DUF4709 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5E6_LEIDO

TriTrypDb:

LdBPK_321280.1 , LdCL_320018500 , LDHU3_32.1640

Length:

797

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5E6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.586
CLV_NRD_NRD_1	10	12	PF00675	0.649
CLV_NRD_NRD_1	104	106	PF00675	0.538
CLV_NRD_NRD_1	157	159	PF00675	0.628
CLV_NRD_NRD_1	269	271	PF00675	0.635
CLV_NRD_NRD_1	320	322	PF00675	0.503
CLV_NRD_NRD_1	361	363	PF00675	0.664
CLV_NRD_NRD_1	763	765	PF00675	0.592
CLV_NRD_NRD_1	777	779	PF00675	0.644
CLV_PCSK_FUR_1	8	12	PF00082	0.697
CLV_PCSK_KEX2_1	10	12	PF00082	0.647
CLV_PCSK_KEX2_1	104	106	PF00082	0.538
CLV_PCSK_KEX2_1	146	148	PF00082	0.495
CLV_PCSK_KEX2_1	156	158	PF00082	0.530
CLV_PCSK_KEX2_1	269	271	PF00082	0.635
CLV_PCSK_KEX2_1	361	363	PF00082	0.631
CLV_PCSK_KEX2_1	715	717	PF00082	0.594
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.576
CLV_PCSK_PC1ET2_1	715	717	PF00082	0.671
CLV_PCSK_SKI1_1	143	147	PF00082	0.545
CLV_PCSK_SKI1_1	157	161	PF00082	0.565
CLV_PCSK_SKI1_1	185	189	PF00082	0.586
CLV_PCSK_SKI1_1	259	263	PF00082	0.574
CLV_PCSK_SKI1_1	322	326	PF00082	0.502
CLV_PCSK_SKI1_1	346	350	PF00082	0.601
CLV_PCSK_SKI1_1	563	567	PF00082	0.556
CLV_PCSK_SKI1_1	587	591	PF00082	0.679
CLV_PCSK_SKI1_1	76	80	PF00082	0.580
CLV_PCSK_SKI1_1	768	772	PF00082	0.575
CLV_PCSK_SKI1_1	781	785	PF00082	0.575
CLV_Separin_Metazoa	358	362	PF03568	0.639
DEG_APCC_DBOX_1	155	163	PF00400	0.621
DEG_APCC_DBOX_1	282	290	PF00400	0.449
DEG_APCC_DBOX_1	345	353	PF00400	0.599
DEG_SCF_TRCP1_1	731	737	PF00400	0.607
DEG_SPOP_SBC_1	415	419	PF00917	0.753
DOC_CKS1_1	646	651	PF01111	0.750
DOC_CYCLIN_RxL_1	320	328	PF00134	0.595
DOC_CYCLIN_RxL_1	560	571	PF00134	0.572
DOC_CYCLIN_RxL_1	709	723	PF00134	0.647
DOC_MAPK_gen_1	321	329	PF00069	0.494
DOC_MAPK_gen_1	361	367	PF00069	0.639
DOC_MAPK_MEF2A_6	321	329	PF00069	0.494
DOC_MAPK_NFAT4_5	322	330	PF00069	0.496
DOC_PP1_RVXF_1	232	238	PF00149	0.611
DOC_PP1_RVXF_1	362	368	PF00149	0.608
DOC_PP1_RVXF_1	689	695	PF00149	0.515
DOC_USP7_MATH_1	415	419	PF00917	0.762
DOC_USP7_MATH_1	42	46	PF00917	0.583
DOC_USP7_MATH_1	420	424	PF00917	0.758
DOC_USP7_MATH_1	426	430	PF00917	0.761
DOC_USP7_MATH_1	442	446	PF00917	0.583
DOC_USP7_MATH_1	499	503	PF00917	0.800
DOC_USP7_MATH_1	729	733	PF00917	0.730
DOC_USP7_MATH_1	748	752	PF00917	0.719
DOC_USP7_UBL2_3	185	189	PF12436	0.586
DOC_USP7_UBL2_3	679	683	PF12436	0.639
DOC_WW_Pin1_4	455	460	PF00397	0.761
DOC_WW_Pin1_4	462	467	PF00397	0.725
DOC_WW_Pin1_4	476	481	PF00397	0.752
DOC_WW_Pin1_4	569	574	PF00397	0.595
DOC_WW_Pin1_4	642	647	PF00397	0.719
DOC_WW_Pin1_4	720	725	PF00397	0.677
DOC_WW_Pin1_4	735	740	PF00397	0.695
