PF00498 0.768
LIG_FHA_1 21 27 PF00498 0.676
LIG_FHA_1 240 246 PF00498 0.230
LIG_FHA_1 295 301 PF00498 0.391
LIG_FHA_1 40 46 PF00498 0.399
LIG_FHA_1 562 568 PF00498 0.279
LIG_FHA_2 16 22 PF00498 0.422
LIG_FHA_2 25 31 PF00498 0.371
LIG_FHA_2 289 295 PF00498 0.401
LIG_FHA_2 529 535 PF00498 0.498
LIG_LIR_Apic_2 359 365 PF02991 0.296
LIG_LIR_Apic_2 411 417 PF02991 0.351
LIG_LIR_Apic_2 612 618 PF02991 0.332
LIG_LIR_Gen_1 142 150 PF02991 0.489
LIG_LIR_Gen_1 222 231 PF02991 0.300
LIG_LIR_Gen_1 297 306 PF02991 0.293
LIG_LIR_Gen_1 328 339 PF02991 0.261
LIG_LIR_Gen_1 555 565 PF02991 0.298
LIG_LIR_Nem_3 142 147 PF02991 0.474
LIG_LIR_Nem_3 222 228 PF02991 0.275
LIG_LIR_Nem_3 297 302 PF02991 0.296
LIG_LIR_Nem_3 328 334 PF02991 0.260
LIG_LIR_Nem_3 537 543 PF02991 0.239
LIG_LIR_Nem_3 555 560 PF02991 0.183
LIG_Pex14_1 553 557 PF04695 0.285
LIG_PTB_Apo_2 161 168 PF02174 0.378
LIG_PTB_Phospho_1 161 167 PF10480 0.372
LIG_SH2_CRK 615 619 PF00017 0.399
LIG_SH2_NCK_1 167 171 PF00017 0.520
LIG_SH2_NCK_1 486 490 PF00017 0.496
LIG_SH2_PTP2 128 131 PF00017 0.499
LIG_SH2_PTP2 144 147 PF00017 0.523
LIG_SH2_SRC 472 475 PF00017 0.213
LIG_SH2_SRC 479 482 PF00017 0.214
LIG_SH2_STAP1 167 171 PF00017 0.319
LIG_SH2_STAP1 231 235 PF00017 0.304
LIG_SH2_STAP1 343 347 PF00017 0.288
LIG_SH2_STAP1 387 391 PF00017 0.299
LIG_SH2_STAP1 486 490 PF00017 0.453
LIG_SH2_STAP1 619 623 PF00017 0.348
LIG_SH2_STAT3 298 301 PF00017 0.295
LIG_SH2_STAT5 128 131 PF00017 0.468
LIG_SH2_STAT5 144 147 PF00017 0.382
LIG_SH2_STAT5 159 162 PF00017 0.343
LIG_SH2_STAT5 194 197 PF00017 0.450
LIG_SH2_STAT5 234 237 PF00017 0.344
LIG_SH2_STAT5 24 27 PF00017 0.675
LIG_SH2_STAT5 298 301 PF00017 0.271
LIG_SH2_STAT5 362 365 PF00017 0.306
LIG_SH2_STAT5 472 475 PF00017 0.362
LIG_SH2_STAT5 479 482 PF00017 0.386
LIG_SH2_STAT5 503 506 PF00017 0.427
LIG_SH2_STAT5 557 560 PF00017 0.299
LIG_SH3_3 184 190 PF00018 0.566
LIG_SH3_3 414 420 PF00018 0.225
LIG_SH3_4 466 473 PF00018 0.230
LIG_SUMO_SIM_anti_2 237 248 PF11976 0.271
LIG_SUMO_SIM_par_1 237 248 PF11976 0.291
LIG_SUMO_SIM_par_1 42 49 PF11976 0.414
LIG_SUMO_SIM_par_1 563 568 PF11976 0.377
LIG_TRAF2_1 459 462 PF00917 0.412
LIG_TRAF2_1 637 640 PF00917 0.234
LIG_TRFH_1 361 365 PF08558 0.280
LIG_TYR_ITIM 126 131 PF00017 0.539
LIG_TYR_ITIM 385 390 PF00017 0.328
LIG_UBA3_1 445 452 PF00899 0.271
LIG_UBA3_1 586 591 PF00899 0.289
MOD_CK1_1 105 111 PF00069 0.721
MOD_CK1_1 273 279 PF00069 0.434
MOD_CK1_1 345 351 PF00069 0.312
MOD_CK1_1 482 488 PF00069 0.449
MOD_CK1_1 589 595 PF00069 0.295
MOD_CK1_1 627 633 PF00069 0.381
MOD_CK2_1 15 21 PF00069 0.641
