Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5H0_LEIDO

TriTrypDb:

LdBPK_321440.1 , LdCL_320020100 , LDHU3_32.1820

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5H0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.595
CLV_NRD_NRD_1	192	194	PF00675	0.594
CLV_NRD_NRD_1	213	215	PF00675	0.563
CLV_NRD_NRD_1	312	314	PF00675	0.380
CLV_NRD_NRD_1	36	38	PF00675	0.477
CLV_NRD_NRD_1	6	8	PF00675	0.401
CLV_PCSK_KEX2_1	192	194	PF00082	0.594
CLV_PCSK_KEX2_1	213	215	PF00082	0.563
CLV_PCSK_KEX2_1	312	314	PF00082	0.380
CLV_PCSK_KEX2_1	36	38	PF00082	0.512
CLV_PCSK_KEX2_1	6	8	PF00082	0.403
CLV_PCSK_SKI1_1	7	11	PF00082	0.358
DEG_Nend_UBRbox_2	1	3	PF02207	0.507
DOC_CDC14_PxL_1	274	282	PF14671	0.545
DOC_CDC14_PxL_1	72	80	PF14671	0.444
DOC_CKS1_1	54	59	PF01111	0.459
DOC_CYCLIN_yClb1_LxF_4	69	75	PF00134	0.380
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.586
DOC_MAPK_DCC_7	159	168	PF00069	0.563
DOC_MAPK_gen_1	159	168	PF00069	0.563
DOC_MAPK_gen_1	213	220	PF00069	0.532
DOC_MAPK_gen_1	6	12	PF00069	0.383
DOC_MAPK_MEF2A_6	161	170	PF00069	0.564
DOC_MAPK_RevD_3	200	214	PF00069	0.535
DOC_PP2B_LxvP_1	168	171	PF13499	0.640
DOC_USP7_MATH_1	108	112	PF00917	0.692
DOC_USP7_MATH_1	127	131	PF00917	0.592
DOC_USP7_MATH_1	182	186	PF00917	0.575
DOC_USP7_MATH_1	289	293	PF00917	0.462
DOC_WW_Pin1_4	150	155	PF00397	0.638
DOC_WW_Pin1_4	161	166	PF00397	0.518
DOC_WW_Pin1_4	201	206	PF00397	0.640
DOC_WW_Pin1_4	259	264	PF00397	0.581
DOC_WW_Pin1_4	279	284	PF00397	0.571
DOC_WW_Pin1_4	53	58	PF00397	0.410
DOC_WW_Pin1_4	94	99	PF00397	0.662
LIG_14-3-3_CanoR_1	113	118	PF00244	0.601
LIG_14-3-3_CanoR_1	241	250	PF00244	0.606
LIG_14-3-3_CanoR_1	313	322	PF00244	0.388
LIG_APCC_ABBA_1	10	15	PF00400	0.446
LIG_BIR_III_2	275	279	PF00653	0.578
LIG_Clathr_ClatBox_1	22	26	PF01394	0.402
LIG_eIF4E_1	157	163	PF01652	0.574
LIG_FHA_1	172	178	PF00498	0.553
LIG_FHA_1	53	59	PF00498	0.432
LIG_FHA_1	90	96	PF00498	0.631
LIG_LIR_Apic_2	155	160	PF02991	0.574
LIG_LIR_Apic_2	71	76	PF02991	0.374
LIG_LIR_Gen_1	227	236	PF02991	0.531
LIG_LIR_Gen_1	257	264	PF02991	0.579
LIG_LIR_Gen_1	28	38	PF02991	0.410
LIG_LIR_Nem_3	227	233	PF02991	0.538
LIG_LIR_Nem_3	257	261	PF02991	0.574
LIG_LIR_Nem_3	28	34	PF02991	0.454
LIG_PDZ_Class_2	317	322	PF00595	0.515
LIG_RPA_C_Fungi	139	151	PF08784	0.541
LIG_SH2_CRK	157	161	PF00017	0.572
LIG_SH2_CRK	195	199	PF00017	0.561
LIG_SH2_CRK	258	262	PF00017	0.578
LIG_SH2_NCK_1	258	262	PF00017	0.578
LIG_SH2_STAT5	120	123	PF00017	0.559
LIG_SH2_STAT5	13	16	PF00017	0.426
LIG_SH2_STAT5	315	318	PF00017	0.448
LIG_SH3_3	172	178	PF00018	0.646
LIG_SH3_3	197	203	PF00018	0.598
LIG_SH3_3	265	271	PF00018	0.557
LIG_TRAF2_1	292	295	PF00917	0.483
LIG_TYR_ITIM	256	261	PF00017	0.547
LIG_UBA3_1	22	30	PF00899	0.402
LIG_WW_3	97	101	PF00397	0.559
MOD_CDC14_SPxK_1	97	100	PF00782	0.559
MOD_CDK_SPxK_1	259	265	PF00069	0.583
MOD_CDK_SPxK_1	94	100	PF00069	0.556
MOD_CK1_1	149	155	PF00069	0.600
MOD_CK1_1	259	265	PF00069	0.546
MOD_CK2_1	284	290	PF00069	0.573
MOD_DYRK1A_RPxSP_1	201	205	PF00069	0.595
MOD_GlcNHglycan	110	113	PF01048	0.638
MOD_GlcNHglycan	130	133	PF01048	0.586
MOD_GlcNHglycan	146	149	PF01048	0.509
MOD_GlcNHglycan	2	6	PF01048	0.531
MOD_GlcNHglycan	207	210	PF01048	0.620
MOD_GSK3_1	108	115	PF00069	0.564
MOD_GSK3_1	146	153	PF00069	0.700
MOD_GSK3_1	201	208	PF00069	0.600
MOD_GSK3_1	84	91	PF00069	0.651
MOD_NEK2_1	1	6	PF00069	0.481
MOD_NEK2_1	256	261	PF00069	0.510
MOD_NEK2_1	78	83	PF00069	0.679
MOD_PIKK_1	177	183	PF00454	0.660
MOD_PKA_2	112	118	PF00069	0.734
MOD_PKA_2	136	142	PF00069	0.651
MOD_PKA_2	171	177	PF00069	0.551
MOD_Plk_1	226	232	PF00069	0.540
MOD_Plk_1	256	262	PF00069	0.538
MOD_Plk_4	136	142	PF00069	0.736
MOD_Plk_4	152	158	PF00069	0.484
MOD_Plk_4	68	74	PF00069	0.374
MOD_ProDKin_1	150	156	PF00069	0.639
MOD_ProDKin_1	161	167	PF00069	0.517
MOD_ProDKin_1	201	207	PF00069	0.643
MOD_ProDKin_1	259	265	PF00069	0.583
MOD_ProDKin_1	279	285	PF00069	0.570
MOD_ProDKin_1	53	59	PF00069	0.418
MOD_ProDKin_1	94	100	PF00069	0.665
TRG_DiLeu_BaEn_1	136	141	PF01217	0.592
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.566
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.492
TRG_ENDOCYTIC_2	258	261	PF00928	0.573
TRG_ER_diArg_1	159	162	PF00400	0.563
TRG_ER_diArg_1	191	193	PF00400	0.597
TRG_ER_diArg_1	212	214	PF00400	0.624
TRG_ER_diArg_1	250	253	PF00400	0.549
TRG_ER_diArg_1	312	314	PF00400	0.378
TRG_ER_diArg_1	35	37	PF00400	0.427
TRG_Pf-PMV_PEXEL_1	21	26	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP1	Leptomonas seymouri	44%	78%
A4HKC6	Leishmania braziliensis	55%	96%
A4I7V1	Leishmania infantum	99%	100%
E9B2R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q5E4	Leishmania major	82%	100%