LeishMANIAdb
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Glutaredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Glutaredoxin domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X5J3_LEIDO
TriTrypDb:
LdBPK_321560.1 , LdCL_320021300 , LDHU3_32.1980
Length:
375

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5J3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5J3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 122 126 PF00656 0.609
CLV_C14_Caspase3-7 181 185 PF00656 0.619
CLV_C14_Caspase3-7 264 268 PF00656 0.461
CLV_C14_Caspase3-7 57 61 PF00656 0.461
CLV_NRD_NRD_1 148 150 PF00675 0.590
CLV_NRD_NRD_1 230 232 PF00675 0.566
CLV_NRD_NRD_1 257 259 PF00675 0.501
CLV_NRD_NRD_1 351 353 PF00675 0.615
CLV_NRD_NRD_1 75 77 PF00675 0.611
CLV_PCSK_KEX2_1 148 150 PF00082 0.593
CLV_PCSK_KEX2_1 230 232 PF00082 0.566
CLV_PCSK_KEX2_1 257 259 PF00082 0.501
CLV_PCSK_KEX2_1 75 77 PF00082 0.609
CLV_PCSK_SKI1_1 137 141 PF00082 0.474
DEG_APCC_DBOX_1 136 144 PF00400 0.517
DEG_APCC_DBOX_1 20 28 PF00400 0.518
DEG_Nend_UBRbox_2 1 3 PF02207 0.607
DOC_CKS1_1 236 241 PF01111 0.502
DOC_CKS1_1 322 327 PF01111 0.432
DOC_CYCLIN_RxL_1 48 57 PF00134 0.491
DOC_CYCLIN_yCln2_LP_2 164 170 PF00134 0.557
DOC_MAPK_gen_1 146 154 PF00069 0.539
DOC_MAPK_gen_1 230 236 PF00069 0.556
DOC_MAPK_gen_1 286 295 PF00069 0.463
DOC_MAPK_gen_1 88 97 PF00069 0.569
DOC_PP1_RVXF_1 255 262 PF00149 0.521
DOC_PP2B_LxvP_1 164 167 PF13499 0.615
DOC_PP4_FxxP_1 322 325 PF00568 0.427
DOC_USP7_MATH_1 155 159 PF00917 0.652
DOC_USP7_MATH_1 265 269 PF00917 0.454
DOC_USP7_MATH_1 82 86 PF00917 0.660
DOC_WW_Pin1_4 157 162 PF00397 0.640
DOC_WW_Pin1_4 200 205 PF00397 0.635
DOC_WW_Pin1_4 235 240 PF00397 0.628
DOC_WW_Pin1_4 321 326 PF00397 0.430
DOC_WW_Pin1_4 65 70 PF00397 0.592
DOC_WW_Pin1_4 78 83 PF00397 0.650
LIG_14-3-3_CanoR_1 127 131 PF00244 0.554
LIG_14-3-3_CanoR_1 352 357 PF00244 0.593
LIG_Actin_WH2_2 5 23 PF00022 0.597
LIG_APCC_ABBA_1 130 135 PF00400 0.532
LIG_BRCT_BRCA1_1 116 120 PF00533 0.557
LIG_BRCT_BRCA1_1 267 271 PF00533 0.429
LIG_BRCT_BRCA1_1 318 322 PF00533 0.457
LIG_FHA_1 126 132 PF00498 0.605
LIG_FHA_1 188 194 PF00498 0.703
LIG_FHA_1 236 242 PF00498 0.497
LIG_FHA_1 289 295 PF00498 0.462
LIG_FHA_1 356 362 PF00498 0.433
LIG_FHA_1 90 96 PF00498 0.623
LIG_FHA_2 117 123 PF00498 0.635
LIG_HCF-1_HBM_1 339 342 PF13415 0.388
LIG_LIR_Apic_2 319 325 PF02991 0.442
LIG_LIR_Gen_1 244 253 PF02991 0.440
LIG_LIR_Gen_1 270 279 PF02991 0.499
LIG_LIR_Gen_1 339 350 PF02991 0.444
LIG_LIR_Nem_3 244 249 PF02991 0.405
LIG_LIR_Nem_3 270 275 PF02991 0.492
LIG_LIR_Nem_3 339 345 PF02991 0.445
LIG_NRBOX 359 365 PF00104 0.421
LIG_RPA_C_Fungi 240 252 PF08784 0.454
LIG_SH2_STAT3 351 354 PF00017 0.459
