Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5F4_LEIDO

TriTrypDb:

LdBPK_321100.1 , LdCL_320016700 , LDHU3_32.1450

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S7X5F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5F4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.724
CLV_C14_Caspase3-7	26	30	PF00656	0.714
CLV_C14_Caspase3-7	279	283	PF00656	0.733
CLV_C14_Caspase3-7	305	309	PF00656	0.712
CLV_C14_Caspase3-7	369	373	PF00656	0.660
CLV_NRD_NRD_1	242	244	PF00675	0.514
CLV_NRD_NRD_1	259	261	PF00675	0.297
CLV_NRD_NRD_1	269	271	PF00675	0.478
CLV_NRD_NRD_1	272	274	PF00675	0.518
CLV_NRD_NRD_1	541	543	PF00675	0.485
CLV_NRD_NRD_1	574	576	PF00675	0.659
CLV_NRD_NRD_1	82	84	PF00675	0.473
CLV_PCSK_FUR_1	270	274	PF00082	0.389
CLV_PCSK_KEX2_1	242	244	PF00082	0.500
CLV_PCSK_KEX2_1	259	261	PF00082	0.335
CLV_PCSK_KEX2_1	269	271	PF00082	0.498
CLV_PCSK_KEX2_1	272	274	PF00082	0.533
CLV_PCSK_KEX2_1	427	429	PF00082	0.494
CLV_PCSK_KEX2_1	541	543	PF00082	0.483
CLV_PCSK_KEX2_1	574	576	PF00082	0.726
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.485
CLV_PCSK_SKI1_1	228	232	PF00082	0.519
CLV_PCSK_SKI1_1	319	323	PF00082	0.572
CLV_PCSK_SKI1_1	495	499	PF00082	0.479
CLV_PCSK_SKI1_1	53	57	PF00082	0.409
CLV_PCSK_SKI1_1	70	74	PF00082	0.465
CLV_Separin_Metazoa	38	42	PF03568	0.665
DEG_APCC_DBOX_1	318	326	PF00400	0.652
DEG_Nend_UBRbox_3	1	3	PF02207	0.679
DOC_MAPK_gen_1	317	325	PF00069	0.717
DOC_MAPK_gen_1	436	444	PF00069	0.700
DOC_MAPK_gen_1	541	550	PF00069	0.659
DOC_MAPK_gen_1	6	14	PF00069	0.668
DOC_MAPK_MEF2A_6	70	79	PF00069	0.696
DOC_PP1_RVXF_1	74	80	PF00149	0.651
DOC_PP2B_LxvP_1	458	461	PF13499	0.710
DOC_USP7_MATH_1	114	118	PF00917	0.769
DOC_USP7_MATH_1	119	123	PF00917	0.778
DOC_USP7_MATH_1	248	252	PF00917	0.722
DOC_USP7_MATH_1	520	524	PF00917	0.622
DOC_USP7_MATH_1	534	538	PF00917	0.767
DOC_WW_Pin1_4	125	130	PF00397	0.800
DOC_WW_Pin1_4	131	136	PF00397	0.626
DOC_WW_Pin1_4	16	21	PF00397	0.678
DOC_WW_Pin1_4	288	293	PF00397	0.738
DOC_WW_Pin1_4	307	312	PF00397	0.735
DOC_WW_Pin1_4	453	458	PF00397	0.763
LIG_14-3-3_CanoR_1	270	276	PF00244	0.640
LIG_14-3-3_CanoR_1	285	293	PF00244	0.790
LIG_14-3-3_CanoR_1	41	51	PF00244	0.673
LIG_14-3-3_CanoR_1	521	529	PF00244	0.810
LIG_14-3-3_CanoR_1	53	59	PF00244	0.573
LIG_Actin_WH2_2	65	80	PF00022	0.697
LIG_APCC_ABBA_1	563	568	PF00400	0.295
LIG_BIR_III_2	308	312	PF00653	0.698
LIG_BRCT_BRCA1_1	116	120	PF00533	0.731
