Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5F7_LEIDO

TriTrypDb:

LdBPK_321450.1 , LdCL_320020200 , LDHU3_32.1840

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5F7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.484
CLV_NRD_NRD_1	382	384	PF00675	0.367
CLV_NRD_NRD_1	53	55	PF00675	0.668
CLV_NRD_NRD_1	676	678	PF00675	0.684
CLV_PCSK_KEX2_1	160	162	PF00082	0.484
CLV_PCSK_KEX2_1	314	316	PF00082	0.377
CLV_PCSK_KEX2_1	52	54	PF00082	0.674
CLV_PCSK_KEX2_1	676	678	PF00082	0.684
CLV_PCSK_KEX2_1	8	10	PF00082	0.572
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.377
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.572
CLV_PCSK_PC7_1	49	55	PF00082	0.538
CLV_PCSK_SKI1_1	210	214	PF00082	0.368
CLV_PCSK_SKI1_1	272	276	PF00082	0.474
CLV_PCSK_SKI1_1	310	314	PF00082	0.407
CLV_PCSK_SKI1_1	351	355	PF00082	0.518
CLV_PCSK_SKI1_1	400	404	PF00082	0.450
CLV_PCSK_SKI1_1	508	512	PF00082	0.404
CLV_PCSK_SKI1_1	74	78	PF00082	0.395
CLV_PCSK_SKI1_1	9	13	PF00082	0.686
DEG_APCC_DBOX_1	159	167	PF00400	0.464
DEG_APCC_DBOX_1	73	81	PF00400	0.381
DEG_MDM2_SWIB_1	276	283	PF02201	0.422
DEG_Nend_Nbox_1	1	3	PF02207	0.639
DOC_ANK_TNKS_1	51	58	PF00023	0.662
DOC_CKS1_1	354	359	PF01111	0.547
DOC_CKS1_1	401	406	PF01111	0.398
DOC_CYCLIN_RxL_1	204	217	PF00134	0.379
DOC_CYCLIN_RxL_1	381	392	PF00134	0.448
DOC_MAPK_gen_1	666	675	PF00069	0.653
DOC_PP1_RVXF_1	280	286	PF00149	0.422
DOC_PP2B_LxvP_1	386	389	PF13499	0.463
DOC_PP2B_LxvP_1	418	421	PF13499	0.454
DOC_PP4_FxxP_1	646	649	PF00568	0.657
DOC_USP7_MATH_1	101	105	PF00917	0.655
DOC_USP7_MATH_1	108	112	PF00917	0.598
DOC_USP7_MATH_1	11	15	PF00917	0.502
DOC_USP7_MATH_1	122	126	PF00917	0.682
DOC_USP7_MATH_1	244	248	PF00917	0.389
DOC_USP7_MATH_1	332	336	PF00917	0.415
DOC_USP7_MATH_1	389	393	PF00917	0.531
DOC_USP7_MATH_1	438	442	PF00917	0.579
DOC_USP7_MATH_1	549	553	PF00917	0.482
DOC_USP7_MATH_1	564	568	PF00917	0.350
DOC_USP7_MATH_1	712	716	PF00917	0.651
DOC_USP7_MATH_1	741	745	PF00917	0.735
DOC_USP7_UBL2_3	268	272	PF12436	0.493
DOC_USP7_UBL2_3	310	314	PF12436	0.347
DOC_WW_Pin1_4	115	120	PF00397	0.819
DOC_WW_Pin1_4	18	23	PF00397	0.528
DOC_WW_Pin1_4	353	358	PF00397	0.562
DOC_WW_Pin1_4	360	365	PF00397	0.545
DOC_WW_Pin1_4	400	405	PF00397	0.432
DOC_WW_Pin1_4	436	441	PF00397	0.591
