CLASP N terminal, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CLASP N terminal, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5E0_LEIDO

TriTrypDb:

LdBPK_320990.1 , LdCL_320015600 , LDHU3_32.1310

Length:

1063

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	1
GO:0005881	cytoplasmic microtubule	7	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X5E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5E0

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.636
CLV_NRD_NRD_1	1023	1025	PF00675	0.581
CLV_NRD_NRD_1	16	18	PF00675	0.534
CLV_NRD_NRD_1	175	177	PF00675	0.307
CLV_NRD_NRD_1	220	222	PF00675	0.308
CLV_NRD_NRD_1	224	226	PF00675	0.299
CLV_NRD_NRD_1	331	333	PF00675	0.699
CLV_NRD_NRD_1	347	349	PF00675	0.671
CLV_NRD_NRD_1	378	380	PF00675	0.691
CLV_NRD_NRD_1	398	400	PF00675	0.397
CLV_NRD_NRD_1	66	68	PF00675	0.532
CLV_NRD_NRD_1	670	672	PF00675	0.607
CLV_NRD_NRD_1	768	770	PF00675	0.728
CLV_NRD_NRD_1	797	799	PF00675	0.499
CLV_NRD_NRD_1	88	90	PF00675	0.356
CLV_PCSK_KEX2_1	1023	1025	PF00082	0.568
CLV_PCSK_KEX2_1	16	18	PF00082	0.476
CLV_PCSK_KEX2_1	174	176	PF00082	0.306
CLV_PCSK_KEX2_1	220	222	PF00082	0.308
CLV_PCSK_KEX2_1	224	226	PF00082	0.299
CLV_PCSK_KEX2_1	331	333	PF00082	0.603
CLV_PCSK_KEX2_1	347	349	PF00082	0.652
CLV_PCSK_KEX2_1	378	380	PF00082	0.691
CLV_PCSK_KEX2_1	398	400	PF00082	0.397
CLV_PCSK_KEX2_1	66	68	PF00082	0.622
CLV_PCSK_KEX2_1	670	672	PF00082	0.607
CLV_PCSK_KEX2_1	768	770	PF00082	0.683
CLV_PCSK_KEX2_1	797	799	PF00082	0.446
CLV_PCSK_KEX2_1	88	90	PF00082	0.356
CLV_PCSK_PC7_1	220	226	PF00082	0.356
CLV_PCSK_SKI1_1	1023	1027	PF00082	0.534
CLV_PCSK_SKI1_1	151	155	PF00082	0.368
CLV_PCSK_SKI1_1	301	305	PF00082	0.697
CLV_PCSK_SKI1_1	318	322	PF00082	0.711
CLV_PCSK_SKI1_1	332	336	PF00082	0.597
CLV_PCSK_SKI1_1	348	352	PF00082	0.748
CLV_PCSK_SKI1_1	487	491	PF00082	0.503
CLV_PCSK_SKI1_1	505	509	PF00082	0.271
CLV_PCSK_SKI1_1	551	555	PF00082	0.581
CLV_PCSK_SKI1_1	611	615	PF00082	0.581
CLV_PCSK_SKI1_1	641	645	PF00082	0.439
CLV_PCSK_SKI1_1	656	660	PF00082	0.589
CLV_PCSK_SKI1_1	66	70	PF00082	0.499
CLV_PCSK_SKI1_1	670	674	PF00082	0.529
CLV_PCSK_SKI1_1	697	701	PF00082	0.620
CLV_PCSK_SKI1_1	798	802	PF00082	0.460
CLV_PCSK_SKI1_1	878	882	PF00082	0.455
CLV_Separin_Metazoa	13	17	PF03568	0.558
CLV_Separin_Metazoa	179	183	PF03568	0.551
DEG_APCC_DBOX_1	174	182	PF00400	0.518
DEG_APCC_DBOX_1	486	494	PF00400	0.468
DEG_APCC_DBOX_1	550	558	PF00400	0.580
DEG_APCC_DBOX_1	797	805	PF00400	0.508
