Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7X5L4_LEIDO

TriTrypDb:

LdBPK_322080.1 , LdCL_320026200 , LDHU3_32.2580

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5L4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.725
CLV_NRD_NRD_1	384	386	PF00675	0.772
CLV_NRD_NRD_1	419	421	PF00675	0.750
CLV_PCSK_FUR_1	417	421	PF00082	0.747
CLV_PCSK_KEX2_1	384	386	PF00082	0.799
CLV_PCSK_KEX2_1	390	392	PF00082	0.741
CLV_PCSK_KEX2_1	419	421	PF00082	0.750
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.653
CLV_PCSK_SKI1_1	15	19	PF00082	0.607
CLV_PCSK_SKI1_1	269	273	PF00082	0.607
CLV_PCSK_SKI1_1	391	395	PF00082	0.613
CLV_PCSK_SKI1_1	453	457	PF00082	0.729
DEG_COP1_1	170	179	PF00400	0.608
DEG_Nend_UBRbox_3	1	3	PF02207	0.722
DEG_SCF_TRCP1_1	468	474	PF00400	0.702
DEG_SIAH_1	402	410	PF03145	0.607
DOC_CKS1_1	87	92	PF01111	0.827
DOC_CYCLIN_RxL_1	385	397	PF00134	0.602
DOC_MAPK_gen_1	262	270	PF00069	0.824
DOC_MAPK_RevD_3	405	420	PF00069	0.706
DOC_PP4_FxxP_1	275	278	PF00568	0.642
DOC_PP4_MxPP_1	149	152	PF00568	0.572
DOC_USP7_MATH_1	138	142	PF00917	0.692
DOC_USP7_MATH_1	167	171	PF00917	0.736
DOC_USP7_MATH_1	218	222	PF00917	0.757
DOC_USP7_MATH_1	303	307	PF00917	0.779
DOC_USP7_MATH_1	310	314	PF00917	0.711
DOC_USP7_MATH_1	340	344	PF00917	0.800
DOC_USP7_MATH_1	409	413	PF00917	0.729
DOC_USP7_MATH_1	5	9	PF00917	0.687
DOC_WW_Pin1_4	124	129	PF00397	0.738
DOC_WW_Pin1_4	169	174	PF00397	0.630
DOC_WW_Pin1_4	191	196	PF00397	0.777
DOC_WW_Pin1_4	252	257	PF00397	0.677
DOC_WW_Pin1_4	274	279	PF00397	0.739
DOC_WW_Pin1_4	336	341	PF00397	0.747
DOC_WW_Pin1_4	35	40	PF00397	0.811
DOC_WW_Pin1_4	86	91	PF00397	0.828
LIG_14-3-3_CanoR_1	233	238	PF00244	0.776
LIG_14-3-3_CanoR_1	262	270	PF00244	0.824
LIG_14-3-3_CanoR_1	309	315	PF00244	0.803
LIG_14-3-3_CanoR_1	338	348	PF00244	0.726
LIG_14-3-3_CanoR_1	391	401	PF00244	0.695
LIG_14-3-3_CanoR_1	413	417	PF00244	0.637
LIG_APCC_ABBA_1	98	103	PF00400	0.556
LIG_BRCT_BRCA1_1	135	139	PF00533	0.749
LIG_BRCT_BRCA1_1	331	335	PF00533	0.810
LIG_BRCT_BRCA1_1	358	362	PF00533	0.714
LIG_CaM_IQ_9	439	455	PF13499	0.731
LIG_eIF4E_1	42	48	PF01652	0.698
LIG_FHA_1	169	175	PF00498	0.743
LIG_FHA_1	309	315	PF00498	0.684
LIG_FHA_2	29	35	PF00498	0.808
LIG_FHA_2	344	350	PF00498	0.803
LIG_FHA_2	77	83	PF00498	0.810
LIG_GBD_Chelix_1	344	352	PF00786	0.724
LIG_IRF3_LxIS_1	348	355	PF10401	0.721
LIG_LIR_Apic_2	272	278	PF02991	0.640
LIG_LIR_Gen_1	136	147	PF02991	0.586
LIG_LIR_Nem_3	129	135	PF02991	0.720
LIG_LIR_Nem_3	136	142	PF02991	0.623
LIG_LIR_Nem_3	197	202	PF02991	0.723
LIG_LIR_Nem_3	99	104	PF02991	0.808
LIG_LYPXL_yS_3	132	135	PF13949	0.685
LIG_MYND_1	173	177	PF01753	0.710
LIG_PCNA_yPIPBox_3	338	348	PF02747	0.629
LIG_PDZ_Class_1	471	476	PF00595	0.714
LIG_SH2_STAP1	438	442	PF00017	0.727
LIG_SH2_STAT5	392	395	PF00017	0.746
LIG_SH2_STAT5	78	81	PF00017	0.725
LIG_SH3_3	145	151	PF00018	0.792
LIG_SH3_3	257	263	PF00018	0.762
LIG_SUMO_SIM_par_1	170	178	PF11976	0.673
LIG_TRAF2_1	151	154	PF00917	0.785
LIG_TRAF2_1	255	258	PF00917	0.760
LIG_TRAF2_1	318	321	PF00917	0.600
LIG_TYR_ITIM	130	135	PF00017	0.686
LIG_UBA3_1	17	23	PF00899	0.568
LIG_WRC_WIRS_1	207	212	PF05994	0.727
LIG_WRC_WIRS_1	344	349	PF05994	0.804
MOD_CK1_1	182	188	PF00069	0.770
MOD_CK1_1	209	215	PF00069	0.745
