LeishMANIAdb
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Cation efflux family, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cation efflux family, putative
Gene product:
Cation efflux family, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X5K5_LEIDO
TriTrypDb:
LdBPK_321960.1 * , LdCL_320025100 , LDHU3_32.2460
Length:
625

Annotations

LeishMANIAdb annotations

Similar to Zn transporters found in animals.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A0A3S7X5K5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5K5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0008324 monoatomic cation transmembrane transporter activity 4 3
GO:0015075 monoatomic ion transmembrane transporter activity 3 3
GO:0022857 transmembrane transporter activity 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 331 335 PF00656 0.419
CLV_NRD_NRD_1 177 179 PF00675 0.295
CLV_NRD_NRD_1 19 21 PF00675 0.354
CLV_NRD_NRD_1 220 222 PF00675 0.295
CLV_NRD_NRD_1 287 289 PF00675 0.709
CLV_NRD_NRD_1 343 345 PF00675 0.570
CLV_PCSK_FUR_1 175 179 PF00082 0.278
CLV_PCSK_KEX2_1 177 179 PF00082 0.295
CLV_PCSK_KEX2_1 19 21 PF00082 0.402
CLV_PCSK_KEX2_1 220 222 PF00082 0.295
CLV_PCSK_KEX2_1 287 289 PF00082 0.625
CLV_PCSK_KEX2_1 343 345 PF00082 0.563
CLV_PCSK_KEX2_1 503 505 PF00082 0.722
CLV_PCSK_PC1ET2_1 503 505 PF00082 0.722
CLV_PCSK_SKI1_1 221 225 PF00082 0.200
CLV_PCSK_SKI1_1 272 276 PF00082 0.485
CLV_PCSK_SKI1_1 281 285 PF00082 0.585
CLV_PCSK_SKI1_1 297 301 PF00082 0.487
CLV_PCSK_SKI1_1 532 536 PF00082 0.657
DEG_APCC_DBOX_1 271 279 PF00400 0.329
DEG_APCC_DBOX_1 342 350 PF00400 0.345
DEG_MDM2_SWIB_1 28 36 PF02201 0.307
DEG_Nend_Nbox_1 1 3 PF02207 0.624
DEG_SPOP_SBC_1 471 475 PF00917 0.473
DOC_CKS1_1 487 492 PF01111 0.529
DOC_CKS1_1 536 541 PF01111 0.459
DOC_CKS1_1 9 14 PF01111 0.598
DOC_CYCLIN_yClb5_NLxxxL_5 288 296 PF00134 0.354
DOC_CYCLIN_yCln2_LP_2 580 586 PF00134 0.508
DOC_MAPK_gen_1 269 277 PF00069 0.278
DOC_MAPK_HePTP_8 91 103 PF00069 0.388
DOC_MAPK_MEF2A_6 272 279 PF00069 0.329
DOC_MAPK_MEF2A_6 88 95 PF00069 0.478
DOC_MAPK_NFAT4_5 272 280 PF00069 0.329
DOC_PP2B_LxvP_1 580 583 PF13499 0.496
DOC_PP4_FxxP_1 189 192 PF00568 0.529
DOC_PP4_FxxP_1 487 490 PF00568 0.544
DOC_USP7_MATH_1 453 457 PF00917 0.500
DOC_USP7_MATH_1 471 475 PF00917 0.485
DOC_USP7_MATH_1 492 496 PF00917 0.508
DOC_USP7_MATH_1 530 534 PF00917 0.499
DOC_USP7_MATH_1 549 553 PF00917 0.460
DOC_USP7_MATH_1 576 580 PF00917 0.550
DOC_USP7_MATH_1 584 588 PF00917 0.511
DOC_WW_Pin1_4 188 193 PF00397 0.505
DOC_WW_Pin1_4 202 207 PF00397 0.451
DOC_WW_Pin1_4 486 491 PF00397 0.519
DOC_WW_Pin1_4 535 540 PF00397 0.547
DOC_WW_Pin1_4 596 601 PF00397 0.517
DOC_WW_Pin1_4 8 13 PF00397 0.563
LIG_14-3-3_CanoR_1 220 230 PF00244 0.450
LIG_14-3-3_CanoR_1 516 521 PF00244 0.450
LIG_14-3-3_CanoR_1 532 537 PF00244 0.417
LIG_14-3-3_CanoR_1 88 92 PF00244 0.529
LIG_Actin_WH2_2 129 145 PF00022 0.340
LIG_APCC_ABBA_1 598 603 PF00400 0.517
LIG_BRCT_BRCA1_1 34 38 PF00533 0.371
LIG_BRCT_BRCA1_1 40 44 PF00533 0.418
LIG_BRCT_BRCA1_1 424 428 PF00533 0.537
LIG_BRCT_BRCA1_1 441 445 PF00533 0.536
LIG_BRCT_BRCA1_1 78 82 PF00533 0.571
LIG_BRCT_BRCA1_1 96 100 PF00533 0.271
LIG_CaM_NSCaTE_8 374 381 PF13499 0.464
LIG_EVH1_1 487 491 PF00568 0.545
LIG_EVH1_2 594 598 PF00568 0.517
LIG_FHA_1 105 111 PF00498 0.296
LIG_FHA_1 146 152 PF00498 0.529
LIG_FHA_1 233 239 PF00498 0.350
LIG_FHA_1 40 46 PF00498 0.369
LIG_FHA_1 452 458 PF00498 0.514
LIG_FHA_1 65 71 PF00498 0.373
LIG_FHA_1 96 102 PF00498 0.388
LIG_FHA_2 106 112 PF00498 0.388
LIG_Integrin_isoDGR_2 270 272 PF01839 0.529
LIG_Integrin_isoDGR_2 407 409 PF01839 0.667
LIG_LIR_Apic_2 187 192 PF02991 0.529
LIG_LIR_Gen_1 351 360 PF02991 0.345
LIG_LIR_Gen_1 619 625 PF02991 0.516
LIG_LIR_Gen_1 97 106 PF02991 0.312
LIG_LIR_Nem_3 27 31 PF02991 0.308
LIG_LIR_Nem_3 310 316 PF02991 0.337
LIG_LIR_Nem_3 35 40 PF02991 0.340
LIG_LIR_Nem_3 351 355 PF02991 0.343
LIG_LIR_Nem_3 442 448 PF02991 0.536
LIG_LIR_Nem_3 540 545 PF02991 0.550
LIG_LIR_Nem_3 619 625 PF02991 0.516
LIG_LIR_Nem_3 97 103 PF02991 0.312
LIG_MLH1_MIPbox_1 34 38 PF16413 0.308
LIG_NRBOX 164 170 PF00104 0.478
LIG_PDZ_Class_3 620 625 PF00595 0.515
LIG_Pex14_1 258 262 PF04695 0.278
LIG_Pex14_2 185 189 PF04695 0.495
LIG_Pex14_2 28 32 PF04695 0.312
LIG_PTB_Apo_2 120 127 PF02174 0.295
LIG_SH2_CRK 263 267 PF00017 0.278
LIG_SH2_GRB2like 441 444 PF00017 0.450
LIG_SH2_NCK_1 527 531 PF00017 0.513
LIG_SH2_PTP2 352 355 PF00017 0.337
LIG_SH2_SRC 263 266 PF00017 0.321
LIG_SH2_SRC 352 355 PF00017 0.391
LIG_SH2_SRC 622 625 PF00017 0.517
LIG_SH2_STAP1 441 445 PF00017 0.453
LIG_SH2_STAT3 463 466 PF00017 0.521
LIG_SH2_STAT5 229 232 PF00017 0.388
LIG_SH2_STAT5 265 268 PF00017 0.285
LIG_SH2_STAT5 352 355 PF00017 0.337
LIG_SH3_3 205 211 PF00018 0.434
LIG_SH3_3 280 286 PF00018 0.353
LIG_SH3_3 431 437 PF00018 0.412
LIG_SH3_3 485 491 PF00018 0.544
LIG_SH3_3 580 586 PF00018 0.546
LIG_SH3_3 588 594 PF00018 0.510
LIG_SUMO_SIM_anti_2 240 249 PF11976 0.352
LIG_SUMO_SIM_anti_2 273 279 PF11976 0.329
LIG_SUMO_SIM_par_1 240 249 PF11976 0.375
LIG_SUMO_SIM_par_1 51 57 PF11976 0.312
LIG_TRFH_1 229 233 PF08558 0.388
LIG_TYR_ITIM 261 266 PF00017 0.329
LIG_UBA3_1 274 281 PF00899 0.329
MOD_CDK_SPxK_1 596 602 PF00069 0.518
MOD_CDK_SPxK_1 8 14 PF00069 0.593
MOD_CK1_1 122 128 PF00069 0.234
MOD_CK1_1 191 197 PF00069 0.526
MOD_CK1_1 537 543 PF00069 0.540
MOD_CK1_1 69 75 PF00069 0.524
MOD_CK2_1 105 111 PF00069 0.388
MOD_CK2_1 427 433 PF00069 0.486
MOD_GlcNHglycan 171 174 PF01048 0.295
MOD_GlcNHglycan 193 196 PF01048 0.326
MOD_GlcNHglycan 28 31 PF01048 0.295
MOD_GlcNHglycan 330 333 PF01048 0.584
MOD_GlcNHglycan 494 497 PF01048 0.747
MOD_GlcNHglycan 508 511 PF01048 0.668
MOD_GlcNHglycan 532 535 PF01048 0.651
MOD_GlcNHglycan 618 621 PF01048 0.717
MOD_GSK3_1 105 112 PF00069 0.414
MOD_GSK3_1 145 152 PF00069 0.529
MOD_GSK3_1 330 337 PF00069 0.351
MOD_GSK3_1 366 373 PF00069 0.507
MOD_GSK3_1 4 11 PF00069 0.586
MOD_GSK3_1 530 537 PF00069 0.458
MOD_GSK3_1 555 562 PF00069 0.527
MOD_GSK3_1 69 76 PF00069 0.563
MOD_N-GLC_1 221 226 PF02516 0.267
MOD_N-GLC_1 316 321 PF02516 0.577
MOD_N-GLC_1 530 535 PF02516 0.689
MOD_N-GLC_2 280 282 PF02516 0.589
MOD_NEK2_1 109 114 PF00069 0.312
MOD_NEK2_1 169 174 PF00069 0.491
MOD_NEK2_1 196 201 PF00069 0.452
MOD_NEK2_1 223 228 PF00069 0.427
MOD_NEK2_1 366 371 PF00069 0.519
MOD_NEK2_1 38 43 PF00069 0.313
MOD_NEK2_1 427 432 PF00069 0.541
MOD_NEK2_1 45 50 PF00069 0.314
MOD_NEK2_1 54 59 PF00069 0.399
MOD_NEK2_1 95 100 PF00069 0.312
MOD_NEK2_2 215 220 PF00069 0.495
MOD_NEK2_2 32 37 PF00069 0.330
MOD_NEK2_2 576 581 PF00069 0.515
MOD_PIKK_1 134 140 PF00454 0.388
MOD_PIKK_1 196 202 PF00454 0.495
MOD_PIKK_1 221 227 PF00454 0.495
MOD_PIKK_1 367 373 PF00454 0.487
MOD_PIKK_1 64 70 PF00454 0.279
MOD_PIKK_1 73 79 PF00454 0.529
MOD_PK_1 516 522 PF00069 0.450
MOD_PKA_2 114 120 PF00069 0.295
MOD_PKA_2 149 155 PF00069 0.522
MOD_PKA_2 515 521 PF00069 0.494
MOD_PKA_2 87 93 PF00069 0.529
MOD_PKB_1 326 334 PF00069 0.381
MOD_Plk_1 246 252 PF00069 0.295
MOD_Plk_4 105 111 PF00069 0.219
MOD_Plk_4 122 128 PF00069 0.300
MOD_Plk_4 237 243 PF00069 0.289
MOD_Plk_4 308 314 PF00069 0.388
MOD_Plk_4 318 324 PF00069 0.308
MOD_Plk_4 348 354 PF00069 0.350
MOD_Plk_4 374 380 PF00069 0.463
MOD_Plk_4 4 10 PF00069 0.567
MOD_Plk_4 40 46 PF00069 0.311
MOD_Plk_4 87 93 PF00069 0.518
MOD_Plk_4 95 101 PF00069 0.455
MOD_ProDKin_1 188 194 PF00069 0.505
MOD_ProDKin_1 202 208 PF00069 0.451
MOD_ProDKin_1 486 492 PF00069 0.520
MOD_ProDKin_1 535 541 PF00069 0.544
MOD_ProDKin_1 596 602 PF00069 0.518
MOD_ProDKin_1 8 14 PF00069 0.570
TRG_DiLeu_BaEn_1 320 325 PF01217 0.367
TRG_DiLeu_BaEn_1 4 9 PF01217 0.577
TRG_ENDOCYTIC_2 263 266 PF00928 0.278
TRG_ENDOCYTIC_2 352 355 PF00928 0.337
TRG_ENDOCYTIC_2 622 625 PF00928 0.517
TRG_ER_diArg_1 18 20 PF00400 0.571
TRG_ER_diArg_1 219 221 PF00400 0.495
TRG_ER_diArg_1 286 288 PF00400 0.429
TRG_ER_diArg_1 325 328 PF00400 0.400
TRG_ER_diArg_1 342 344 PF00400 0.324
TRG_ER_FFAT_2 187 194 PF00635 0.495
TRG_NES_CRM1_1 138 149 PF08389 0.340
TRG_NES_CRM1_1 345 356 PF08389 0.397
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.517
TRG_Pf-PMV_PEXEL_1 344 348 PF00026 0.552

Homologs

Protein Taxonomy Sequence identity Coverage
A4HKH5 Leishmania braziliensis 58% 95%
A4I802 Leishmania infantum 99% 100%
E9B2W4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q592 Leishmania major 89% 100%
V5DFX4 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS