PSP1 C-terminal conserved region containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5G4_LEIDO

TriTrypDb:

LdBPK_321630.1 , LdCL_320021900 , LDHU3_32.2060

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X5G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5G4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.571
CLV_NRD_NRD_1	200	202	PF00675	0.605
CLV_NRD_NRD_1	221	223	PF00675	0.500
CLV_NRD_NRD_1	385	387	PF00675	0.754
CLV_NRD_NRD_1	69	71	PF00675	0.715
CLV_NRD_NRD_1	88	90	PF00675	0.432
CLV_PCSK_FUR_1	198	202	PF00082	0.468
CLV_PCSK_FUR_1	219	223	PF00082	0.507
CLV_PCSK_KEX2_1	131	133	PF00082	0.784
CLV_PCSK_KEX2_1	198	200	PF00082	0.691
CLV_PCSK_KEX2_1	216	218	PF00082	0.354
CLV_PCSK_KEX2_1	221	223	PF00082	0.500
CLV_PCSK_KEX2_1	385	387	PF00082	0.768
CLV_PCSK_KEX2_1	69	71	PF00082	0.633
CLV_PCSK_KEX2_1	88	90	PF00082	0.432
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.784
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.523
CLV_PCSK_PC7_1	217	223	PF00082	0.516
CLV_PCSK_SKI1_1	160	164	PF00082	0.766
CLV_PCSK_SKI1_1	221	225	PF00082	0.488
CLV_PCSK_SKI1_1	287	291	PF00082	0.513
CLV_PCSK_SKI1_1	306	310	PF00082	0.411
CLV_PCSK_SKI1_1	354	358	PF00082	0.416
CLV_PCSK_SKI1_1	74	78	PF00082	0.629
DEG_APCC_DBOX_1	146	154	PF00400	0.684
DEG_APCC_DBOX_1	220	228	PF00400	0.611
DEG_APCC_DBOX_1	73	81	PF00400	0.566
DOC_MAPK_DCC_7	219	229	PF00069	0.607
DOC_MAPK_gen_1	219	229	PF00069	0.568
DOC_MAPK_gen_1	385	392	PF00069	0.682
DOC_MAPK_GRA24_9	213	229	PF00069	0.601
DOC_PP1_RVXF_1	334	340	PF00149	0.411
DOC_PP1_RVXF_1	387	393	PF00149	0.693
DOC_PP4_FxxP_1	223	226	PF00568	0.589
DOC_USP7_MATH_1	130	134	PF00917	0.744
DOC_USP7_MATH_1	146	150	PF00917	0.588
DOC_USP7_MATH_1	180	184	PF00917	0.702
DOC_USP7_MATH_1	47	51	PF00917	0.815
DOC_USP7_MATH_2	3	9	PF00917	0.666
DOC_WW_Pin1_4	122	127	PF00397	0.742
DOC_WW_Pin1_4	154	159	PF00397	0.737
DOC_WW_Pin1_4	161	166	PF00397	0.791
DOC_WW_Pin1_4	175	180	PF00397	0.710
DOC_WW_Pin1_4	222	227	PF00397	0.559
DOC_WW_Pin1_4	38	43	PF00397	0.659
LIG_14-3-3_CanoR_1	147	151	PF00244	0.725
LIG_14-3-3_CanoR_1	177	187	PF00244	0.732
LIG_14-3-3_CanoR_1	201	210	PF00244	0.499
LIG_14-3-3_CanoR_1	287	294	PF00244	0.411
LIG_14-3-3_CanoR_1	306	315	PF00244	0.513
LIG_14-3-3_CanoR_1	318	324	PF00244	0.315
LIG_14-3-3_CanoR_1	69	78	PF00244	0.647
LIG_Actin_WH2_1	147	162	PF00022	0.583
LIG_Actin_WH2_2	144	162	PF00022	0.581
LIG_BRCT_BRCA1_1	337	341	PF00533	0.397
LIG_FHA_1	162	168	PF00498	0.797
LIG_FHA_1	85	91	PF00498	0.560
LIG_FHA_2	209	215	PF00498	0.565
LIG_FHA_2	288	294	PF00498	0.454
LIG_FHA_2	309	315	PF00498	0.389
LIG_FHA_2	80	86	PF00498	0.601
LIG_GBD_Chelix_1	315	323	PF00786	0.389
LIG_HP1_1	146	150	PF01393	0.681
LIG_LIR_Gen_1	205	215	PF02991	0.551
LIG_LIR_LC3C_4	244	249	PF02991	0.552
LIG_LIR_Nem_3	348	352	PF02991	0.411
LIG_LIR_Nem_3	355	360	PF02991	0.411
