Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5E8_LEIDO

TriTrypDb:

LdBPK_321240.1 , LdCL_320018100 , LDHU3_32.1600

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5E8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	508	512	PF00656	0.702
CLV_C14_Caspase3-7	609	613	PF00656	0.615
CLV_NRD_NRD_1	182	184	PF00675	0.571
CLV_NRD_NRD_1	188	190	PF00675	0.558
CLV_NRD_NRD_1	206	208	PF00675	0.662
CLV_NRD_NRD_1	25	27	PF00675	0.479
CLV_NRD_NRD_1	441	443	PF00675	0.624
CLV_PCSK_KEX2_1	182	184	PF00082	0.571
CLV_PCSK_KEX2_1	188	190	PF00082	0.606
CLV_PCSK_KEX2_1	206	208	PF00082	0.665
CLV_PCSK_KEX2_1	221	223	PF00082	0.513
CLV_PCSK_KEX2_1	25	27	PF00082	0.479
CLV_PCSK_KEX2_1	441	443	PF00082	0.624
CLV_PCSK_KEX2_1	648	650	PF00082	0.635
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.668
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.594
CLV_PCSK_PC7_1	202	208	PF00082	0.750
CLV_PCSK_PC7_1	437	443	PF00082	0.618
CLV_PCSK_SKI1_1	109	113	PF00082	0.524
CLV_PCSK_SKI1_1	121	125	PF00082	0.510
CLV_PCSK_SKI1_1	163	167	PF00082	0.683
CLV_PCSK_SKI1_1	206	210	PF00082	0.647
CLV_PCSK_SKI1_1	249	253	PF00082	0.620
CLV_PCSK_SKI1_1	353	357	PF00082	0.451
DEG_Nend_UBRbox_3	1	3	PF02207	0.623
DEG_SPOP_SBC_1	151	155	PF00917	0.567
DEG_SPOP_SBC_1	311	315	PF00917	0.588
DOC_CYCLIN_yCln2_LP_2	543	546	PF00134	0.587
DOC_MAPK_gen_1	221	228	PF00069	0.544
DOC_MAPK_JIP1_4	222	228	PF00069	0.543
DOC_MAPK_MEF2A_6	281	288	PF00069	0.532
DOC_PP2B_LxvP_1	169	172	PF13499	0.704
DOC_PP2B_LxvP_1	288	291	PF13499	0.592
DOC_PP2B_LxvP_1	543	546	PF13499	0.587
DOC_USP7_MATH_1	151	155	PF00917	0.567
DOC_USP7_MATH_1	236	240	PF00917	0.683
DOC_USP7_MATH_1	311	315	PF00917	0.642
DOC_USP7_MATH_1	376	380	PF00917	0.486
DOC_USP7_MATH_1	409	413	PF00917	0.694
DOC_USP7_MATH_1	605	609	PF00917	0.679
DOC_USP7_MATH_1	655	659	PF00917	0.651
DOC_USP7_MATH_2	471	477	PF00917	0.661
DOC_USP7_UBL2_3	346	350	PF12436	0.618
DOC_WW_Pin1_4	141	146	PF00397	0.620
DOC_WW_Pin1_4	15	20	PF00397	0.538
DOC_WW_Pin1_4	163	168	PF00397	0.616
DOC_WW_Pin1_4	206	211	PF00397	0.681
DOC_WW_Pin1_4	322	327	PF00397	0.591
DOC_WW_Pin1_4	407	412	PF00397	0.710
DOC_WW_Pin1_4	419	424	PF00397	0.561
DOC_WW_Pin1_4	443	448	PF00397	0.698
DOC_WW_Pin1_4	467	472	PF00397	0.613
DOC_WW_Pin1_4	479	484	PF00397	0.754
DOC_WW_Pin1_4	485	490	PF00397	0.805
DOC_WW_Pin1_4	497	502	PF00397	0.622
DOC_WW_Pin1_4	523	528	PF00397	0.747
DOC_WW_Pin1_4	537	542	PF00397	0.750
DOC_WW_Pin1_4	73	78	PF00397	0.335
LIG_14-3-3_CanoR_1	392	398	PF00244	0.584
LIG_14-3-3_CanoR_1	41	45	PF00244	0.453
LIG_Actin_WH2_2	110	126	PF00022	0.521
LIG_APCC_ABBA_1	282	287	PF00400	0.520
LIG_APCC_ABBAyCdc20_2	281	287	PF00400	0.564
LIG_BIR_III_2	408	412	PF00653	0.559
LIG_BRCT_BRCA1_1	243	247	PF00533	0.503
LIG_BRCT_BRCA1_1	5	9	PF00533	0.563
LIG_deltaCOP1_diTrp_1	372	377	PF00928	0.522
