LeishMANIAdb
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WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
WD domain, G-beta repeat-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X5H5_LEIDO
TriTrypDb:
LdBPK_321730.1 , LdCL_320022800 , LDHU3_32.2190
Length:
920

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0000159 protein phosphatase type 2A complex 5 7
GO:0008287 protein serine/threonine phosphatase complex 4 7
GO:0032991 protein-containing complex 1 7
GO:1902494 catalytic complex 2 7
GO:1903293 phosphatase complex 3 7
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X5H5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5H5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0019208 phosphatase regulator activity 3 7
GO:0019888 protein phosphatase regulator activity 4 7
GO:0030234 enzyme regulator activity 2 7
GO:0098772 molecular function regulator activity 1 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 120 124 PF00656 0.590
CLV_C14_Caspase3-7 291 295 PF00656 0.682
CLV_C14_Caspase3-7 53 57 PF00656 0.596
CLV_C14_Caspase3-7 844 848 PF00656 0.378
CLV_NRD_NRD_1 3 5 PF00675 0.637
CLV_NRD_NRD_1 435 437 PF00675 0.617
CLV_NRD_NRD_1 504 506 PF00675 0.435
CLV_NRD_NRD_1 558 560 PF00675 0.404
CLV_NRD_NRD_1 695 697 PF00675 0.486
CLV_NRD_NRD_1 747 749 PF00675 0.423
CLV_NRD_NRD_1 857 859 PF00675 0.451
CLV_NRD_NRD_1 86 88 PF00675 0.643
CLV_NRD_NRD_1 914 916 PF00675 0.408
CLV_PCSK_KEX2_1 141 143 PF00082 0.648
CLV_PCSK_KEX2_1 435 437 PF00082 0.617
CLV_PCSK_KEX2_1 504 506 PF00082 0.435
CLV_PCSK_KEX2_1 558 560 PF00082 0.404
CLV_PCSK_KEX2_1 857 859 PF00082 0.451
CLV_PCSK_KEX2_1 86 88 PF00082 0.643
CLV_PCSK_PC1ET2_1 141 143 PF00082 0.648
CLV_PCSK_PC7_1 500 506 PF00082 0.460
CLV_PCSK_SKI1_1 161 165 PF00082 0.697
CLV_PCSK_SKI1_1 500 504 PF00082 0.507
CLV_PCSK_SKI1_1 528 532 PF00082 0.550
CLV_PCSK_SKI1_1 550 554 PF00082 0.386
CLV_PCSK_SKI1_1 887 891 PF00082 0.394
CLV_Separin_Metazoa 279 283 PF03568 0.634
CLV_Separin_Metazoa 501 505 PF03568 0.468
DEG_APCC_DBOX_1 160 168 PF00400 0.698
DEG_Nend_UBRbox_2 1 3 PF02207 0.626
DEG_SCF_FBW7_1 140 147 PF00400 0.612
DEG_SPOP_SBC_1 311 315 PF00917 0.633
DOC_CDC14_PxL_1 402 410 PF14671 0.419
DOC_CYCLIN_yCln2_LP_2 223 229 PF00134 0.511
DOC_MAPK_MEF2A_6 737 744 PF00069 0.346
DOC_MAPK_NFAT4_5 737 745 PF00069 0.347
DOC_PP1_RVXF_1 526 533 PF00149 0.357
DOC_PP2B_LxvP_1 646 649 PF13499 0.439
DOC_PP4_FxxP_1 374 377 PF00568 0.819