DOC_WW_Pin1_4	750	755	PF00397	0.750
LIG_14-3-3_CanoR_1	104	112	PF00244	0.528
LIG_14-3-3_CanoR_1	16	23	PF00244	0.655
LIG_14-3-3_CanoR_1	234	238	PF00244	0.526
LIG_14-3-3_CanoR_1	252	262	PF00244	0.404
LIG_14-3-3_CanoR_1	269	278	PF00244	0.640
LIG_14-3-3_CanoR_1	299	307	PF00244	0.483
LIG_14-3-3_CanoR_1	362	368	PF00244	0.544
LIG_14-3-3_CanoR_1	416	424	PF00244	0.747
LIG_14-3-3_CanoR_1	472	480	PF00244	0.809
LIG_14-3-3_CanoR_1	484	488	PF00244	0.785
LIG_14-3-3_CanoR_1	500	510	PF00244	0.648
LIG_14-3-3_CanoR_1	749	754	PF00244	0.578
LIG_14-3-3_CanoR_1	8	14	PF00244	0.704
LIG_Actin_WH2_2	330	345	PF00022	0.637
LIG_BIR_II_1	1	5	PF00653	0.775
LIG_BRCT_BRCA1_1	113	117	PF00533	0.524
LIG_BRCT_BRCA1_1	636	640	PF00533	0.776
LIG_BRCT_BRCA1_1	99	103	PF00533	0.532
LIG_BRCT_BRCA1_2	636	642	PF00533	0.777
LIG_CaM_IQ_9	135	150	PF13499	0.589
LIG_CaM_IQ_9	671	687	PF13499	0.604
LIG_FHA_1	104	110	PF00498	0.540
LIG_FHA_1	2	8	PF00498	0.770
LIG_FHA_1	354	360	PF00498	0.623
LIG_FHA_1	687	693	PF00498	0.657
LIG_FHA_1	91	97	PF00498	0.536
LIG_FHA_2	190	196	PF00498	0.510
LIG_FHA_2	274	280	PF00498	0.442
LIG_FHA_2	304	310	PF00498	0.564
LIG_FHA_2	371	377	PF00498	0.586
LIG_FHA_2	621	627	PF00498	0.732
LIG_FHA_2	646	652	PF00498	0.740
LIG_LIR_Gen_1	272	282	PF02991	0.596
LIG_LIR_Gen_1	290	300	PF02991	0.338
LIG_LIR_Gen_1	328	337	PF02991	0.591
LIG_LIR_Gen_1	45	54	PF02991	0.533
LIG_LIR_Gen_1	532	541	PF02991	0.501
LIG_LIR_Gen_1	635	643	PF02991	0.700
LIG_LIR_Gen_1	68	78	PF02991	0.582
LIG_LIR_Nem_3	114	120	PF02991	0.617
LIG_LIR_Nem_3	272	278	PF02991	0.617
LIG_LIR_Nem_3	290	296	PF02991	0.329
LIG_LIR_Nem_3	328	332	PF02991	0.586
LIG_LIR_Nem_3	37	43	PF02991	0.573
LIG_LIR_Nem_3	376	381	PF02991	0.691
LIG_LIR_Nem_3	45	51	PF02991	0.492
LIG_LIR_Nem_3	532	537	PF02991	0.505
LIG_LIR_Nem_3	635	639	PF02991	0.763
LIG_LIR_Nem_3	68	73	PF02991	0.533
LIG_LIR_Nem_3	74	78	PF02991	0.498
LIG_MLH1_MIPbox_1	113	117	PF16413	0.623
LIG_NRBOX	108	114	PF00104	0.544
LIG_PDZ_Class_3	792	797	PF00595	0.737
LIG_Pex14_1	386	390	PF04695	0.652
LIG_Pex14_2	117	121	PF04695	0.538
LIG_Pex14_2	636	640	PF04695	0.698
LIG_SH2_CRK	217	221	PF00017	0.526
LIG_SH2_CRK	40	44	PF00017	0.634
LIG_SH2_CRK	48	52	PF00017	0.628
LIG_SH2_CRK	70	74	PF00017	0.580
LIG_SH2_NCK_1	275	279	PF00017	0.659
LIG_SH2_NCK_1	390	394	PF00017	0.610
LIG_SH2_NCK_1	70	74	PF00017	0.548
LIG_SH2_SRC	171	174	PF00017	0.578
LIG_SH2_STAP1	48	52	PF00017	0.628
LIG_SH2_STAP1	699	703	PF00017	0.521
LIG_SH2_STAT3	335	338	PF00017	0.488
LIG_SH2_STAT5	275	278	PF00017	0.552
LIG_SH2_STAT5	390	393	PF00017	0.623
LIG_SH3_3	362	368	PF00018	0.569
LIG_SH3_3	475	481	PF00018	0.733
LIG_SH3_3	509	515	PF00018	0.770
LIG_SH3_3	643	649	PF00018	0.692
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.673
LIG_SUMO_SIM_anti_2	93	100	PF11976	0.567
LIG_SUMO_SIM_par_1	563	568	PF11976	0.571
LIG_SUMO_SIM_par_1	93	100	PF11976	0.556
LIG_TRAF2_1	151	154	PF00917	0.543
LIG_TRAF2_1	310	313	PF00917	0.523
LIG_TRAF2_1	317	320	PF00917	0.502
LIG_TRAF2_1	629	632	PF00917	0.670
LIG_UBA3_1	314	323	PF00899	0.511
LIG_WRC_WIRS_1	72	77	PF05994	0.546
MOD_CDK_SPK_2	569	574	PF00069	0.595
MOD_CDK_SPxxK_3	462	469	PF00069	0.746
MOD_CDK_SPxxK_3	720	727	PF00069	0.685
MOD_CDK_SPxxK_3	750	757	PF00069	0.773
MOD_CK1_1	476	482	PF00069	0.771
MOD_CK1_1	502	508	PF00069	0.735
MOD_CK1_1	513	519	PF00069	0.656
MOD_CK1_1	568	574	PF00069	0.587
MOD_CK1_1	60	66	PF00069	0.673
MOD_CK1_1	617	623	PF00069	0.711
MOD_CK1_1	635	641	PF00069	0.511
MOD_CK1_1	645	651	PF00069	0.699
MOD_CK1_1	734	740	PF00069	0.814
MOD_CK2_1	147	153	PF00069	0.587
MOD_CK2_1	16	22	PF00069	0.708
MOD_CK2_1	189	195	PF00069	0.481
MOD_CK2_1	204	210	PF00069	0.525
MOD_CK2_1	240	246	PF00069	0.583
MOD_CK2_1	273	279	PF00069	0.452
MOD_CK2_1	303	309	PF00069	0.554
MOD_CK2_1	47	53	PF00069	0.621
MOD_CK2_1	620	626	PF00069	0.767
MOD_CK2_1	645	651	PF00069	0.774
MOD_CK2_1	653	659	PF00069	0.795
MOD_Cter_Amidation	267	270	PF01082	0.693
MOD_Cter_Amidation	8	11	PF01082	0.740
MOD_GlcNHglycan	149	152	PF01048	0.623
MOD_GlcNHglycan	206	209	PF01048	0.491
MOD_GlcNHglycan	368	371	PF01048	0.685
MOD_GlcNHglycan	455	458	PF01048	0.624
MOD_GlcNHglycan	475	478	PF01048	0.634
MOD_GlcNHglycan	485	488	PF01048	0.785
MOD_GlcNHglycan	489	492	PF01048	0.710
MOD_GlcNHglycan	497	500	PF01048	0.708
MOD_GlcNHglycan	512	515	PF01048	0.658
MOD_GlcNHglycan	516	519	PF01048	0.478
MOD_GlcNHglycan	531	534	PF01048	0.494
MOD_GlcNHglycan	567	570	PF01048	0.635
MOD_GlcNHglycan	617	620	PF01048	0.714
MOD_GlcNHglycan	731	734	PF01048	0.818
MOD_GSK3_1	233	240	PF00069	0.516
MOD_GSK3_1	269	276	PF00069	0.503
MOD_GSK3_1	303	310	PF00069	0.564
MOD_GSK3_1	366	373	PF00069	0.688
MOD_GSK3_1	416	423	PF00069	0.725
MOD_GSK3_1	467	474	PF00069	0.795
MOD_GSK3_1	483	490	PF00069	0.679
MOD_GSK3_1	491	498	PF00069	0.700
MOD_GSK3_1	499	506	PF00069	0.594
MOD_GSK3_1	510	517	PF00069	0.518
MOD_GSK3_1	563	570	PF00069	0.565
MOD_GSK3_1	620	627	PF00069	0.749
MOD_GSK3_1	634	641	PF00069	0.596
MOD_GSK3_1	731	738	PF00069	0.779
MOD_GSK3_1	81	88	PF00069	0.608
MOD_N-GLC_1	354	359	PF02516	0.624
MOD_N-GLC_1	370	375	PF02516	0.581
MOD_N-GLC_1	379	384	PF02516	0.637
MOD_N-GLC_1	624	629	PF02516	0.700
MOD_N-GLC_1	659	664	PF02516	0.746
MOD_NEK2_1	1	6	PF00069	0.691
MOD_NEK2_1	179	184	PF00069	0.565
MOD_NEK2_1	248	253	PF00069	0.526
MOD_NEK2_1	263	268	PF00069	0.501
MOD_NEK2_1	325	330	PF00069	0.515
MOD_NEK2_1	414	419	PF00069	0.621