LIG_MLH1_MIPbox_1	337	341	PF16413	0.411
LIG_PCNA_yPIPBox_3	350	360	PF02747	0.389
LIG_PCNA_yPIPBox_3	88	102	PF02747	0.599
LIG_SH2_PTP2	234	237	PF00017	0.551
LIG_SH2_SRC	234	237	PF00017	0.551
LIG_SH2_STAT3	78	81	PF00017	0.662
LIG_SH2_STAT5	16	19	PF00017	0.533
LIG_SH2_STAT5	234	237	PF00017	0.551
LIG_SH2_STAT5	78	81	PF00017	0.532
LIG_SH3_3	232	238	PF00018	0.559
LIG_SH3_3	270	276	PF00018	0.739
LIG_SH3_3	53	59	PF00018	0.724
LIG_SUMO_SIM_par_1	2	9	PF11976	0.625
LIG_TRAF2_1	290	293	PF00917	0.436
LIG_ULM_U2AF65_1	198	203	PF00076	0.459
MOD_CDC14_SPxK_1	157	160	PF00782	0.789
MOD_CDK_SPxK_1	154	160	PF00069	0.792
MOD_CK1_1	103	109	PF00069	0.616
MOD_CK1_1	225	231	PF00069	0.611
MOD_CK1_1	33	39	PF00069	0.740
MOD_CK2_1	118	124	PF00069	0.697
MOD_CK2_1	208	214	PF00069	0.570
MOD_CK2_1	278	284	PF00069	0.529
MOD_CK2_1	287	293	PF00069	0.438
MOD_CK2_1	79	85	PF00069	0.543
MOD_GlcNHglycan	108	111	PF01048	0.706
MOD_GlcNHglycan	112	115	PF01048	0.607
MOD_GlcNHglycan	180	183	PF01048	0.741
MOD_GlcNHglycan	32	35	PF01048	0.739
MOD_GlcNHglycan	342	345	PF01048	0.430
MOD_GlcNHglycan	398	401	PF01048	0.651
MOD_GlcNHglycan	45	48	PF01048	0.648
MOD_GlcNHglycan	49	52	PF01048	0.637
MOD_GSK3_1	105	112	PF00069	0.668
MOD_GSK3_1	114	121	PF00069	0.709
MOD_GSK3_1	163	170	PF00069	0.806
MOD_GSK3_1	178	185	PF00069	0.530
MOD_GSK3_1	36	43	PF00069	0.714
MOD_NEK2_1	307	312	PF00069	0.433
MOD_NEK2_1	366	371	PF00069	0.622
MOD_NEK2_1	394	399	PF00069	0.735
MOD_NEK2_1	79	84	PF00069	0.579
MOD_NEK2_2	308	313	PF00069	0.389
MOD_PIKK_1	182	188	PF00454	0.758
MOD_PIKK_1	202	208	PF00454	0.553
MOD_PIKK_1	59	65	PF00454	0.733
MOD_PIKK_1	91	97	PF00454	0.630
MOD_PKA_1	69	75	PF00069	0.665
MOD_PKA_2	103	109	PF00069	0.612
MOD_PKA_2	146	152	PF00069	0.723
MOD_PKA_2	172	178	PF00069	0.787
MOD_PKA_2	187	193	PF00069	0.500
MOD_PKA_2	69	75	PF00069	0.589
MOD_Plk_2-3	300	306	PF00069	0.389
MOD_Plk_4	146	152	PF00069	0.768
MOD_Plk_4	278	284	PF00069	0.465
MOD_Plk_4	79	85	PF00069	0.655
MOD_Plk_4	97	103	PF00069	0.357
MOD_ProDKin_1	122	128	PF00069	0.741
MOD_ProDKin_1	154	160	PF00069	0.738
MOD_ProDKin_1	161	167	PF00069	0.794
MOD_ProDKin_1	175	181	PF00069	0.708
MOD_ProDKin_1	222	228	PF00069	0.563
MOD_ProDKin_1	38	44	PF00069	0.660
TRG_DiLeu_BaEn_4	292	298	PF01217	0.436
TRG_ENDOCYTIC_2	16	19	PF00928	0.644
TRG_ENDOCYTIC_2	234	237	PF00928	0.450
TRG_ER_diArg_1	197	200	PF00400	0.584
TRG_ER_diArg_1	217	220	PF00400	0.596
TRG_ER_diArg_1	221	223	PF00400	0.500
TRG_ER_diArg_1	389	392	PF00400	0.700
TRG_ER_diArg_1	68	70	PF00400	0.648
TRG_ER_diArg_1	88	90	PF00400	0.422
TRG_NES_CRM1_1	314	329	PF08389	0.436
TRG_NLS_Bipartite_1	198	220	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P982	Leptomonas seymouri	48%	93%
A4HKE2	Leishmania braziliensis	70%	100%
A4I7X0	Leishmania infantum	100%	100%
E9B2T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q5C6	Leishmania major	93%	100%