Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5B4_LEIDO

TriTrypDb:

LdBPK_320590.1 , LdCL_320011400 , LDHU3_32.0740

Length:

178

Annotations

LeishMANIAdb annotations

Might be a component of some unusual ubiquitin ligase (due to its C-terminal RING domain). Probably membrane-associated, although a purely cytoplasmic protein cannot be excluded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7X5B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5B4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	79	81	PF00675	0.515
CLV_PCSK_FUR_1	77	81	PF00082	0.511
CLV_PCSK_KEX2_1	77	79	PF00082	0.508
CLV_PCSK_SKI1_1	109	113	PF00082	0.586
CLV_PCSK_SKI1_1	120	124	PF00082	0.500
DOC_CYCLIN_RxL_1	106	115	PF00134	0.756
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.742
DOC_MAPK_gen_1	89	97	PF00069	0.778
DOC_PP1_RVXF_1	45	51	PF00149	0.483
DOC_PP4_FxxP_1	19	22	PF00568	0.449
DOC_USP7_MATH_1	91	95	PF00917	0.723
DOC_WW_Pin1_4	112	117	PF00397	0.772
DOC_WW_Pin1_4	25	30	PF00397	0.519
LIG_14-3-3_CanoR_1	77	85	PF00244	0.564
LIG_14-3-3_CanoR_1	92	96	PF00244	0.788
LIG_BRCT_BRCA1_1	15	19	PF00533	0.465
LIG_FHA_1	139	145	PF00498	0.664
LIG_FHA_1	38	44	PF00498	0.575
LIG_GBD_Chelix_1	61	69	PF00786	0.530
LIG_Integrin_isoDGR_2	129	131	PF01839	0.522
LIG_LIR_Apic_2	16	22	PF02991	0.466
LIG_LIR_Nem_3	160	164	PF02991	0.567
LIG_LIR_Nem_3	28	33	PF02991	0.474
LIG_LIR_Nem_3	71	76	PF02991	0.365
LIG_PDZ_Class_2	173	178	PF00595	0.740
LIG_REV1ctd_RIR_1	72	83	PF16727	0.627
LIG_SH2_STAT5	161	164	PF00017	0.568
LIG_SH2_STAT5	73	76	PF00017	0.501
LIG_SH3_3	100	106	PF00018	0.702
LIG_SH3_3	118	124	PF00018	0.747
LIG_SH3_3	139	145	PF00018	0.618
LIG_TYR_ITSM	69	76	PF00017	0.452
MOD_GlcNHglycan	35	38	PF01048	0.723
MOD_GlcNHglycan	5	8	PF01048	0.831
MOD_GlcNHglycan	52	55	PF01048	0.536
MOD_GSK3_1	110	117	PF00069	0.790
MOD_GSK3_1	153	160	PF00069	0.686
MOD_GSK3_1	33	40	PF00069	0.533
MOD_NEK2_1	3	8	PF00069	0.633
MOD_NEK2_1	42	47	PF00069	0.557
MOD_NEK2_1	68	73	PF00069	0.425
MOD_NEK2_1	85	90	PF00069	0.633
MOD_NEK2_2	14	19	PF00069	0.492
MOD_NEK2_2	37	42	PF00069	0.521
MOD_NEK2_2	91	96	PF00069	0.727
MOD_PIKK_1	8	14	PF00454	0.528
MOD_PKA_1	78	84	PF00069	0.563
MOD_PKA_2	78	84	PF00069	0.580
MOD_PKA_2	91	97	PF00069	0.744
MOD_Plk_1	14	20	PF00069	0.487
MOD_Plk_1	37	43	PF00069	0.464
MOD_Plk_4	138	144	PF00069	0.607
MOD_Plk_4	14	20	PF00069	0.488
MOD_Plk_4	37	43	PF00069	0.488
MOD_Plk_4	68	74	PF00069	0.474
MOD_ProDKin_1	112	118	PF00069	0.774
MOD_ProDKin_1	25	31	PF00069	0.517
TRG_DiLeu_BaEn_2	37	43	PF01217	0.576
TRG_ENDOCYTIC_2	161	164	PF00928	0.634
TRG_ENDOCYTIC_2	73	76	PF00928	0.530
TRG_ER_diArg_1	172	175	PF00400	0.587
TRG_ER_diArg_1	76	79	PF00400	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HK37	Leishmania braziliensis	77%	99%
A4I7M6	Leishmania infantum	100%	100%
E9B2H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q5M7	Leishmania major	92%	100%