Pentatricopeptide repeat domain/PPR repeat/PPR repeat family, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pentatricopeptide repeat domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5H9_LEIDO

TriTrypDb:

LdBPK_321270.1 , LdCL_320018400 , LDHU3_32.1630

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X5H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5H9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.558
CLV_NRD_NRD_1	301	303	PF00675	0.479
CLV_NRD_NRD_1	381	383	PF00675	0.687
CLV_NRD_NRD_1	453	455	PF00675	0.468
CLV_NRD_NRD_1	709	711	PF00675	0.519
CLV_PCSK_KEX2_1	101	103	PF00082	0.431
CLV_PCSK_KEX2_1	14	16	PF00082	0.472
CLV_PCSK_KEX2_1	301	303	PF00082	0.488
CLV_PCSK_KEX2_1	5	7	PF00082	0.586
CLV_PCSK_KEX2_1	709	711	PF00082	0.472
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.431
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.616
CLV_PCSK_SKI1_1	101	105	PF00082	0.490
CLV_PCSK_SKI1_1	145	149	PF00082	0.407
CLV_PCSK_SKI1_1	151	155	PF00082	0.312
CLV_PCSK_SKI1_1	36	40	PF00082	0.546
CLV_PCSK_SKI1_1	476	480	PF00082	0.345
CLV_PCSK_SKI1_1	491	495	PF00082	0.395
CLV_PCSK_SKI1_1	552	556	PF00082	0.408
CLV_PCSK_SKI1_1	619	623	PF00082	0.487
CLV_PCSK_SKI1_1	709	713	PF00082	0.388
CLV_PCSK_SKI1_1	771	775	PF00082	0.480
CLV_PCSK_SKI1_1	780	784	PF00082	0.477
DEG_APCC_DBOX_1	770	778	PF00400	0.508
DEG_APCC_KENBOX_2	123	127	PF00400	0.524
DEG_Nend_Nbox_1	1	3	PF02207	0.541
DEG_SPOP_SBC_1	377	381	PF00917	0.516
DOC_CKS1_1	495	500	PF01111	0.412
DOC_CKS1_1	783	788	PF01111	0.548
DOC_CYCLIN_RxL_1	777	785	PF00134	0.492
DOC_MAPK_gen_1	454	460	PF00069	0.602
DOC_MAPK_gen_1	5	13	PF00069	0.574
DOC_MAPK_MEF2A_6	624	633	PF00069	0.288
DOC_PP1_RVXF_1	474	481	PF00149	0.423
DOC_PP1_SILK_1	341	346	PF00149	0.262
DOC_PP1_SILK_1	728	733	PF00149	0.351
DOC_PP4_FxxP_1	23	26	PF00568	0.656
DOC_PP4_FxxP_1	783	786	PF00568	0.513
DOC_USP7_MATH_1	377	381	PF00917	0.644
DOC_USP7_MATH_1	548	552	PF00917	0.504
DOC_USP7_MATH_1	591	595	PF00917	0.570
DOC_USP7_MATH_1	644	648	PF00917	0.538
DOC_USP7_MATH_1	65	69	PF00917	0.654
DOC_USP7_MATH_1	756	760	PF00917	0.494
DOC_WW_Pin1_4	494	499	PF00397	0.432
DOC_WW_Pin1_4	604	609	PF00397	0.369
DOC_WW_Pin1_4	782	787	PF00397	0.528
LIG_14-3-3_CanoR_1	105	112	PF00244	0.482
LIG_14-3-3_CanoR_1	83	91	PF00244	0.490
LIG_Actin_WH2_2	223	238	PF00022	0.330
LIG_Actin_WH2_2	464	481	PF00022	0.299
LIG_APCC_ABBA_1	112	117	PF00400	0.355
LIG_APCC_ABBA_1	224	229	PF00400	0.348
LIG_APCC_ABBA_1	353	358	PF00400	0.484
LIG_APCC_ABBAyCdc20_2	66	72	PF00400	0.530
LIG_BIR_III_4	767	771	PF00653	0.445
LIG_BRCT_BRCA1_1	257	261	PF00533	0.197
LIG_Clathr_ClatBox_1	466	470	PF01394	0.401
LIG_eIF4E_1	149	155	PF01652	0.335