LIG_BRCT_BRCA1_1	282	286	PF00533	0.639
LIG_Clathr_ClatBox_1	322	326	PF01394	0.788
LIG_FHA_1	132	138	PF00498	0.721
LIG_FHA_1	418	424	PF00498	0.650
LIG_FHA_1	448	454	PF00498	0.629
LIG_FHA_1	46	52	PF00498	0.631
LIG_FHA_2	272	278	PF00498	0.727
LIG_FHA_2	496	502	PF00498	0.667
LIG_LIR_Gen_1	169	179	PF02991	0.689
LIG_LIR_Gen_1	57	66	PF02991	0.556
LIG_LIR_Nem_3	57	61	PF02991	0.585
LIG_PDZ_Class_3	575	580	PF00595	0.486
LIG_SH2_NCK_1	493	497	PF00017	0.742
LIG_SH2_STAP1	211	215	PF00017	0.674
LIG_SH2_STAP1	493	497	PF00017	0.694
LIG_SH2_STAT5	141	144	PF00017	0.603
LIG_SH2_STAT5	314	317	PF00017	0.674
LIG_SH3_1	541	547	PF00018	0.679
LIG_SH3_3	110	116	PF00018	0.782
LIG_SH3_3	475	481	PF00018	0.721
LIG_SH3_3	541	547	PF00018	0.679
LIG_SUMO_SIM_par_1	10	19	PF11976	0.727
LIG_SUMO_SIM_par_1	321	327	PF11976	0.720
LIG_TRAF2_1	159	162	PF00917	0.703
LIG_TRAF2_1	380	383	PF00917	0.633
LIG_TRAF2_1	57	60	PF00917	0.634
LIG_UBA3_1	441	449	PF00899	0.527
LIG_WW_3	518	522	PF00397	0.645
MOD_CK1_1	182	188	PF00069	0.694
MOD_CK1_1	280	286	PF00069	0.777
MOD_CK1_1	291	297	PF00069	0.756
MOD_CK1_1	307	313	PF00069	0.731
MOD_CK1_1	324	330	PF00069	0.752
MOD_CK1_1	430	436	PF00069	0.618
MOD_CK1_1	45	51	PF00069	0.713
MOD_CK2_1	141	147	PF00069	0.601
MOD_CK2_1	156	162	PF00069	0.627
MOD_CK2_1	210	216	PF00069	0.643
MOD_CK2_1	248	254	PF00069	0.716
MOD_CK2_1	27	33	PF00069	0.705
MOD_CK2_1	271	277	PF00069	0.707
MOD_CK2_1	377	383	PF00069	0.639
MOD_CK2_1	482	488	PF00069	0.675
MOD_CK2_1	54	60	PF00069	0.663
MOD_Cter_Amidation	270	273	PF01082	0.381
MOD_GlcNHglycan	109	112	PF01048	0.437
MOD_GlcNHglycan	158	161	PF01048	0.434
MOD_GlcNHglycan	181	184	PF01048	0.462
MOD_GlcNHglycan	250	253	PF01048	0.551
MOD_GlcNHglycan	279	282	PF01048	0.549
MOD_GlcNHglycan	293	296	PF01048	0.600
MOD_GlcNHglycan	326	329	PF01048	0.516
MOD_GlcNHglycan	363	367	PF01048	0.486
MOD_GlcNHglycan	429	432	PF01048	0.436
MOD_GlcNHglycan	536	539	PF01048	0.537
MOD_GlcNHglycan	568	571	PF01048	0.624
MOD_GSK3_1	115	122	PF00069	0.764
MOD_GSK3_1	161	168	PF00069	0.740
MOD_GSK3_1	210	217	PF00069	0.685
MOD_GSK3_1	23	30	PF00069	0.699
MOD_GSK3_1	244	251	PF00069	0.710
MOD_GSK3_1	271	278	PF00069	0.754
MOD_GSK3_1	280	287	PF00069	0.748
MOD_GSK3_1	291	298	PF00069	0.732
MOD_GSK3_1	358	365	PF00069	0.672
MOD_GSK3_1	462	469	PF00069	0.783
MOD_GSK3_1	85	92	PF00069	0.661
MOD_N-GLC_1	295	300	PF02516	0.499
MOD_N-GLC_1	331	336	PF02516	0.438
MOD_N-GLC_1	377	382	PF02516	0.456
MOD_N-GLC_1	482	487	PF02516	0.492
MOD_N-GLC_1	89	94	PF02516	0.512
MOD_NEK2_1	179	184	PF00069	0.677
MOD_NEK2_1	276	281	PF00069	0.740
MOD_NEK2_1	286	291	PF00069	0.759
MOD_NEK2_1	4	9	PF00069	0.687
MOD_NEK2_1	482	487	PF00069	0.679
MOD_NEK2_1	566	571	PF00069	0.531
MOD_NEK2_1	85	90	PF00069	0.598
MOD_NEK2_1	93	98	PF00069	0.613
MOD_NEK2_2	141	146	PF00069	0.645
MOD_PIKK_1	161	167	PF00454	0.692
MOD_PIKK_1	23	29	PF00454	0.759
MOD_PIKK_1	284	290	PF00454	0.785
MOD_PIKK_1	295	301	PF00454	0.808
MOD_PIKK_1	45	51	PF00454	0.640
MOD_PIKK_1	520	526	PF00454	0.693
MOD_PK_1	62	68	PF00069	0.601
MOD_PKA_1	427	433	PF00069	0.626
MOD_PKA_2	114	120	PF00069	0.743
MOD_PKA_2	27	33	PF00069	0.630
MOD_PKA_2	271	277	PF00069	0.665
MOD_PKA_2	284	290	PF00069	0.791
MOD_PKA_2	358	364	PF00069	0.665
MOD_PKA_2	427	433	PF00069	0.626
MOD_PKA_2	520	526	PF00069	0.805
MOD_PKA_2	534	540	PF00069	0.711
MOD_Plk_1	161	167	PF00069	0.693
MOD_Plk_1	377	383	PF00069	0.656
MOD_Plk_1	482	488	PF00069	0.718
MOD_Plk_1	70	76	PF00069	0.653
MOD_Plk_1	89	95	PF00069	0.589
MOD_Plk_2-3	377	383	PF00069	0.596
MOD_Plk_2-3	64	70	PF00069	0.699
MOD_Plk_4	210	216	PF00069	0.668
MOD_Plk_4	482	488	PF00069	0.670
MOD_ProDKin_1	125	131	PF00069	0.796
MOD_ProDKin_1	16	22	PF00069	0.680
MOD_ProDKin_1	288	294	PF00069	0.739
MOD_ProDKin_1	307	313	PF00069	0.731
MOD_ProDKin_1	453	459	PF00069	0.765
MOD_SUMO_for_1	236	239	PF00179	0.681
MOD_SUMO_rev_2	424	429	PF00179	0.649
MOD_SUMO_rev_2	430	437	PF00179	0.645
TRG_DiLeu_BaEn_1	227	232	PF01217	0.691
TRG_DiLeu_BaEn_4	161	167	PF01217	0.706
TRG_DiLeu_BaEn_4	256	262	PF01217	0.550
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.663
TRG_ENDOCYTIC_2	172	175	PF00928	0.657
TRG_ENDOCYTIC_2	211	214	PF00928	0.671
TRG_ENDOCYTIC_2	561	564	PF00928	0.466
TRG_ENDOCYTIC_2	58	61	PF00928	0.678
TRG_ER_diArg_1	258	260	PF00400	0.689
TRG_ER_diArg_1	268	270	PF00400	0.711
TRG_ER_diArg_1	540	542	PF00400	0.711
TRG_ER_diArg_1	574	577	PF00400	0.463
TRG_ER_diArg_1	74	77	PF00400	0.615
TRG_NES_CRM1_1	147	161	PF08389	0.647
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	351	355	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4B6	Leptomonas seymouri	40%	99%
A0A1X0NV17	Trypanosomatidae	25%	100%
A0A3S5ISI9	Trypanosoma rangeli	24%	100%
A4HK86	Leishmania braziliensis	63%	100%
A4I7S1	Leishmania infantum	99%	100%
E9B2M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5H8	Leishmania major	85%	100%
V5BGM1	Trypanosoma cruzi	24%	100%