MOD_CK2_1 235 241 PF00069 0.423
MOD_CK2_1 288 294 PF00069 0.324
MOD_CK2_1 398 404 PF00069 0.331
MOD_CK2_1 456 462 PF00069 0.362
MOD_CK2_1 528 534 PF00069 0.493
MOD_CK2_1 591 597 PF00069 0.341
MOD_CK2_1 634 640 PF00069 0.269
MOD_Cter_Amidation 369 372 PF01082 0.271
MOD_Cter_Amidation 373 376 PF01082 0.242
MOD_Cter_Amidation 392 395 PF01082 0.296
MOD_GlcNHglycan 104 107 PF01048 0.577
MOD_GlcNHglycan 262 265 PF01048 0.407
MOD_GlcNHglycan 309 312 PF01048 0.358
MOD_GlcNHglycan 320 323 PF01048 0.329
MOD_GlcNHglycan 39 42 PF01048 0.684
MOD_GlcNHglycan 422 425 PF01048 0.321
MOD_GlcNHglycan 458 461 PF01048 0.268
MOD_GlcNHglycan 536 539 PF01048 0.460
MOD_GlcNHglycan 636 639 PF01048 0.285
MOD_GlcNHglycan 66 69 PF01048 0.687
MOD_GlcNHglycan 91 94 PF01048 0.693
MOD_GSK3_1 100 107 PF00069 0.730
MOD_GSK3_1 15 22 PF00069 0.611
MOD_GSK3_1 235 242 PF00069 0.461
MOD_GSK3_1 270 277 PF00069 0.391
MOD_GSK3_1 342 349 PF00069 0.310
MOD_GSK3_1 352 359 PF00069 0.301
MOD_GSK3_1 39 46 PF00069 0.673
MOD_GSK3_1 415 422 PF00069 0.440
MOD_GSK3_1 530 537 PF00069 0.574
MOD_GSK3_1 561 568 PF00069 0.314
MOD_GSK3_1 585 592 PF00069 0.294
MOD_N-GLC_1 112 117 PF02516 0.640
MOD_N-GLC_1 260 265 PF02516 0.432
MOD_N-GLC_1 283 288 PF02516 0.164
MOD_N-GLC_1 534 539 PF02516 0.572
MOD_N-GLC_1 54 59 PF02516 0.750
MOD_NEK2_1 219 224 PF00069 0.340
MOD_NEK2_1 325 330 PF00069 0.291
MOD_NEK2_1 337 342 PF00069 0.284
MOD_NEK2_1 5 10 PF00069 0.701
MOD_NEK2_1 565 570 PF00069 0.264
MOD_NEK2_1 586 591 PF00069 0.343
MOD_NEK2_1 625 630 PF00069 0.282
MOD_NMyristoyl 1 7 PF02799 0.575
MOD_PIKK_1 185 191 PF00454 0.531
MOD_PIKK_1 203 209 PF00454 0.347
MOD_PIKK_1 270 276 PF00454 0.381
MOD_PIKK_1 337 343 PF00454 0.291
MOD_PIKK_1 427 433 PF00454 0.426
MOD_PIKK_1 5 11 PF00454 0.692
MOD_PK_1 146 152 PF00069 0.513
MOD_PK_1 43 49 PF00069 0.417
MOD_PKA_1 456 462 PF00069 0.309
MOD_PKA_2 100 106 PF00069 0.552
MOD_PKA_2 456 462 PF00069 0.301
MOD_Plk_1 20 26 PF00069 0.554
MOD_Plk_1 239 245 PF00069 0.286
MOD_Plk_1 260 266 PF00069 0.427
MOD_Plk_1 283 289 PF00069 0.167
MOD_Plk_1 343 349 PF00069 0.257
MOD_Plk_2-3 398 404 PF00069 0.318
MOD_Plk_4 20 26 PF00069 0.610
MOD_Plk_4 239 245 PF00069 0.306
MOD_Plk_4 294 300 PF00069 0.384
MOD_Plk_4 352 358 PF00069 0.300
MOD_Plk_4 43 49 PF00069 0.629
MOD_Plk_4 479 485 PF00069 0.374
MOD_Plk_4 627 633 PF00069 0.306
MOD_ProDKin_1 112 118 PF00069 0.641
MOD_ProDKin_1 356 362 PF00069 0.310
MOD_ProDKin_1 591 597 PF00069 0.337
MOD_ProDKin_1 607 613 PF00069 0.342
TRG_DiLeu_BaEn_1 555 560 PF01217 0.325
TRG_DiLeu_BaEn_4 78 84 PF01217 0.474
TRG_ENDOCYTIC_2 128 131 PF00928 0.513