LIG_FHA_1	187	193	PF00498	0.429
LIG_FHA_1	221	227	PF00498	0.361
LIG_FHA_1	361	367	PF00498	0.573
LIG_FHA_1	44	50	PF00498	0.470
LIG_FHA_1	536	542	PF00498	0.356
LIG_FHA_1	559	565	PF00498	0.523
LIG_FHA_1	574	580	PF00498	0.398
LIG_FHA_1	758	764	PF00498	0.436
LIG_FHA_1	93	99	PF00498	0.370
LIG_FHA_2	111	117	PF00498	0.492
LIG_FHA_2	280	286	PF00498	0.390
LIG_FHA_2	37	43	PF00498	0.641
LIG_FHA_2	731	737	PF00498	0.430
LIG_GBD_Chelix_1	317	325	PF00786	0.413
LIG_LIR_Apic_2	20	26	PF02991	0.642
LIG_LIR_Gen_1	113	123	PF02991	0.244
LIG_LIR_Gen_1	134	142	PF02991	0.328
LIG_LIR_Gen_1	161	171	PF02991	0.383
LIG_LIR_Gen_1	206	215	PF02991	0.313
LIG_LIR_Gen_1	229	239	PF02991	0.305
LIG_LIR_Gen_1	241	249	PF02991	0.218
LIG_LIR_Gen_1	256	265	PF02991	0.254
LIG_LIR_Gen_1	275	283	PF02991	0.168
LIG_LIR_Gen_1	44	55	PF02991	0.496
LIG_LIR_Gen_1	518	527	PF02991	0.509
LIG_LIR_Gen_1	557	567	PF02991	0.492
LIG_LIR_Gen_1	57	65	PF02991	0.311
LIG_LIR_Gen_1	690	699	PF02991	0.493
LIG_LIR_Gen_1	93	103	PF02991	0.359
LIG_LIR_Nem_3	113	118	PF02991	0.225
LIG_LIR_Nem_3	134	139	PF02991	0.327
LIG_LIR_Nem_3	161	166	PF02991	0.412
LIG_LIR_Nem_3	169	175	PF02991	0.307
LIG_LIR_Nem_3	206	210	PF02991	0.321
LIG_LIR_Nem_3	229	235	PF02991	0.320
LIG_LIR_Nem_3	241	245	PF02991	0.209
LIG_LIR_Nem_3	256	262	PF02991	0.254
LIG_LIR_Nem_3	275	280	PF02991	0.168
LIG_LIR_Nem_3	350	356	PF02991	0.453
LIG_LIR_Nem_3	44	50	PF02991	0.519
LIG_LIR_Nem_3	514	520	PF02991	0.420
LIG_LIR_Nem_3	57	63	PF02991	0.319
LIG_LIR_Nem_3	673	679	PF02991	0.519
LIG_LIR_Nem_3	689	695	PF02991	0.523
LIG_LIR_Nem_3	93	99	PF02991	0.361
LIG_NRBOX	463	469	PF00104	0.464
LIG_PALB2_WD40_1	628	636	PF16756	0.493
LIG_Pex14_1	331	335	PF04695	0.383
LIG_PTB_Apo_2	147	154	PF02174	0.422
LIG_Rb_pABgroove_1	109	117	PF01858	0.452
LIG_REV1ctd_RIR_1	618	628	PF16727	0.418
LIG_SH2_CRK	136	140	PF00017	0.336
LIG_SH2_CRK	156	160	PF00017	0.377
LIG_SH2_CRK	172	176	PF00017	0.229
LIG_SH2_CRK	207	211	PF00017	0.321
LIG_SH2_CRK	242	246	PF00017	0.288
LIG_SH2_CRK	277	281	PF00017	0.254
LIG_SH2_CRK	47	51	PF00017	0.531
LIG_SH2_CRK	614	618	PF00017	0.406
LIG_SH2_CRK	656	660	PF00017	0.427
LIG_SH2_CRK	727	731	PF00017	0.327
LIG_SH2_CRK	743	747	PF00017	0.450
LIG_SH2_CRK	784	788	PF00017	0.534
LIG_SH2_CRK	96	100	PF00017	0.335
LIG_SH2_GRB2like	232	235	PF00017	0.281
LIG_SH2_NCK_1	149	153	PF00017	0.382
LIG_SH2_NCK_1	567	571	PF00017	0.504
LIG_SH2_NCK_1	669	673	PF00017	0.475
LIG_SH2_NCK_1	784	788	PF00017	0.534
LIG_SH2_SRC	47	50	PF00017	0.395
LIG_SH2_SRC	545	548	PF00017	0.423
LIG_SH2_STAP1	220	224	PF00017	0.342
LIG_SH2_STAP1	255	259	PF00017	0.254
LIG_SH2_STAP1	56	60	PF00017	0.377
LIG_SH2_STAP1	560	564	PF00017	0.441
LIG_SH2_STAP1	567	571	PF00017	0.491
LIG_SH2_STAP1	656	660	PF00017	0.452
LIG_SH2_STAT5	178	181	PF00017	0.425
LIG_SH2_STAT5	232	235	PF00017	0.464
LIG_SH2_STAT5	279	282	PF00017	0.316
LIG_SH2_STAT5	290	293	PF00017	0.333
LIG_SH2_STAT5	335	338	PF00017	0.478
LIG_SH2_STAT5	443	446	PF00017	0.440
LIG_SH2_STAT5	56	59	PF00017	0.387
LIG_SH2_STAT5	560	563	PF00017	0.456
LIG_SH2_STAT5	656	659	PF00017	0.373
LIG_SH2_STAT5	663	666	PF00017	0.337
LIG_SH2_STAT5	784	787	PF00017	0.608
LIG_SH3_3	783	789	PF00018	0.650
LIG_SUMO_SIM_par_1	279	285	PF11976	0.306
LIG_SUMO_SIM_par_1	465	470	PF11976	0.398
LIG_TRAF2_1	219	222	PF00917	0.480
LIG_TRAF2_1	572	575	PF00917	0.567
LIG_TRFH_1	163	167	PF08558	0.508
LIG_TYR_ITAM	229	245	PF00017	0.281
LIG_TYR_ITIM	154	159	PF00017	0.382
LIG_TYR_ITIM	230	235	PF00017	0.281
LIG_TYR_ITIM	725	730	PF00017	0.484
LIG_UBA3_1	111	119	PF00899	0.411
LIG_UBA3_1	191	196	PF00899	0.442
LIG_UBA3_1	230	236	PF00899	0.281
MOD_CK1_1	241	247	PF00069	0.369
MOD_CK1_1	378	384	PF00069	0.752
MOD_CK1_1	456	462	PF00069	0.588
MOD_CK1_1	558	564	PF00069	0.426
MOD_CK1_1	607	613	PF00069	0.320
MOD_CK1_1	688	694	PF00069	0.502
MOD_CK2_1	279	285	PF00069	0.404
MOD_CK2_1	515	521	PF00069	0.480
MOD_CK2_1	65	71	PF00069	0.673
MOD_CK2_1	680	686	PF00069	0.559
MOD_CK2_1	730	736	PF00069	0.479
MOD_GlcNHglycan	144	148	PF01048	0.504
MOD_GlcNHglycan	216	219	PF01048	0.432
MOD_GlcNHglycan	297	300	PF01048	0.537
MOD_GlcNHglycan	448	452	PF01048	0.520
MOD_GlcNHglycan	455	458	PF01048	0.540
MOD_GlcNHglycan	636	639	PF01048	0.430
MOD_GlcNHglycan	642	645	PF01048	0.527
MOD_GlcNHglycan	646	649	PF01048	0.469
MOD_GSK3_1	291	298	PF00069	0.529
MOD_GSK3_1	32	39	PF00069	0.672
MOD_GSK3_1	339	346	PF00069	0.477
MOD_GSK3_1	456	463	PF00069	0.536
MOD_GSK3_1	511	518	PF00069	0.297
MOD_GSK3_1	600	607	PF00069	0.538
MOD_GSK3_1	640	647	PF00069	0.579
MOD_GSK3_1	726	733	PF00069	0.384
MOD_LATS_1	81	87	PF00433	0.541
MOD_N-GLC_1	125	130	PF02516	0.485
MOD_N-GLC_1	460	465	PF02516	0.371
MOD_N-GLC_1	604	609	PF02516	0.495
MOD_N-GLC_1	644	649	PF02516	0.644
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	214	219	PF00069	0.389
MOD_NEK2_1	317	322	PF00069	0.302
MOD_NEK2_1	453	458	PF00069	0.507
MOD_NEK2_1	460	465	PF00069	0.373
MOD_NEK2_1	555	560	PF00069	0.365
MOD_NEK2_1	613	618	PF00069	0.448
MOD_NEK2_2	110	115	PF00069	0.419
MOD_NEK2_2	220	225	PF00069	0.347
MOD_NEK2_2	65	70	PF00069	0.529
MOD_PIKK_1	90	96	PF00454	0.455
MOD_PK_1	339	345	PF00069	0.504
MOD_PKA_1	101	107	PF00069	0.406
MOD_PKA_2	101	107	PF00069	0.529
MOD_PKA_2	291	297	PF00069	0.527
MOD_PKA_2	300	306	PF00069	0.474
MOD_PKA_2	453	459	PF00069	0.482
MOD_PKA_2	634	640	PF00069	0.552
MOD_PKB_1	14	22	PF00069	0.520
MOD_Plk_1	124	130	PF00069	0.462
MOD_Plk_1	143	149	PF00069	0.263
MOD_Plk_1	220	226	PF00069	0.403
MOD_Plk_1	255	261	PF00069	0.228
MOD_Plk_1	43	49	PF00069	0.615
MOD_Plk_1	460	466	PF00069	0.558
MOD_Plk_1	573	579	PF00069	0.437
MOD_Plk_1	757	763	PF00069	0.494
MOD_Plk_4	132	138	PF00069	0.483
MOD_Plk_4	171	177	PF00069	0.309
MOD_Plk_4	186	192	PF00069	0.338
MOD_Plk_4	209	215	PF00069	0.387
MOD_Plk_4	241	247	PF00069	0.368
MOD_Plk_4	317	323	PF00069	0.317
MOD_Plk_4	339	345	PF00069	0.350
MOD_Plk_4	555	561	PF00069	0.410
MOD_Plk_4	591	597	PF00069	0.544
MOD_Plk_4	613	619	PF00069	0.390
MOD_Plk_4	654	660	PF00069	0.517
MOD_Plk_4	688	694	PF00069	0.552
MOD_Plk_4	726	732	PF00069	0.455
MOD_ProDKin_1	494	500	PF00069	0.424
MOD_ProDKin_1	604	610	PF00069	0.368
MOD_ProDKin_1	782	788	PF00069	0.538
MOD_SUMO_for_1	118	121	PF00179	0.401
MOD_SUMO_rev_2	116	120	PF00179	0.398
MOD_SUMO_rev_2	193	198	PF00179	0.489
TRG_DiLeu_BaEn_1	134	139	PF01217	0.452
TRG_DiLeu_BaEn_1	161	166	PF01217	0.499
TRG_DiLeu_BaEn_1	490	495	PF01217	0.398
TRG_DiLeu_BaEn_3	44	50	PF01217	0.443
TRG_DiLeu_BaEn_4	193	199	PF01217	0.497
TRG_ENDOCYTIC_2	115	118	PF00928	0.352
TRG_ENDOCYTIC_2	136	139	PF00928	0.349
TRG_ENDOCYTIC_2	156	159	PF00928	0.189
TRG_ENDOCYTIC_2	172	175	PF00928	0.303
TRG_ENDOCYTIC_2	207	210	PF00928	0.307
TRG_ENDOCYTIC_2	232	235	PF00928	0.310
TRG_ENDOCYTIC_2	242	245	PF00928	0.243
TRG_ENDOCYTIC_2	277	280	PF00928	0.254
TRG_ENDOCYTIC_2	356	359	PF00928	0.357
TRG_ENDOCYTIC_2	47	50	PF00928	0.571
TRG_ENDOCYTIC_2	520	523	PF00928	0.507
TRG_ENDOCYTIC_2	560	563	PF00928	0.358
TRG_ENDOCYTIC_2	614	617	PF00928	0.315
TRG_ENDOCYTIC_2	656	659	PF00928	0.405
TRG_ENDOCYTIC_2	669	672	PF00928	0.399
TRG_ENDOCYTIC_2	692	695	PF00928	0.378
TRG_ENDOCYTIC_2	727	730	PF00928	0.367
TRG_ENDOCYTIC_2	743	746	PF00928	0.399
TRG_ENDOCYTIC_2	96	99	PF00928	0.338
TRG_ER_diArg_1	13	16	PF00400	0.598
TRG_ER_diArg_1	301	304	PF00400	0.517
TRG_ER_diArg_1	708	710	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	732	736	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAW5	Leptomonas seymouri	57%	100%
A0A0S4JD08	Bodo saltans	32%	95%
A0A1X0NW71	Trypanosomatidae	40%	100%
A0A422P1H7	Trypanosoma rangeli	39%	100%
A4HKA8	Leishmania braziliensis	80%	100%
A4I7T8	Leishmania infantum	100%	100%
D0A9Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	97%
E9B2P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q0WPZ6	Arabidopsis thaliana	20%	92%
Q4Q5G1	Leishmania major	95%	100%
Q76C99	Oryza sativa subsp. indica	21%	100%
Q9FIT7	Arabidopsis thaliana	21%	82%
Q9LSL9	Arabidopsis thaliana	21%	88%
Q9LYZ9	Arabidopsis thaliana	21%	98%
Q9SH60	Arabidopsis thaliana	22%	100%
Q9SS81	Arabidopsis thaliana	21%	100%
V5BL80	Trypanosoma cruzi	42%	100%