Putative cyclase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative cyclase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5K2_LEIDO

TriTrypDb:

LdBPK_321470.1 , LdCL_320020400 , LDHU3_32.1860

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S7X5K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5K2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0006520	amino acid metabolic process	3	10
GO:0006568	tryptophan metabolic process	5	10
GO:0006569	tryptophan catabolic process	5	10
GO:0006576	biogenic amine metabolic process	5	10
GO:0006586	indolalkylamine metabolic process	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009063	amino acid catabolic process	4	10
GO:0009072	aromatic amino acid metabolic process	4	10
GO:0009074	aromatic amino acid family catabolic process	5	10
GO:0009308	amine metabolic process	4	10
GO:0009987	cellular process	1	10
GO:0016054	organic acid catabolic process	4	10
GO:0019439	aromatic compound catabolic process	4	10
GO:0019441	tryptophan catabolic process to kynurenine	5	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0042180	cellular ketone metabolic process	3	10
GO:0042430	indole-containing compound metabolic process	4	10
GO:0042436	indole-containing compound catabolic process	5	10
GO:0042537	benzene-containing compound metabolic process	4	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044248	cellular catabolic process	3	10
GO:0044270	cellular nitrogen compound catabolic process	4	10
GO:0044281	small molecule metabolic process	2	10
GO:0044282	small molecule catabolic process	3	10
GO:0046395	carboxylic acid catabolic process	5	10
GO:0046483	heterocycle metabolic process	3	10
GO:0046700	heterocycle catabolic process	4	10
GO:0070189	kynurenine metabolic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901361	organic cyclic compound catabolic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901565	organonitrogen compound catabolic process	4	10
GO:1901575	organic substance catabolic process	3	10
GO:1901605	alpha-amino acid metabolic process	4	10
GO:1901606	alpha-amino acid catabolic process	5	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004061	arylformamidase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	10
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.343
CLV_NRD_NRD_1	105	107	PF00675	0.439
CLV_NRD_NRD_1	12	14	PF00675	0.551
CLV_PCSK_KEX2_1	105	107	PF00082	0.452
CLV_PCSK_KEX2_1	19	21	PF00082	0.599
CLV_PCSK_KEX2_1	92	94	PF00082	0.338
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.615
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.348
CLV_PCSK_SKI1_1	157	161	PF00082	0.541
CLV_PCSK_SKI1_1	20	24	PF00082	0.635
CLV_PCSK_SKI1_1	243	247	PF00082	0.463
CLV_PCSK_SKI1_1	289	293	PF00082	0.421
CLV_PCSK_SKI1_1	321	325	PF00082	0.529
