Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5D7_LEIDO

TriTrypDb:

LdBPK_321250.1 , LdCL_320018200 , LDHU3_32.1610

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.591
CLV_C14_Caspase3-7	389	393	PF00656	0.684
CLV_C14_Caspase3-7	451	455	PF00656	0.727
CLV_NRD_NRD_1	103	105	PF00675	0.790
CLV_NRD_NRD_1	352	354	PF00675	0.764
CLV_NRD_NRD_1	442	444	PF00675	0.741
CLV_NRD_NRD_1	446	448	PF00675	0.721
CLV_NRD_NRD_1	517	519	PF00675	0.735
CLV_PCSK_KEX2_1	103	105	PF00082	0.779
CLV_PCSK_KEX2_1	267	269	PF00082	0.641
CLV_PCSK_KEX2_1	27	29	PF00082	0.566
CLV_PCSK_KEX2_1	352	354	PF00082	0.825
CLV_PCSK_KEX2_1	380	382	PF00082	0.798
CLV_PCSK_KEX2_1	442	444	PF00082	0.741
CLV_PCSK_KEX2_1	446	448	PF00082	0.721
CLV_PCSK_KEX2_1	515	517	PF00082	0.737
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.618
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.459
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.798
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.737
CLV_PCSK_PC7_1	348	354	PF00082	0.742
CLV_PCSK_PC7_1	442	448	PF00082	0.832
DEG_APCC_DBOX_1	27	35	PF00400	0.453
DOC_ANK_TNKS_1	212	219	PF00023	0.730
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.611
DOC_MAPK_gen_1	491	498	PF00069	0.671
DOC_MAPK_gen_1	55	65	PF00069	0.721
DOC_MAPK_MEF2A_6	267	276	PF00069	0.824
DOC_MAPK_MEF2A_6	58	65	PF00069	0.820
DOC_PP1_RVXF_1	115	122	PF00149	0.592
DOC_PP1_RVXF_1	218	225	PF00149	0.712
DOC_PP1_RVXF_1	492	499	PF00149	0.710
DOC_PP2B_LxvP_1	330	333	PF13499	0.780
DOC_PP2B_LxvP_1	357	360	PF13499	0.615
DOC_PP2B_LxvP_1	412	415	PF13499	0.744
DOC_PP4_FxxP_1	51	54	PF00568	0.567
DOC_USP7_MATH_1	132	136	PF00917	0.656
DOC_USP7_MATH_1	187	191	PF00917	0.690
DOC_USP7_MATH_1	229	233	PF00917	0.626
DOC_USP7_MATH_1	258	262	PF00917	0.646
DOC_USP7_MATH_1	299	303	PF00917	0.779
DOC_USP7_MATH_1	331	335	PF00917	0.574
DOC_USP7_MATH_1	415	419	PF00917	0.769
DOC_USP7_MATH_1	448	452	PF00917	0.660
DOC_WW_Pin1_4	130	135	PF00397	0.676
DOC_WW_Pin1_4	169	174	PF00397	0.813
DOC_WW_Pin1_4	225	230	PF00397	0.691
DOC_WW_Pin1_4	254	259	PF00397	0.737
DOC_WW_Pin1_4	266	271	PF00397	0.623
DOC_WW_Pin1_4	295	300	PF00397	0.752
DOC_WW_Pin1_4	307	312	PF00397	0.541
DOC_WW_Pin1_4	374	379	PF00397	0.712
DOC_WW_Pin1_4	384	389	PF00397	0.606
DOC_WW_Pin1_4	434	439	PF00397	0.663
DOC_WW_Pin1_4	455	460	PF00397	0.811
DOC_WW_Pin1_4	65	70	PF00397	0.802
DOC_WW_Pin1_4	79	84	PF00397	0.697
LIG_14-3-3_CanoR_1	124	134	PF00244	0.615
LIG_14-3-3_CanoR_1	223	231	PF00244	0.640
LIG_14-3-3_CanoR_1	291	296	PF00244	0.663
LIG_14-3-3_CanoR_1	312	322	PF00244	0.594
LIG_14-3-3_CanoR_1	326	330	PF00244	0.639
LIG_14-3-3_CanoR_1	381	385	PF00244	0.618
LIG_14-3-3_CanoR_1	77	85	PF00244	0.723
LIG_14-3-3_CanoR_1	88	97	PF00244	0.587
LIG_BIR_III_4	215	219	PF00653	0.593
LIG_BRCT_BRCA1_1	134	138	PF00533	0.760
LIG_BRCT_BRCA1_1	198	202	PF00533	0.784
LIG_BRCT_BRCA1_1	302	306	PF00533	0.656
LIG_BRCT_BRCA1_1	436	440	PF00533	0.697
LIG_BRCT_BRCA1_1	9	13	PF00533	0.625
LIG_BRCT_BRCA1_1	92	96	PF00533	0.696
LIG_EVH1_1	471	475	PF00568	0.600
LIG_FHA_1	231	237	PF00498	0.654
LIG_FHA_1	385	391	PF00498	0.780
LIG_FHA_1	97	103	PF00498	0.626
LIG_FHA_2	153	159	PF00498	0.712
LIG_FHA_2	318	324	PF00498	0.640
LIG_GBD_Chelix_1	94	102	PF00786	0.566
LIG_Integrin_RGD_1	213	215	PF01839	0.734
LIG_LIR_Apic_2	50	54	PF02991	0.564
LIG_LIR_Gen_1	245	255	PF02991	0.716
LIG_LIR_Gen_1	303	311	PF02991	0.708
LIG_LIR_Nem_3	303	309	PF02991	0.712
LIG_RPA_C_Fungi	477	489	PF08784	0.609
LIG_SH2_STAT3	35	38	PF00017	0.572
LIG_SH2_STAT5	194	197	PF00017	0.688
LIG_SH3_1	108	114	PF00018	0.726
LIG_SH3_2	472	477	PF14604	0.608
LIG_SH3_3	108	114	PF00018	0.728
LIG_SH3_3	305	311	PF00018	0.694
LIG_SH3_3	357	363	PF00018	0.703
LIG_SH3_3	418	424	PF00018	0.665
LIG_SH3_3	466	472	PF00018	0.766
LIG_SH3_3	486	492	PF00018	0.626
LIG_SUMO_SIM_anti_2	273	278	PF11976	0.781
LIG_TRAF2_1	23	26	PF00917	0.472
LIG_TRAF2_1	242	245	PF00917	0.699
LIG_TRAF2_1	481	484	PF00917	0.753
LIG_WRC_WIRS_1	231	236	PF05994	0.689
MOD_CDC14_SPxK_1	133	136	PF00782	0.764
MOD_CDK_SPK_2	307	312	PF00069	0.649
MOD_CDK_SPxK_1	130	136	PF00069	0.769
MOD_CDK_SPxK_1	374	380	PF00069	0.713
MOD_CDK_SPxxK_3	374	381	PF00069	0.618
MOD_CK1_1	125	131	PF00069	0.800
MOD_CK1_1	190	196	PF00069	0.708
MOD_CK1_1	197	203	PF00069	0.706
MOD_CK1_1	225	231	PF00069	0.692
MOD_CK1_1	232	238	PF00069	0.691
MOD_CK1_1	455	461	PF00069	0.830
MOD_CK1_1	510	516	PF00069	0.633
MOD_CK1_1	526	532	PF00069	0.684
MOD_CK2_1	152	158	PF00069	0.670
MOD_CK2_1	260	266	PF00069	0.727
MOD_CK2_1	317	323	PF00069	0.615
MOD_CK2_1	478	484	PF00069	0.756
MOD_CK2_1	65	71	PF00069	0.619
MOD_GlcNHglycan	148	151	PF01048	0.744
MOD_GlcNHglycan	188	192	PF01048	0.683
MOD_GlcNHglycan	208	211	PF01048	0.516
MOD_GlcNHglycan	260	263	PF01048	0.718
MOD_GlcNHglycan	281	284	PF01048	0.751
MOD_GlcNHglycan	338	341	PF01048	0.820
MOD_GlcNHglycan	406	409	PF01048	0.768
MOD_GlcNHglycan	41	44	PF01048	0.678
MOD_GlcNHglycan	417	420	PF01048	0.695
MOD_GlcNHglycan	483	487	PF01048	0.738
MOD_GlcNHglycan	509	512	PF01048	0.754
MOD_GlcNHglycan	526	529	PF01048	0.583
MOD_GSK3_1	169	176	PF00069	0.658
MOD_GSK3_1	190	197	PF00069	0.731
MOD_GSK3_1	225	232	PF00069	0.635
MOD_GSK3_1	254	261	PF00069	0.685
MOD_GSK3_1	291	298	PF00069	0.672
MOD_GSK3_1	307	314	PF00069	0.730
MOD_GSK3_1	380	387	PF00069	0.791
MOD_GSK3_1	400	407	PF00069	0.514
MOD_GSK3_1	427	434	PF00069	0.736
MOD_GSK3_1	448	455	PF00069	0.779
MOD_GSK3_1	478	485	PF00069	0.806
MOD_GSK3_1	498	505	PF00069	0.782
MOD_GSK3_1	506	513	PF00069	0.693
MOD_GSK3_1	520	527	PF00069	0.641
MOD_LATS_1	221	227	PF00433	0.711
MOD_N-GLC_1	197	202	PF02516	0.637
MOD_N-GLC_1	401	406	PF02516	0.725
MOD_N-GLC_1	462	467	PF02516	0.831
MOD_NEK2_1	1	6	PF00069	0.753
MOD_NEK2_1	300	305	PF00069	0.628
MOD_NEK2_1	325	330	PF00069	0.663
MOD_NEK2_1	390	395	PF00069	0.724
MOD_NEK2_1	90	95	PF00069	0.586
MOD_PIKK_1	125	131	PF00454	0.703
MOD_PIKK_1	317	323	PF00454	0.662
MOD_PIKK_1	449	455	PF00454	0.840
MOD_PIKK_1	77	83	PF00454	0.728
MOD_PKA_1	380	386	PF00069	0.630
MOD_PKA_2	140	146	PF00069	0.742
MOD_PKA_2	222	228	PF00069	0.647
MOD_PKA_2	311	317	PF00069	0.604
MOD_PKA_2	325	331	PF00069	0.696
MOD_PKA_2	336	342	PF00069	0.707
MOD_PKA_2	380	386	PF00069	0.738
MOD_PKA_2	478	484	PF00069	0.659
MOD_PKA_2	498	504	PF00069	0.688
MOD_Plk_1	197	203	PF00069	0.674
MOD_Plk_1	236	242	PF00069	0.671
MOD_Plk_1	401	407	PF00069	0.727
MOD_Plk_4	190	196	PF00069	0.793
MOD_Plk_4	197	203	PF00069	0.665
MOD_Plk_4	325	331	PF00069	0.636
MOD_Plk_4	361	367	PF00069	0.707
MOD_Plk_4	559	565	PF00069	0.656
MOD_ProDKin_1	130	136	PF00069	0.676
MOD_ProDKin_1	169	175	PF00069	0.816
MOD_ProDKin_1	225	231	PF00069	0.692
MOD_ProDKin_1	254	260	PF00069	0.738
MOD_ProDKin_1	266	272	PF00069	0.620
MOD_ProDKin_1	295	301	PF00069	0.752
MOD_ProDKin_1	307	313	PF00069	0.538
MOD_ProDKin_1	374	380	PF00069	0.713
MOD_ProDKin_1	384	390	PF00069	0.606
MOD_ProDKin_1	434	440	PF00069	0.665
MOD_ProDKin_1	455	461	PF00069	0.811
MOD_ProDKin_1	65	71	PF00069	0.804
MOD_ProDKin_1	79	85	PF00069	0.694
MOD_SUMO_rev_2	19	29	PF00179	0.594
TRG_DiLeu_BaEn_2	91	97	PF01217	0.582
TRG_DiLeu_BaLyEn_6	456	461	PF01217	0.713
TRG_ER_diArg_1	102	104	PF00400	0.783
TRG_ER_diArg_1	105	108	PF00400	0.757
TRG_ER_diArg_1	352	354	PF00400	0.667
TRG_ER_diArg_1	441	443	PF00400	0.744
TRG_ER_diArg_1	477	480	PF00400	0.671
TRG_ER_diArg_1	516	518	PF00400	0.739
TRG_ER_diArg_1	63	66	PF00400	0.742
TRG_NLS_MonoCore_2	514	519	PF00514	0.833
TRG_NLS_MonoExtC_3	514	519	PF00514	0.740
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.736

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P995	Leptomonas seymouri	29%	100%
A4HKA6	Leishmania braziliensis	52%	97%
A4I7T6	Leishmania infantum	99%	100%
E9B2P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4Q5G3	Leishmania major	82%	100%