NYN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5I4_LEIDO

TriTrypDb:

LdBPK_321690.1 , LdCL_320022400 , LDHU3_32.2150

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5I4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.552
CLV_C14_Caspase3-7	56	60	PF00656	0.622
CLV_NRD_NRD_1	231	233	PF00675	0.443
CLV_NRD_NRD_1	239	241	PF00675	0.535
CLV_PCSK_FUR_1	229	233	PF00082	0.555
CLV_PCSK_KEX2_1	173	175	PF00082	0.422
CLV_PCSK_KEX2_1	231	233	PF00082	0.445
CLV_PCSK_KEX2_1	239	241	PF00082	0.538
CLV_PCSK_KEX2_1	260	262	PF00082	0.388
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.493
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.388
CLV_PCSK_SKI1_1	231	235	PF00082	0.555
DEG_APCC_DBOX_1	273	281	PF00400	0.450
DEG_Nend_Nbox_1	1	3	PF02207	0.544
DOC_CKS1_1	187	192	PF01111	0.483
DOC_CYCLIN_RxL_1	228	238	PF00134	0.488
DOC_MAPK_DCC_7	95	105	PF00069	0.480
DOC_MAPK_gen_1	173	181	PF00069	0.435
DOC_PP4_FxxP_1	187	190	PF00568	0.469
DOC_PP4_FxxP_1	40	43	PF00568	0.459
DOC_USP7_MATH_1	148	152	PF00917	0.548
DOC_USP7_MATH_1	282	286	PF00917	0.529
DOC_USP7_MATH_1	71	75	PF00917	0.582
DOC_WW_Pin1_4	186	191	PF00397	0.336
DOC_WW_Pin1_4	98	103	PF00397	0.411
LIG_14-3-3_CanoR_1	162	167	PF00244	0.570
LIG_14-3-3_CanoR_1	90	98	PF00244	0.389
LIG_APCC_ABBA_1	120	125	PF00400	0.508
LIG_Clathr_ClatBox_1	106	110	PF01394	0.311
LIG_eIF4E_1	123	129	PF01652	0.402
LIG_eIF4E_1	228	234	PF01652	0.505
LIG_FHA_1	212	218	PF00498	0.471
LIG_FHA_1	82	88	PF00498	0.411
LIG_FHA_2	152	158	PF00498	0.567
LIG_FHA_2	274	280	PF00498	0.493
LIG_LIR_Gen_1	175	181	PF02991	0.370
LIG_LIR_Gen_1	4	15	PF02991	0.651
LIG_LIR_Gen_1	45	54	PF02991	0.412
LIG_LIR_Gen_1	89	98	PF02991	0.510
LIG_LIR_Nem_3	175	180	PF02991	0.327
LIG_LIR_Nem_3	259	265	PF02991	0.505
LIG_LIR_Nem_3	4	10	PF02991	0.581
LIG_LIR_Nem_3	45	51	PF02991	0.443
LIG_LYPXL_yS_3	123	126	PF13949	0.331
LIG_PDZ_Class_1	286	291	PF00595	0.490
LIG_Pex14_2	138	142	PF04695	0.377
LIG_Pex14_2	262	266	PF04695	0.348
LIG_PTB_Apo_2	108	115	PF02174	0.354
LIG_PTB_Apo_2	222	229	PF02174	0.390
LIG_PTB_Phospho_1	222	228	PF10480	0.383
LIG_SH3_1	118	124	PF00018	0.326
LIG_SH3_3	118	124	PF00018	0.432
LIG_SH3_3	152	158	PF00018	0.537
LIG_SUMO_SIM_anti_2	101	108	PF11976	0.310
LIG_SUMO_SIM_anti_2	125	130	PF11976	0.467
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.449
LIG_SUMO_SIM_par_1	101	108	PF11976	0.319
LIG_SUMO_SIM_par_1	213	218	PF11976	0.331
LIG_TRAF2_1	43	46	PF00917	0.515
LIG_UBA3_1	233	237	PF00899	0.570
LIG_WRC_WIRS_1	134	139	PF05994	0.420
MOD_CK1_1	13	19	PF00069	0.683
MOD_CK1_1	140	146	PF00069	0.431
MOD_CK1_1	151	157	PF00069	0.480
MOD_CK1_1	89	95	PF00069	0.455
MOD_CK2_1	151	157	PF00069	0.486
MOD_CK2_1	172	178	PF00069	0.447
MOD_GlcNHglycan	67	70	PF01048	0.606
MOD_GSK3_1	133	140	PF00069	0.441
MOD_GSK3_1	168	175	PF00069	0.615
MOD_GSK3_1	211	218	PF00069	0.431
MOD_GSK3_1	244	251	PF00069	0.513
MOD_GSK3_1	282	289	PF00069	0.655
MOD_N-GLC_1	286	291	PF02516	0.552
MOD_N-GLC_1	98	103	PF02516	0.522
MOD_NEK2_1	133	138	PF00069	0.341
MOD_NEK2_1	273	278	PF00069	0.422
MOD_PIKK_1	192	198	PF00454	0.413
MOD_PK_1	162	168	PF00069	0.620
MOD_PKA_2	273	279	PF00069	0.434
MOD_PKA_2	89	95	PF00069	0.391
MOD_Plk_1	151	157	PF00069	0.432
MOD_Plk_1	3	9	PF00069	0.598
MOD_Plk_2-3	3	9	PF00069	0.415
MOD_Plk_4	211	217	PF00069	0.472
MOD_Plk_4	248	254	PF00069	0.535
MOD_ProDKin_1	186	192	PF00069	0.346
MOD_ProDKin_1	98	104	PF00069	0.402
TRG_DiLeu_BaEn_1	18	23	PF01217	0.489
TRG_DiLeu_BaEn_3	45	51	PF01217	0.488
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.642
TRG_ENDOCYTIC_2	123	126	PF00928	0.491
TRG_ENDOCYTIC_2	91	94	PF00928	0.528
TRG_ER_diArg_1	228	231	PF00400	0.450
TRG_NES_CRM1_1	207	220	PF08389	0.429
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW3	Leptomonas seymouri	68%	98%
A0A1X0NUU9	Trypanosomatidae	47%	94%
A0A422NL68	Trypanosoma rangeli	40%	100%
A4HKE8	Leishmania braziliensis	80%	100%
A4I7X6	Leishmania infantum	100%	100%
D0AA41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	93%
E9B2T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q5C0	Leishmania major	96%	100%
V5BF01	Trypanosoma cruzi	39%	100%