Proteasome regulatory non-ATP-ase subunit, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5G0_LEIDO

TriTrypDb:

LdBPK_321260.1 , LdCL_320018300 , LDHU3_32.1620

Length:

274

Annotations

Annotations by Jardim et al.

Proteasome, proteasome regulatory non-ATP-ase subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005838	proteasome regulatory particle	2	11
GO:0032991	protein-containing complex	1	12
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X5G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5G0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.559
CLV_NRD_NRD_1	171	173	PF00675	0.434
CLV_NRD_NRD_1	42	44	PF00675	0.580
CLV_PCSK_KEX2_1	41	43	PF00082	0.581
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.581
CLV_PCSK_SKI1_1	167	171	PF00082	0.391
CLV_PCSK_SKI1_1	19	23	PF00082	0.582
DOC_CYCLIN_yClb5_NLxxxL_5	115	124	PF00134	0.548
DOC_MAPK_gen_1	41	47	PF00069	0.526
DOC_MAPK_MEF2A_6	68	75	PF00069	0.569
DOC_MAPK_NFAT4_5	68	76	PF00069	0.568
DOC_PP1_RVXF_1	41	48	PF00149	0.602
DOC_PP2B_LxvP_1	206	209	PF13499	0.634
DOC_PP4_FxxP_1	50	53	PF00568	0.559
DOC_SPAK_OSR1_1	151	155	PF12202	0.560
DOC_USP7_MATH_1	53	57	PF00917	0.660
DOC_WW_Pin1_4	106	111	PF00397	0.556
LIG_Actin_WH2_2	7	24	PF00022	0.584
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_FHA_1	237	243	PF00498	0.653
LIG_FHA_2	188	194	PF00498	0.634
LIG_FHA_2	242	248	PF00498	0.552
LIG_FHA_2	57	63	PF00498	0.587
LIG_LIR_Apic_2	49	53	PF02991	0.550
LIG_LIR_Gen_1	109	120	PF02991	0.478
LIG_LIR_Gen_1	146	156	PF02991	0.584
LIG_LIR_Gen_1	162	169	PF02991	0.459
LIG_LIR_Gen_1	69	77	PF02991	0.531
LIG_LIR_Gen_1	88	98	PF02991	0.308
LIG_LIR_Nem_3	109	115	PF02991	0.512
LIG_LIR_Nem_3	146	152	PF02991	0.584
LIG_LIR_Nem_3	162	168	PF02991	0.459
LIG_LIR_Nem_3	177	183	PF02991	0.548
LIG_LIR_Nem_3	201	206	PF02991	0.564
LIG_LIR_Nem_3	69	73	PF02991	0.521
LIG_LIR_Nem_3	86	90	PF02991	0.346
LIG_LRP6_Inhibitor_1	116	122	PF00058	0.434
LIG_NRBOX	119	125	PF00104	0.548
LIG_Pex14_2	87	91	PF04695	0.469
LIG_SH2_CRK	165	169	PF00017	0.548
LIG_SH2_CRK	203	207	PF00017	0.540
LIG_SH2_GRB2like	90	93	PF00017	0.472
LIG_SH2_NCK_1	98	102	PF00017	0.526
LIG_SH2_SRC	180	183	PF00017	0.560
LIG_SH2_STAT3	90	93	PF00017	0.472
LIG_SH2_STAT5	112	115	PF00017	0.574
LIG_SH2_STAT5	149	152	PF00017	0.539
LIG_SH2_STAT5	159	162	PF00017	0.539
LIG_SH2_STAT5	180	183	PF00017	0.548
LIG_SH2_STAT5	70	73	PF00017	0.563
LIG_SH2_STAT5	90	93	PF00017	0.273
LIG_SH3_3	104	110	PF00018	0.590
LIG_SUMO_SIM_par_1	213	220	PF11976	0.565
LIG_TYR_ITIM	96	101	PF00017	0.520
LIG_UBA3_1	36	41	PF00899	0.520
LIG_WRC_WIRS_1	47	52	PF05994	0.533
LIG_WRC_WIRS_1	84	89	PF05994	0.507
MOD_CK1_1	56	62	PF00069	0.580
MOD_CK2_1	131	137	PF00069	0.548
MOD_CK2_1	56	62	PF00069	0.606
MOD_GlcNHglycan	1	4	PF01048	0.683
MOD_GlcNHglycan	234	237	PF01048	0.374
MOD_GlcNHglycan	77	80	PF01048	0.463
MOD_GSK3_1	232	239	PF00069	0.585
MOD_GSK3_1	54	61	PF00069	0.636
MOD_GSK3_1	96	103	PF00069	0.557
MOD_NEK2_1	124	129	PF00069	0.609
MOD_NEK2_1	161	166	PF00069	0.533
MOD_NEK2_1	168	173	PF00069	0.540
MOD_NEK2_1	187	192	PF00069	0.449
MOD_NEK2_1	7	12	PF00069	0.659
MOD_PK_1	204	210	PF00069	0.626
MOD_Plk_1	187	193	PF00069	0.555
MOD_Plk_1	246	252	PF00069	0.711
MOD_Plk_1	5	11	PF00069	0.633
MOD_Plk_1	62	68	PF00069	0.550
MOD_Plk_2-3	100	106	PF00069	0.588
MOD_Plk_2-3	131	137	PF00069	0.609
MOD_Plk_2-3	83	89	PF00069	0.508
MOD_Plk_4	46	52	PF00069	0.564
MOD_ProDKin_1	106	112	PF00069	0.548
MOD_SUMO_rev_2	16	21	PF00179	0.638
MOD_SUMO_rev_2	218	223	PF00179	0.609
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.548
TRG_ENDOCYTIC_2	112	115	PF00928	0.461
TRG_ENDOCYTIC_2	149	152	PF00928	0.548
TRG_ENDOCYTIC_2	165	168	PF00928	0.548
TRG_ENDOCYTIC_2	180	183	PF00928	0.548
TRG_ENDOCYTIC_2	203	206	PF00928	0.539
TRG_ENDOCYTIC_2	70	73	PF00928	0.533
TRG_ENDOCYTIC_2	98	101	PF00928	0.522
TRG_ER_diArg_1	42	44	PF00400	0.620
TRG_NLS_MonoExtC_3	171	176	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A9	Leptomonas seymouri	84%	100%
A0A0S4J927	Bodo saltans	51%	79%
A0A1X0NUT6	Trypanosomatidae	59%	100%
A0A3R7M9M8	Trypanosoma rangeli	62%	100%
A4HKA7	Leishmania braziliensis	91%	100%
A4I7T7	Leishmania infantum	100%	100%
D0A9Z7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B2P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P02889	Dictyostelium discoideum	36%	100%
P32496	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P48556	Homo sapiens	36%	78%
P50524	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q23449	Caenorhabditis elegans	34%	100%
Q3SYT7	Bos taurus	35%	95%
Q4Q5G2	Leishmania major	98%	100%
Q5RE15	Pongo abelii	36%	95%
Q9CX56	Mus musculus	36%	78%
Q9SGW3	Arabidopsis thaliana	33%	100%
V5DHL8	Trypanosoma cruzi	63%	100%