DEG_ODPH_VHL_1	1035	1048	PF01847	0.587
DEG_SCF_FBW7_1	320	325	PF00400	0.581
DEG_SPOP_SBC_1	128	132	PF00917	0.551
DEG_SPOP_SBC_1	2	6	PF00917	0.588
DEG_SPOP_SBC_1	322	326	PF00917	0.583
DEG_SPOP_SBC_1	541	545	PF00917	0.507
DOC_ANK_TNKS_1	808	815	PF00023	0.465
DOC_CKS1_1	351	356	PF01111	0.717
DOC_CYCLIN_RxL_1	329	337	PF00134	0.695
DOC_CYCLIN_RxL_1	638	647	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	736	742	PF00134	0.793
DOC_MAPK_gen_1	174	180	PF00069	0.520
DOC_MAPK_gen_1	224	232	PF00069	0.556
DOC_MAPK_gen_1	30	38	PF00069	0.639
DOC_MAPK_gen_1	797	804	PF00069	0.485
DOC_MAPK_gen_1	88	94	PF00069	0.556
DOC_MAPK_MEF2A_6	1012	1020	PF00069	0.460
DOC_MAPK_MEF2A_6	30	38	PF00069	0.600
DOC_MAPK_MEF2A_6	43	51	PF00069	0.284
DOC_MAPK_MEF2A_6	495	503	PF00069	0.378
DOC_MAPK_RevD_3	1009	1024	PF00069	0.552
DOC_PP4_FxxP_1	1034	1037	PF00568	0.588
DOC_USP7_MATH_1	128	132	PF00917	0.574
DOC_USP7_MATH_1	2	6	PF00917	0.724
DOC_USP7_MATH_1	280	284	PF00917	0.830
DOC_USP7_MATH_1	297	301	PF00917	0.679
DOC_USP7_MATH_1	541	545	PF00917	0.551
DOC_USP7_MATH_1	559	563	PF00917	0.571
DOC_USP7_MATH_1	565	569	PF00917	0.615
DOC_USP7_MATH_1	576	580	PF00917	0.417
DOC_USP7_MATH_1	683	687	PF00917	0.618
DOC_USP7_MATH_1	740	744	PF00917	0.653
DOC_USP7_MATH_1	764	768	PF00917	0.633
DOC_USP7_MATH_1	84	88	PF00917	0.524
DOC_USP7_MATH_1	871	875	PF00917	0.487
DOC_USP7_MATH_1	923	927	PF00917	0.525
DOC_USP7_MATH_1	958	962	PF00917	0.466
DOC_WW_Pin1_4	273	278	PF00397	0.752
DOC_WW_Pin1_4	318	323	PF00397	0.662
DOC_WW_Pin1_4	350	355	PF00397	0.697
DOC_WW_Pin1_4	724	729	PF00397	0.791
DOC_WW_Pin1_4	744	749	PF00397	0.739
LIG_14-3-3_CanoR_1	174	179	PF00244	0.607
LIG_14-3-3_CanoR_1	301	306	PF00244	0.663
LIG_14-3-3_CanoR_1	323	327	PF00244	0.777
LIG_14-3-3_CanoR_1	347	351	PF00244	0.723
LIG_14-3-3_CanoR_1	473	482	PF00244	0.528
LIG_14-3-3_CanoR_1	492	501	PF00244	0.518
LIG_14-3-3_CanoR_1	970	975	PF00244	0.592
LIG_14-3-3_CterR_2	1060	1063	PF00244	0.620
LIG_AP2alpha_2	893	895	PF02296	0.598
LIG_APCC_ABBA_1	1046	1051	PF00400	0.500
LIG_APCC_ABBA_1	836	841	PF00400	0.564
LIG_APCC_ABBAyCdc20_2	835	841	PF00400	0.570
LIG_BIR_II_1	1	5	PF00653	0.756
LIG_CaM_NSCaTE_8	580	587	PF13499	0.466
LIG_deltaCOP1_diTrp_1	622	629	PF00928	0.452
LIG_DLG_GKlike_1	174	181	PF00625	0.454
LIG_EH1_1	465	473	PF00400	0.555
LIG_eIF4E_1	76	82	PF01652	0.404
LIG_EVH1_1	269	273	PF00568	0.587
LIG_FHA_1	132	138	PF00498	0.515
LIG_FHA_1	199	205	PF00498	0.499