LIG_SH2_STAT5 301 304 PF00017 0.434
LIG_SH2_STAT5 323 326 PF00017 0.434
LIG_SH2_STAT5 342 345 PF00017 0.233
LIG_SH2_STAT5 365 368 PF00017 0.435
LIG_SH3_3 10 16 PF00018 0.617
LIG_SH3_3 128 134 PF00018 0.580
LIG_SH3_3 149 155 PF00018 0.745
LIG_SH3_3 164 170 PF00018 0.656
LIG_SH3_3 233 239 PF00018 0.530
LIG_SUMO_SIM_par_1 206 213 PF11976 0.603
LIG_SUMO_SIM_par_1 51 57 PF11976 0.489
LIG_TRFH_1 130 134 PF08558 0.488
LIG_TRFH_1 342 346 PF08558 0.413
LIG_UBA3_1 139 146 PF00899 0.516
LIG_ULM_U2AF65_1 257 262 PF00076 0.526
MOD_CK1_1 156 162 PF00069 0.567
MOD_CK1_1 263 269 PF00069 0.549
MOD_CK1_1 282 288 PF00069 0.424
MOD_CK1_1 34 40 PF00069 0.569
MOD_CK1_1 355 361 PF00069 0.394
MOD_CK1_1 68 74 PF00069 0.615
MOD_CK1_1 81 87 PF00069 0.620
MOD_CK1_1 98 104 PF00069 0.519
MOD_CK2_1 116 122 PF00069 0.562
MOD_CK2_1 206 212 PF00069 0.577
MOD_CK2_1 34 40 PF00069 0.578
MOD_GlcNHglycan 115 119 PF01048 0.587
MOD_GlcNHglycan 2 6 PF01048 0.623
MOD_GlcNHglycan 249 252 PF01048 0.550
MOD_GlcNHglycan 281 284 PF01048 0.526
MOD_GlcNHglycan 33 36 PF01048 0.537
MOD_GSK3_1 153 160 PF00069 0.590
MOD_GSK3_1 263 270 PF00069 0.502
MOD_GSK3_1 71 78 PF00069 0.639
MOD_GSK3_1 95 102 PF00069 0.589
MOD_N-GLC_1 156 161 PF02516 0.548
MOD_N-GLC_1 182 187 PF02516 0.626
MOD_NEK2_1 1 6 PF00069 0.629
MOD_NEK2_1 116 121 PF00069 0.613
MOD_NEK2_1 144 149 PF00069 0.537
MOD_NEK2_1 241 246 PF00069 0.465
MOD_NEK2_1 95 100 PF00069 0.649
MOD_PK_1 352 358 PF00069 0.415
MOD_PKA_1 352 358 PF00069 0.596
MOD_PKA_1 75 81 PF00069 0.612
MOD_PKA_2 126 132 PF00069 0.549
MOD_PKA_2 20 26 PF00069 0.483
MOD_PKA_2 75 81 PF00069 0.651
MOD_PKB_1 258 266 PF00069 0.537
MOD_PKB_1 286 294 PF00069 0.471
MOD_Plk_1 150 156 PF00069 0.546
MOD_Plk_1 182 188 PF00069 0.606
MOD_Plk_4 126 132 PF00069 0.526
MOD_Plk_4 75 81 PF00069 0.692
MOD_ProDKin_1 157 163 PF00069 0.640
MOD_ProDKin_1 200 206 PF00069 0.635
MOD_ProDKin_1 235 241 PF00069 0.623
MOD_ProDKin_1 321 327 PF00069 0.431
MOD_ProDKin_1 65 71 PF00069 0.592
MOD_ProDKin_1 78 84 PF00069 0.650
TRG_DiLeu_BaEn_1 339 344 PF01217 0.416
TRG_DiLeu_BaEn_4 40 46 PF01217 0.552
TRG_ENDOCYTIC_2 299 302 PF00928 0.467
TRG_ENDOCYTIC_2 342 345 PF00928 0.448
TRG_ER_diArg_1 229 231 PF00400 0.610
TRG_ER_diArg_1 257 260 PF00400 0.515
TRG_ER_diArg_1 295 298 PF00400 0.468
TRG_ER_diArg_1 49 52 PF00400 0.525
TRG_Pf-PMV_PEXEL_1 215 220 PF00026 0.607
TRG_Pf-PMV_PEXEL_1 331 335 PF00026 0.435
TRG_Pf-PMV_PEXEL_1 43 48 PF00026 0.532

Homologs

Protein Taxonomy Sequence identity Coverage
A4HKD7 Leishmania braziliensis 61% 100%
A4I808 Leishmania infantum 99% 100%
E9B2S5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
Q4Q5D2 Leishmania major 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS