Ubiquitin hydrolase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin hydrolase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5G6_LEIDO

TriTrypDb:

LdBPK_321310.1 , LdCL_320018800 , LDHU3_32.1670

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5G6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	10
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	10
GO:0009057	macromolecule catabolic process	4	10
GO:0009987	cellular process	1	10
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	10
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044265	obsolete cellular macromolecule catabolic process	4	10
GO:0051603	proteolysis involved in protein catabolic process	5	10
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	294	296	PF00675	0.337
CLV_PCSK_FUR_1	312	316	PF00082	0.293
CLV_PCSK_KEX2_1	294	296	PF00082	0.313
CLV_PCSK_KEX2_1	314	316	PF00082	0.222
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.359
CLV_PCSK_SKI1_1	274	278	PF00082	0.256
CLV_PCSK_SKI1_1	315	319	PF00082	0.445
DEG_Nend_UBRbox_3	1	3	PF02207	0.247
DEG_SPOP_SBC_1	145	149	PF00917	0.233
DOC_CYCLIN_RxL_1	312	322	PF00134	0.283
DOC_MAPK_DCC_7	281	290	PF00069	0.264
DOC_MAPK_gen_1	190	197	PF00069	0.283
DOC_MAPK_gen_1	225	234	PF00069	0.271
DOC_MAPK_gen_1	274	282	PF00069	0.277
DOC_MAPK_gen_1	312	319	PF00069	0.329
DOC_MAPK_MEF2A_6	227	236	PF00069	0.368
DOC_MAPK_MEF2A_6	238	246	PF00069	0.302
DOC_MAPK_MEF2A_6	281	290	PF00069	0.264
DOC_MAPK_RevD_3	280	295	PF00069	0.343
DOC_PP2B_LxvP_1	141	144	PF13499	0.197
DOC_PP2B_LxvP_1	317	320	PF13499	0.249
DOC_USP7_MATH_1	128	132	PF00917	0.310
DOC_USP7_MATH_1	134	138	PF00917	0.281
DOC_USP7_MATH_1	176	180	PF00917	0.382
DOC_USP7_MATH_1	75	79	PF00917	0.355
DOC_USP7_UBL2_3	190	194	PF12436	0.309
DOC_USP7_UBL2_3	274	278	PF12436	0.253
DOC_USP7_UBL2_3	406	410	PF12436	0.393
DOC_WW_Pin1_4	361	366	PF00397	0.345
DOC_WW_Pin1_4	382	387	PF00397	0.309
LIG_14-3-3_CanoR_1	231	235	PF00244	0.404
LIG_14-3-3_CanoR_1	260	268	PF00244	0.326
LIG_14-3-3_CanoR_1	312	318	PF00244	0.345
LIG_14-3-3_CanoR_1	337	342	PF00244	0.381
LIG_BRCT_BRCA1_1	286	290	PF00533	0.284
LIG_Clathr_ClatBox_1	118	122	PF01394	0.393
LIG_Clathr_ClatBox_1	304	308	PF01394	0.283
LIG_FHA_1	24	30	PF00498	0.368
LIG_FHA_1	262	268	PF00498	0.296
LIG_FHA_1	277	283	PF00498	0.180
LIG_FHA_1	314	320	PF00498	0.237
LIG_FHA_1	354	360	PF00498	0.290
LIG_FHA_1	362	368	PF00498	0.254
LIG_FHA_1	378	384	PF00498	0.423
LIG_FHA_1	389	395	PF00498	0.451
LIG_FHA_2	133	139	PF00498	0.284
LIG_Integrin_RGD_1	345	347	PF01839	0.393
LIG_LIR_Apic_2	237	243	PF02991	0.393
LIG_LIR_Apic_2	49	55	PF02991	0.299
LIG_LIR_Gen_1	21	29	PF02991	0.331
LIG_LIR_Gen_1	287	298	PF02991	0.442
LIG_LIR_Gen_1	4	13	PF02991	0.228
LIG_LIR_Nem_3	21	25	PF02991	0.440
LIG_LIR_Nem_3	237	242	PF02991	0.255
LIG_LIR_Nem_3	287	293	PF02991	0.438
LIG_LIR_Nem_3	333	339	PF02991	0.276
LIG_LIR_Nem_3	411	417	PF02991	0.249
LIG_MYND_1	65	69	PF01753	0.322
LIG_NRBOX	106	112	PF00104	0.309
LIG_Pex14_1	48	52	PF04695	0.264
LIG_Pex14_1	53	57	PF04695	0.264
LIG_Pex14_2	18	22	PF04695	0.283
LIG_SH2_CRK	240	244	PF00017	0.322
LIG_SH2_CRK	336	340	PF00017	0.309
LIG_SH2_STAT5	240	243	PF00017	0.396
LIG_SH2_STAT5	354	357	PF00017	0.249
LIG_SH2_STAT5	414	417	PF00017	0.249
LIG_SH3_3	66	72	PF00018	0.421
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.354
LIG_SUMO_SIM_par_1	25	30	PF11976	0.344
LIG_TRAF2_1	98	101	PF00917	0.283
LIG_TYR_ITSM	410	417	PF00017	0.393
LIG_WRC_WIRS_1	19	24	PF05994	0.297
MOD_CK2_1	132	138	PF00069	0.342
MOD_CK2_1	267	273	PF00069	0.339
MOD_CK2_1	95	101	PF00069	0.300
MOD_GlcNHglycan	79	82	PF01048	0.384
MOD_GlcNHglycan	84	87	PF01048	0.387
MOD_GSK3_1	128	135	PF00069	0.328
MOD_GSK3_1	145	152	PF00069	0.396
MOD_GSK3_1	23	30	PF00069	0.365
MOD_GSK3_1	325	332	PF00069	0.295
MOD_LATS_1	182	188	PF00433	0.197
MOD_N-GLC_1	1	6	PF02516	0.233
MOD_N-GLC_1	398	403	PF02516	0.402
MOD_N-GLC_1	75	80	PF02516	0.392
MOD_N-GLC_2	5	7	PF02516	0.264
MOD_NEK2_1	1	6	PF00069	0.310
MOD_NEK2_1	209	214	PF00069	0.354
MOD_NEK2_1	25	30	PF00069	0.180
MOD_NEK2_1	258	263	PF00069	0.250
MOD_NEK2_1	276	281	PF00069	0.264
MOD_NEK2_1	8	13	PF00069	0.292
MOD_NEK2_1	95	100	PF00069	0.295
MOD_PIKK_1	88	94	PF00454	0.343
MOD_PK_1	284	290	PF00069	0.197
MOD_PK_1	337	343	PF00069	0.322
MOD_PKA_2	230	236	PF00069	0.423
MOD_Plk_1	250	256	PF00069	0.263
MOD_Plk_1	258	264	PF00069	0.164
MOD_Plk_1	325	331	PF00069	0.256
MOD_Plk_1	398	404	PF00069	0.393
MOD_Plk_2-3	132	138	PF00069	0.416
MOD_Plk_4	209	215	PF00069	0.383
MOD_Plk_4	230	236	PF00069	0.251
MOD_Plk_4	284	290	PF00069	0.326
MOD_Plk_4	337	343	PF00069	0.320
MOD_Plk_4	353	359	PF00069	0.280
MOD_Plk_4	388	394	PF00069	0.399
MOD_Plk_4	409	415	PF00069	0.393
MOD_Plk_4	63	69	PF00069	0.401
MOD_Plk_4	8	14	PF00069	0.393
MOD_ProDKin_1	361	367	PF00069	0.345
MOD_ProDKin_1	382	388	PF00069	0.309
MOD_SUMO_rev_2	269	276	PF00179	0.197
TRG_DiLeu_BaEn_2	410	416	PF01217	0.343
TRG_DiLeu_BaEn_4	116	122	PF01217	0.322
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.393
TRG_ENDOCYTIC_2	239	242	PF00928	0.393
TRG_ENDOCYTIC_2	336	339	PF00928	0.283
TRG_ENDOCYTIC_2	414	417	PF00928	0.249
TRG_ER_diArg_1	293	295	PF00400	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP3	Leptomonas seymouri	62%	82%
A0A0S4IXL6	Bodo saltans	32%	77%
A0A1X0NUI1	Trypanosomatidae	44%	95%
A0A422P1B8	Trypanosoma rangeli	42%	96%
A4HKB2	Leishmania braziliensis	78%	97%
A4I7U2	Leishmania infantum	98%	100%
D0AA02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	95%
E9B2Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	97%
O94269	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	82%
O96612	Dictyostelium discoideum	23%	94%
Q4Q5F7	Leishmania major	91%	97%
Q9FPS3	Arabidopsis thaliana	25%	77%
V5DHM6	Trypanosoma cruzi	42%	100%