CLV_PCSK_SKI1_1	93	97	PF00082	0.353
CLV_Separin_Metazoa	267	271	PF03568	0.215
DEG_APCC_DBOX_1	320	328	PF00400	0.329
DEG_MDM2_SWIB_1	103	111	PF02201	0.565
DOC_CYCLIN_RxL_1	239	248	PF00134	0.267
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.238
DOC_MAPK_FxFP_2	306	309	PF00069	0.329
DOC_MAPK_gen_1	19	30	PF00069	0.475
DOC_MAPK_MEF2A_6	270	277	PF00069	0.215
DOC_MAPK_MEF2A_6	317	324	PF00069	0.290
DOC_MAPK_MEF2A_6	57	65	PF00069	0.358
DOC_PP4_FxxP_1	306	309	PF00568	0.343
DOC_USP7_MATH_1	118	122	PF00917	0.499
DOC_USP7_MATH_1	22	26	PF00917	0.478
DOC_USP7_MATH_1	294	298	PF00917	0.313
DOC_USP7_MATH_1	75	79	PF00917	0.345
DOC_USP7_MATH_2	296	302	PF00917	0.215
DOC_USP7_UBL2_3	19	23	PF12436	0.447
DOC_USP7_UBL2_3	225	229	PF12436	0.345
DOC_WW_Pin1_4	144	149	PF00397	0.475
DOC_WW_Pin1_4	296	301	PF00397	0.262
DOC_WW_Pin1_4	326	331	PF00397	0.309
DOC_WW_Pin1_4	362	367	PF00397	0.387
DOC_WW_Pin1_4	48	53	PF00397	0.456
LIG_14-3-3_CanoR_1	113	123	PF00244	0.476
LIG_14-3-3_CanoR_1	137	144	PF00244	0.528
LIG_14-3-3_CanoR_1	157	162	PF00244	0.345
LIG_14-3-3_CanoR_1	178	185	PF00244	0.343
LIG_14-3-3_CanoR_1	258	268	PF00244	0.317
LIG_14-3-3_CanoR_1	398	403	PF00244	0.406
LIG_14-3-3_CanoR_1	57	65	PF00244	0.470
LIG_14-3-3_CanoR_1	93	99	PF00244	0.619
LIG_Actin_WH2_2	346	362	PF00022	0.381
LIG_BIR_III_4	396	400	PF00653	0.398
LIG_BRCT_BRCA1_1	120	124	PF00533	0.421
LIG_BRCT_BRCA1_1	400	404	PF00533	0.361
LIG_BRCT_BRCA1_1	77	81	PF00533	0.366
LIG_Clathr_ClatBox_1	324	328	PF01394	0.343
LIG_CtBP_PxDLS_1	27	31	PF00389	0.474
LIG_FHA_1	198	204	PF00498	0.310
LIG_FHA_1	217	223	PF00498	0.242
LIG_FHA_1	260	266	PF00498	0.334
LIG_FHA_1	35	41	PF00498	0.445
LIG_FHA_1	56	62	PF00498	0.391
LIG_FHA_2	166	172	PF00498	0.281
LIG_FHA_2	4	10	PF00498	0.445
LIG_GBD_Chelix_1	195	203	PF00786	0.529
LIG_GBD_Chelix_1	30	38	PF00786	0.569
LIG_LIR_Gen_1	121	132	PF02991	0.418
LIG_LIR_Gen_1	139	148	PF02991	0.344
LIG_LIR_Gen_1	2	11	PF02991	0.483
LIG_LIR_Gen_1	301	312	PF02991	0.337
LIG_LIR_Gen_1	51	61	PF02991	0.419
LIG_LIR_Nem_3	121	127	PF02991	0.368
LIG_LIR_Nem_3	130	135	PF02991	0.403
LIG_LIR_Nem_3	139	144	PF02991	0.439
LIG_LIR_Nem_3	2	8	PF02991	0.497
LIG_LIR_Nem_3	301	307	PF02991	0.346
LIG_LIR_Nem_3	51	56	PF02991	0.406
LIG_LIR_Nem_3	78	84	PF02991	0.386
LIG_LYPXL_yS_3	132	135	PF13949	0.453
LIG_MYND_1	48	52	PF01753	0.427
LIG_NRBOX	83	89	PF00104	0.398
LIG_Pex14_2	103	107	PF04695	0.576
LIG_PTB_Apo_2	355	362	PF02174	0.338
LIG_PTB_Phospho_1	355	361	PF10480	0.370
LIG_SH2_CRK	304	308	PF00017	0.310
LIG_SH2_CRK	361	365	PF00017	0.409
LIG_SH2_GRB2like	141	144	PF00017	0.463
LIG_SH2_SRC	185	188	PF00017	0.343
LIG_SH2_SRC	394	397	PF00017	0.412
LIG_SH2_STAP1	304	308	PF00017	0.298
LIG_SH2_STAT5	314	317	PF00017	0.293
LIG_SH2_STAT5	361	364	PF00017	0.407
LIG_SH3_3	145	151	PF00018	0.281
LIG_SH3_3	209	215	PF00018	0.334