MOD_NEK2_1	435	440	PF00069	0.685
MOD_NEK2_1	471	476	PF00069	0.724
MOD_NEK2_1	483	488	PF00069	0.597
MOD_NEK2_1	565	570	PF00069	0.611
MOD_NEK2_1	57	62	PF00069	0.595
MOD_NEK2_1	96	101	PF00069	0.531
MOD_NEK2_2	233	238	PF00069	0.653
MOD_NEK2_2	467	472	PF00069	0.713
MOD_PIKK_1	16	22	PF00454	0.682
MOD_PIKK_1	263	269	PF00454	0.611
MOD_PIKK_1	380	386	PF00454	0.563
MOD_PIKK_1	435	441	PF00454	0.701
MOD_PKA_1	188	194	PF00069	0.576
MOD_PKA_1	269	275	PF00069	0.380
MOD_PKA_2	103	109	PF00069	0.532
MOD_PKA_2	233	239	PF00069	0.541
MOD_PKA_2	248	254	PF00069	0.458
MOD_PKA_2	268	274	PF00069	0.397
MOD_PKA_2	298	304	PF00069	0.478
MOD_PKA_2	363	369	PF00069	0.622
MOD_PKA_2	415	421	PF00069	0.749
MOD_PKA_2	471	477	PF00069	0.797
MOD_PKA_2	483	489	PF00069	0.695
MOD_PKA_2	499	505	PF00069	0.637
MOD_PKA_2	708	714	PF00069	0.629
MOD_PKA_2	748	754	PF00069	0.666
MOD_PKA_2	758	764	PF00069	0.557
MOD_PKA_2	9	15	PF00069	0.669
MOD_Plk_1	25	31	PF00069	0.593
MOD_Plk_1	370	376	PF00069	0.694
MOD_Plk_1	624	630	PF00069	0.734
MOD_Plk_1	709	715	PF00069	0.693
MOD_Plk_2-3	71	77	PF00069	0.545
MOD_Plk_4	25	31	PF00069	0.693
MOD_Plk_4	303	309	PF00069	0.589
MOD_Plk_4	47	53	PF00069	0.662
MOD_Plk_4	60	66	PF00069	0.550
MOD_Plk_4	635	641	PF00069	0.646
MOD_ProDKin_1	455	461	PF00069	0.762
MOD_ProDKin_1	462	468	PF00069	0.726
MOD_ProDKin_1	476	482	PF00069	0.753
MOD_ProDKin_1	569	575	PF00069	0.600
MOD_ProDKin_1	642	648	PF00069	0.719
MOD_ProDKin_1	720	726	PF00069	0.680
MOD_ProDKin_1	735	741	PF00069	0.694
MOD_ProDKin_1	750	756	PF00069	0.744
TRG_DiLeu_BaEn_1	108	113	PF01217	0.574
TRG_DiLeu_BaEn_1	786	791	PF01217	0.629
TRG_DiLeu_BaEn_2	556	562	PF01217	0.524
TRG_DiLeu_BaEn_4	154	160	PF01217	0.573
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.569
TRG_DiLeu_LyEn_5	108	113	PF01217	0.574
TRG_ENDOCYTIC_2	217	220	PF00928	0.493
TRG_ENDOCYTIC_2	275	278	PF00928	0.622
TRG_ENDOCYTIC_2	40	43	PF00928	0.606
TRG_ENDOCYTIC_2	48	51	PF00928	0.551
TRG_ENDOCYTIC_2	70	73	PF00928	0.569
TRG_ER_diArg_1	103	105	PF00400	0.539
TRG_ER_diArg_1	156	158	PF00400	0.553
TRG_ER_diArg_1	360	362	PF00400	0.654
TRG_ER_diArg_1	7	10	PF00400	0.673
TRG_NES_CRM1_1	108	123	PF08389	0.584
TRG_NES_CRM1_1	53	68	PF08389	0.675
TRG_NES_CRM1_1	543	557	PF08389	0.624
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	252	257	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICL4	Leptomonas seymouri	63%	100%
A0A1X0NVY2	Trypanosomatidae	41%	100%
A0A3S5ISI8	Trypanosoma rangeli	41%	100%
A4HKA9	Leishmania braziliensis	77%	100%
A4I7T9	Leishmania infantum	100%	100%
D0A9Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B2P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5G0	Leishmania major	93%	100%