LIG_eIF4E_1	11	17	PF01652	0.490
LIG_FHA_1	101	107	PF00498	0.601
LIG_FHA_1	164	170	PF00498	0.703
LIG_FHA_1	394	400	PF00498	0.666
LIG_FHA_1	408	414	PF00498	0.567
LIG_FHA_1	455	461	PF00498	0.565
LIG_FHA_1	480	486	PF00498	0.681
LIG_FHA_1	493	499	PF00498	0.606
LIG_FHA_1	512	518	PF00498	0.593
LIG_FHA_2	110	116	PF00498	0.495
LIG_FHA_2	546	552	PF00498	0.711
LIG_KLC1_Yacidic_2	283	287	PF13176	0.454
LIG_LIR_Gen_1	283	292	PF02991	0.640
LIG_LIR_Gen_1	6	17	PF02991	0.509
LIG_LIR_Gen_1	632	642	PF02991	0.489
LIG_LIR_Nem_3	21	27	PF02991	0.439
LIG_LIR_Nem_3	283	288	PF02991	0.669
LIG_LIR_Nem_3	329	335	PF02991	0.612
LIG_LIR_Nem_3	372	377	PF02991	0.584
LIG_LIR_Nem_3	472	477	PF02991	0.639
LIG_LIR_Nem_3	6	12	PF02991	0.538
LIG_LIR_Nem_3	632	637	PF02991	0.498
LIG_MYND_1	541	545	PF01753	0.678
LIG_NRBOX	12	18	PF00104	0.447
LIG_NRBOX	132	138	PF00104	0.550
LIG_Pex14_1	127	131	PF04695	0.409
LIG_RPA_C_Fungi	260	272	PF08784	0.543
LIG_SH2_CRK	332	336	PF00017	0.557
LIG_SH2_CRK	58	62	PF00017	0.389
LIG_SH2_NCK_1	359	363	PF00017	0.448
LIG_SH2_PTP2	285	288	PF00017	0.461
LIG_SH2_SRC	27	30	PF00017	0.521
LIG_SH2_STAP1	296	300	PF00017	0.577
LIG_SH2_STAP1	393	397	PF00017	0.638
LIG_SH2_STAT5	11	14	PF00017	0.500
LIG_SH2_STAT5	27	30	PF00017	0.356
LIG_SH2_STAT5	285	288	PF00017	0.512
LIG_SH2_STAT5	296	299	PF00017	0.586
LIG_SH2_STAT5	389	392	PF00017	0.518
LIG_SH3_2	201	206	PF14604	0.630
LIG_SH3_3	195	201	PF00018	0.647
LIG_SH3_3	320	326	PF00018	0.675
LIG_SH3_3	370	376	PF00018	0.529
LIG_SH3_3	87	93	PF00018	0.555
LIG_TRAF2_1	171	174	PF00917	0.702
LIG_TRAF2_1	19	22	PF00917	0.512
LIG_TRAF2_1	552	555	PF00917	0.602
MOD_CDK_SPK_2	206	211	PF00069	0.570
MOD_CDK_SPxxK_3	497	504	PF00069	0.602
MOD_CK1_1	105	111	PF00069	0.517
MOD_CK1_1	158	164	PF00069	0.622
MOD_CK1_1	238	244	PF00069	0.676
MOD_CK1_1	294	300	PF00069	0.578
MOD_CK1_1	3	9	PF00069	0.605
MOD_CK1_1	40	46	PF00069	0.313
MOD_CK1_1	446	452	PF00069	0.746
MOD_CK1_1	559	565	PF00069	0.618
MOD_CK1_1	595	601	PF00069	0.703
MOD_CK2_1	109	115	PF00069	0.555
MOD_CK2_1	15	21	PF00069	0.454
MOD_CK2_1	442	448	PF00069	0.744
MOD_CK2_1	467	473	PF00069	0.648
MOD_CK2_1	545	551	PF00069	0.712
MOD_Cter_Amidation	180	183	PF01082	0.620
MOD_GlcNHglycan	132	136	PF01048	0.477
MOD_GlcNHglycan	157	160	PF01048	0.620
MOD_GlcNHglycan	238	241	PF01048	0.563
MOD_GlcNHglycan	243	246	PF01048	0.603
MOD_GlcNHglycan	249	252	PF01048	0.622
MOD_GlcNHglycan	4	9	PF01048	0.658
MOD_GlcNHglycan	419	422	PF01048	0.643
MOD_GlcNHglycan	448	451	PF01048	0.697
MOD_GlcNHglycan	558	561	PF01048	0.704
MOD_GlcNHglycan	594	597	PF01048	0.826
MOD_GlcNHglycan	612	615	PF01048	0.595
MOD_GlcNHglycan	640	643	PF01048	0.626
MOD_GlcNHglycan	657	660	PF01048	0.500
MOD_GSK3_1	109	116	PF00069	0.560
MOD_GSK3_1	151	158	PF00069	0.722
MOD_GSK3_1	234	241	PF00069	0.598
MOD_GSK3_1	3	10	PF00069	0.604
MOD_GSK3_1	312	319	PF00069	0.593
MOD_GSK3_1	393	400	PF00069	0.548
MOD_GSK3_1	419	426	PF00069	0.601
MOD_GSK3_1	442	449	PF00069	0.804
MOD_GSK3_1	463	470	PF00069	0.646
MOD_GSK3_1	479	486	PF00069	0.793
MOD_GSK3_1	592	599	PF00069	0.727
MOD_GSK3_1	606	613	PF00069	0.642
MOD_GSK3_1	98	105	PF00069	0.487
MOD_LATS_1	35	41	PF00433	0.513
MOD_N-GLC_1	109	114	PF02516	0.527
MOD_N-GLC_1	453	458	PF02516	0.705
MOD_NEK2_1	102	107	PF00069	0.488
MOD_NEK2_1	117	122	PF00069	0.444
MOD_NEK2_1	131	136	PF00069	0.331
MOD_NEK2_1	150	155	PF00069	0.731
MOD_NEK2_1	226	231	PF00069	0.611
MOD_NEK2_1	247	252	PF00069	0.611
MOD_NEK2_1	292	297	PF00069	0.554
MOD_NEK2_1	399	404	PF00069	0.715
MOD_NEK2_1	453	458	PF00069	0.705
MOD_NEK2_1	610	615	PF00069	0.593
MOD_NEK2_1	626	631	PF00069	0.550
MOD_NEK2_1	638	643	PF00069	0.530
MOD_NEK2_2	597	602	PF00069	0.709
MOD_PIKK_1	600	606	PF00454	0.708
MOD_PIKK_1	626	632	PF00454	0.549
MOD_PK_1	182	188	PF00069	0.483
MOD_PKA_1	182	188	PF00069	0.563
MOD_PKA_2	181	187	PF00069	0.700
MOD_PKA_2	391	397	PF00069	0.579
MOD_PKA_2	40	46	PF00069	0.453
MOD_PKA_2	610	616	PF00069	0.705
MOD_PKA_2	638	644	PF00069	0.654
MOD_Plk_1	131	137	PF00069	0.485
MOD_Plk_1	328	334	PF00069	0.626
MOD_Plk_1	4	10	PF00069	0.433
MOD_Plk_2-3	473	479	PF00069	0.672
MOD_Plk_4	113	119	PF00069	0.450
MOD_Plk_4	312	318	PF00069	0.592
MOD_Plk_4	40	46	PF00069	0.335
MOD_Plk_4	409	415	PF00069	0.758
MOD_ProDKin_1	141	147	PF00069	0.616
MOD_ProDKin_1	15	21	PF00069	0.540
MOD_ProDKin_1	163	169	PF00069	0.619
MOD_ProDKin_1	206	212	PF00069	0.681
MOD_ProDKin_1	322	328	PF00069	0.587
MOD_ProDKin_1	407	413	PF00069	0.712
MOD_ProDKin_1	419	425	PF00069	0.557
MOD_ProDKin_1	443	449	PF00069	0.700
MOD_ProDKin_1	467	473	PF00069	0.617
MOD_ProDKin_1	479	485	PF00069	0.758
MOD_ProDKin_1	497	503	PF00069	0.674
MOD_ProDKin_1	523	529	PF00069	0.751
MOD_ProDKin_1	537	543	PF00069	0.753
MOD_ProDKin_1	73	79	PF00069	0.335
MOD_SUMO_rev_2	302	311	PF00179	0.636
MOD_SUMO_rev_2	466	471	PF00179	0.641
TRG_DiLeu_BaEn_1	132	137	PF01217	0.544
TRG_DiLeu_BaEn_3	433	439	PF01217	0.709
TRG_DiLeu_BaEn_4	173	179	PF01217	0.711
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.618
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.755
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.552
TRG_ENDOCYTIC_2	27	30	PF00928	0.521
TRG_ENDOCYTIC_2	285	288	PF00928	0.557
TRG_ENDOCYTIC_2	332	335	PF00928	0.588
TRG_ENDOCYTIC_2	58	61	PF00928	0.453
TRG_ENDOCYTIC_2	634	637	PF00928	0.557
TRG_ER_diArg_1	206	208	PF00400	0.747
TRG_ER_diArg_1	24	26	PF00400	0.469
TRG_ER_diArg_1	440	442	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	636	640	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9L2	Leptomonas seymouri	39%	100%
A4HKA5	Leishmania braziliensis	57%	100%
A4I7T5	Leishmania infantum	99%	100%
E9B2P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q5G4	Leishmania major	87%	100%