DOC_PP4_FxxP_1 728 731 PF00568 0.366
DOC_PP4_FxxP_1 824 827 PF00568 0.468
DOC_USP7_MATH_1 117 121 PF00917 0.656
DOC_USP7_MATH_1 163 167 PF00917 0.682
DOC_USP7_MATH_1 176 180 PF00917 0.601
DOC_USP7_MATH_1 274 278 PF00917 0.677
DOC_USP7_MATH_1 304 308 PF00917 0.655
DOC_USP7_MATH_1 311 315 PF00917 0.597
DOC_USP7_MATH_1 322 326 PF00917 0.504
DOC_USP7_MATH_1 382 386 PF00917 0.530
DOC_USP7_MATH_1 517 521 PF00917 0.441
DOC_USP7_MATH_1 61 65 PF00917 0.676
DOC_USP7_MATH_1 667 671 PF00917 0.415
DOC_USP7_MATH_1 699 703 PF00917 0.463
DOC_USP7_MATH_1 79 83 PF00917 0.527
DOC_USP7_MATH_1 805 809 PF00917 0.548
DOC_USP7_MATH_1 89 93 PF00917 0.636
DOC_USP7_MATH_2 111 117 PF00917 0.723
DOC_USP7_UBL2_3 5 9 PF12436 0.646
DOC_USP7_UBL2_3 509 513 PF12436 0.408
DOC_WW_Pin1_4 12 17 PF00397 0.643
DOC_WW_Pin1_4 136 141 PF00397 0.630
DOC_WW_Pin1_4 261 266 PF00397 0.673
DOC_WW_Pin1_4 281 286 PF00397 0.613
DOC_WW_Pin1_4 340 345 PF00397 0.599
DOC_WW_Pin1_4 446 451 PF00397 0.556
DOC_WW_Pin1_4 475 480 PF00397 0.636
DOC_WW_Pin1_4 535 540 PF00397 0.462
DOC_WW_Pin1_4 560 565 PF00397 0.444
DOC_WW_Pin1_4 77 82 PF00397 0.634
LIG_14-3-3_CanoR_1 190 196 PF00244 0.679
LIG_14-3-3_CanoR_1 212 218 PF00244 0.471
LIG_14-3-3_CanoR_1 312 321 PF00244 0.733
LIG_14-3-3_CanoR_1 435 441 PF00244 0.582
LIG_14-3-3_CanoR_1 504 512 PF00244 0.416
LIG_14-3-3_CanoR_1 899 905 PF00244 0.361
LIG_14-3-3_CanoR_1 915 919 PF00244 0.511
LIG_Actin_WH2_2 450 468 PF00022 0.551
LIG_AP2alpha_2 822 824 PF02296 0.441
LIG_BRCT_BRCA1_1 344 348 PF00533 0.567
LIG_BRCT_BRCA1_1 370 374 PF00533 0.595
LIG_BRCT_BRCA1_1 50 54 PF00533 0.617
LIG_BRCT_BRCA1_1 581 585 PF00533 0.474
LIG_BRCT_BRCA1_1 669 673 PF00533 0.380
LIG_EH_1 708 712 PF12763 0.521
LIG_eIF4E_1 904 910 PF01652 0.397
LIG_FHA_1 358 364 PF00498 0.538
LIG_FHA_1 488 494 PF00498 0.603
LIG_FHA_1 602 608 PF00498 0.372
LIG_FHA_1 883 889 PF00498 0.408
LIG_FHA_2 241 247 PF00498 0.703
LIG_FHA_2 378 384 PF00498 0.750
LIG_FHA_2 395 401 PF00498 0.352
LIG_FHA_2 544 550 PF00498 0.390
LIG_FHA_2 83 89 PF00498 0.714
LIG_FHA_2 863 869 PF00498 0.585
LIG_Integrin_isoDGR_2 906 908 PF01839 0.414
LIG_LIR_Apic_2 371 377 PF02991 0.701
LIG_LIR_Apic_2 727 731 PF02991 0.374
LIG_LIR_Apic_2 822 827 PF02991 0.459
LIG_LIR_Gen_1 563 571 PF02991 0.471
LIG_LIR_Gen_1 582 593 PF02991 0.470
LIG_LIR_Gen_1 617 627 PF02991 0.347
LIG_LIR_Gen_1 736 747 PF02991 0.349
LIG_LIR_Gen_1 774 784 PF02991 0.381
LIG_LIR_Nem_3 214 220 PF02991 0.433
LIG_LIR_Nem_3 420 424 PF02991 0.403
