Hypothetical_protein_conserved

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5I1_LEIDO

TriTrypDb:

LdBPK_321540.1 , LdCL_320021100 , LDHU3_32.1940

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 450, 459, 470

Expansion

Sequence features

A0A3S7X5I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5I1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	412	418	PF00089	0.666
CLV_NRD_NRD_1	188	190	PF00675	0.408
CLV_NRD_NRD_1	212	214	PF00675	0.502
CLV_NRD_NRD_1	273	275	PF00675	0.474
CLV_NRD_NRD_1	410	412	PF00675	0.606
CLV_NRD_NRD_1	428	430	PF00675	0.484
CLV_NRD_NRD_1	51	53	PF00675	0.541
CLV_PCSK_KEX2_1	190	192	PF00082	0.572
CLV_PCSK_KEX2_1	273	275	PF00082	0.474
CLV_PCSK_KEX2_1	410	412	PF00082	0.608
CLV_PCSK_KEX2_1	51	53	PF00082	0.549
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.572
CLV_PCSK_SKI1_1	184	188	PF00082	0.523
CLV_PCSK_SKI1_1	273	277	PF00082	0.459
CLV_PCSK_SKI1_1	291	295	PF00082	0.481
CLV_PCSK_SKI1_1	429	433	PF00082	0.587
CLV_PCSK_SKI1_1	435	439	PF00082	0.540
CLV_PCSK_SKI1_1	83	87	PF00082	0.577
CLV_PCSK_SKI1_1	9	13	PF00082	0.804
CLV_PCSK_SKI1_1	95	99	PF00082	0.557
DEG_APCC_DBOX_1	414	422	PF00400	0.654
DEG_APCC_KENBOX_2	354	358	PF00400	0.650
DEG_SPOP_SBC_1	446	450	PF00917	0.784
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.600
DOC_MAPK_gen_1	189	200	PF00069	0.469
DOC_MAPK_gen_1	294	303	PF00069	0.564
DOC_MAPK_MEF2A_6	193	202	PF00069	0.452
DOC_PP1_RVXF_1	136	143	PF00149	0.499
DOC_PP1_RVXF_1	170	177	PF00149	0.423
DOC_PP1_RVXF_1	182	189	PF00149	0.402
DOC_PP1_RVXF_1	44	51	PF00149	0.678
DOC_PP1_RVXF_1	81	87	PF00149	0.586
DOC_PP1_RVXF_1	93	100	PF00149	0.571
DOC_PP2B_LxvP_1	390	393	PF13499	0.580
DOC_PP2B_LxvP_1	422	425	PF13499	0.567
DOC_PP4_FxxP_1	202	205	PF00568	0.509
DOC_PP4_FxxP_1	248	251	PF00568	0.533
DOC_PP4_FxxP_1	283	286	PF00568	0.459
DOC_USP7_MATH_1	447	451	PF00917	0.784
DOC_USP7_UBL2_3	210	214	PF12436	0.522
DOC_USP7_UBL2_3	91	95	PF12436	0.710
DOC_WW_Pin1_4	319	324	PF00397	0.501
DOC_WW_Pin1_4	467	472	PF00397	0.764
DOC_WW_Pin1_4	90	95	PF00397	0.599
LIG_14-3-3_CanoR_1	191	200	PF00244	0.489
LIG_14-3-3_CanoR_1	415	419	PF00244	0.654
LIG_APCC_ABBA_1	71	76	PF00400	0.590
LIG_BRCT_BRCA1_1	150	154	PF00533	0.463
LIG_BRCT_BRCA1_1	387	391	PF00533	0.578
LIG_BRCT_BRCA1_1	57	61	PF00533	0.497
LIG_deltaCOP1_diTrp_1	329	338	PF00928	0.455
