Peptide deformylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peptide deformylase

Gene product:

polypeptide deformylase-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5G9_LEIDO

TriTrypDb:

LdBPK_321360.1 , LdCL_320019300 , LDHU3_32.1730

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X5G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5G9

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0019538	protein metabolic process	3	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0043043	peptide biosynthetic process	5	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0043686	co-translational protein modification	5	1
GO:0006508	proteolysis	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0005488	binding	1	14
GO:0016787	hydrolase activity	2	14
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	14
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	14
GO:0042586	peptide deformylase activity	5	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.613
CLV_NRD_NRD_1	51	53	PF00675	0.391
CLV_NRD_NRD_1	8	10	PF00675	0.609
CLV_PCSK_KEX2_1	2	4	PF00082	0.614
CLV_PCSK_KEX2_1	51	53	PF00082	0.391
CLV_PCSK_KEX2_1	8	10	PF00082	0.605
CLV_PCSK_SKI1_1	197	201	PF00082	0.377
CLV_PCSK_SKI1_1	59	63	PF00082	0.326
CLV_PCSK_SKI1_1	8	12	PF00082	0.589
DEG_Nend_UBRbox_1	1	4	PF02207	0.708
DEG_SPOP_SBC_1	27	31	PF00917	0.687
DOC_CKS1_1	232	237	PF01111	0.459
DOC_CYCLIN_RxL_1	2	15	PF00134	0.492
DOC_PP4_FxxP_1	97	100	PF00568	0.358
DOC_PP4_MxPP_1	247	250	PF00568	0.327
DOC_USP7_MATH_1	28	32	PF00917	0.616
DOC_USP7_MATH_1	57	61	PF00917	0.358
DOC_WW_Pin1_4	231	236	PF00397	0.465
DOC_WW_Pin1_4	29	34	PF00397	0.607
DOC_WW_Pin1_4	72	77	PF00397	0.376
LIG_14-3-3_CanoR_1	162	168	PF00244	0.403
LIG_Actin_WH2_2	36	53	PF00022	0.516
LIG_BRCT_BRCA1_1	31	35	PF00533	0.665
LIG_BRCT_BRCA1_1	74	78	PF00533	0.402
LIG_FHA_1	13	19	PF00498	0.679
LIG_FHA_1	152	158	PF00498	0.392
LIG_FHA_1	60	66	PF00498	0.411
LIG_FHA_2	116	122	PF00498	0.453
LIG_LIR_Apic_2	121	126	PF02991	0.318
LIG_LIR_Apic_2	96	100	PF02991	0.358
LIG_Pex14_1	221	225	PF04695	0.423
LIG_SH2_SRC	168	171	PF00017	0.463
LIG_SH2_STAP1	120	124	PF00017	0.451
LIG_SH2_STAP1	256	260	PF00017	0.521
LIG_SH2_STAT5	231	234	PF00017	0.406
LIG_SH2_STAT5	241	244	PF00017	0.448
LIG_SH3_3	123	129	PF00018	0.358
LIG_SH3_3	154	160	PF00018	0.343
LIG_SH3_3	229	235	PF00018	0.468
LIG_SH3_3	61	67	PF00018	0.368
LIG_SUMO_SIM_par_1	107	113	PF11976	0.385
LIG_TRAF2_2	235	240	PF00917	0.398
MOD_CDK_SPxxK_3	29	36	PF00069	0.599
MOD_CK1_1	149	155	PF00069	0.463
MOD_CK1_1	29	35	PF00069	0.642
MOD_CK2_1	115	121	PF00069	0.444
MOD_CK2_1	31	37	PF00069	0.584
MOD_GlcNHglycan	165	168	PF01048	0.347
MOD_GlcNHglycan	226	229	PF01048	0.509
MOD_GlcNHglycan	97	100	PF01048	0.330
MOD_GSK3_1	27	34	PF00069	0.664
MOD_GSK3_1	68	75	PF00069	0.399
MOD_N-GLC_1	243	248	PF02516	0.512
MOD_NEK2_1	110	115	PF00069	0.261
MOD_NEK2_1	195	200	PF00069	0.402
MOD_NEK2_1	208	213	PF00069	0.336
MOD_NEK2_1	78	83	PF00069	0.358
MOD_NEK2_1	95	100	PF00069	0.315
MOD_PIKK_1	68	74	PF00454	0.392
MOD_PKA_2	161	167	PF00069	0.451
MOD_Plk_1	243	249	PF00069	0.505
MOD_Plk_4	195	201	PF00069	0.343
MOD_Plk_4	243	249	PF00069	0.480
MOD_Plk_4	78	84	PF00069	0.434
MOD_ProDKin_1	231	237	PF00069	0.462
MOD_ProDKin_1	29	35	PF00069	0.603
MOD_ProDKin_1	72	78	PF00069	0.376
MOD_SUMO_rev_2	34	43	PF00179	0.610
TRG_DiLeu_BaEn_1	190	195	PF01217	0.445
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.727
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.489
TRG_ER_diArg_1	1	3	PF00400	0.663
TRG_ER_diArg_1	182	185	PF00400	0.342
TRG_ER_diArg_1	50	52	PF00400	0.458
TRG_ER_diArg_1	7	9	PF00400	0.655
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A0	Leptomonas seymouri	73%	99%
A0A0S4JJP7	Bodo saltans	22%	72%
A0A0S4KJX6	Bodo saltans	53%	98%
A0A1X0NUS7	Trypanosomatidae	66%	100%
A0A3R7P233	Trypanosoma rangeli	65%	100%
A4HKB8	Leishmania braziliensis	84%	100%
A4I7U7	Leishmania infantum	100%	100%
D0AA05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9B2Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q5F2	Leishmania major	96%	100%
V5B173	Trypanosoma cruzi	65%	100%
V5BDN2	Trypanosoma cruzi	23%	78%