LIG_LIR_Nem_3 560 565 PF02991 0.453
LIG_LIR_Nem_3 582 588 PF02991 0.477
LIG_LIR_Nem_3 599 603 PF02991 0.394
LIG_LIR_Nem_3 617 622 PF02991 0.350
LIG_LIR_Nem_3 736 742 PF02991 0.342
LIG_LIR_Nem_3 774 780 PF02991 0.387
LIG_LIR_Nem_3 88 93 PF02991 0.658
LIG_MAD2 887 895 PF02301 0.385
LIG_MLH1_MIPbox_1 581 585 PF16413 0.474
LIG_MYND_1 12 16 PF01753 0.644
LIG_PCNA_yPIPBox_3 548 559 PF02747 0.365
LIG_Pex14_2 353 357 PF04695 0.553
LIG_Pex14_2 50 54 PF04695 0.579
LIG_Pex14_2 628 632 PF04695 0.363
LIG_PTB_Apo_2 356 363 PF02174 0.612
LIG_Rb_pABgroove_1 790 798 PF01858 0.343
LIG_SH2_CRK 207 211 PF00017 0.559
LIG_SH2_CRK 220 224 PF00017 0.435
LIG_SH2_GRB2like 771 774 PF00017 0.409
LIG_SH2_NCK_1 132 136 PF00017 0.601
LIG_SH2_SRC 698 701 PF00017 0.629
LIG_SH2_SRC 716 719 PF00017 0.284
LIG_SH2_SRC 766 769 PF00017 0.358
LIG_SH2_STAP1 250 254 PF00017 0.599
LIG_SH2_STAP1 716 720 PF00017 0.383
LIG_SH2_STAP1 796 800 PF00017 0.372
LIG_SH2_STAT5 421 424 PF00017 0.415
LIG_SH2_STAT5 526 529 PF00017 0.354
LIG_SH2_STAT5 544 547 PF00017 0.342
LIG_SH2_STAT5 584 587 PF00017 0.487
LIG_SH2_STAT5 739 742 PF00017 0.347
LIG_SH2_STAT5 762 765 PF00017 0.378
LIG_SH2_STAT5 766 769 PF00017 0.379
LIG_SH2_STAT5 902 905 PF00017 0.368
LIG_SH2_STAT5 911 914 PF00017 0.374
LIG_SH3_1 132 138 PF00018 0.659
LIG_SH3_3 132 138 PF00018 0.659
LIG_SH3_3 15 21 PF00018 0.635
LIG_SH3_3 254 260 PF00018 0.775
LIG_SH3_3 43 49 PF00018 0.594
LIG_SH3_3 586 592 PF00018 0.476
LIG_SH3_3 747 753 PF00018 0.423
LIG_SH3_3 799 805 PF00018 0.348
LIG_SH3_CIN85_PxpxPR_1 263 268 PF14604 0.629
LIG_SUMO_SIM_anti_2 389 394 PF11976 0.388
LIG_SUMO_SIM_par_1 780 786 PF11976 0.381
LIG_TRAF2_1 865 868 PF00917 0.607
LIG_TYR_ITIM 419 424 PF00017 0.368
LIG_UBA3_1 594 598 PF00899 0.412
LIG_UBA3_1 756 765 PF00899 0.382
MOD_CDC14_SPxK_1 139 142 PF00782 0.618
MOD_CDK_SPK_2 136 141 PF00069 0.613
MOD_CDK_SPxK_1 136 142 PF00069 0.633
MOD_CDK_SPxK_1 475 481 PF00069 0.560
MOD_CDK_SPxxK_3 261 268 PF00069 0.634
MOD_CK1_1 116 122 PF00069 0.653
MOD_CK1_1 157 163 PF00069 0.694
MOD_CK1_1 30 36 PF00069 0.644
MOD_CK1_1 313 319 PF00069 0.620
MOD_CK1_1 340 346 PF00069 0.690
MOD_CK1_1 484 490 PF00069 0.651
MOD_CK1_1 540 546 PF00069 0.431
MOD_CK1_1 692 698 PF00069 0.581
MOD_CK1_1 702 708 PF00069 0.445
MOD_CK1_1 724 730 PF00069 0.352
MOD_CK1_1 80 86 PF00069 0.832
MOD_CK1_1 808 814 PF00069 0.550
MOD_CK1_1 859 865 PF00069 0.670
MOD_CK1_1 92 98 PF00069 0.619
MOD_CK2_1 191 197 PF00069 0.594
MOD_CK2_1 240 246 PF00069 0.746
MOD_CK2_1 377 383 PF00069 0.591
MOD_CK2_1 543 549 PF00069 0.349
MOD_CK2_1 766 772 PF00069 0.407
MOD_CK2_1 862 868 PF00069 0.572
MOD_GlcNHglycan 113 118 PF01048 0.654
MOD_GlcNHglycan 161 164 PF01048 0.674
MOD_GlcNHglycan 173 176 PF01048 0.800
MOD_GlcNHglycan 178 181 PF01048 0.660
MOD_GlcNHglycan 306 309 PF01048 0.665
MOD_GlcNHglycan 324 327 PF01048 0.622
MOD_GlcNHglycan 334 337 PF01048 0.609
MOD_GlcNHglycan 364 368 PF01048 0.594
MOD_GlcNHglycan 383 387 PF01048 0.531
MOD_GlcNHglycan 402 405 PF01048 0.457
MOD_GlcNHglycan 414 418 PF01048 0.371
MOD_GlcNHglycan 475 478 PF01048 0.641
MOD_GlcNHglycan 486 489 PF01048 0.577
MOD_GlcNHglycan 50 53 PF01048 0.660
MOD_GlcNHglycan 612 615 PF01048 0.387
MOD_GlcNHglycan 649 652 PF01048 0.474
MOD_GlcNHglycan 678 681 PF01048 0.383
MOD_GlcNHglycan 723 726 PF01048 0.520
MOD_GlcNHglycan 785 790 PF01048 0.403
MOD_GlcNHglycan 797 800 PF01048 0.409
MOD_GlcNHglycan 82 85 PF01048 0.825
MOD_GSK3_1 113 120 PF00069 0.725
MOD_GSK3_1 136 143 PF00069 0.629
MOD_GSK3_1 155 162 PF00069 0.678
MOD_GSK3_1 27 34 PF00069 0.643
MOD_GSK3_1 306 313 PF00069 0.626
MOD_GSK3_1 338 345 PF00069 0.769
MOD_GSK3_1 35 42 PF00069 0.643
MOD_GSK3_1 353 360 PF00069 0.585
MOD_GSK3_1 382 389 PF00069 0.569
MOD_GSK3_1 422 429 PF00069 0.515
MOD_GSK3_1 430 437 PF00069 0.552
MOD_GSK3_1 461 468 PF00069 0.683
MOD_GSK3_1 487 494 PF00069 0.672
MOD_GSK3_1 575 582 PF00069 0.489
MOD_GSK3_1 62 69 PF00069 0.735
MOD_GSK3_1 628 635 PF00069 0.428
MOD_GSK3_1 661 668 PF00069 0.376
MOD_GSK3_1 698 705 PF00069 0.532
MOD_GSK3_1 73 80 PF00069 0.684
MOD_GSK3_1 808 815 PF00069 0.495
MOD_GSK3_1 856 863 PF00069 0.616
MOD_GSK3_1 89 96 PF00069 0.642
MOD_N-GLC_1 294 299 PF02516 0.670
MOD_N-GLC_1 331 336 PF02516 0.583
MOD_N-GLC_1 353 358 PF02516 0.614
MOD_N-GLC_1 430 435 PF02516 0.627
MOD_N-GLC_1 491 496 PF02516 0.624
MOD_N-GLC_1 772 777 PF02516 0.395
MOD_N-GLC_2 480 482 PF02516 0.703
MOD_NEK2_1 154 159 PF00069 0.696
MOD_NEK2_1 206 211 PF00069 0.557
MOD_NEK2_1 31 36 PF00069 0.645
MOD_NEK2_1 357 362 PF00069 0.700
MOD_NEK2_1 370 375 PF00069 0.581
MOD_NEK2_1 422 427 PF00069 0.408
MOD_NEK2_1 50 55 PF00069 0.634
MOD_NEK2_1 511 516 PF00069 0.449
MOD_NEK2_1 579 584 PF00069 0.482
MOD_NEK2_1 673 678 PF00069 0.349
MOD_NEK2_1 795 800 PF00069 0.400
MOD_NEK2_1 806 811 PF00069 0.429
MOD_NEK2_1 812 817 PF00069 0.414
MOD_NEK2_1 841 846 PF00069 0.396
MOD_NEK2_1 900 905 PF00069 0.373
MOD_NEK2_2 163 168 PF00069 0.765
