Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5C7_LEIDO

TriTrypDb:

LdBPK_320910.1 , LdCL_320014600 , LDHU3_32.1190

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X5C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5C7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.633
CLV_C14_Caspase3-7	374	378	PF00656	0.647
CLV_NRD_NRD_1	114	116	PF00675	0.667
CLV_NRD_NRD_1	221	223	PF00675	0.427
CLV_NRD_NRD_1	522	524	PF00675	0.781
CLV_NRD_NRD_1	559	561	PF00675	0.636
CLV_NRD_NRD_1	563	565	PF00675	0.628
CLV_PCSK_FUR_1	112	116	PF00082	0.662
CLV_PCSK_KEX2_1	114	116	PF00082	0.629
CLV_PCSK_KEX2_1	133	135	PF00082	0.279
CLV_PCSK_KEX2_1	220	222	PF00082	0.410
CLV_PCSK_KEX2_1	290	292	PF00082	0.603
CLV_PCSK_KEX2_1	435	437	PF00082	0.522
CLV_PCSK_KEX2_1	520	522	PF00082	0.665
CLV_PCSK_KEX2_1	559	561	PF00082	0.633
CLV_PCSK_KEX2_1	565	567	PF00082	0.630
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.470
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.603
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.502
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.645
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.545
CLV_PCSK_PC7_1	286	292	PF00082	0.530
CLV_PCSK_SKI1_1	133	137	PF00082	0.529
CLV_PCSK_SKI1_1	145	149	PF00082	0.538
CLV_PCSK_SKI1_1	226	230	PF00082	0.468
CLV_PCSK_SKI1_1	254	258	PF00082	0.519
CLV_PCSK_SKI1_1	290	294	PF00082	0.628
CLV_PCSK_SKI1_1	432	436	PF00082	0.509
CLV_PCSK_SKI1_1	522	526	PF00082	0.635
DEG_APCC_DBOX_1	337	345	PF00400	0.410
DEG_APCC_DBOX_1	72	80	PF00400	0.435
DEG_Nend_UBRbox_1	1	4	PF02207	0.498
DEG_SCF_FBW7_1	361	368	PF00400	0.406
DEG_SPOP_SBC_1	307	311	PF00917	0.696
DOC_CKS1_1	362	367	PF01111	0.406
DOC_CYCLIN_RxL_1	286	296	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	281	284	PF00134	0.549
DOC_MAPK_gen_1	251	261	PF00069	0.478
DOC_MAPK_gen_1	273	281	PF00069	0.610
DOC_MAPK_MEF2A_6	254	261	PF00069	0.468
DOC_MAPK_MEF2A_6	406	415	PF00069	0.575
DOC_MAPK_NFAT4_5	254	262	PF00069	0.471
DOC_PP1_RVXF_1	69	75	PF00149	0.495
DOC_PP2B_LxvP_1	281	284	PF13499	0.549
DOC_PP4_MxPP_1	438	441	PF00568	0.620
DOC_USP7_MATH_1	175	179	PF00917	0.693
DOC_USP7_MATH_1	305	309	PF00917	0.723
DOC_USP7_MATH_1	365	369	PF00917	0.535
DOC_USP7_MATH_1	503	507	PF00917	0.697
DOC_USP7_MATH_1	509	513	PF00917	0.680
DOC_WW_Pin1_4	361	366	PF00397	0.397
DOC_WW_Pin1_4	513	518	PF00397	0.505
LIG_14-3-3_CanoR_1	145	155	PF00244	0.472
LIG_14-3-3_CanoR_1	22	30	PF00244	0.420
LIG_14-3-3_CanoR_1	32	41	PF00244	0.446
LIG_14-3-3_CanoR_1	394	398	PF00244	0.499
LIG_14-3-3_CanoR_1	406	412	PF00244	0.596
LIG_14-3-3_CanoR_1	414	421	PF00244	0.574
