Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5J7_LEIDO

TriTrypDb:

LdBPK_321860.1 , LdCL_320024100 , LDHU3_32.2350

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5J7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.607
CLV_NRD_NRD_1	56	58	PF00675	0.556
CLV_PCSK_FUR_1	17	21	PF00082	0.518
CLV_PCSK_KEX2_1	19	21	PF00082	0.609
CLV_PCSK_KEX2_1	55	57	PF00082	0.550
CLV_PCSK_PC7_1	52	58	PF00082	0.530
CLV_PCSK_SKI1_1	166	170	PF00082	0.576
DEG_Nend_UBRbox_1	1	4	PF02207	0.499
DOC_MAPK_gen_1	17	27	PF00069	0.667
DOC_PP2B_LxvP_1	158	161	PF13499	0.605
DOC_PP2B_LxvP_1	25	28	PF13499	0.633
DOC_USP7_MATH_1	171	175	PF00917	0.662
DOC_USP7_UBL2_3	172	176	PF12436	0.690
LIG_14-3-3_CanoR_1	118	126	PF00244	0.545
LIG_deltaCOP1_diTrp_1	121	131	PF00928	0.558
LIG_FHA_2	134	140	PF00498	0.644
LIG_FHA_2	34	40	PF00498	0.709
LIG_FXI_DFP_1	29	33	PF00024	0.435
LIG_LIR_Gen_1	31	40	PF02991	0.575
LIG_LIR_Gen_1	9	18	PF02991	0.533
LIG_LIR_Nem_3	106	112	PF02991	0.516
LIG_LIR_Nem_3	31	35	PF02991	0.573
LIG_LIR_Nem_3	9	15	PF02991	0.553
LIG_REV1ctd_RIR_1	167	177	PF16727	0.678
LIG_SH2_CRK	88	92	PF00017	0.653
LIG_SH2_STAP1	119	123	PF00017	0.516
LIG_SH2_STAT5	100	103	PF00017	0.677
LIG_SH2_STAT5	119	122	PF00017	0.583
LIG_SH2_STAT5	145	148	PF00017	0.561
LIG_SUMO_SIM_anti_2	21	26	PF11976	0.641
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.592
LIG_TRAF2_1	36	39	PF00917	0.616
MOD_CK2_1	133	139	PF00069	0.671
MOD_CK2_1	171	177	PF00069	0.502
MOD_CK2_1	33	39	PF00069	0.670
MOD_LATS_1	92	98	PF00433	0.675
MOD_NEK2_1	70	75	PF00069	0.431
MOD_PKA_2	117	123	PF00069	0.524
MOD_PKA_2	62	68	PF00069	0.647
MOD_PKB_1	55	63	PF00069	0.474
MOD_Plk_1	38	44	PF00069	0.644
MOD_Plk_1	63	69	PF00069	0.651
MOD_Plk_4	86	92	PF00069	0.660
TRG_ENDOCYTIC_2	109	112	PF00928	0.548
TRG_ENDOCYTIC_2	12	15	PF00928	0.557
TRG_ENDOCYTIC_2	88	91	PF00928	0.650
TRG_ER_diArg_1	142	145	PF00400	0.558
TRG_ER_diArg_1	55	57	PF00400	0.481
TRG_ER_diLys_1	175	179	PF00400	0.710
TRG_NLS_MonoExtC_3	171	176	PF00514	0.683
TRG_Pf-PMV_PEXEL_1	2	6	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN5	Leptomonas seymouri	40%	98%
A4HKG5	Leishmania braziliensis	67%	99%
A4I7Z3	Leishmania infantum	99%	100%
E9B2V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5A2	Leishmania major	87%	100%