LIG_FHA_1	2	8	PF00498	0.648
LIG_FHA_1	236	242	PF00498	0.607
LIG_FHA_1	300	306	PF00498	0.651
LIG_FHA_1	351	357	PF00498	0.752
LIG_FHA_1	382	388	PF00498	0.693
LIG_FHA_1	54	60	PF00498	0.435
LIG_FHA_1	966	972	PF00498	0.756
LIG_FHA_1	987	993	PF00498	0.491
LIG_FHA_2	302	308	PF00498	0.687
LIG_FHA_2	386	392	PF00498	0.639
LIG_FHA_2	454	460	PF00498	0.612
LIG_FHA_2	8	14	PF00498	0.520
LIG_GBD_Chelix_1	419	427	PF00786	0.566
LIG_GBD_Chelix_1	996	1004	PF00786	0.538
LIG_GSK3_LRP6_1	273	279	PF00069	0.604
LIG_KLC1_Yacidic_2	1047	1051	PF13176	0.523
LIG_LIR_Apic_2	1031	1037	PF02991	0.591
LIG_LIR_Gen_1	459	468	PF02991	0.509
LIG_LIR_Gen_1	579	589	PF02991	0.469
LIG_LIR_Gen_1	698	707	PF02991	0.544
LIG_LIR_Gen_1	941	952	PF02991	0.436
LIG_LIR_Nem_3	1056	1062	PF02991	0.667
LIG_LIR_Nem_3	432	438	PF02991	0.505
LIG_LIR_Nem_3	459	463	PF02991	0.611
LIG_LIR_Nem_3	579	584	PF02991	0.464
LIG_LIR_Nem_3	593	598	PF02991	0.545
LIG_LIR_Nem_3	626	632	PF02991	0.613
LIG_LIR_Nem_3	659	665	PF02991	0.587
LIG_LIR_Nem_3	698	702	PF02991	0.456
LIG_LIR_Nem_3	941	947	PF02991	0.450
LIG_MYND_1	1033	1037	PF01753	0.594
LIG_NRBOX	422	428	PF00104	0.481
LIG_NRBOX	862	868	PF00104	0.542
LIG_NRBOX	905	911	PF00104	0.514
LIG_PALB2_WD40_1	576	584	PF16756	0.474
LIG_PCNA_yPIPBox_3	637	649	PF02747	0.403
LIG_Pex14_1	625	629	PF04695	0.438
LIG_Pex14_1	72	76	PF04695	0.464
LIG_RPA_C_Fungi	701	713	PF08784	0.528
LIG_SH2_PTP2	531	534	PF00017	0.459
LIG_SH2_SRC	184	187	PF00017	0.385
LIG_SH2_SRC	531	534	PF00017	0.459
LIG_SH2_STAP1	200	204	PF00017	0.501
LIG_SH2_STAT5	1049	1052	PF00017	0.524
LIG_SH2_STAT5	184	187	PF00017	0.501
LIG_SH2_STAT5	200	203	PF00017	0.237
LIG_SH2_STAT5	531	534	PF00017	0.412
LIG_SH2_STAT5	790	793	PF00017	0.424
LIG_SH3_3	1027	1033	PF00018	0.608
LIG_SH3_3	229	235	PF00018	0.424
LIG_SH3_3	264	270	PF00018	0.642
LIG_SH3_3	271	277	PF00018	0.696
LIG_SH3_3	531	537	PF00018	0.475
LIG_SH3_3	820	826	PF00018	0.675
LIG_SH3_3	909	915	PF00018	0.459
LIG_SH3_3	971	977	PF00018	0.724
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.501
LIG_SUMO_SIM_par_1	152	157	PF11976	0.423
LIG_SUMO_SIM_par_1	300	308	PF11976	0.769
LIG_SUMO_SIM_par_1	800	806	PF11976	0.583
LIG_TRAF2_1	10	13	PF00917	0.520
LIG_TRAF2_1	260	263	PF00917	0.637
LIG_TRAF2_1	605	608	PF00917	0.639
LIG_TYR_ITIM	529	534	PF00017	0.457
LIG_UBA3_1	145	151	PF00899	0.424
LIG_Vh1_VBS_1	148	166	PF01044	0.326
MOD_CDC14_SPxK_1	326	329	PF00782	0.681
MOD_CDK_SPK_2	318	323	PF00069	0.723
MOD_CDK_SPxK_1	323	329	PF00069	0.712
MOD_CK1_1	131	137	PF00069	0.429
MOD_CK1_1	276	282	PF00069	0.790
MOD_CK1_1	385	391	PF00069	0.460
MOD_CK1_1	413	419	PF00069	0.507
MOD_CK1_1	579	585	PF00069	0.511
MOD_CK1_1	874	880	PF00069	0.489
MOD_CK2_1	180	186	PF00069	0.385
MOD_CK2_1	2	8	PF00069	0.552
MOD_CK2_1	334	340	PF00069	0.742
MOD_CK2_1	385	391	PF00069	0.571
MOD_CK2_1	453	459	PF00069	0.559
MOD_CK2_1	602	608	PF00069	0.538
MOD_CK2_1	698	704	PF00069	0.613
MOD_CK2_1	800	806	PF00069	0.583
MOD_CK2_1	842	848	PF00069	0.593
MOD_Cter_Amidation	64	67	PF01082	0.482
MOD_DYRK1A_RPxSP_1	318	322	PF00069	0.722
MOD_DYRK1A_RPxSP_1	323	327	PF00069	0.708
MOD_GlcNHglycan	1038	1041	PF01048	0.510
MOD_GlcNHglycan	131	134	PF01048	0.392
MOD_GlcNHglycan	137	140	PF01048	0.357
MOD_GlcNHglycan	169	172	PF01048	0.462
MOD_GlcNHglycan	191	194	PF01048	0.323
MOD_GlcNHglycan	278	281	PF01048	0.698
MOD_GlcNHglycan	282	285	PF01048	0.657
MOD_GlcNHglycan	310	313	PF01048	0.657
MOD_GlcNHglycan	336	339	PF01048	0.758
MOD_GlcNHglycan	358	361	PF01048	0.731
MOD_GlcNHglycan	410	413	PF01048	0.660
MOD_GlcNHglycan	468	471	PF01048	0.475
MOD_GlcNHglycan	517	520	PF01048	0.591
MOD_GlcNHglycan	61	66	PF01048	0.476
MOD_GlcNHglycan	709	712	PF01048	0.652
MOD_GlcNHglycan	843	847	PF01048	0.576
MOD_GlcNHglycan	873	876	PF01048	0.500
MOD_GlcNHglycan	921	924	PF01048	0.409
MOD_GlcNHglycan	941	944	PF01048	0.538
MOD_GSK3_1	127	134	PF00069	0.387
MOD_GSK3_1	189	196	PF00069	0.501
MOD_GSK3_1	272	279	PF00069	0.746
MOD_GSK3_1	297	304	PF00069	0.675
MOD_GSK3_1	3	10	PF00069	0.585
MOD_GSK3_1	318	325	PF00069	0.708
MOD_GSK3_1	346	353	PF00069	0.715
MOD_GSK3_1	356	363	PF00069	0.603
MOD_GSK3_1	381	388	PF00069	0.568
MOD_GSK3_1	389	396	PF00069	0.537
MOD_GSK3_1	740	747	PF00069	0.771
MOD_GSK3_1	874	881	PF00069	0.362
MOD_GSK3_1	919	926	PF00069	0.392
MOD_N-GLC_1	473	478	PF02516	0.518
MOD_N-GLC_1	690	695	PF02516	0.670
MOD_N-GLC_1	740	745	PF02516	0.573
MOD_N-GLC_2	1001	1003	PF02516	0.469
MOD_N-GLC_2	1005	1007	PF02516	0.453
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	127	132	PF00069	0.375
MOD_NEK2_1	334	339	PF00069	0.774
MOD_NEK2_1	356	361	PF00069	0.688
MOD_NEK2_1	408	413	PF00069	0.631
MOD_NEK2_1	444	449	PF00069	0.522
MOD_NEK2_1	466	471	PF00069	0.433
MOD_NEK2_1	540	545	PF00069	0.516
MOD_NEK2_1	614	619	PF00069	0.643
MOD_NEK2_1	707	712	PF00069	0.591
MOD_NEK2_1	919	924	PF00069	0.489
MOD_NEK2_2	1007	1012	PF00069	0.585
MOD_NEK2_2	193	198	PF00069	0.287
MOD_NEK2_2	71	76	PF00069	0.495
MOD_OFUCOSY	920	927	PF10250	0.456
MOD_PIKK_1	453	459	PF00454	0.549
MOD_PK_1	882	888	PF00069	0.463
MOD_PK_1	970	976	PF00069	0.552
MOD_PKA_1	174	180	PF00069	0.501
MOD_PKA_1	670	676	PF00069	0.598
MOD_PKA_2	174	180	PF00069	0.501
MOD_PKA_2	29	35	PF00069	0.703
MOD_PKA_2	322	328	PF00069	0.753
MOD_PKA_2	346	352	PF00069	0.703
MOD_PKA_2	472	478	PF00069	0.544
MOD_PKA_2	614	620	PF00069	0.631
MOD_PKA_2	670	676	PF00069	0.740
MOD_PKA_2	791	797	PF00069	0.541
MOD_Plk_1	393	399	PF00069	0.507
MOD_Plk_1	53	59	PF00069	0.436
MOD_Plk_1	541	547	PF00069	0.608
MOD_Plk_1	690	696	PF00069	0.515
MOD_Plk_1	756	762	PF00069	0.663
MOD_Plk_2-3	698	704	PF00069	0.581
MOD_Plk_4	115	121	PF00069	0.363
MOD_Plk_4	158	164	PF00069	0.478
MOD_Plk_4	382	388	PF00069	0.586
MOD_Plk_4	410	416	PF00069	0.593
MOD_Plk_4	459	465	PF00069	0.517
MOD_Plk_4	535	541	PF00069	0.513
MOD_Plk_4	576	582	PF00069	0.442
MOD_Plk_4	690	696	PF00069	0.441
MOD_Plk_4	71	77	PF00069	0.478
MOD_Plk_4	905	911	PF00069	0.481
MOD_Plk_4	970	976	PF00069	0.677
MOD_Plk_4	99	105	PF00069	0.407
MOD_ProDKin_1	273	279	PF00069	0.755
MOD_ProDKin_1	318	324	PF00069	0.664
MOD_ProDKin_1	350	356	PF00069	0.698
MOD_ProDKin_1	724	730	PF00069	0.793
MOD_ProDKin_1	744	750	PF00069	0.741
MOD_SUMO_rev_2	259	267	PF00179	0.601
MOD_SUMO_rev_2	622	630	PF00179	0.589
MOD_SUMO_rev_2	646	650	PF00179	0.521
TRG_DiLeu_BaEn_1	410	415	PF01217	0.637
TRG_DiLeu_BaEn_1	459	464	PF01217	0.601
TRG_DiLeu_BaEn_1	54	59	PF01217	0.548
TRG_DiLeu_BaEn_1	616	621	PF01217	0.602
TRG_DiLeu_BaLyEn_6	1057	1062	PF01217	0.632
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.553
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.527
TRG_DiLeu_BaLyEn_6	832	837	PF01217	0.441
TRG_ENDOCYTIC_2	531	534	PF00928	0.460
TRG_ER_diArg_1	1022	1024	PF00400	0.559
TRG_ER_diArg_1	15	17	PF00400	0.542
TRG_ER_diArg_1	173	176	PF00400	0.430
TRG_ER_diArg_1	219	221	PF00400	0.365
TRG_ER_diArg_1	397	399	PF00400	0.522
TRG_ER_diArg_1	670	672	PF00400	0.670
TRG_ER_diArg_1	785	788	PF00400	0.549
TRG_NES_CRM1_1	417	432	PF08389	0.464
TRG_Pf-PMV_PEXEL_1	1024	1028	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	641	646	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	714	718	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICN1	Leptomonas seymouri	40%	100%
A0A3R7M9H6	Trypanosoma rangeli	24%	100%
A4HK75	Leishmania braziliensis	68%	99%
A4I7R0	Leishmania infantum	99%	100%
E9B2L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5I8	Leishmania major	88%	100%