GTPase activating protein for Arf, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5J1_LEIDO

TriTrypDb:

LdBPK_321650.1 , LdCL_320022100 , LDHU3_32.2090

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5J1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	6
GO:0008047	enzyme activator activity	3	6
GO:0030234	enzyme regulator activity	2	6
GO:0030695	GTPase regulator activity	4	6
GO:0060589	nucleoside-triphosphatase regulator activity	3	6
GO:0098772	molecular function regulator activity	1	6
GO:0140677	molecular function activator activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.570
CLV_C14_Caspase3-7	285	289	PF00656	0.600
CLV_C14_Caspase3-7	642	646	PF00656	0.615
CLV_NRD_NRD_1	127	129	PF00675	0.530
CLV_NRD_NRD_1	314	316	PF00675	0.766
CLV_NRD_NRD_1	396	398	PF00675	0.825
CLV_NRD_NRD_1	399	401	PF00675	0.826
CLV_NRD_NRD_1	467	469	PF00675	0.719
CLV_NRD_NRD_1	564	566	PF00675	0.630
CLV_NRD_NRD_1	616	618	PF00675	0.717
CLV_NRD_NRD_1	669	671	PF00675	0.527
CLV_NRD_NRD_1	711	713	PF00675	0.598
CLV_PCSK_FUR_1	312	316	PF00082	0.691
CLV_PCSK_FUR_1	319	323	PF00082	0.632
CLV_PCSK_FUR_1	394	398	PF00082	0.828
CLV_PCSK_FUR_1	399	403	PF00082	0.793
CLV_PCSK_FUR_1	91	95	PF00082	0.530
CLV_PCSK_KEX2_1	127	129	PF00082	0.530
CLV_PCSK_KEX2_1	312	314	PF00082	0.767
CLV_PCSK_KEX2_1	318	320	PF00082	0.696
CLV_PCSK_KEX2_1	321	323	PF00082	0.666
CLV_PCSK_KEX2_1	324	326	PF00082	0.633
CLV_PCSK_KEX2_1	396	398	PF00082	0.830
CLV_PCSK_KEX2_1	399	401	PF00082	0.821
CLV_PCSK_KEX2_1	564	566	PF00082	0.630
CLV_PCSK_KEX2_1	616	618	PF00082	0.717
CLV_PCSK_KEX2_1	668	670	PF00082	0.569
CLV_PCSK_KEX2_1	711	713	PF00082	0.598
CLV_PCSK_KEX2_1	93	95	PF00082	0.524
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.766
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.736
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.703
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.853
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.524
CLV_PCSK_PC7_1	314	320	PF00082	0.767
CLV_PCSK_PC7_1	397	403	PF00082	0.812
CLV_PCSK_SKI1_1	17	21	PF00082	0.406
CLV_PCSK_SKI1_1	208	212	PF00082	0.693
CLV_PCSK_SKI1_1	229	233	PF00082	0.657
CLV_PCSK_SKI1_1	315	319	PF00082	0.790
CLV_PCSK_SKI1_1	357	361	PF00082	0.726
CLV_PCSK_SKI1_1	443	447	PF00082	0.722
CLV_PCSK_SKI1_1	484	488	PF00082	0.730
CLV_PCSK_SKI1_1	504	508	PF00082	0.506
CLV_PCSK_SKI1_1	603	607	PF00082	0.730