MOD_CK1_1	217	223	PF00069	0.688
MOD_CK1_1	3	9	PF00069	0.680
MOD_CK1_1	336	342	PF00069	0.807
MOD_CK1_1	343	349	PF00069	0.688
MOD_CK1_1	412	418	PF00069	0.734
MOD_CK1_1	85	91	PF00069	0.729
MOD_CK2_1	251	257	PF00069	0.851
MOD_CK2_1	314	320	PF00069	0.636
MOD_CK2_1	369	375	PF00069	0.736
MOD_CK2_1	5	11	PF00069	0.613
MOD_CK2_1	76	82	PF00069	0.811
MOD_Cter_Amidation	382	385	PF01082	0.776
MOD_GlcNHglycan	216	219	PF01048	0.815
MOD_GlcNHglycan	235	238	PF01048	0.493
MOD_GlcNHglycan	264	267	PF01048	0.783
MOD_GlcNHglycan	287	290	PF01048	0.785
MOD_GlcNHglycan	300	303	PF01048	0.692
MOD_GlcNHglycan	314	317	PF01048	0.578
MOD_GlcNHglycan	358	361	PF01048	0.756
MOD_GlcNHglycan	386	389	PF01048	0.750
MOD_GlcNHglycan	430	433	PF01048	0.566
MOD_GlcNHglycan	468	471	PF01048	0.698
MOD_GlcNHglycan	5	8	PF01048	0.678
MOD_GSK3_1	120	127	PF00069	0.746
MOD_GSK3_1	133	140	PF00069	0.533
MOD_GSK3_1	175	182	PF00069	0.785
MOD_GSK3_1	191	198	PF00069	0.575
MOD_GSK3_1	206	213	PF00069	0.607
MOD_GSK3_1	214	221	PF00069	0.672
MOD_GSK3_1	269	276	PF00069	0.625
MOD_GSK3_1	28	35	PF00069	0.783
MOD_GSK3_1	308	315	PF00069	0.751
MOD_GSK3_1	329	336	PF00069	0.737
MOD_GSK3_1	339	346	PF00069	0.602
MOD_GSK3_1	352	359	PF00069	0.559
MOD_GSK3_1	369	376	PF00069	0.537
MOD_GSK3_1	392	399	PF00069	0.805
MOD_GSK3_1	424	431	PF00069	0.616
MOD_GSK3_1	57	64	PF00069	0.660
MOD_GSK3_1	82	89	PF00069	0.779
MOD_N-GLC_1	295	300	PF02516	0.667
MOD_N-GLC_1	340	345	PF02516	0.649
MOD_NEK2_1	208	213	PF00069	0.805
MOD_NEK2_1	273	278	PF00069	0.597
MOD_NEK2_1	297	302	PF00069	0.762
MOD_NEK2_1	308	313	PF00069	0.718
MOD_NEK2_1	352	357	PF00069	0.734
MOD_NEK2_1	394	399	PF00069	0.786
MOD_NEK2_1	411	416	PF00069	0.569
MOD_NEK2_2	96	101	PF00069	0.599
MOD_PIKK_1	158	164	PF00454	0.735
MOD_PIKK_1	218	224	PF00454	0.733
MOD_PIKK_1	28	34	PF00454	0.722
MOD_PIKK_1	76	82	PF00454	0.762
MOD_PKA_1	384	390	PF00069	0.772
MOD_PKA_2	303	309	PF00069	0.808
MOD_PKA_2	384	390	PF00069	0.786
MOD_PKA_2	397	403	PF00069	0.623
MOD_PKA_2	412	418	PF00069	0.579
MOD_PKA_2	466	472	PF00069	0.772
MOD_Plk_1	102	108	PF00069	0.585
MOD_Plk_1	121	127	PF00069	0.683
MOD_Plk_1	283	289	PF00069	0.795
MOD_Plk_1	333	339	PF00069	0.813
MOD_Plk_1	340	346	PF00069	0.685
MOD_Plk_1	68	74	PF00069	0.801
MOD_Plk_1	82	88	PF00069	0.777
MOD_Plk_2-3	373	379	PF00069	0.725
MOD_Plk_4	211	217	PF00069	0.784
MOD_Plk_4	340	346	PF00069	0.800
MOD_Plk_4	373	379	PF00069	0.760
MOD_Plk_4	397	403	PF00069	0.697
MOD_Plk_4	82	88	PF00069	0.804
MOD_Plk_4	96	102	PF00069	0.560
MOD_ProDKin_1	124	130	PF00069	0.734
MOD_ProDKin_1	169	175	PF00069	0.633
MOD_ProDKin_1	191	197	PF00069	0.775
MOD_ProDKin_1	252	258	PF00069	0.676
MOD_ProDKin_1	274	280	PF00069	0.740
MOD_ProDKin_1	336	342	PF00069	0.744
MOD_ProDKin_1	35	41	PF00069	0.812
MOD_ProDKin_1	86	92	PF00069	0.827
TRG_DiLeu_BaEn_1	373	378	PF01217	0.743
TRG_DiLeu_BaEn_1	43	48	PF01217	0.694
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.686
TRG_ENDOCYTIC_2	132	135	PF00928	0.724
TRG_ENDOCYTIC_2	42	45	PF00928	0.607
TRG_ER_diArg_1	416	419	PF00400	0.742
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HKI6	Leishmania braziliensis	50%	100%
A4I817	Leishmania infantum	98%	100%
E9B2X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q581	Leishmania major	83%	100%