Vacuolar protein sorting-associated protein 29

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar sorting-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X5E5_LEIDO

TriTrypDb:

LdBPK_321110.1 , LdCL_320016800 , LDHU3_32.1460

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	11
GO:0030904	retromer complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A3S7X5E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5E5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0016197	endosomal transport	4	11
GO:0016482	cytosolic transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0042147	retrograde transport, endosome to Golgi	5	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006886	intracellular protein transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_COP1_1	141	152	PF00400	0.327
DOC_MAPK_MEF2A_6	106	114	PF00069	0.251
DOC_PP4_FxxP_1	131	134	PF00568	0.251
DOC_USP7_UBL2_3	199	203	PF12436	0.377
DOC_WW_Pin1_4	25	30	PF00397	0.251
LIG_14-3-3_CanoR_1	66	73	PF00244	0.265
LIG_Actin_WH2_2	69	86	PF00022	0.383
LIG_BRCT_BRCA1_1	120	124	PF00533	0.323
LIG_BRCT_BRCA1_1	127	131	PF00533	0.340
LIG_CSL_BTD_1	10	13	PF09270	0.383
LIG_FHA_1	186	192	PF00498	0.433
LIG_FHA_1	36	42	PF00498	0.282
LIG_FHA_1	59	65	PF00498	0.393
LIG_FHA_2	140	146	PF00498	0.350
LIG_FHA_2	178	184	PF00498	0.691
LIG_LIR_Apic_2	128	134	PF02991	0.383
LIG_LIR_Gen_1	151	157	PF02991	0.265
LIG_LIR_Gen_1	21	29	PF02991	0.330
LIG_LIR_Gen_1	45	55	PF02991	0.250
LIG_LIR_Nem_3	121	126	PF02991	0.384
LIG_LIR_Nem_3	151	155	PF02991	0.294
LIG_LIR_Nem_3	45	50	PF02991	0.248
LIG_MLH1_MIPbox_1	120	124	PF16413	0.364
LIG_Pex14_2	23	27	PF04695	0.270
LIG_SH2_CRK	47	51	PF00017	0.383
LIG_SH2_SRC	167	170	PF00017	0.333
LIG_SH2_STAP1	144	148	PF00017	0.279
LIG_SH2_STAT5	123	126	PF00017	0.383
LIG_SH2_STAT5	49	52	PF00017	0.291
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.251
LIG_SUMO_SIM_par_1	153	159	PF11976	0.277
LIG_SUMO_SIM_par_1	3	10	PF11976	0.251
LIG_SUMO_SIM_par_1	74	81	PF11976	0.333
LIG_UBA3_1	153	160	PF00899	0.233
LIG_WRC_WIRS_1	149	154	PF05994	0.328
LIG_WRC_WIRS_1	162	167	PF05994	0.248
MOD_CDC14_SPxK_1	28	31	PF00782	0.327
MOD_CDK_SPxK_1	25	31	PF00069	0.251
MOD_CK1_1	115	121	PF00069	0.251
MOD_CK1_1	161	167	PF00069	0.430
MOD_CK2_1	177	183	PF00069	0.686
MOD_GlcNHglycan	114	117	PF01048	0.251
MOD_GlcNHglycan	137	140	PF01048	0.404
MOD_GlcNHglycan	16	19	PF01048	0.383
MOD_GSK3_1	114	121	PF00069	0.292
MOD_GSK3_1	135	142	PF00069	0.281
MOD_GSK3_1	72	79	PF00069	0.383
MOD_NEK2_1	185	190	PF00069	0.420
MOD_NEK2_1	35	40	PF00069	0.279
MOD_PKA_2	14	20	PF00069	0.385
MOD_Plk_1	158	164	PF00069	0.353
MOD_Plk_4	148	154	PF00069	0.270
MOD_Plk_4	158	164	PF00069	0.328
MOD_Plk_4	7	13	PF00069	0.383
MOD_Plk_4	72	78	PF00069	0.327
MOD_ProDKin_1	25	31	PF00069	0.251
TRG_ENDOCYTIC_2	123	126	PF00928	0.383
TRG_ENDOCYTIC_2	47	50	PF00928	0.307
TRG_NES_CRM1_1	99	111	PF08389	0.270
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAX5	Leptomonas seymouri	78%	98%
A0A0S4KLN9	Bodo saltans	50%	100%
A0A1X0NUK2	Trypanosomatidae	51%	100%
A0A422P1G5	Trypanosoma rangeli	54%	100%
A4HK87	Leishmania braziliensis	83%	100%
A4I7S2	Leishmania infantum	100%	100%
B2RZ78	Rattus norvegicus	47%	100%
D0A9Y0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	90%
E9B2N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P38759	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	72%
Q3T0M0	Bos taurus	47%	100%
Q4Q5H7	Leishmania major	97%	100%
Q54IF7	Dictyostelium discoideum	42%	100%
Q58040	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	32%	100%
Q5R9Z1	Pongo abelii	47%	100%
Q5ZIL2	Gallus gallus	47%	100%
Q6DEU3	Xenopus tropicalis	46%	100%
Q6GP62	Xenopus laevis	46%	100%
Q7ZV68	Danio rerio	48%	100%
Q9QZ88	Mus musculus	47%	100%
Q9STT2	Arabidopsis thaliana	44%	100%
Q9UBQ0	Homo sapiens	47%	100%
Q9UTI5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%