LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X5B4_LEIDO
TriTrypDb:
LdBPK_320590.1 , LdCL_320011400 , LDHU3_32.0740
Length:
178

Annotations

LeishMANIAdb annotations

Might be a component of some unusual ubiquitin ligase (due to its C-terminal RING domain). Probably membrane-associated, although a purely cytoplasmic protein cannot be excluded.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A0A3S7X5B4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5B4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 79 81 PF00675 0.515
CLV_PCSK_FUR_1 77 81 PF00082 0.511
CLV_PCSK_KEX2_1 77 79 PF00082 0.508
CLV_PCSK_SKI1_1 109 113 PF00082 0.586
CLV_PCSK_SKI1_1 120 124 PF00082 0.500
DOC_CYCLIN_RxL_1 106 115 PF00134 0.756
DOC_CYCLIN_yCln2_LP_2 118 124 PF00134 0.742
DOC_MAPK_gen_1 89 97 PF00069 0.778
DOC_PP1_RVXF_1 45 51 PF00149 0.483
DOC_PP4_FxxP_1 19 22 PF00568 0.449
DOC_USP7_MATH_1 91 95 PF00917 0.723
DOC_WW_Pin1_4 112 117 PF00397 0.772
DOC_WW_Pin1_4 25 30 PF00397 0.519
LIG_14-3-3_CanoR_1 77 85 PF00244 0.564
LIG_14-3-3_CanoR_1 92 96 PF00244 0.788
LIG_BRCT_BRCA1_1 15 19 PF00533 0.465
LIG_FHA_1 139 145 PF00498 0.664
LIG_FHA_1 38 44 PF00498 0.575
LIG_GBD_Chelix_1 61 69 PF00786 0.530
LIG_Integrin_isoDGR_2 129 131 PF01839 0.522
LIG_LIR_Apic_2 16 22 PF02991 0.466
LIG_LIR_Nem_3 160 164 PF02991 0.567
LIG_LIR_Nem_3 28 33 PF02991 0.474
LIG_LIR_Nem_3 71 76 PF02991 0.365
LIG_PDZ_Class_2 173 178 PF00595 0.740
LIG_REV1ctd_RIR_1 72 83 PF16727 0.627
LIG_SH2_STAT5 161 164 PF00017 0.568
LIG_SH2_STAT5 73 76 PF00017 0.501
LIG_SH3_3 100 106 PF00018 0.702
LIG_SH3_3 118 124 PF00018 0.747
LIG_SH3_3 139 145 PF00018 0.618
LIG_TYR_ITSM 69 76 PF00017 0.452
MOD_GlcNHglycan 35 38 PF01048 0.723
MOD_GlcNHglycan 5 8 PF01048 0.831
MOD_GlcNHglycan 52 55 PF01048 0.536
MOD_GSK3_1 110 117 PF00069 0.790
MOD_GSK3_1 153 160 PF00069 0.686
MOD_GSK3_1 33 40 PF00069 0.533
MOD_NEK2_1 3 8 PF00069 0.633
MOD_NEK2_1 42 47 PF00069 0.557
MOD_NEK2_1 68 73 PF00069 0.425
MOD_NEK2_1 85 90 PF00069 0.633
MOD_NEK2_2 14 19 PF00069 0.492
MOD_NEK2_2 37 42 PF00069 0.521
MOD_NEK2_2 91 96 PF00069 0.727
MOD_PIKK_1 8 14 PF00454 0.528
MOD_PKA_1 78 84 PF00069 0.563
MOD_PKA_2 78 84 PF00069 0.580
MOD_PKA_2 91 97 PF00069 0.744
MOD_Plk_1 14 20 PF00069 0.487
MOD_Plk_1 37 43 PF00069 0.464
MOD_Plk_4 138 144 PF00069 0.607
MOD_Plk_4 14 20 PF00069 0.488
MOD_Plk_4 37 43 PF00069 0.488
MOD_Plk_4 68 74 PF00069 0.474
MOD_ProDKin_1 112 118 PF00069 0.774
MOD_ProDKin_1 25 31 PF00069 0.517
TRG_DiLeu_BaEn_2 37 43 PF01217 0.576
TRG_ENDOCYTIC_2 161 164 PF00928 0.634
TRG_ENDOCYTIC_2 73 76 PF00928 0.530
TRG_ER_diArg_1 172 175 PF00400 0.587
TRG_ER_diArg_1 76 79 PF00400 0.704

Homologs

Protein Taxonomy Sequence identity Coverage
A4HK37 Leishmania braziliensis 77% 99%
A4I7M6 Leishmania infantum 100% 100%
E9B2H9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q5M7 Leishmania major 92% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS