Phosphotransferase enzyme family/Protein kinase domain/Protein tyrosine kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5E9_LEIDO

TriTrypDb:

LdBPK_321350.1 , LdCL_320019200 , LDHU3_32.1720

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5E9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.651
CLV_C14_Caspase3-7	324	328	PF00656	0.591
CLV_C14_Caspase3-7	466	470	PF00656	0.562
CLV_C14_Caspase3-7	47	51	PF00656	0.581
CLV_NRD_NRD_1	421	423	PF00675	0.357
CLV_NRD_NRD_1	498	500	PF00675	0.523
CLV_NRD_NRD_1	545	547	PF00675	0.500
CLV_NRD_NRD_1	563	565	PF00675	0.555
CLV_PCSK_FUR_1	561	565	PF00082	0.381
CLV_PCSK_KEX2_1	421	423	PF00082	0.357
CLV_PCSK_KEX2_1	498	500	PF00082	0.479
CLV_PCSK_KEX2_1	505	507	PF00082	0.383
CLV_PCSK_KEX2_1	545	547	PF00082	0.440
CLV_PCSK_KEX2_1	563	565	PF00082	0.570
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.471
CLV_PCSK_SKI1_1	105	109	PF00082	0.497
CLV_PCSK_SKI1_1	511	515	PF00082	0.439
CLV_PCSK_SKI1_1	553	557	PF00082	0.485
CLV_Separin_Metazoa	528	532	PF03568	0.487
DEG_SCF_FBW7_1	408	415	PF00400	0.410
DEG_SPOP_SBC_1	140	144	PF00917	0.614
DEG_SPOP_SBC_1	326	330	PF00917	0.588
DEG_SPOP_SBC_1	335	339	PF00917	0.445
DOC_CKS1_1	251	256	PF01111	0.468
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.362
DOC_CYCLIN_yCln2_LP_2	76	79	PF00134	0.564
DOC_MAPK_gen_1	274	284	PF00069	0.377
DOC_MAPK_MEF2A_6	274	282	PF00069	0.405
DOC_MAPK_MEF2A_6	490	497	PF00069	0.543
DOC_PP1_RVXF_1	479	486	PF00149	0.548
DOC_PP2B_LxvP_1	264	267	PF13499	0.350
DOC_PP2B_LxvP_1	280	283	PF13499	0.461
DOC_PP2B_LxvP_1	76	79	PF13499	0.564
DOC_PP4_FxxP_1	251	254	PF00568	0.532
DOC_PP4_FxxP_1	80	83	PF00568	0.746
DOC_USP7_MATH_1	207	211	PF00917	0.651
DOC_USP7_MATH_1	304	308	PF00917	0.689
DOC_USP7_MATH_1	326	330	PF00917	0.685
DOC_USP7_MATH_1	335	339	PF00917	0.556
DOC_USP7_MATH_1	348	352	PF00917	0.469
DOC_USP7_MATH_1	412	416	PF00917	0.381
DOC_USP7_UBL2_3	213	217	PF12436	0.442
DOC_WW_Pin1_4	136	141	PF00397	0.641
DOC_WW_Pin1_4	246	251	PF00397	0.636
DOC_WW_Pin1_4	408	413	PF00397	0.349
DOC_WW_Pin1_4	427	432	PF00397	0.306
LIG_14-3-3_CanoR_1	208	216	PF00244	0.397
LIG_14-3-3_CanoR_1	243	252	PF00244	0.493
LIG_14-3-3_CanoR_1	341	347	PF00244	0.455
LIG_14-3-3_CanoR_1	531	536	PF00244	0.458
LIG_14-3-3_CanoR_1	94	102	PF00244	0.552
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BRCT_BRCA1_1	2	6	PF00533	0.674
LIG_BRCT_BRCA1_1	247	251	PF00533	0.604
LIG_BRCT_BRCA1_1	336	340	PF00533	0.480
LIG_deltaCOP1_diTrp_1	440	444	PF00928	0.426
LIG_eIF4E_1	259	265	PF01652	0.474
LIG_FHA_1	458	464	PF00498	0.356
LIG_FHA_1	478	484	PF00498	0.503
LIG_FHA_1	550	556	PF00498	0.456
LIG_FHA_1	72	78	PF00498	0.503
LIG_FHA_2	143	149	PF00498	0.635
LIG_FHA_2	200	206	PF00498	0.735
LIG_FHA_2	251	257	PF00498	0.519
LIG_FHA_2	381	387	PF00498	0.297
LIG_FHA_2	451	457	PF00498	0.279
LIG_FHA_2	552	558	PF00498	0.417
LIG_LIR_Apic_2	248	254	PF02991	0.551
LIG_LIR_Gen_1	121	130	PF02991	0.745
LIG_LIR_Gen_1	256	267	PF02991	0.445
LIG_LIR_Gen_1	404	412	PF02991	0.279
LIG_LIR_Nem_3	121	125	PF02991	0.745
LIG_LIR_Nem_3	151	157	PF02991	0.527
LIG_LIR_Nem_3	256	262	PF02991	0.466
LIG_LIR_Nem_3	343	349	PF02991	0.459
LIG_LIR_Nem_3	404	408	PF02991	0.291
LIG_LIR_Nem_3	538	544	PF02991	0.383
LIG_MYND_1	250	254	PF01753	0.542
LIG_PCNA_TLS_4	105	112	PF02747	0.440
LIG_RPA_C_Fungi	494	506	PF08784	0.372
LIG_SH2_CRK	259	263	PF00017	0.483
LIG_SH2_STAT5	24	27	PF00017	0.697
LIG_SH2_STAT5	292	295	PF00017	0.391
LIG_SH2_STAT5	382	385	PF00017	0.482
LIG_SH3_3	179	185	PF00018	0.535
LIG_SH3_3	23	29	PF00018	0.580
LIG_SUMO_SIM_par_1	447	453	PF11976	0.281
LIG_TRAF2_1	253	256	PF00917	0.548
LIG_UBA3_1	513	519	PF00899	0.324
MOD_CDK_SPxK_1	410	416	PF00069	0.355
MOD_CK1_1	135	141	PF00069	0.701
MOD_CK1_1	142	148	PF00069	0.639
MOD_CK1_1	150	156	PF00069	0.659
MOD_CK1_1	229	235	PF00069	0.501
MOD_CK1_1	246	252	PF00069	0.593
MOD_CK1_1	342	348	PF00069	0.353
MOD_CK1_1	410	416	PF00069	0.429
MOD_CK1_1	427	433	PF00069	0.410
MOD_CK1_1	43	49	PF00069	0.714
MOD_CK1_1	450	456	PF00069	0.285
MOD_CK1_1	549	555	PF00069	0.360
MOD_CK1_1	71	77	PF00069	0.504
MOD_CK1_1	96	102	PF00069	0.631
MOD_CK2_1	120	126	PF00069	0.608
MOD_CK2_1	199	205	PF00069	0.560
MOD_CK2_1	221	227	PF00069	0.402
MOD_CK2_1	250	256	PF00069	0.574
MOD_CK2_1	285	291	PF00069	0.457
MOD_CK2_1	531	537	PF00069	0.444
MOD_CK2_1	551	557	PF00069	0.526
MOD_Cter_Amidation	503	506	PF01082	0.428
MOD_GlcNHglycan	114	117	PF01048	0.673
MOD_GlcNHglycan	121	125	PF01048	0.641
MOD_GlcNHglycan	2	5	PF01048	0.717
MOD_GlcNHglycan	355	358	PF01048	0.482
MOD_GlcNHglycan	50	53	PF01048	0.666
MOD_GSK3_1	120	127	PF00069	0.675
MOD_GSK3_1	132	139	PF00069	0.694
MOD_GSK3_1	140	147	PF00069	0.600
MOD_GSK3_1	226	233	PF00069	0.497
MOD_GSK3_1	246	253	PF00069	0.576
MOD_GSK3_1	309	316	PF00069	0.681
MOD_GSK3_1	335	342	PF00069	0.501
MOD_GSK3_1	376	383	PF00069	0.413
MOD_GSK3_1	38	45	PF00069	0.633
MOD_GSK3_1	408	415	PF00069	0.351
MOD_GSK3_1	423	430	PF00069	0.404
MOD_GSK3_1	92	99	PF00069	0.684
MOD_N-GLC_1	132	137	PF02516	0.739
MOD_N-GLC_1	285	290	PF02516	0.481
MOD_N-GLC_2	132	134	PF02516	0.694
MOD_NEK2_1	112	117	PF00069	0.563
MOD_NEK2_1	120	125	PF00069	0.581
MOD_NEK2_1	230	235	PF00069	0.498
MOD_NEK2_1	313	318	PF00069	0.732
MOD_NEK2_1	340	345	PF00069	0.418
MOD_NEK2_1	407	412	PF00069	0.387
MOD_NEK2_1	447	452	PF00069	0.441
MOD_NEK2_2	285	290	PF00069	0.474
MOD_NEK2_2	551	556	PF00069	0.463
MOD_PIKK_1	28	34	PF00454	0.471
MOD_PKA_2	174	180	PF00069	0.400
MOD_PKA_2	207	213	PF00069	0.523
MOD_PKA_2	340	346	PF00069	0.521
MOD_PKA_2	477	483	PF00069	0.542
MOD_PKA_2	56	62	PF00069	0.614
MOD_PKA_2	93	99	PF00069	0.699
MOD_PKB_1	241	249	PF00069	0.497
MOD_PKB_1	40	48	PF00069	0.471
MOD_Plk_1	120	126	PF00069	0.542
MOD_Plk_1	132	138	PF00069	0.570
MOD_Plk_1	226	232	PF00069	0.454
MOD_Plk_1	285	291	PF00069	0.398
MOD_Plk_1	546	552	PF00069	0.371
MOD_Plk_4	174	180	PF00069	0.373
MOD_Plk_4	199	205	PF00069	0.717
MOD_Plk_4	226	232	PF00069	0.480
MOD_Plk_4	447	453	PF00069	0.288
MOD_Plk_4	531	537	PF00069	0.511
MOD_ProDKin_1	136	142	PF00069	0.641
MOD_ProDKin_1	246	252	PF00069	0.623
MOD_ProDKin_1	408	414	PF00069	0.349
MOD_ProDKin_1	427	433	PF00069	0.298
MOD_SUMO_rev_2	205	215	PF00179	0.511
TRG_DiLeu_BaEn_1	276	281	PF01217	0.412
TRG_DiLeu_BaEn_1	509	514	PF01217	0.476
TRG_DiLeu_BaEn_2	363	369	PF01217	0.355
TRG_DiLeu_BaEn_2	536	542	PF01217	0.413
TRG_DiLeu_BaEn_4	537	543	PF01217	0.396
TRG_DiLeu_BaLyEn_6	468	473	PF01217	0.501
TRG_ENDOCYTIC_2	122	125	PF00928	0.595
TRG_ENDOCYTIC_2	259	262	PF00928	0.445
TRG_ENDOCYTIC_2	346	349	PF00928	0.478
TRG_ER_diArg_1	420	422	PF00400	0.360
TRG_ER_diArg_1	497	499	PF00400	0.507
TRG_ER_diArg_1	544	546	PF00400	0.426
TRG_ER_diArg_1	561	564	PF00400	0.417
TRG_Pf-PMV_PEXEL_1	481	486	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH1	Leptomonas seymouri	66%	100%
A0A1X0NUL0	Trypanosomatidae	38%	100%
A0A422P1A6	Trypanosoma rangeli	39%	100%
A4HKB7	Leishmania braziliensis	73%	99%
A4I7U6	Leishmania infantum	97%	98%
D0AA04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B2Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q5F3	Leishmania major	93%	100%
V5BGP5	Trypanosoma cruzi	40%	100%