LIG_14-3-3_CanoR_1	444	452	PF00244	0.550
LIG_14-3-3_CanoR_1	510	518	PF00244	0.596
LIG_14-3-3_CanoR_1	536	541	PF00244	0.555
LIG_14-3-3_CanoR_1	84	90	PF00244	0.492
LIG_Actin_WH2_2	431	446	PF00022	0.623
LIG_AP_GAE_1	547	553	PF02883	0.566
LIG_AP2alpha_2	348	350	PF02296	0.377
LIG_BIR_III_4	102	106	PF00653	0.528
LIG_BRCT_BRCA1_1	362	366	PF00533	0.434
LIG_deltaCOP1_diTrp_1	478	487	PF00928	0.652
LIG_FHA_1	142	148	PF00498	0.489
LIG_FHA_1	38	44	PF00498	0.387
LIG_FHA_1	444	450	PF00498	0.659
LIG_FHA_1	466	472	PF00498	0.586
LIG_FHA_1	556	562	PF00498	0.598
LIG_FHA_2	381	387	PF00498	0.482
LIG_FHA_2	445	451	PF00498	0.525
LIG_FHA_2	55	61	PF00498	0.329
LIG_LIR_Apic_2	360	365	PF02991	0.400
LIG_LIR_Gen_1	363	373	PF02991	0.481
LIG_LIR_Gen_1	547	556	PF02991	0.546
LIG_LIR_LC3C_4	40	44	PF02991	0.454
LIG_LIR_Nem_3	234	239	PF02991	0.480
LIG_LIR_Nem_3	363	369	PF02991	0.453
LIG_LIR_Nem_3	399	404	PF02991	0.487
LIG_LIR_Nem_3	547	553	PF02991	0.538
LIG_PCNA_yPIPBox_3	265	275	PF02747	0.428
LIG_Pex14_1	289	293	PF04695	0.404
LIG_PTAP_UEV_1	12	17	PF05743	0.494
LIG_SH2_CRK	362	366	PF00017	0.418
LIG_SH2_GRB2like	129	132	PF00017	0.363
LIG_SH2_GRB2like	387	390	PF00017	0.420
LIG_SH2_NCK_1	362	366	PF00017	0.503
LIG_SH2_SRC	140	143	PF00017	0.413
LIG_SH2_SRC	160	163	PF00017	0.448
LIG_SH2_STAP1	546	550	PF00017	0.594
LIG_SH2_STAT5	129	132	PF00017	0.369
LIG_SH2_STAT5	160	163	PF00017	0.551
LIG_SH2_STAT5	236	239	PF00017	0.489
LIG_SH2_STAT5	30	33	PF00017	0.486
LIG_SH2_STAT5	64	67	PF00017	0.371
LIG_SH3_3	10	16	PF00018	0.489
LIG_SH3_3	550	556	PF00018	0.640
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.557
LIG_SUMO_SIM_anti_2	40	45	PF11976	0.333
LIG_SUMO_SIM_par_1	39	45	PF11976	0.370
LIG_TRAF2_1	467	470	PF00917	0.607
LIG_TRAF2_1	57	60	PF00917	0.472
LIG_TYR_ITIM	62	67	PF00017	0.502
LIG_TYR_ITSM	232	239	PF00017	0.270
MOD_CDK_SPxxK_3	513	520	PF00069	0.505
MOD_CK1_1	308	314	PF00069	0.665
MOD_CK1_1	360	366	PF00069	0.422
MOD_CK1_1	511	517	PF00069	0.693
MOD_CK1_1	92	98	PF00069	0.715
MOD_CK2_1	307	313	PF00069	0.605
MOD_CK2_1	380	386	PF00069	0.490
MOD_CK2_1	414	420	PF00069	0.657
MOD_CK2_1	54	60	PF00069	0.343
MOD_Cter_Amidation	112	115	PF01082	0.687
MOD_Cter_Amidation	562	565	PF01082	0.544
MOD_GlcNHglycan	12	16	PF01048	0.583
MOD_GlcNHglycan	148	151	PF01048	0.531
MOD_GlcNHglycan	185	188	PF01048	0.688
MOD_GlcNHglycan	198	201	PF01048	0.715
MOD_GlcNHglycan	301	304	PF01048	0.636
MOD_GlcNHglycan	330	333	PF01048	0.665
MOD_GlcNHglycan	459	462	PF01048	0.679
MOD_GSK3_1	146	153	PF00069	0.502
MOD_GSK3_1	295	302	PF00069	0.599
MOD_GSK3_1	319	326	PF00069	0.636
MOD_GSK3_1	357	364	PF00069	0.551
MOD_GSK3_1	367	374	PF00069	0.654
MOD_GSK3_1	504	511	PF00069	0.640
MOD_GSK3_1	532	539	PF00069	0.550
MOD_LATS_1	412	418	PF00433	0.655
MOD_N-GLC_1	320	325	PF02516	0.649
MOD_N-GLC_1	444	449	PF02516	0.524
MOD_NEK2_1	146	151	PF00069	0.421
MOD_NEK2_1	183	188	PF00069	0.609
MOD_NEK2_1	196	201	PF00069	0.739
MOD_NEK2_1	21	26	PF00069	0.485
MOD_NEK2_1	231	236	PF00069	0.419
MOD_NEK2_1	242	247	PF00069	0.406
MOD_NEK2_1	306	311	PF00069	0.520
MOD_NEK2_1	31	36	PF00069	0.426
MOD_NEK2_1	443	448	PF00069	0.583
MOD_NEK2_1	452	457	PF00069	0.640
MOD_NEK2_1	487	492	PF00069	0.615
MOD_NEK2_1	534	539	PF00069	0.522
MOD_NEK2_1	540	545	PF00069	0.641
MOD_NEK2_1	83	88	PF00069	0.391
MOD_NEK2_2	357	362	PF00069	0.367
MOD_OFUCOSY	230	235	PF10250	0.491
MOD_PIKK_1	295	301	PF00454	0.700
MOD_PIKK_1	414	420	PF00454	0.647
MOD_PIKK_1	465	471	PF00454	0.756
MOD_PKA_1	522	528	PF00069	0.623
MOD_PKA_2	21	27	PF00069	0.428
MOD_PKA_2	31	37	PF00069	0.449
MOD_PKA_2	393	399	PF00069	0.539
MOD_PKA_2	443	449	PF00069	0.628
MOD_PKA_2	487	493	PF00069	0.614
MOD_PKA_2	509	515	PF00069	0.715
MOD_PKA_2	522	528	PF00069	0.567
MOD_PKA_2	83	89	PF00069	0.516
MOD_PKB_1	486	494	PF00069	0.566
MOD_Plk_1	175	181	PF00069	0.602
MOD_Plk_1	444	450	PF00069	0.528
MOD_Plk_1	504	510	PF00069	0.708
MOD_Plk_2-3	371	377	PF00069	0.642
MOD_Plk_2-3	380	386	PF00069	0.630
MOD_Plk_2-3	54	60	PF00069	0.386
MOD_Plk_4	274	280	PF00069	0.556
MOD_Plk_4	357	363	PF00069	0.393
MOD_Plk_4	37	43	PF00069	0.357
MOD_Plk_4	371	377	PF00069	0.596
MOD_Plk_4	536	542	PF00069	0.593
MOD_Plk_4	92	98	PF00069	0.592
MOD_ProDKin_1	361	367	PF00069	0.409
MOD_ProDKin_1	513	519	PF00069	0.504
MOD_SUMO_rev_2	527	532	PF00179	0.652
TRG_DiLeu_BaEn_1	274	279	PF01217	0.548
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.511
TRG_ENDOCYTIC_2	132	135	PF00928	0.366
TRG_ENDOCYTIC_2	236	239	PF00928	0.446
TRG_ENDOCYTIC_2	30	33	PF00928	0.354
TRG_ENDOCYTIC_2	64	67	PF00928	0.371
TRG_ER_diArg_1	112	115	PF00400	0.609
TRG_ER_diArg_1	219	222	PF00400	0.410
TRG_ER_diArg_1	521	523	PF00400	0.650
TRG_ER_diArg_1	559	562	PF00400	0.655
TRG_ER_diArg_1	71	74	PF00400	0.498
TRG_NLS_MonoCore_2	519	524	PF00514	0.599
TRG_NLS_MonoExtN_4	517	524	PF00514	0.671
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I873	Leptomonas seymouri	56%	98%
A0A1X0NWB4	Trypanosomatidae	34%	100%
A0A422N8X2	Trypanosoma rangeli	31%	100%
A4HK67	Leishmania braziliensis	78%	100%
A4I7Q2	Leishmania infantum	100%	100%
D0A9V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B2L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q5J6	Leishmania major	93%	100%
V5BQN4	Trypanosoma cruzi	35%	100%