Translation initiation factor eIF3 subunit 135, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translation initiation factor eIF3 subunit 135, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5I2_LEIDO

TriTrypDb:

LdBPK_321640.1 , LdCL_320022000 , LDHU3_32.2070

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2

Previous1Next

Expansion

Sequence features

A0A3S7X5I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5I2

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003743	translation initiation factor activity	4	3
GO:0005488	binding	1	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.530
CLV_C14_Caspase3-7	432	436	PF00656	0.560
CLV_NRD_NRD_1	327	329	PF00675	0.300
CLV_NRD_NRD_1	42	44	PF00675	0.661
CLV_NRD_NRD_1	456	458	PF00675	0.300
CLV_NRD_NRD_1	652	654	PF00675	0.414
CLV_NRD_NRD_1	77	79	PF00675	0.708
CLV_NRD_NRD_1	809	811	PF00675	0.680
CLV_NRD_NRD_1	882	884	PF00675	0.521
CLV_PCSK_FUR_1	454	458	PF00082	0.300

Previous1 2 3 4 5…30Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B5	Leptomonas seymouri	45%	100%
A0A0S4IN68	Bodo saltans	26%	100%
A0A1X0NUD8	Trypanosomatidae	28%	100%
A0A422NLC9	Trypanosoma rangeli	29%	100%
A4HKE3	Leishmania braziliensis	70%	100%
A4I7X1	Leishmania infantum	100%	100%
E9B2T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q5C5	Leishmania major	92%	100%
V5BP08	Trypanosoma cruzi	30%	100%

Previous1Next