Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5C4_LEIDO

TriTrypDb:

LdBPK_321030.1 , LdCL_320016000 , LDHU3_32.1370

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5C4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	538	540	PF00675	0.694
CLV_PCSK_KEX2_1	242	244	PF00082	0.506
CLV_PCSK_KEX2_1	538	540	PF00082	0.694
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.506
CLV_PCSK_SKI1_1	161	165	PF00082	0.532
CLV_PCSK_SKI1_1	213	217	PF00082	0.536
CLV_PCSK_SKI1_1	242	246	PF00082	0.498
CLV_PCSK_SKI1_1	279	283	PF00082	0.558
DEG_APCC_DBOX_1	270	278	PF00400	0.564
DEG_SPOP_SBC_1	123	127	PF00917	0.751
DOC_CKS1_1	39	44	PF01111	0.741
DOC_CYCLIN_RxL_1	153	162	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.649
DOC_MAPK_gen_1	220	229	PF00069	0.514
DOC_PP4_FxxP_1	397	400	PF00568	0.636
DOC_PP4_FxxP_1	92	95	PF00568	0.594
DOC_USP7_MATH_1	122	126	PF00917	0.727
DOC_USP7_MATH_1	326	330	PF00917	0.655
DOC_USP7_MATH_1	433	437	PF00917	0.570
DOC_USP7_MATH_1	472	476	PF00917	0.683
DOC_USP7_MATH_1	523	527	PF00917	0.685
DOC_USP7_MATH_1	76	80	PF00917	0.777
DOC_USP7_MATH_1	81	85	PF00917	0.593
DOC_USP7_MATH_1	95	99	PF00917	0.759
DOC_WW_Pin1_4	124	129	PF00397	0.657
DOC_WW_Pin1_4	285	290	PF00397	0.593
DOC_WW_Pin1_4	302	307	PF00397	0.622
DOC_WW_Pin1_4	316	321	PF00397	0.676
DOC_WW_Pin1_4	342	347	PF00397	0.705
DOC_WW_Pin1_4	360	365	PF00397	0.664
DOC_WW_Pin1_4	38	43	PF00397	0.739
DOC_WW_Pin1_4	401	406	PF00397	0.648
DOC_WW_Pin1_4	448	453	PF00397	0.741
DOC_WW_Pin1_4	56	61	PF00397	0.630
DOC_WW_Pin1_4	97	102	PF00397	0.615
LIG_Actin_WH2_2	259	277	PF00022	0.537
LIG_APCC_ABBA_1	169	174	PF00400	0.622
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BRCT_BRCA1_1	135	139	PF00533	0.670
LIG_BRCT_BRCA1_1	156	160	PF00533	0.643
LIG_BRCT_BRCA1_1	384	388	PF00533	0.680
LIG_FHA_1	112	118	PF00498	0.641
LIG_FHA_1	12	18	PF00498	0.753
LIG_FHA_1	239	245	PF00498	0.536
LIG_FHA_1	313	319	PF00498	0.729
LIG_FHA_1	39	45	PF00498	0.789
LIG_FHA_1	410	416	PF00498	0.630
LIG_FHA_1	464	470	PF00498	0.717
LIG_LIR_Apic_2	396	400	PF02991	0.762
LIG_LIR_Gen_1	136	146	PF02991	0.698
LIG_LIR_Gen_1	223	234	PF02991	0.419
LIG_LIR_Gen_1	308	318	PF02991	0.586
LIG_LIR_Nem_3	136	142	PF02991	0.662
LIG_LIR_Nem_3	157	163	PF02991	0.663
LIG_LIR_Nem_3	223	229	PF02991	0.443
LIG_LIR_Nem_3	308	313	PF02991	0.585
LIG_LIR_Nem_3	439	443	PF02991	0.675
LIG_LIR_Nem_3	506	512	PF02991	0.661
LIG_SH2_CRK	145	149	PF00017	0.583
LIG_SH2_CRK	310	314	PF00017	0.585
LIG_SH2_NCK_1	145	149	PF00017	0.554
LIG_SH2_NCK_1	310	314	PF00017	0.585
LIG_SH2_STAP1	145	149	PF00017	0.554
LIG_SH2_STAP1	411	415	PF00017	0.643
LIG_SH2_STAT3	411	414	PF00017	0.649
LIG_SH2_STAT3	489	492	PF00017	0.601
LIG_SH2_STAT5	118	121	PF00017	0.639
LIG_SH2_STAT5	310	313	PF00017	0.648
LIG_SH2_STAT5	370	373	PF00017	0.670
LIG_SH2_STAT5	411	414	PF00017	0.655
LIG_SH3_1	387	393	PF00018	0.726
LIG_SH3_3	387	393	PF00018	0.720
LIG_SH3_3	446	452	PF00018	0.731
LIG_SH3_3	458	464	PF00018	0.599
LIG_SH3_3	498	504	PF00018	0.636
LIG_SUMO_SIM_par_1	482	487	PF11976	0.680
LIG_TYR_ITIM	507	512	PF00017	0.599
LIG_TYR_ITSM	306	313	PF00017	0.585
LIG_WRC_WIRS_1	394	399	PF05994	0.558
MOD_CDK_SPxxK_3	285	292	PF00069	0.660
MOD_CDK_SPxxK_3	448	455	PF00069	0.742
MOD_CK1_1	100	106	PF00069	0.757
MOD_CK1_1	127	133	PF00069	0.649
MOD_CK1_1	138	144	PF00069	0.646
MOD_CK1_1	293	299	PF00069	0.724
MOD_CK1_1	305	311	PF00069	0.615
MOD_CK1_1	329	335	PF00069	0.678
MOD_CK1_1	409	415	PF00069	0.627
MOD_CK1_1	451	457	PF00069	0.636
MOD_CK1_1	541	547	PF00069	0.774
MOD_CK2_1	186	192	PF00069	0.478
MOD_CK2_1	433	439	PF00069	0.684
MOD_CK2_1	450	456	PF00069	0.783
MOD_CK2_1	5	11	PF00069	0.676
MOD_Cter_Amidation	536	539	PF01082	0.684
MOD_GlcNHglycan	1	4	PF01048	0.704
MOD_GlcNHglycan	231	234	PF01048	0.395
MOD_GlcNHglycan	342	345	PF01048	0.635
MOD_GlcNHglycan	35	38	PF01048	0.726
MOD_GlcNHglycan	355	359	PF01048	0.675
MOD_GlcNHglycan	417	420	PF01048	0.638
MOD_GlcNHglycan	456	460	PF01048	0.734
MOD_GlcNHglycan	512	515	PF01048	0.634
MOD_GlcNHglycan	540	543	PF01048	0.634
MOD_GSK3_1	123	130	PF00069	0.684
MOD_GSK3_1	133	140	PF00069	0.616
MOD_GSK3_1	293	300	PF00069	0.710
MOD_GSK3_1	301	308	PF00069	0.692
MOD_GSK3_1	312	319	PF00069	0.710
MOD_GSK3_1	340	347	PF00069	0.594
MOD_GSK3_1	409	416	PF00069	0.746
MOD_GSK3_1	447	454	PF00069	0.653
MOD_GSK3_1	472	479	PF00069	0.736
MOD_GSK3_1	72	79	PF00069	0.667
MOD_LATS_1	218	224	PF00433	0.555
MOD_N-GLC_1	133	138	PF02516	0.748
MOD_N-GLC_1	229	234	PF02516	0.410
MOD_N-GLC_1	55	60	PF02516	0.712
MOD_NEK2_1	238	243	PF00069	0.500
MOD_NEK2_1	354	359	PF00069	0.655
MOD_NEK2_1	365	370	PF00069	0.586
MOD_NEK2_1	382	387	PF00069	0.715
MOD_NEK2_1	413	418	PF00069	0.640
MOD_NEK2_1	431	436	PF00069	0.462
MOD_NEK2_1	484	489	PF00069	0.590
MOD_NEK2_1	72	77	PF00069	0.658
MOD_NEK2_2	393	398	PF00069	0.729
MOD_NEK2_2	406	411	PF00069	0.479
MOD_OFUCOSY	217	224	PF10250	0.607
MOD_PIKK_1	133	139	PF00454	0.714
MOD_PIKK_1	484	490	PF00454	0.610
MOD_PIKK_1	543	549	PF00454	0.618
MOD_PKA_1	538	544	PF00069	0.608
MOD_PKA_2	293	299	PF00069	0.700
MOD_PKA_2	538	544	PF00069	0.809
MOD_Plk_1	229	235	PF00069	0.388
MOD_Plk_1	354	360	PF00069	0.684
MOD_Plk_1	72	78	PF00069	0.652
MOD_Plk_2-3	5	11	PF00069	0.650
MOD_Plk_4	326	332	PF00069	0.693
MOD_Plk_4	393	399	PF00069	0.700
MOD_Plk_4	406	412	PF00069	0.482
MOD_ProDKin_1	124	130	PF00069	0.659
MOD_ProDKin_1	285	291	PF00069	0.597
MOD_ProDKin_1	302	308	PF00069	0.620
MOD_ProDKin_1	316	322	PF00069	0.676
MOD_ProDKin_1	342	348	PF00069	0.706
MOD_ProDKin_1	360	366	PF00069	0.665
MOD_ProDKin_1	38	44	PF00069	0.742
MOD_ProDKin_1	401	407	PF00069	0.647
MOD_ProDKin_1	448	454	PF00069	0.742
MOD_ProDKin_1	56	62	PF00069	0.630
MOD_ProDKin_1	97	103	PF00069	0.618
MOD_SUMO_rev_2	541	546	PF00179	0.668
TRG_ENDOCYTIC_2	145	148	PF00928	0.587
TRG_ENDOCYTIC_2	310	313	PF00928	0.648
TRG_ENDOCYTIC_2	509	512	PF00928	0.609
TRG_ER_diArg_1	538	540	PF00400	0.691
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP7	Leptomonas seymouri	53%	100%
A0A1X0NUL4	Trypanosomatidae	29%	87%
A4HK79	Leishmania braziliensis	74%	99%
A4I7R4	Leishmania infantum	99%	100%
E9B2M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5I4	Leishmania major	94%	100%