MOD_NEK2_2 430 435 PF00069 0.627
MOD_NEK2_2 766 771 PF00069 0.377
MOD_PIKK_1 699 705 PF00454 0.580
MOD_PIKK_1 847 853 PF00454 0.487
MOD_PIKK_1 860 866 PF00454 0.538
MOD_PKA_1 504 510 PF00069 0.405
MOD_PKA_2 117 123 PF00069 0.645
MOD_PKA_2 211 217 PF00069 0.473
MOD_PKA_2 31 37 PF00069 0.644
MOD_PKA_2 311 317 PF00069 0.672
MOD_PKA_2 434 440 PF00069 0.611
MOD_PKA_2 461 467 PF00069 0.709
MOD_PKA_2 504 510 PF00069 0.411
MOD_PKA_2 62 68 PF00069 0.639
MOD_PKA_2 676 682 PF00069 0.375
MOD_PKA_2 692 698 PF00069 0.560
MOD_PKA_2 73 79 PF00069 0.645
MOD_PKA_2 856 862 PF00069 0.563
MOD_PKA_2 914 920 PF00069 0.608
MOD_PKA_2 93 99 PF00069 0.665
MOD_PKB_1 858 866 PF00069 0.577
MOD_Plk_1 353 359 PF00069 0.591
MOD_Plk_1 382 388 PF00069 0.523
MOD_Plk_1 430 436 PF00069 0.633
MOD_Plk_1 772 778 PF00069 0.392
MOD_Plk_1 841 847 PF00069 0.399
MOD_Plk_2-3 240 246 PF00069 0.706
MOD_Plk_2-3 772 778 PF00069 0.392
MOD_Plk_4 316 322 PF00069 0.550
MOD_Plk_4 388 394 PF00069 0.401
MOD_Plk_4 436 442 PF00069 0.594
MOD_Plk_4 528 534 PF00069 0.373
MOD_Plk_4 537 543 PF00069 0.441
MOD_Plk_4 615 621 PF00069 0.369
MOD_Plk_4 668 674 PF00069 0.382
MOD_Plk_4 724 730 PF00069 0.352
MOD_Plk_4 766 772 PF00069 0.383
MOD_Plk_4 787 793 PF00069 0.366
MOD_Plk_4 812 818 PF00069 0.574
MOD_ProDKin_1 12 18 PF00069 0.639
MOD_ProDKin_1 136 142 PF00069 0.633
MOD_ProDKin_1 261 267 PF00069 0.667
MOD_ProDKin_1 281 287 PF00069 0.608
MOD_ProDKin_1 340 346 PF00069 0.599
MOD_ProDKin_1 446 452 PF00069 0.555
MOD_ProDKin_1 475 481 PF00069 0.638
MOD_ProDKin_1 535 541 PF00069 0.456
MOD_ProDKin_1 560 566 PF00069 0.444
MOD_ProDKin_1 77 83 PF00069 0.633
MOD_SUMO_rev_2 253 263 PF00179 0.614
TRG_DiLeu_BaEn_1 655 660 PF01217 0.425
TRG_DiLeu_BaEn_2 357 363 PF01217 0.532
TRG_ENDOCYTIC_2 207 210 PF00928 0.566
TRG_ENDOCYTIC_2 220 223 PF00928 0.511
TRG_ENDOCYTIC_2 421 424 PF00928 0.376
TRG_ENDOCYTIC_2 716 719 PF00928 0.394
TRG_ENDOCYTIC_2 739 742 PF00928 0.347
TRG_ER_diArg_1 434 436 PF00400 0.608
TRG_ER_diArg_1 497 500 PF00400 0.548
TRG_ER_diArg_1 503 505 PF00400 0.470
TRG_ER_diArg_1 533 536 PF00400 0.441
TRG_ER_diArg_1 557 559 PF00400 0.376
TRG_ER_diArg_1 857 860 PF00400 0.648

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMN7 Leptomonas seymouri 70% 99%
A4HKF2 Leishmania braziliensis 82% 100%
A4I7Y0 Leishmania infantum 99% 100%
E9B2U1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q5B5 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS