Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5K4_LEIDO

TriTrypDb:

LdBPK_321890.1 , LdCL_320024400 , LDHU3_32.2380

Length:

153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.669
CLV_C14_Caspase3-7	67	71	PF00656	0.680
CLV_NRD_NRD_1	148	150	PF00675	0.670
CLV_NRD_NRD_1	5	7	PF00675	0.673
CLV_PCSK_KEX2_1	150	152	PF00082	0.644
CLV_PCSK_KEX2_1	5	7	PF00082	0.673
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.629
CLV_PCSK_SKI1_1	13	17	PF00082	0.707
DEG_SPOP_SBC_1	80	84	PF00917	0.669
DOC_USP7_MATH_1	4	8	PF00917	0.686
DOC_USP7_MATH_1	80	84	PF00917	0.679
DOC_USP7_UBL2_3	146	150	PF12436	0.661
LIG_14-3-3_CanoR_1	96	106	PF00244	0.735
LIG_APCC_ABBA_1	34	39	PF00400	0.590
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BRCT_BRCA1_1	106	110	PF00533	0.716
LIG_FHA_1	71	77	PF00498	0.635
LIG_FHA_2	52	58	PF00498	0.731
LIG_FHA_2	62	68	PF00498	0.638
LIG_LIR_Nem_3	107	113	PF02991	0.667
LIG_NRP_CendR_1	150	153	PF00754	0.722
LIG_PCNA_PIPBox_1	121	130	PF02747	0.545
LIG_Pex14_1	28	32	PF04695	0.620
LIG_PTB_Apo_2	126	133	PF02174	0.553
LIG_SH2_NCK_1	20	24	PF00017	0.676
LIG_SH2_STAT5	32	35	PF00017	0.589
LIG_TRAF2_1	50	53	PF00917	0.634
LIG_WRC_WIRS_1	124	129	PF05994	0.588
MOD_CK1_1	100	106	PF00069	0.745
MOD_CK1_1	109	115	PF00069	0.683
MOD_CK1_1	141	147	PF00069	0.654
MOD_CK1_1	60	66	PF00069	0.640
MOD_CK1_1	79	85	PF00069	0.618
MOD_CK2_1	61	67	PF00069	0.686
MOD_CK2_1	85	91	PF00069	0.638
MOD_Cter_Amidation	147	150	PF01082	0.607
MOD_GlcNHglycan	2	5	PF01048	0.642
MOD_GlcNHglycan	44	47	PF01048	0.645
MOD_GlcNHglycan	78	81	PF01048	0.647
MOD_GlcNHglycan	99	102	PF01048	0.604
MOD_GSK3_1	100	107	PF00069	0.673
MOD_GSK3_1	57	64	PF00069	0.626
MOD_GSK3_1	66	73	PF00069	0.650
MOD_GSK3_1	76	83	PF00069	0.561
MOD_N-GLC_1	141	146	PF02516	0.514
MOD_N-GLC_1	42	47	PF02516	0.593
MOD_NEK2_1	123	128	PF00069	0.565
MOD_PIKK_1	51	57	PF00454	0.674
MOD_PKA_2	4	10	PF00069	0.757
MOD_PKA_2	95	101	PF00069	0.739
MOD_Plk_1	42	48	PF00069	0.723
MOD_Plk_1	57	63	PF00069	0.671
MOD_Plk_4	123	129	PF00069	0.554
MOD_Plk_4	57	63	PF00069	0.639
MOD_SUMO_for_1	101	104	PF00179	0.657
TRG_DiLeu_BaEn_2	132	138	PF01217	0.594
TRG_ER_diArg_1	5	8	PF00400	0.722
TRG_NLS_MonoExtC_3	148	153	PF00514	0.681
TRG_NLS_MonoExtN_4	146	153	PF00514	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P974	Leptomonas seymouri	51%	100%
A0A1X0NT35	Trypanosomatidae	32%	90%
A0A422NH51	Trypanosoma rangeli	29%	95%
A4HKG8	Leishmania braziliensis	74%	100%
A4I7Z5	Leishmania infantum	99%	100%
D0AA62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
E9B2V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q599	Leishmania major	93%	100%