LIG_deltaCOP1_diTrp_1	76	86	PF00928	0.586
LIG_eIF4E_1	284	290	PF01652	0.501
LIG_FHA_1	135	141	PF00498	0.516
LIG_FHA_1	153	159	PF00498	0.424
LIG_FHA_1	181	187	PF00498	0.402
LIG_FHA_1	193	199	PF00498	0.491
LIG_FHA_1	252	258	PF00498	0.487
LIG_FHA_1	290	296	PF00498	0.578
LIG_FHA_1	302	308	PF00498	0.522
LIG_FHA_1	387	393	PF00498	0.617
LIG_FHA_1	426	432	PF00498	0.555
LIG_FHA_1	452	458	PF00498	0.738
LIG_FHA_2	295	301	PF00498	0.607
LIG_FHA_2	320	326	PF00498	0.472
LIG_FHA_2	436	442	PF00498	0.581
LIG_FHA_2	63	69	PF00498	0.623
LIG_FHA_2	96	102	PF00498	0.594
LIG_LIR_Apic_2	245	251	PF02991	0.543
LIG_LIR_Apic_2	282	286	PF02991	0.462
LIG_LIR_Gen_1	121	130	PF02991	0.545
LIG_LIR_Gen_1	151	161	PF02991	0.443
LIG_LIR_Gen_1	196	205	PF02991	0.536
LIG_LIR_Gen_1	206	215	PF02991	0.545
LIG_LIR_Gen_1	240	251	PF02991	0.559
LIG_LIR_Gen_1	265	272	PF02991	0.436
LIG_LIR_Gen_1	362	370	PF02991	0.571
LIG_LIR_Nem_3	121	127	PF02991	0.500
LIG_LIR_Nem_3	151	157	PF02991	0.448
LIG_LIR_Nem_3	196	202	PF02991	0.476
LIG_LIR_Nem_3	206	211	PF02991	0.427
LIG_LIR_Nem_3	240	246	PF02991	0.581
LIG_LIR_Nem_3	25	29	PF02991	0.633
LIG_LIR_Nem_3	265	269	PF02991	0.425
LIG_LIR_Nem_3	315	321	PF02991	0.497
LIG_LIR_Nem_3	362	366	PF02991	0.587
LIG_LIR_Nem_3	388	394	PF02991	0.614
LIG_LIR_Nem_3	433	437	PF02991	0.577
LIG_LIR_Nem_3	47	53	PF02991	0.547
LIG_PCNA_yPIPBox_3	397	411	PF02747	0.622
LIG_Pex14_2	124	128	PF04695	0.382
LIG_Pex14_2	86	90	PF04695	0.589
LIG_PTB_Apo_2	354	361	PF02174	0.565
LIG_SH2_CRK	26	30	PF00017	0.625
LIG_SH2_NCK_1	321	325	PF00017	0.503
LIG_SH2_STAP1	194	198	PF00017	0.488
LIG_SH2_STAP1	220	224	PF00017	0.514
LIG_SH2_STAP1	255	259	PF00017	0.472
LIG_SH2_STAT5	129	132	PF00017	0.456
LIG_SH2_STAT5	194	197	PF00017	0.505
LIG_SH2_STAT5	199	202	PF00017	0.416
LIG_SH2_STAT5	321	324	PF00017	0.482
LIG_SH2_STAT5	352	355	PF00017	0.558
LIG_SH3_3	18	24	PF00018	0.648
LIG_SUMO_SIM_par_1	110	117	PF11976	0.505
LIG_TRAF2_1	36	39	PF00917	0.641
LIG_TRAF2_1	75	78	PF00917	0.605
MOD_CDK_SPK_2	90	95	PF00069	0.611
MOD_CK1_1	192	198	PF00069	0.502
MOD_CK1_1	362	368	PF00069	0.586
MOD_CK1_1	414	420	PF00069	0.571
MOD_CK1_1	44	50	PF00069	0.676
MOD_CK2_1	146	152	PF00069	0.436
MOD_CK2_1	294	300	PF00069	0.676
MOD_CK2_1	319	325	PF00069	0.502
MOD_CK2_1	33	39	PF00069	0.684
MOD_CK2_1	62	68	PF00069	0.638
MOD_CK2_1	95	101	PF00069	0.582
MOD_GlcNHglycan	142	145	PF01048	0.484
MOD_GlcNHglycan	259	262	PF01048	0.454
MOD_GlcNHglycan	459	462	PF01048	0.670
MOD_GSK3_1	128	135	PF00069	0.510
MOD_GSK3_1	148	155	PF00069	0.424
MOD_GSK3_1	180	187	PF00069	0.441
MOD_GSK3_1	189	196	PF00069	0.479
MOD_GSK3_1	29	36	PF00069	0.679
MOD_GSK3_1	392	399	PF00069	0.628
MOD_GSK3_1	441	448	PF00069	0.670
MOD_GSK3_1	453	460	PF00069	0.671
MOD_GSK3_1	463	470	PF00069	0.776
MOD_N-GLC_1	396	401	PF02516	0.629
MOD_NEK2_1	140	145	PF00069	0.525
MOD_NEK2_1	289	294	PF00069	0.547
MOD_NEK2_1	29	34	PF00069	0.645
MOD_NEK2_1	41	46	PF00069	0.601
MOD_NEK2_2	386	391	PF00069	0.591
MOD_PIKK_1	284	290	PF00454	0.485
MOD_PIKK_1	448	454	PF00454	0.650
MOD_PKA_1	189	195	PF00069	0.484
MOD_PKA_2	192	198	PF00069	0.493
MOD_PKA_2	284	290	PF00069	0.485
MOD_PKA_2	29	35	PF00069	0.607
MOD_PKA_2	414	420	PF00069	0.656
MOD_PKA_2	441	447	PF00069	0.608
MOD_PKB_1	191	199	PF00069	0.611
MOD_Plk_1	146	152	PF00069	0.506
MOD_Plk_1	184	190	PF00069	0.428
MOD_Plk_1	220	226	PF00069	0.586
MOD_Plk_1	396	402	PF00069	0.608
MOD_Plk_1	463	469	PF00069	0.802
MOD_Plk_4	234	240	PF00069	0.579
MOD_Plk_4	359	365	PF00069	0.625
MOD_Plk_4	386	392	PF00069	0.592
MOD_ProDKin_1	319	325	PF00069	0.502
MOD_ProDKin_1	90	96	PF00069	0.597
MOD_SUMO_for_1	353	356	PF00179	0.658
MOD_SUMO_rev_2	242	251	PF00179	0.625
MOD_SUMO_rev_2	38	47	PF00179	0.602
MOD_SUMO_rev_2	427	437	PF00179	0.602
TRG_DiLeu_BaEn_3	121	127	PF01217	0.367
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.433
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.591
TRG_ENDOCYTIC_2	199	202	PF00928	0.509
TRG_ENDOCYTIC_2	208	211	PF00928	0.538
TRG_ENDOCYTIC_2	26	29	PF00928	0.625
TRG_ENDOCYTIC_2	321	324	PF00928	0.456
TRG_ER_diArg_1	188	191	PF00400	0.552
TRG_ER_diArg_1	272	274	PF00400	0.474
TRG_ER_diArg_1	410	412	PF00400	0.608
TRG_ER_diArg_1	50	52	PF00400	0.570
TRG_NLS_MonoExtC_3	188	193	PF00514	0.542
TRG_NLS_MonoExtN_4	189	194	PF00514	0.559
TRG_NLS_MonoExtN_4	8	13	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICK2	Leptomonas seymouri	85%	71%
A0A0S4J6R5	Bodo saltans	66%	82%
A0A1X0NV16	Trypanosomatidae	75%	86%
A0A422NID9	Trypanosoma rangeli	72%	100%
A4HKD5	Leishmania braziliensis	90%	100%
A4I7W5	Leishmania infantum	100%	100%
D0AA28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	86%
E9B2S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q5D4	Leishmania major	96%	100%
V5DFT8	Trypanosoma cruzi	72%	90%