CLV_PCSK_SKI1_1	616	620	PF00082	0.640
CLV_PCSK_SKI1_1	718	722	PF00082	0.658
DEG_APCC_DBOX_1	16	24	PF00400	0.394
DEG_APCC_DBOX_1	401	409	PF00400	0.764
DEG_ODPH_VHL_1	436	447	PF01847	0.632
DEG_SCF_FBW7_1	169	175	PF00400	0.715
DEG_SCF_FBW7_1	546	553	PF00400	0.585
DEG_SPOP_SBC_1	240	244	PF00917	0.542
DEG_SPOP_SBC_1	521	525	PF00917	0.813
DOC_CDC14_PxL_1	434	442	PF14671	0.657
DOC_CKS1_1	169	174	PF01111	0.706
DOC_CKS1_1	685	690	PF01111	0.754
DOC_CYCLIN_yCln2_LP_2	606	612	PF00134	0.604
DOC_MAPK_DCC_7	427	436	PF00069	0.642
DOC_MAPK_gen_1	14	22	PF00069	0.478
DOC_MAPK_gen_1	174	182	PF00069	0.616
DOC_MAPK_gen_1	321	332	PF00069	0.622
DOC_MAPK_gen_1	67	75	PF00069	0.530
DOC_MAPK_gen_1	711	719	PF00069	0.596
DOC_MAPK_MEF2A_6	229	237	PF00069	0.686
DOC_MAPK_MEF2A_6	324	332	PF00069	0.748
DOC_MAPK_MEF2A_6	427	436	PF00069	0.740
DOC_PP2B_LxvP_1	620	623	PF13499	0.723
DOC_PP4_FxxP_1	581	584	PF00568	0.824
DOC_PP4_MxPP_1	326	329	PF00568	0.650
DOC_USP7_MATH_1	137	141	PF00917	0.684
DOC_USP7_MATH_1	172	176	PF00917	0.735
DOC_USP7_MATH_1	181	185	PF00917	0.675
DOC_USP7_MATH_1	194	198	PF00917	0.686
DOC_USP7_MATH_1	254	258	PF00917	0.698
DOC_USP7_MATH_1	273	277	PF00917	0.574
DOC_USP7_MATH_1	304	308	PF00917	0.846
DOC_USP7_MATH_1	413	417	PF00917	0.626
DOC_USP7_MATH_1	449	453	PF00917	0.784
DOC_USP7_MATH_1	456	460	PF00917	0.679
DOC_USP7_MATH_1	461	465	PF00917	0.620
DOC_USP7_MATH_1	521	525	PF00917	0.610
DOC_USP7_MATH_1	550	554	PF00917	0.587
DOC_USP7_MATH_1	556	560	PF00917	0.585
DOC_USP7_MATH_1	589	593	PF00917	0.811
DOC_USP7_MATH_1	659	663	PF00917	0.805
DOC_WW_Pin1_4	168	173	PF00397	0.823
DOC_WW_Pin1_4	203	208	PF00397	0.713
DOC_WW_Pin1_4	229	234	PF00397	0.665
DOC_WW_Pin1_4	261	266	PF00397	0.757
DOC_WW_Pin1_4	271	276	PF00397	0.620
DOC_WW_Pin1_4	357	362	PF00397	0.756
DOC_WW_Pin1_4	427	432	PF00397	0.772
DOC_WW_Pin1_4	478	483	PF00397	0.772
DOC_WW_Pin1_4	499	504	PF00397	0.671
DOC_WW_Pin1_4	507	512	PF00397	0.680
DOC_WW_Pin1_4	517	522	PF00397	0.613
DOC_WW_Pin1_4	546	551	PF00397	0.629
DOC_WW_Pin1_4	570	575	PF00397	0.772
DOC_WW_Pin1_4	618	623	PF00397	0.700
DOC_WW_Pin1_4	657	662	PF00397	0.762
DOC_WW_Pin1_4	672	677	PF00397	0.628
DOC_WW_Pin1_4	684	689	PF00397	0.630
LIG_14-3-3_CanoR_1	355	364	PF00244	0.722
LIG_14-3-3_CanoR_1	462	466	PF00244	0.666
LIG_14-3-3_CanoR_1	484	492	PF00244	0.716
LIG_14-3-3_CanoR_1	531	536	PF00244	0.636
LIG_14-3-3_CanoR_1	564	569	PF00244	0.718
LIG_14-3-3_CanoR_1	637	641	PF00244	0.647
