LicD family, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LicD family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5H6_LEIDO

TriTrypDb:

LdBPK_321410.1 , LdCL_320019800 , LDHU3_32.1780

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X5H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5H6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.478
CLV_C14_Caspase3-7	155	159	PF00656	0.498
CLV_C14_Caspase3-7	224	228	PF00656	0.554
CLV_C14_Caspase3-7	70	74	PF00656	0.618
CLV_NRD_NRD_1	214	216	PF00675	0.533
CLV_NRD_NRD_1	241	243	PF00675	0.550
CLV_NRD_NRD_1	285	287	PF00675	0.546
CLV_NRD_NRD_1	421	423	PF00675	0.414
CLV_NRD_NRD_1	89	91	PF00675	0.477
CLV_PCSK_KEX2_1	240	242	PF00082	0.573
CLV_PCSK_KEX2_1	285	287	PF00082	0.546
CLV_PCSK_KEX2_1	89	91	PF00082	0.512
CLV_PCSK_SKI1_1	215	219	PF00082	0.545
CLV_PCSK_SKI1_1	258	262	PF00082	0.310
CLV_PCSK_SKI1_1	273	277	PF00082	0.519
CLV_PCSK_SKI1_1	36	40	PF00082	0.495
CLV_PCSK_SKI1_1	452	456	PF00082	0.355
CLV_PCSK_SKI1_1	90	94	PF00082	0.504
DEG_Nend_UBRbox_3	1	3	PF02207	0.611
DEG_SPOP_SBC_1	172	176	PF00917	0.564
DOC_CKS1_1	470	475	PF01111	0.384
DOC_CKS1_1	66	71	PF01111	0.561
DOC_CYCLIN_RxL_1	252	265	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	455	458	PF00134	0.400
DOC_MAPK_DCC_7	106	114	PF00069	0.518
DOC_MAPK_MEF2A_6	106	114	PF00069	0.518
DOC_MAPK_MEF2A_6	316	323	PF00069	0.492
DOC_PP1_RVXF_1	150	157	PF00149	0.478
DOC_PP1_RVXF_1	250	257	PF00149	0.416
DOC_PP1_RVXF_1	269	275	PF00149	0.399
DOC_PP2B_LxvP_1	201	204	PF13499	0.589
DOC_PP2B_LxvP_1	455	458	PF13499	0.401
DOC_PP4_FxxP_1	454	457	PF00568	0.325
DOC_USP7_MATH_1	179	183	PF00917	0.585
DOC_USP7_MATH_1	209	213	PF00917	0.717
DOC_USP7_MATH_1	30	34	PF00917	0.469
DOC_USP7_MATH_1	344	348	PF00917	0.426
DOC_USP7_MATH_1	60	64	PF00917	0.739
DOC_USP7_MATH_2	121	127	PF00917	0.490
DOC_USP7_UBL2_3	487	491	PF12436	0.477
DOC_WW_Pin1_4	168	173	PF00397	0.664
DOC_WW_Pin1_4	469	474	PF00397	0.377
DOC_WW_Pin1_4	65	70	PF00397	0.782
LIG_14-3-3_CanoR_1	215	222	PF00244	0.538
LIG_14-3-3_CanoR_1	26	35	PF00244	0.455
LIG_APCC_ABBA_1	290	295	PF00400	0.315
LIG_APCC_ABBAyCdc20_2	17	23	PF00400	0.571
LIG_BRCT_BRCA1_1	82	86	PF00533	0.643
LIG_deltaCOP1_diTrp_1	95	100	PF00928	0.532
LIG_FHA_1	133	139	PF00498	0.412
LIG_FHA_1	216	222	PF00498	0.748
LIG_FHA_1	224	230	PF00498	0.589
LIG_FHA_1	249	255	PF00498	0.387
LIG_FHA_1	30	36	PF00498	0.448
LIG_FHA_1	445	451	PF00498	0.579
LIG_FHA_1	477	483	PF00498	0.403
LIG_FHA_2	142	148	PF00498	0.530
LIG_FHA_2	209	215	PF00498	0.524
LIG_FHA_2	309	315	PF00498	0.471
LIG_FHA_2	68	74	PF00498	0.610
LIG_LIR_Apic_2	468	473	PF02991	0.430
LIG_LIR_Gen_1	147	157	PF02991	0.559
LIG_LIR_Gen_1	332	341	PF02991	0.461
LIG_LIR_Gen_1	348	359	PF02991	0.280
LIG_LIR_Nem_3	131	137	PF02991	0.418
LIG_LIR_Nem_3	147	153	PF02991	0.488
LIG_LIR_Nem_3	189	195	PF02991	0.580
LIG_LIR_Nem_3	234	238	PF02991	0.388
LIG_LIR_Nem_3	287	293	PF02991	0.381
LIG_LIR_Nem_3	348	354	PF02991	0.342
LIG_LIR_Nem_3	485	489	PF02991	0.355
LIG_LYPXL_yS_3	383	386	PF13949	0.379
LIG_NBox_RRM_1	256	266	PF00076	0.261
LIG_PCNA_yPIPBox_3	335	349	PF02747	0.375
LIG_Pex14_1	411	415	PF04695	0.408
LIG_Pex14_1	96	100	PF04695	0.594
LIG_PTB_Apo_2	317	324	PF02174	0.471
LIG_SH2_CRK	339	343	PF00017	0.400
LIG_SH2_NCK_1	303	307	PF00017	0.264
LIG_SH2_NCK_1	416	420	PF00017	0.367
LIG_SH2_SRC	303	306	PF00017	0.248
LIG_SH2_STAP1	134	138	PF00017	0.462
LIG_SH2_STAP1	293	297	PF00017	0.308
LIG_SH2_STAP1	303	307	PF00017	0.295
LIG_SH2_STAT5	134	137	PF00017	0.482
LIG_SH2_STAT5	238	241	PF00017	0.371
LIG_SH2_STAT5	40	43	PF00017	0.579
LIG_SH2_STAT5	461	464	PF00017	0.325
LIG_SH2_STAT5	478	481	PF00017	0.423
LIG_SH3_2	66	71	PF14604	0.534
LIG_SH3_3	109	115	PF00018	0.598
LIG_SH3_3	161	167	PF00018	0.472
LIG_SH3_3	192	198	PF00018	0.525
LIG_SH3_3	63	69	PF00018	0.566
LIG_SxIP_EBH_1	44	55	PF03271	0.498
LIG_TRAF2_1	144	147	PF00917	0.636
LIG_TRAF2_1	262	265	PF00917	0.418
LIG_TYR_ITIM	301	306	PF00017	0.248
LIG_TYR_ITIM	381	386	PF00017	0.330
MOD_CDK_SPK_2	469	474	PF00069	0.377
MOD_CDK_SPxK_1	65	71	PF00069	0.761
MOD_CK1_1	168	174	PF00069	0.719
MOD_CK1_1	29	35	PF00069	0.413
MOD_CK1_1	322	328	PF00069	0.621
MOD_CK1_1	43	49	PF00069	0.652
MOD_CK1_1	58	64	PF00069	0.662
MOD_CK2_1	141	147	PF00069	0.640
MOD_CK2_1	208	214	PF00069	0.584
MOD_CK2_1	411	417	PF00069	0.334
MOD_CK2_1	474	480	PF00069	0.420
MOD_CK2_1	81	87	PF00069	0.540
MOD_CK2_1	98	104	PF00069	0.648
MOD_DYRK1A_RPxSP_1	65	69	PF00069	0.629
MOD_GlcNHglycan	100	103	PF01048	0.572
MOD_GlcNHglycan	167	170	PF01048	0.640
MOD_GlcNHglycan	175	178	PF01048	0.547
MOD_GlcNHglycan	181	184	PF01048	0.510
MOD_GlcNHglycan	28	31	PF01048	0.624
MOD_GlcNHglycan	32	35	PF01048	0.475
MOD_GlcNHglycan	324	327	PF01048	0.616
MOD_GlcNHglycan	373	376	PF01048	0.412
MOD_GlcNHglycan	58	61	PF01048	0.689
MOD_GSK3_1	168	175	PF00069	0.674
MOD_GSK3_1	26	33	PF00069	0.399
MOD_GSK3_1	36	43	PF00069	0.646
MOD_GSK3_1	56	63	PF00069	0.693
MOD_N-GLC_1	319	324	PF02516	0.566
MOD_NEK2_1	345	350	PF00069	0.513
MOD_NEK2_1	371	376	PF00069	0.416
MOD_NEK2_2	411	416	PF00069	0.418
MOD_PIKK_1	60	66	PF00454	0.726
MOD_PK_1	446	452	PF00069	0.442
MOD_PKA_1	215	221	PF00069	0.548
MOD_PKA_2	2	8	PF00069	0.639
MOD_PKA_2	98	104	PF00069	0.619
MOD_Plk_1	124	130	PF00069	0.556
MOD_Plk_1	319	325	PF00069	0.543
MOD_Plk_1	36	42	PF00069	0.481
MOD_Plk_1	72	78	PF00069	0.687
MOD_Plk_4	217	223	PF00069	0.559
MOD_Plk_4	234	240	PF00069	0.486
MOD_Plk_4	36	42	PF00069	0.486
MOD_Plk_4	411	417	PF00069	0.425
MOD_Plk_4	46	52	PF00069	0.749
MOD_Plk_4	72	78	PF00069	0.661
MOD_Plk_4	81	87	PF00069	0.567
MOD_ProDKin_1	168	174	PF00069	0.665
MOD_ProDKin_1	469	475	PF00069	0.383
MOD_ProDKin_1	65	71	PF00069	0.786
MOD_SUMO_rev_2	113	121	PF00179	0.699
MOD_SUMO_rev_2	212	218	PF00179	0.540
MOD_SUMO_rev_2	480	489	PF00179	0.362
TRG_DiLeu_BaEn_2	404	410	PF01217	0.428
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.390
TRG_ENDOCYTIC_2	303	306	PF00928	0.248
TRG_ENDOCYTIC_2	333	336	PF00928	0.391
TRG_ENDOCYTIC_2	339	342	PF00928	0.353
TRG_ENDOCYTIC_2	383	386	PF00928	0.378
TRG_ER_diArg_1	239	242	PF00400	0.557
TRG_ER_diArg_1	88	90	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW8	Leptomonas seymouri	46%	100%
A0A1X0NUG9	Trypanosomatidae	32%	100%
A0A422P1A8	Trypanosoma rangeli	35%	100%
A4HKC3	Leishmania braziliensis	71%	99%
A4I7V4	Leishmania infantum	100%	100%
E9B2R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q5E7	Leishmania major	89%	100%