DOC_WW_Pin1_4	707	712	PF00397	0.628
LIG_14-3-3_CanoR_1	315	324	PF00244	0.370
LIG_14-3-3_CanoR_1	340	349	PF00244	0.329
LIG_14-3-3_CanoR_1	383	387	PF00244	0.462
LIG_14-3-3_CanoR_1	414	421	PF00244	0.431
LIG_14-3-3_CanoR_1	516	520	PF00244	0.434
LIG_14-3-3_CanoR_1	659	667	PF00244	0.562
LIG_14-3-3_CanoR_1	676	684	PF00244	0.772
LIG_14-3-3_CanoR_1	9	18	PF00244	0.528
LIG_Actin_WH2_2	401	416	PF00022	0.297
LIG_BIR_III_2	437	441	PF00653	0.543
LIG_BRCT_BRCA1_1	482	486	PF00533	0.403
LIG_BRCT_BRCA1_1	663	667	PF00533	0.554
LIG_BRCT_BRCA1_2	663	669	PF00533	0.530
LIG_CtBP_PxDLS_1	364	368	PF00389	0.468
LIG_EH1_1	205	213	PF00400	0.428
LIG_eIF4E_1	307	313	PF01652	0.392
LIG_FHA_1	10	16	PF00498	0.533
LIG_FHA_1	124	130	PF00498	0.670
LIG_FHA_1	165	171	PF00498	0.342
LIG_FHA_1	203	209	PF00498	0.482
LIG_FHA_1	222	228	PF00498	0.264
LIG_FHA_1	397	403	PF00498	0.559
LIG_FHA_1	414	420	PF00498	0.341
LIG_FHA_1	45	51	PF00498	0.503
LIG_FHA_1	540	546	PF00498	0.427
LIG_FHA_1	636	642	PF00498	0.667
LIG_FHA_2	116	122	PF00498	0.661
LIG_FHA_2	420	426	PF00498	0.494
LIG_FHA_2	731	737	PF00498	0.644
LIG_Integrin_RGD_1	54	56	PF01839	0.557
LIG_LIR_Apic_2	399	404	PF02991	0.409
LIG_LIR_Apic_2	644	649	PF02991	0.651
LIG_LIR_Gen_1	277	286	PF02991	0.449
LIG_LIR_Gen_1	463	473	PF02991	0.328
LIG_LIR_Gen_1	671	679	PF02991	0.622
LIG_LIR_Gen_1	718	727	PF02991	0.595
LIG_LIR_Nem_3	111	115	PF02991	0.672
LIG_LIR_Nem_3	277	283	PF02991	0.458
LIG_LIR_Nem_3	463	468	PF02991	0.324
LIG_LIR_Nem_3	483	489	PF02991	0.202
LIG_LIR_Nem_3	531	537	PF02991	0.414
LIG_LIR_Nem_3	671	675	PF02991	0.628
LIG_LIR_Nem_3	715	719	PF02991	0.621
LIG_LIR_Nem_3	85	91	PF02991	0.446
LIG_MLH1_MIPbox_1	482	486	PF16413	0.399
LIG_NRBOX	165	171	PF00104	0.402
LIG_NRBOX	86	92	PF00104	0.439
LIG_PCNA_APIM_2	533	539	PF02747	0.369
LIG_Pex14_2	216	220	PF04695	0.459
LIG_Pex14_2	276	280	PF04695	0.361
LIG_Pex14_2	663	667	PF04695	0.530
LIG_PTB_Apo_2	718	725	PF02174	0.573
LIG_Rb_LxCxE_1	339	358	PF01857	0.483
LIG_REV1ctd_RIR_1	306	314	PF16727	0.339
LIG_SH2_NCK_1	395	399	PF00017	0.572
LIG_SH2_PTP2	401	404	PF00017	0.431
LIG_SH2_PTP2	672	675	PF00017	0.650
LIG_SH2_SRC	292	295	PF00017	0.386
LIG_SH2_SRC	38	41	PF00017	0.477
LIG_SH2_STAP1	317	321	PF00017	0.444
LIG_SH2_STAT5	292	295	PF00017	0.387