TRG_ENDOCYTIC_2 144 147 PF00928 0.485
TRG_ENDOCYTIC_2 387 390 PF00928 0.306
TRG_ENDOCYTIC_2 472 475 PF00928 0.349
TRG_ENDOCYTIC_2 557 560 PF00928 0.301
TRG_ER_diArg_1 255 257 PF00400 0.378
TRG_ER_diArg_1 312 314 PF00400 0.286
TRG_ER_diArg_1 394 396 PF00400 0.314
TRG_Pf-PMV_PEXEL_1 287 292 PF00026 0.361
TRG_Pf-PMV_PEXEL_1 530 534 PF00026 0.588
TRG_Pf-PMV_PEXEL_1 556 561 PF00026 0.353
TRG_Pf-PMV_PEXEL_1 650 655 PF00026 0.550

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P953 Leptomonas seymouri 30% 100%
A0A0N1I9A0 Leptomonas seymouri 68% 100%
A0A0N1PD05 Leptomonas seymouri 33% 100%
A0A0S4IMB7 Bodo saltans 34% 100%
A0A0S4IRZ7 Bodo saltans 40% 100%
A0A0S4J804 Bodo saltans 31% 100%
A0A0S4JPZ1 Bodo saltans 28% 100%
A0A1X0NIX2 Trypanosomatidae 28% 100%
A0A1X0NUB2 Trypanosomatidae 47% 100%
A0A1X0P527 Trypanosomatidae 31% 100%
A0A1X0P549 Trypanosomatidae 30% 100%
A0A1X0P863 Trypanosomatidae 30% 100%
A0A1X0P8W3 Trypanosomatidae 26% 88%
A0A1X0P994 Trypanosomatidae 30% 100%
A0A3Q8IFK8 Leishmania donovani 31% 100%
A0A3Q8IHH8 Leishmania donovani 31% 100%
A0A3Q8IIH5 Leishmania donovani 27% 100%
A0A3Q8IJM9 Leishmania donovani 30% 100%
A0A3R7MKG5 Trypanosoma rangeli 27% 100%
A0A3S7X6T8 Leishmania donovani 34% 100%
A0A3S7XAL3 Leishmania donovani 31% 100%
A0A3S7XAT9 Leishmania donovani 31% 100%
A0A422NCP0 Trypanosoma rangeli 32% 100%
A0A422NH41 Trypanosoma rangeli 45% 100%
A4HHQ5 Leishmania braziliensis 32% 100%
A4HJT5 Leishmania braziliensis 30% 100%
A4HKG9 Leishmania braziliensis 74% 100%
A4HLR0 Leishmania braziliensis 34% 100%
A4HNI1 Leishmania braziliensis 29% 100%
A4HP12 Leishmania braziliensis 30% 100%
A4HP13 Leishmania braziliensis 30% 100%
A4HW88 Leishmania infantum 27% 100%
A4I4X0 Leishmania infantum 31% 100%
A4I7A1 Leishmania infantum 31% 100%
A4I7Z6 Leishmania infantum 100% 100%
A4I960 Leishmania infantum 34% 100%
A4IC37 Leishmania infantum 29% 100%
A4IDC1 Leishmania infantum 30% 100%
A4IDC2 Leishmania infantum 31% 100%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AEB9 Leishmania major 32% 100%
E9AFZ2 Leishmania major 29% 100%
E9ALG7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
Q4Q1S3 Leishmania major 30% 100%
Q4Q1S4 Leishmania major 30% 100%
Q4Q3Y9 Leishmania major 32% 85%
Q4Q598 Leishmania major 93% 100%
Q4Q5W2 Leishmania major 31% 100%
Q4QFJ2 Leishmania major 27% 100%
Q8N5S9 Homo sapiens 25% 100%
Q8VBY2 Mus musculus 25% 100%
V5BC28 Trypanosoma cruzi 28% 100%
V5BPJ0 Trypanosoma cruzi 32% 100%
V5D7G4 Trypanosoma cruzi 30% 79%
V5DFW9 Trypanosoma cruzi 46% 100%
V5DKY9 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS