Ethanolamine-phosphate cytidylyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ethanolamine-phosphate cytidylyltransferase

Species:

Leishmania donovani

UniProt:

A0A3S7X5B3_LEIDO

TriTrypDb:

LdBPK_320940.1 , LdCL_320015000 , LDHU3_32.1230

Length:

402

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, ethanolamine-phosphate cytidylyltransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X5B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5B3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006646	phosphatidylethanolamine biosynthetic process	6	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046337	phosphatidylethanolamine metabolic process	6	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0070567	cytidylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.417
CLV_C14_Caspase3-7	311	315	PF00656	0.555
CLV_NRD_NRD_1	215	217	PF00675	0.403
CLV_NRD_NRD_1	74	76	PF00675	0.308
CLV_PCSK_KEX2_1	167	169	PF00082	0.206
CLV_PCSK_KEX2_1	375	377	PF00082	0.410
CLV_PCSK_KEX2_1	74	76	PF00082	0.308
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.217
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.461
CLV_PCSK_SKI1_1	164	168	PF00082	0.225
CLV_PCSK_SKI1_1	180	184	PF00082	0.405
CLV_PCSK_SKI1_1	370	374	PF00082	0.396
CLV_PCSK_SKI1_1	380	384	PF00082	0.523
CLV_Separin_Metazoa	89	93	PF03568	0.510
DEG_SCF_TRCP1_1	352	358	PF00400	0.357
DEG_SPOP_SBC_1	4	8	PF00917	0.673
DOC_ANK_TNKS_1	51	58	PF00023	0.271
DOC_CYCLIN_RxL_1	177	185	PF00134	0.330
DOC_CYCLIN_yClb1_LxF_4	368	373	PF00134	0.427
DOC_MAPK_gen_1	126	135	PF00069	0.420
DOC_MAPK_gen_1	275	284	PF00069	0.473
DOC_MAPK_gen_1	338	347	PF00069	0.284
DOC_MAPK_gen_1	74	82	PF00069	0.508
DOC_MAPK_MEF2A_6	46	55	PF00069	0.300
DOC_PP1_RVXF_1	215	222	PF00149	0.439
DOC_PP1_RVXF_1	368	374	PF00149	0.452
DOC_PP4_FxxP_1	93	96	PF00568	0.510
DOC_WW_Pin1_4	203	208	PF00397	0.570
DOC_WW_Pin1_4	223	228	PF00397	0.340
DOC_WW_Pin1_4	5	10	PF00397	0.626
LIG_14-3-3_CanoR_1	151	155	PF00244	0.436
LIG_Actin_WH2_2	175	193	PF00022	0.543
LIG_Actin_WH2_2	55	73	PF00022	0.417
LIG_APCC_ABBA_1	345	350	PF00400	0.425
LIG_BRCT_BRCA1_1	199	203	PF00533	0.489
LIG_FHA_1	167	173	PF00498	0.441
LIG_FHA_1	357	363	PF00498	0.322
LIG_FHA_1	38	44	PF00498	0.370
LIG_FHA_1	48	54	PF00498	0.258
LIG_Integrin_isoDGR_2	149	151	PF01839	0.214
LIG_LIR_Apic_2	336	342	PF02991	0.343
LIG_LIR_Gen_1	102	110	PF02991	0.431
LIG_LIR_Gen_1	153	160	PF02991	0.406
LIG_LIR_Gen_1	237	248	PF02991	0.406
LIG_LIR_Gen_1	33	43	PF02991	0.384
LIG_LIR_Gen_1	56	67	PF02991	0.417
LIG_LIR_LC3C_4	327	331	PF02991	0.398
LIG_LIR_Nem_3	102	108	PF02991	0.406
LIG_LIR_Nem_3	153	157	PF02991	0.406
LIG_LIR_Nem_3	237	243	PF02991	0.406
LIG_LIR_Nem_3	33	38	PF02991	0.329
LIG_LIR_Nem_3	393	398	PF02991	0.505
LIG_LIR_Nem_3	56	62	PF02991	0.417
LIG_LYPXL_yS_3	279	282	PF13949	0.473
LIG_OCRL_FandH_1	58	70	PF00620	0.406
LIG_PCNA_yPIPBox_3	285	295	PF02747	0.417
LIG_PTB_Apo_2	117	124	PF02174	0.449
LIG_PTB_Phospho_1	117	123	PF10480	0.449
LIG_Rb_LxCxE_1	33	50	PF01857	0.390
LIG_SH2_CRK	339	343	PF00017	0.263
LIG_SH2_CRK	395	399	PF00017	0.434
LIG_SH2_SRC	154	157	PF00017	0.417
LIG_SH2_SRC	235	238	PF00017	0.406
LIG_SH2_SRC	260	263	PF00017	0.406
LIG_SH2_STAP1	266	270	PF00017	0.510
LIG_SH2_STAT3	266	269	PF00017	0.453
LIG_SH2_STAT5	116	119	PF00017	0.420
LIG_SH2_STAT5	123	126	PF00017	0.394
LIG_SH2_STAT5	137	140	PF00017	0.406
LIG_SH2_STAT5	235	238	PF00017	0.406
LIG_SH2_STAT5	260	263	PF00017	0.406
LIG_SH2_STAT5	296	299	PF00017	0.406
LIG_SH3_3	14	20	PF00018	0.524
LIG_SH3_3	42	48	PF00018	0.407
LIG_TRAF2_1	153	156	PF00917	0.417
LIG_TRAF2_1	86	89	PF00917	0.431
MOD_CDK_SPK_2	223	228	PF00069	0.460
MOD_CK1_1	222	228	PF00069	0.521
MOD_CK1_1	353	359	PF00069	0.355
MOD_CK1_1	7	13	PF00069	0.690
MOD_CK2_1	150	156	PF00069	0.444
MOD_CK2_1	189	195	PF00069	0.542
MOD_CK2_1	198	204	PF00069	0.541
MOD_CK2_1	83	89	PF00069	0.406
MOD_GlcNHglycan	12	15	PF01048	0.681
MOD_GlcNHglycan	228	231	PF01048	0.446
MOD_GlcNHglycan	352	355	PF01048	0.384
MOD_GSK3_1	166	173	PF00069	0.432
MOD_GSK3_1	219	226	PF00069	0.439
MOD_GSK3_1	3	10	PF00069	0.645
MOD_GSK3_1	33	40	PF00069	0.452
MOD_N-GLC_1	222	227	PF02516	0.420
MOD_NEK2_1	182	187	PF00069	0.497
MOD_NEK2_1	198	203	PF00069	0.476
MOD_NEK2_1	212	217	PF00069	0.322
MOD_NEK2_2	290	295	PF00069	0.417
MOD_PIKK_1	384	390	PF00454	0.508
MOD_PKA_2	150	156	PF00069	0.402
MOD_Plk_1	142	148	PF00069	0.406
MOD_Plk_1	198	204	PF00069	0.571
MOD_Plk_1	33	39	PF00069	0.307
MOD_Plk_2-3	142	148	PF00069	0.417
MOD_Plk_4	198	204	PF00069	0.615
MOD_Plk_4	33	39	PF00069	0.435
MOD_Plk_4	358	364	PF00069	0.457
MOD_ProDKin_1	203	209	PF00069	0.567
MOD_ProDKin_1	223	229	PF00069	0.343
MOD_ProDKin_1	5	11	PF00069	0.626
MOD_SUMO_rev_2	379	387	PF00179	0.483
TRG_ENDOCYTIC_2	105	108	PF00928	0.406
TRG_ENDOCYTIC_2	154	157	PF00928	0.424
TRG_ENDOCYTIC_2	279	282	PF00928	0.492
TRG_ENDOCYTIC_2	348	351	PF00928	0.413
TRG_ENDOCYTIC_2	35	38	PF00928	0.393
TRG_ENDOCYTIC_2	395	398	PF00928	0.499
TRG_ER_diArg_1	74	76	PF00400	0.507
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9A3	Leptomonas seymouri	82%	100%
A0A0S4KIJ8	Bodo saltans	69%	96%
A0A1X0NUM2	Trypanosomatidae	71%	100%
A0A422N8Y0	Trypanosoma rangeli	69%	100%
A4HK70	Leishmania braziliensis	88%	100%
A4I7Q5	Leishmania infantum	100%	100%
A9N9S2	Coxiella burnetii (strain RSA 331 / Henzerling II)	25%	85%
D0A9W0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B2L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O88637	Rattus norvegicus	44%	100%
P33412	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
Q4Q5J3	Leishmania major	94%	100%
Q55BZ4	Dictyostelium discoideum	54%	100%
Q5EA75	Bos taurus	46%	100%
Q83B60	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	25%	85%
Q8SQW6	Encephalitozoon cuniculi (strain GB-M1)	35%	100%
Q922E4	Mus musculus	44%	100%
Q99447	Homo sapiens	46%	100%
Q9UTI6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q9ZVI9	Arabidopsis thaliana	46%	95%
V5DHH9	Trypanosoma cruzi	67%	100%