LIG_SH2_STAT5	305	308	PF00017	0.358
LIG_SH2_STAT5	337	340	PF00017	0.403
LIG_SH2_STAT5	38	41	PF00017	0.446
LIG_SH2_STAT5	401	404	PF00017	0.431
LIG_SH2_STAT5	536	539	PF00017	0.401
LIG_SH2_STAT5	672	675	PF00017	0.590
LIG_SH2_STAT5	79	82	PF00017	0.432
LIG_SH3_3	681	687	PF00018	0.682
LIG_SH3_4	268	275	PF00018	0.417
LIG_Sin3_3	147	154	PF02671	0.562
LIG_SUMO_SIM_par_1	125	132	PF11976	0.566
LIG_SUMO_SIM_par_1	293	299	PF11976	0.391
LIG_SUMO_SIM_par_1	690	696	PF11976	0.603
LIG_TRAF2_1	154	157	PF00917	0.481
LIG_TRAF2_1	422	425	PF00917	0.512
LIG_TRAF2_1	605	608	PF00917	0.478
LIG_TRFH_1	452	456	PF08558	0.489
LIG_UBA3_1	378	384	PF00899	0.402
LIG_UBA3_1	87	94	PF00899	0.425
LIG_WRC_WIRS_1	169	174	PF05994	0.349
LIG_WRC_WIRS_1	716	721	PF05994	0.587
MOD_CK1_1	111	117	PF00069	0.749
MOD_CK1_1	21	27	PF00069	0.519
MOD_CK1_1	259	265	PF00069	0.464
MOD_CK1_1	41	47	PF00069	0.346
MOD_CK1_1	441	447	PF00069	0.570
MOD_CK1_1	567	573	PF00069	0.348
MOD_CK1_1	655	661	PF00069	0.619
MOD_CK1_1	665	671	PF00069	0.601
MOD_CK1_1	715	721	PF00069	0.589
MOD_CK2_1	11	17	PF00069	0.503
MOD_CK2_1	115	121	PF00069	0.622
MOD_CK2_1	340	346	PF00069	0.371
MOD_CK2_1	419	425	PF00069	0.477
MOD_CK2_1	92	98	PF00069	0.483
MOD_GlcNHglycan	145	148	PF01048	0.678
MOD_GlcNHglycan	258	261	PF01048	0.435
MOD_GlcNHglycan	319	322	PF01048	0.371
MOD_GlcNHglycan	351	354	PF01048	0.526
MOD_GlcNHglycan	434	437	PF01048	0.595
MOD_GlcNHglycan	443	446	PF01048	0.528
MOD_GlcNHglycan	482	485	PF01048	0.422
MOD_GlcNHglycan	524	527	PF01048	0.441
MOD_GlcNHglycan	677	680	PF01048	0.567
MOD_GlcNHglycan	70	73	PF01048	0.510
MOD_GlcNHglycan	727	730	PF01048	0.803
MOD_GSK3_1	111	118	PF00069	0.675
MOD_GSK3_1	164	171	PF00069	0.411
MOD_GSK3_1	174	181	PF00069	0.398
MOD_GSK3_1	192	199	PF00069	0.478
MOD_GSK3_1	227	234	PF00069	0.520
MOD_GSK3_1	270	277	PF00069	0.412
MOD_GSK3_1	349	356	PF00069	0.578
MOD_GSK3_1	396	403	PF00069	0.453
MOD_GSK3_1	432	439	PF00069	0.578
MOD_GSK3_1	472	479	PF00069	0.433
MOD_GSK3_1	563	570	PF00069	0.408
MOD_GSK3_1	574	581	PF00069	0.392
MOD_GSK3_1	658	665	PF00069	0.639
MOD_GSK3_1	737	744	PF00069	0.655
MOD_N-GLC_1	164	169	PF02516	0.356
MOD_N-GLC_1	564	569	PF02516	0.407
MOD_N-GLC_1	577	582	PF02516	0.283
MOD_N-GLC_1	737	742	PF02516	0.768
MOD_NEK2_1	172	177	PF00069	0.424
MOD_NEK2_1	220	225	PF00069	0.454
MOD_NEK2_1	231	236	PF00069	0.445
MOD_NEK2_1	256	261	PF00069	0.463
MOD_NEK2_1	275	280	PF00069	0.354
MOD_NEK2_1	394	399	PF00069	0.410
MOD_NEK2_1	413	418	PF00069	0.421
MOD_NEK2_1	480	485	PF00069	0.422
MOD_NEK2_1	584	589	PF00069	0.490
MOD_NEK2_2	509	514	PF00069	0.467
MOD_PIKK_1	174	180	PF00454	0.451
MOD_PIKK_1	221	227	PF00454	0.441
MOD_PIKK_1	275	281	PF00454	0.513
MOD_PIKK_1	739	745	PF00454	0.691
MOD_PIKK_1	92	98	PF00454	0.456
MOD_PKA_2	382	388	PF00069	0.395
MOD_PKA_2	413	419	PF00069	0.422
MOD_PKA_2	515	521	PF00069	0.429
MOD_PKA_2	624	630	PF00069	0.640
MOD_PKA_2	635	641	PF00069	0.529
MOD_PKA_2	655	661	PF00069	0.646
MOD_PKA_2	675	681	PF00069	0.474
MOD_Plk_1	196	202	PF00069	0.465
MOD_Plk_1	389	395	PF00069	0.440
MOD_Plk_1	466	472	PF00069	0.383
MOD_Plk_1	476	482	PF00069	0.411
MOD_Plk_1	564	570	PF00069	0.517
MOD_Plk_1	577	583	PF00069	0.326
MOD_Plk_2-3	192	198	PF00069	0.347
MOD_Plk_2-3	730	736	PF00069	0.642
MOD_Plk_4	244	250	PF00069	0.341
MOD_Plk_4	374	380	PF00069	0.325
MOD_Plk_4	382	388	PF00069	0.395
MOD_Plk_4	466	472	PF00069	0.357
MOD_Plk_4	476	482	PF00069	0.468
MOD_Plk_4	509	515	PF00069	0.367
MOD_Plk_4	539	545	PF00069	0.448
MOD_Plk_4	549	555	PF00069	0.298
MOD_Plk_4	668	674	PF00069	0.601
MOD_Plk_4	83	89	PF00069	0.456
MOD_ProDKin_1	115	121	PF00069	0.819
MOD_ProDKin_1	18	24	PF00069	0.523
MOD_ProDKin_1	353	359	PF00069	0.562
MOD_ProDKin_1	360	366	PF00069	0.530
MOD_ProDKin_1	400	406	PF00069	0.431
MOD_ProDKin_1	436	442	PF00069	0.590
MOD_ProDKin_1	707	713	PF00069	0.630
MOD_SUMO_for_1	698	701	PF00179	0.599
TRG_DiLeu_BaEn_4	700	706	PF01217	0.576
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.357
TRG_ENDOCYTIC_2	292	295	PF00928	0.371
TRG_ENDOCYTIC_2	303	306	PF00928	0.322
TRG_ENDOCYTIC_2	672	675	PF00928	0.650
TRG_ENDOCYTIC_2	716	719	PF00928	0.558
TRG_ER_diArg_1	52	54	PF00400	0.623
TRG_ER_diArg_1	675	677	PF00400	0.685
TRG_NES_CRM1_1	463	477	PF08389	0.348
TRG_NES_CRM1_1	574	586	PF08389	0.432
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J2	Leptomonas seymouri	58%	98%
A0A1X0NUI7	Trypanosomatidae	31%	100%
A4HKC7	Leishmania braziliensis	74%	100%
A4I7V6	Leishmania infantum	99%	100%
E9B2R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q5E3	Leishmania major	93%	100%