LIG_14-3-3_CanoR_1	725	730	PF00244	0.682
LIG_ActinCP_TwfCPI_2	581	591	PF01115	0.612
LIG_BIR_II_1	1	5	PF00653	0.775
LIG_BIR_III_2	547	551	PF00653	0.587
LIG_BRCT_BRCA1_1	688	692	PF00533	0.761
LIG_CaM_IQ_9	1	16	PF13499	0.635
LIG_deltaCOP1_diTrp_1	74	83	PF00928	0.530
LIG_FHA_1	100	106	PF00498	0.316
LIG_FHA_1	171	177	PF00498	0.785
LIG_FHA_1	190	196	PF00498	0.490
LIG_FHA_1	230	236	PF00498	0.682
LIG_FHA_1	264	270	PF00498	0.727
LIG_FHA_1	278	284	PF00498	0.604
LIG_FHA_1	358	364	PF00498	0.802
LIG_FHA_1	373	379	PF00498	0.581
LIG_FHA_1	404	410	PF00498	0.774
LIG_FHA_1	442	448	PF00498	0.799
LIG_FHA_1	485	491	PF00498	0.781
LIG_FHA_1	508	514	PF00498	0.722
LIG_FHA_1	6	12	PF00498	0.590
LIG_FHA_1	698	704	PF00498	0.758
LIG_FHA_1	70	76	PF00498	0.530
LIG_FHA_2	283	289	PF00498	0.715
LIG_FHA_2	531	537	PF00498	0.757
LIG_LIR_Apic_2	102	107	PF02991	0.519
LIG_LIR_Apic_2	627	633	PF02991	0.686
LIG_LIR_Gen_1	40	49	PF02991	0.530
LIG_LIR_Nem_3	40	44	PF02991	0.400
LIG_LIR_Nem_3	417	423	PF02991	0.742
LIG_NRBOX	18	24	PF00104	0.530
LIG_PCNA_yPIPBox_3	9	23	PF02747	0.571
LIG_SH2_CRK	130	134	PF00017	0.658
LIG_SH2_PTP2	104	107	PF00017	0.530
LIG_SH2_PTP2	630	633	PF00017	0.609
LIG_SH2_SRC	630	633	PF00017	0.609
LIG_SH2_STAP1	96	100	PF00017	0.413
LIG_SH2_STAT5	104	107	PF00017	0.530
LIG_SH2_STAT5	124	127	PF00017	0.199
LIG_SH2_STAT5	215	218	PF00017	0.661
LIG_SH2_STAT5	611	614	PF00017	0.610
LIG_SH2_STAT5	630	633	PF00017	0.595
LIG_SH3_1	129	135	PF00018	0.581
LIG_SH3_1	166	172	PF00018	0.715
LIG_SH3_1	325	331	PF00018	0.612
LIG_SH3_2	169	174	PF14604	0.609
LIG_SH3_3	129	135	PF00018	0.604
LIG_SH3_3	166	172	PF00018	0.765
LIG_SH3_3	244	250	PF00018	0.814
LIG_SH3_3	259	265	PF00018	0.572
LIG_SH3_3	284	290	PF00018	0.631
LIG_SH3_3	325	331	PF00018	0.675
LIG_SH3_3	344	350	PF00018	0.582
LIG_SH3_3	429	435	PF00018	0.621
LIG_SH3_3	479	485	PF00018	0.816
LIG_SH3_3	515	521	PF00018	0.661
LIG_SH3_3	619	625	PF00018	0.666
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.742
LIG_SUMO_SIM_par_1	263	271	PF11976	0.750
LIG_SUMO_SIM_par_1	276	286	PF11976	0.574
LIG_SUMO_SIM_par_1	443	448	PF11976	0.720
LIG_TRAF2_1	236	239	PF00917	0.528
LIG_TRAF2_1	303	306	PF00917	0.643
LIG_TRAF2_1	371	374	PF00917	0.663
LIG_TRAF2_1	385	388	PF00917	0.686
LIG_TRAF2_1	534	537	PF00917	0.569
LIG_UBA3_1	19	24	PF00899	0.394
LIG_WW_3	490	494	PF00397	0.774
MOD_CDC14_SPxK_1	481	484	PF00782	0.733
MOD_CDK_SPK_2	203	208	PF00069	0.697
MOD_CDK_SPK_2	499	504	PF00069	0.615
MOD_CDK_SPxK_1	168	174	PF00069	0.691
MOD_CDK_SPxK_1	478	484	PF00069	0.736
MOD_CK1_1	214	220	PF00069	0.616
MOD_CK1_1	261	267	PF00069	0.763
MOD_CK1_1	274	280	PF00069	0.653
MOD_CK1_1	389	395	PF00069	0.743
MOD_CK1_1	416	422	PF00069	0.671
MOD_CK1_1	426	432	PF00069	0.716
MOD_CK1_1	520	526	PF00069	0.710
MOD_CK1_1	560	566	PF00069	0.803
MOD_CK1_1	639	645	PF00069	0.748
MOD_CK1_1	662	668	PF00069	0.763
MOD_CK1_1	672	678	PF00069	0.682
MOD_CK2_1	530	536	PF00069	0.764
MOD_GlcNHglycan	111	115	PF01048	0.452
MOD_GlcNHglycan	135	138	PF01048	0.560
MOD_GlcNHglycan	139	143	PF01048	0.569
MOD_GlcNHglycan	243	246	PF01048	0.794
MOD_GlcNHglycan	305	309	PF01048	0.819
MOD_GlcNHglycan	33	37	PF01048	0.413
MOD_GlcNHglycan	423	426	PF01048	0.699
MOD_GlcNHglycan	524	527	PF01048	0.746
MOD_GlcNHglycan	54	57	PF01048	0.369
MOD_GlcNHglycan	552	555	PF01048	0.726
MOD_GlcNHglycan	560	563	PF01048	0.688
MOD_GlcNHglycan	679	684	PF01048	0.699
MOD_GSK3_1	133	140	PF00069	0.550
MOD_GSK3_1	168	175	PF00069	0.715
MOD_GSK3_1	176	183	PF00069	0.661
MOD_GSK3_1	254	261	PF00069	0.689
MOD_GSK3_1	271	278	PF00069	0.700
MOD_GSK3_1	313	320	PF00069	0.721
MOD_GSK3_1	423	430	PF00069	0.773
MOD_GSK3_1	517	524	PF00069	0.694
MOD_GSK3_1	546	553	PF00069	0.758
MOD_GSK3_1	556	563	PF00069	0.708
MOD_GSK3_1	566	573	PF00069	0.550
MOD_GSK3_1	63	70	PF00069	0.436
MOD_GSK3_1	635	642	PF00069	0.825
MOD_GSK3_1	651	658	PF00069	0.546
MOD_GSK3_1	693	700	PF00069	0.679
MOD_GSK3_1	96	103	PF00069	0.522
MOD_N-GLC_1	203	208	PF02516	0.705
MOD_N-GLC_1	557	562	PF02516	0.754
MOD_N-GLC_1	662	667	PF02516	0.714
MOD_NEK2_1	211	216	PF00069	0.680
MOD_NEK2_1	241	246	PF00069	0.778
MOD_NEK2_1	258	263	PF00069	0.523
MOD_NEK2_1	32	37	PF00069	0.413
MOD_NEK2_1	423	428	PF00069	0.758
MOD_NEK2_1	557	562	PF00069	0.763
MOD_NEK2_1	612	617	PF00069	0.785
MOD_NEK2_1	692	697	PF00069	0.621
MOD_NEK2_2	172	177	PF00069	0.714
MOD_NEK2_2	438	443	PF00069	0.592
MOD_PIKK_1	450	456	PF00454	0.574
MOD_PIKK_1	484	490	PF00454	0.849
MOD_PIKK_1	687	693	PF00454	0.751
MOD_PK_1	531	537	PF00069	0.582
MOD_PKA_1	313	319	PF00069	0.768
MOD_PKA_1	564	570	PF00069	0.625
MOD_PKA_1	669	675	PF00069	0.527
MOD_PKA_2	109	115	PF00069	0.355
MOD_PKA_2	176	182	PF00069	0.751
MOD_PKA_2	313	319	PF00069	0.768
MOD_PKA_2	426	432	PF00069	0.735
MOD_PKA_2	461	467	PF00069	0.663
MOD_PKA_2	5	11	PF00069	0.564
MOD_PKA_2	52	58	PF00069	0.369
MOD_PKA_2	530	536	PF00069	0.638
MOD_PKA_2	563	569	PF00069	0.718
MOD_PKA_2	582	588	PF00069	0.547
MOD_PKA_2	636	642	PF00069	0.747
MOD_PKA_2	655	661	PF00069	0.533
MOD_PKA_2	669	675	PF00069	0.668
MOD_PKB_1	353	361	PF00069	0.716
MOD_PKB_1	723	731	PF00069	0.684
MOD_Plk_1	211	217	PF00069	0.636
MOD_Plk_1	373	379	PF00069	0.625
MOD_Plk_1	416	422	PF00069	0.701
MOD_Plk_1	662	668	PF00069	0.729
MOD_Plk_1	96	102	PF00069	0.530
MOD_Plk_4	100	106	PF00069	0.530
MOD_Plk_4	211	217	PF00069	0.679
MOD_Plk_4	248	254	PF00069	0.657
MOD_Plk_4	263	269	PF00069	0.652
MOD_Plk_4	277	283	PF00069	0.583
MOD_Plk_4	373	379	PF00069	0.691
MOD_Plk_4	669	675	PF00069	0.726
MOD_ProDKin_1	168	174	PF00069	0.825
MOD_ProDKin_1	203	209	PF00069	0.711
MOD_ProDKin_1	229	235	PF00069	0.673
MOD_ProDKin_1	261	267	PF00069	0.761
MOD_ProDKin_1	271	277	PF00069	0.622
MOD_ProDKin_1	357	363	PF00069	0.760
MOD_ProDKin_1	427	433	PF00069	0.775
MOD_ProDKin_1	478	484	PF00069	0.775
MOD_ProDKin_1	499	505	PF00069	0.671
MOD_ProDKin_1	507	513	PF00069	0.684
MOD_ProDKin_1	517	523	PF00069	0.614
MOD_ProDKin_1	546	552	PF00069	0.625
MOD_ProDKin_1	570	576	PF00069	0.773
MOD_ProDKin_1	618	624	PF00069	0.702
MOD_ProDKin_1	657	663	PF00069	0.763
MOD_ProDKin_1	672	678	PF00069	0.629
MOD_ProDKin_1	684	690	PF00069	0.632
MOD_SUMO_for_1	371	374	PF00179	0.622
MOD_SUMO_rev_2	382	392	PF00179	0.682
MOD_SUMO_rev_2	621	631	PF00179	0.677
TRG_DiLeu_BaEn_1	715	720	PF01217	0.463
TRG_DiLeu_BaEn_2	78	84	PF01217	0.530
TRG_DiLeu_BaEn_3	536	542	PF01217	0.578
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.626
TRG_DiLeu_LyEn_5	509	514	PF01217	0.705
TRG_DiLeu_LyEn_5	715	720	PF01217	0.463
TRG_ENDOCYTIC_2	130	133	PF00928	0.611
TRG_ER_diArg_1	127	129	PF00400	0.530
TRG_ER_diArg_1	311	314	PF00400	0.759
TRG_ER_diArg_1	394	397	PF00400	0.829
TRG_ER_diArg_1	399	402	PF00400	0.794
TRG_ER_diArg_1	465	468	PF00400	0.629
TRG_ER_diArg_1	590	593	PF00400	0.716
TRG_ER_diArg_1	668	670	PF00400	0.526
TRG_ER_diArg_1	711	713	PF00400	0.656
TRG_NES_CRM1_1	708	722	PF08389	0.602
TRG_NLS_MonoExtC_3	317	322	PF00514	0.634
TRG_NLS_MonoExtC_3	399	404	PF00514	0.766
TRG_NLS_MonoExtN_4	315	322	PF00514	0.634
TRG_NLS_MonoExtN_4	397	404	PF00514	0.840
TRG_NLS_MonoExtN_4	466	472	PF00514	0.621
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HKE4	Leishmania braziliensis	48%	100%
A4I7X2	Leishmania infantum	99%	100%
E9B2T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q5C4	Leishmania major	80%	100%