Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5F5_LEIDO

TriTrypDb:

LdBPK_321210.1 , LdCL_320017800 , LDHU3_32.1560

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5F5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_ODPH_VHL_1	148	160	PF01847	0.295
DEG_SPOP_SBC_1	87	91	PF00917	0.456
DOC_MAPK_gen_1	74	81	PF00069	0.416
DOC_MAPK_gen_1	98	108	PF00069	0.285
DOC_MAPK_MEF2A_6	101	108	PF00069	0.453
DOC_MAPK_RevD_3	235	250	PF00069	0.486
DOC_PP1_RVXF_1	160	166	PF00149	0.411
DOC_PP1_RVXF_1	241	248	PF00149	0.396
DOC_PP4_FxxP_1	30	33	PF00568	0.489
DOC_USP7_MATH_1	187	191	PF00917	0.553
DOC_USP7_MATH_1	2	6	PF00917	0.561
DOC_USP7_MATH_1	87	91	PF00917	0.492
DOC_USP7_MATH_2	124	130	PF00917	0.404
DOC_WW_Pin1_4	238	243	PF00397	0.475
LIG_14-3-3_CanoR_1	14	21	PF00244	0.480
LIG_14-3-3_CanoR_1	205	215	PF00244	0.727
LIG_14-3-3_CanoR_1	52	57	PF00244	0.494
LIG_Actin_WH2_2	21	37	PF00022	0.256
LIG_Actin_WH2_2	245	261	PF00022	0.413
LIG_APCC_ABBA_1	65	70	PF00400	0.377
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_BRCT_BRCA1_1	129	133	PF00533	0.377
LIG_Clathr_ClatBox_1	286	290	PF01394	0.495
LIG_deltaCOP1_diTrp_1	226	235	PF00928	0.470
LIG_FHA_1	150	156	PF00498	0.374
LIG_FHA_1	219	225	PF00498	0.553
LIG_FHA_1	232	238	PF00498	0.332
LIG_FHA_1	298	304	PF00498	0.637
LIG_FHA_2	205	211	PF00498	0.660
LIG_FHA_2	221	227	PF00498	0.603
LIG_FHA_2	259	265	PF00498	0.566
LIG_FHA_2	286	292	PF00498	0.562
LIG_FHA_2	52	58	PF00498	0.539
LIG_FHA_2	89	95	PF00498	0.555
LIG_GBD_Chelix_1	104	112	PF00786	0.431
LIG_LIR_Apic_2	27	33	PF02991	0.405
LIG_LIR_Gen_1	102	109	PF02991	0.463
LIG_LIR_Nem_3	102	106	PF02991	0.473
LIG_LIR_Nem_3	226	232	PF02991	0.407
LIG_LIR_Nem_3	254	258	PF02991	0.489
LIG_LIR_Nem_3	73	79	PF02991	0.348
LIG_MYND_1	142	146	PF01753	0.511
LIG_PDZ_Class_2	300	305	PF00595	0.700
LIG_SH2_CRK	21	25	PF00017	0.387
LIG_SH2_SRC	26	29	PF00017	0.269
LIG_SH2_STAP1	26	30	PF00017	0.371
LIG_SH2_STAT5	78	81	PF00017	0.425
LIG_SH3_1	250	256	PF00018	0.497
LIG_SH3_3	250	256	PF00018	0.497
LIG_WRC_WIRS_1	155	160	PF05994	0.322
LIG_WRC_WIRS_1	232	237	PF05994	0.420
LIG_WRC_WIRS_1	78	83	PF05994	0.373
MOD_CDK_SPK_2	238	243	PF00069	0.469
MOD_CK1_1	190	196	PF00069	0.609
MOD_CK1_1	44	50	PF00069	0.466
MOD_CK2_1	204	210	PF00069	0.734
MOD_CK2_1	220	226	PF00069	0.539
MOD_CK2_1	238	244	PF00069	0.362
MOD_CK2_1	285	291	PF00069	0.519
MOD_GlcNHglycan	189	192	PF01048	0.640
MOD_GlcNHglycan	218	221	PF01048	0.736
MOD_GSK3_1	154	161	PF00069	0.328
MOD_GSK3_1	195	202	PF00069	0.735
MOD_GSK3_1	2	9	PF00069	0.630
MOD_GSK3_1	216	223	PF00069	0.602
MOD_N-GLC_1	170	175	PF02516	0.529
MOD_N-GLC_1	44	49	PF02516	0.324
MOD_NEK2_1	1	6	PF00069	0.567
MOD_NEK2_1	12	17	PF00069	0.508
MOD_NEK2_1	158	163	PF00069	0.329
MOD_NEK2_1	258	263	PF00069	0.565
MOD_NEK2_1	278	283	PF00069	0.434
MOD_NEK2_2	220	225	PF00069	0.663
MOD_NEK2_2	77	82	PF00069	0.369
MOD_PIKK_1	107	113	PF00454	0.474
MOD_PK_1	52	58	PF00069	0.309
MOD_PKA_2	13	19	PF00069	0.427
MOD_PKA_2	204	210	PF00069	0.538
MOD_PKA_2	258	264	PF00069	0.445
MOD_PKA_2	51	57	PF00069	0.429
MOD_Plk_1	170	176	PF00069	0.495
MOD_Plk_1	26	32	PF00069	0.409
MOD_Plk_2-3	199	205	PF00069	0.728
MOD_Plk_4	154	160	PF00069	0.403
MOD_Plk_4	6	12	PF00069	0.558
MOD_Plk_4	77	83	PF00069	0.346
MOD_ProDKin_1	238	244	PF00069	0.470
MOD_SUMO_rev_2	145	155	PF00179	0.372
MOD_SUMO_rev_2	266	276	PF00179	0.443
MOD_SUMO_rev_2	70	76	PF00179	0.402
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.498
TRG_ENDOCYTIC_2	21	24	PF00928	0.388
TRG_ENDOCYTIC_2	78	81	PF00928	0.457
TRG_ER_diArg_1	162	165	PF00400	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E0	Leptomonas seymouri	58%	100%
A0A0S4J915	Bodo saltans	31%	100%
A0A1X0NV05	Trypanosomatidae	36%	100%
A0A3R7N1Z4	Trypanosoma rangeli	37%	100%
A4HKA2	Leishmania braziliensis	68%	100%
A4I7T2	Leishmania infantum	98%	100%
D0A9Z3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B2P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5G7	Leishmania major	87%	100%
V5BGN1	Trypanosoma cruzi	40%	100%