LIG_SH3_3	225	231	PF00018	0.360
LIG_SH3_3	268	274	PF00018	0.291
LIG_SH3_3	329	335	PF00018	0.310
LIG_SH3_3	43	49	PF00018	0.417
LIG_SH3_3	63	69	PF00018	0.312
LIG_SUMO_SIM_anti_2	219	224	PF11976	0.343
LIG_SUMO_SIM_par_1	195	202	PF11976	0.248
LIG_SUMO_SIM_par_1	213	219	PF11976	0.345
LIG_SUMO_SIM_par_1	243	248	PF11976	0.281
LIG_SUMO_SIM_par_1	273	279	PF11976	0.250
LIG_TYR_ITIM	359	364	PF00017	0.398
MOD_CK1_1	251	257	PF00069	0.394
MOD_CK1_1	344	350	PF00069	0.317
MOD_CK1_1	383	389	PF00069	0.370
MOD_CK1_1	70	76	PF00069	0.322
MOD_CK1_1	94	100	PF00069	0.679
MOD_CK2_1	136	142	PF00069	0.497
MOD_GlcNHglycan	190	193	PF01048	0.511
MOD_GlcNHglycan	24	27	PF01048	0.636
MOD_GlcNHglycan	254	257	PF01048	0.575
MOD_GlcNHglycan	278	281	PF01048	0.587
MOD_GlcNHglycan	380	383	PF01048	0.571
MOD_GlcNHglycan	77	80	PF01048	0.492
MOD_GSK3_1	114	121	PF00069	0.478
MOD_GSK3_1	157	164	PF00069	0.265
MOD_GSK3_1	22	29	PF00069	0.467
MOD_GSK3_1	245	252	PF00069	0.326
MOD_GSK3_1	254	261	PF00069	0.289
MOD_GSK3_1	290	297	PF00069	0.360
MOD_GSK3_1	67	74	PF00069	0.236
MOD_N-GLC_1	142	147	PF02516	0.672
MOD_N-GLC_1	388	393	PF02516	0.639
MOD_NEK2_1	159	164	PF00069	0.284
MOD_NEK2_1	176	181	PF00069	0.344
MOD_NEK2_1	245	250	PF00069	0.271
MOD_NEK2_1	359	364	PF00069	0.396
MOD_NEK2_1	388	393	PF00069	0.439
MOD_NEK2_1	88	93	PF00069	0.525
MOD_PIKK_1	136	142	PF00454	0.491
MOD_PIKK_1	161	167	PF00454	0.329
MOD_PIKK_1	388	394	PF00454	0.384
MOD_PK_1	398	404	PF00069	0.399
MOD_PKA_2	136	142	PF00069	0.518
MOD_PKA_2	248	254	PF00069	0.310
MOD_PKA_2	359	365	PF00069	0.424
MOD_PKA_2	56	62	PF00069	0.468
MOD_PKB_1	129	137	PF00069	0.455
MOD_Plk_1	34	40	PF00069	0.321
MOD_Plk_2-3	328	334	PF00069	0.281
MOD_Plk_4	118	124	PF00069	0.425
MOD_Plk_4	344	350	PF00069	0.314
MOD_Plk_4	380	386	PF00069	0.329
MOD_Plk_4	398	404	PF00069	0.254
MOD_Plk_4	83	89	PF00069	0.373
MOD_ProDKin_1	144	150	PF00069	0.318
MOD_ProDKin_1	296	302	PF00069	0.262
MOD_ProDKin_1	326	332	PF00069	0.309
MOD_ProDKin_1	362	368	PF00069	0.383
MOD_ProDKin_1	48	54	PF00069	0.454
MOD_SUMO_rev_2	17	25	PF00179	0.430
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.631
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.281
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.418
TRG_ENDOCYTIC_2	132	135	PF00928	0.423
TRG_ENDOCYTIC_2	141	144	PF00928	0.495
TRG_ENDOCYTIC_2	304	307	PF00928	0.356
TRG_ENDOCYTIC_2	361	364	PF00928	0.407
TRG_ER_diArg_1	104	106	PF00400	0.651
TRG_NES_CRM1_1	263	276	PF08389	0.262
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9C3	Leptomonas seymouri	52%	100%
A0A0S4J7K0	Bodo saltans	28%	100%
A0A1X0NW41	Trypanosomatidae	37%	100%
A0A422NIA6	Trypanosoma rangeli	29%	100%
A4HKC9	Leishmania braziliensis	73%	100%
A4I7V8	Leishmania infantum	100%	100%
E9B2R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q5E1	Leishmania major	90%	100%