LeishMANIAdb
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DnaJ_domain_containing_protein_putative/Pfam:PF00 226

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DnaJ_domain_containing_protein_putative/Pfam:PF00 226
Gene product:
DnaJ domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X5A0_LEIDO
TriTrypDb:
LdBPK_320620.1 , LdCL_320011700 , LDHU3_32.0770
Length:
316

Annotations

LeishMANIAdb annotations

A tail-anchored chaperone, with homology to ER-associated (secreted) heat shock proteins (plant ERDJ3). However, this subfamily appears to be oriented towards the cytoplasm.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A0A3S7X5A0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5A0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 100 102 PF00675 0.372
CLV_NRD_NRD_1 137 139 PF00675 0.434
CLV_NRD_NRD_1 153 155 PF00675 0.366
CLV_NRD_NRD_1 193 195 PF00675 0.387
CLV_NRD_NRD_1 209 211 PF00675 0.343
CLV_NRD_NRD_1 230 232 PF00675 0.400
CLV_NRD_NRD_1 253 255 PF00675 0.314
CLV_NRD_NRD_1 5 7 PF00675 0.531
CLV_PCSK_FUR_1 3 7 PF00082 0.454
CLV_PCSK_KEX2_1 100 102 PF00082 0.354
CLV_PCSK_KEX2_1 137 139 PF00082 0.434
CLV_PCSK_KEX2_1 153 155 PF00082 0.366
CLV_PCSK_KEX2_1 230 232 PF00082 0.371
CLV_PCSK_KEX2_1 310 312 PF00082 0.607
CLV_PCSK_KEX2_1 5 7 PF00082 0.531
CLV_PCSK_PC1ET2_1 310 312 PF00082 0.603
CLV_PCSK_SKI1_1 100 104 PF00082 0.361
CLV_PCSK_SKI1_1 156 160 PF00082 0.469
CLV_PCSK_SKI1_1 17 21 PF00082 0.376
CLV_PCSK_SKI1_1 195 199 PF00082 0.448
CLV_PCSK_SKI1_1 23 27 PF00082 0.369
CLV_PCSK_SKI1_1 278 282 PF00082 0.319
CLV_PCSK_SKI1_1 311 315 PF00082 0.660
CLV_PCSK_SKI1_1 89 93 PF00082 0.238
CLV_Separin_Metazoa 227 231 PF03568 0.531
DEG_APCC_KENBOX_2 91 95 PF00400 0.498
DOC_AGCK_PIF_1 296 301 PF00069 0.507
DOC_CKS1_1 33 38 PF01111 0.550
DOC_MAPK_gen_1 291 299 PF00069 0.360
DOC_PP1_RVXF_1 276 282 PF00149 0.467
DOC_USP7_MATH_1 121 125 PF00917 0.750
DOC_USP7_MATH_1 175 179 PF00917 0.577
DOC_USP7_MATH_1 236 240 PF00917 0.531
DOC_USP7_MATH_1 74 78 PF00917 0.442
DOC_USP7_UBL2_3 191 195 PF12436 0.650
DOC_USP7_UBL2_3 211 215 PF12436 0.497
DOC_WW_Pin1_4 32 37 PF00397 0.559
LIG_14-3-3_CanoR_1 153 159 PF00244 0.594
LIG_14-3-3_CanoR_1 194 200 PF00244 0.569
LIG_14-3-3_CanoR_1 210 214 PF00244 0.525
LIG_14-3-3_CanoR_1 231 241 PF00244 0.551
LIG_14-3-3_CanoR_1 262 270 PF00244 0.528
LIG_14-3-3_CanoR_1 51 56 PF00244 0.431
LIG_14-3-3_CterR_2 311 316 PF00244 0.412
LIG_Actin_WH2_2 195 212 PF00022 0.515
LIG_Actin_WH2_2 214 232 PF00022 0.512
LIG_BRCT_BRCA1_1 21 25 PF00533 0.503
LIG_BRCT_BRCA1_1 58 62 PF00533 0.442
LIG_deltaCOP1_diTrp_1 206 213 PF00928 0.510
LIG_FHA_1 153 159 PF00498 0.660
LIG_FHA_1 302 308 PF00498 0.410
LIG_FHA_2 196 202 PF00498 0.569
LIG_FHA_2 32 38 PF00498 0.654
LIG_FHA_2 51 57 PF00498 0.432
LIG_IBAR_NPY_1 40 42 PF08397 0.431
LIG_LIR_Gen_1 258 268 PF02991 0.515
LIG_LIR_LC3C_4 64 67 PF02991 0.442
LIG_LIR_Nem_3 162 168 PF02991 0.518
LIG_LIR_Nem_3 258 263 PF02991 0.520
LIG_LIR_Nem_3 277 283 PF02991 0.560
LIG_LIR_Nem_3 59 65 PF02991 0.446
LIG_Pex14_1 295 299 PF04695 0.364
LIG_REV1ctd_RIR_1 190 199 PF16727 0.534
LIG_SH2_CRK 88 92 PF00017 0.474
LIG_SH2_STAP1 183 187 PF00017 0.495
LIG_SH3_1 30 36 PF00018 0.532
LIG_SH3_1 68 74 PF00018 0.474
LIG_SH3_3 30 36 PF00018 0.546
LIG_SH3_3 68 74 PF00018 0.442
LIG_SUMO_SIM_anti_2 285 291 PF11976 0.373
LIG_SUMO_SIM_par_1 43 48 PF11976 0.456
LIG_TYR_ITIM 86 91 PF00017 0.478
LIG_UBA3_1 98 103 PF00899 0.506
LIG_WRC_WIRS_1 245 250 PF05994 0.547
MOD_CDK_SPxxK_3 32 39 PF00069 0.545
MOD_CK1_1 140 146 PF00069 0.721
MOD_CK1_1 247 253 PF00069 0.579
MOD_CK2_1 121 127 PF00069 0.687
MOD_CK2_1 154 160 PF00069 0.552
MOD_CK2_1 195 201 PF00069 0.575
MOD_CK2_1 31 37 PF00069 0.597
MOD_CK2_1 51 57 PF00069 0.500
MOD_GlcNHglycan 131 134 PF01048 0.398
MOD_GlcNHglycan 195 198 PF01048 0.393
MOD_GlcNHglycan 234 237 PF01048 0.374
MOD_GSK3_1 232 239 PF00069 0.570
MOD_GSK3_1 244 251 PF00069 0.528
MOD_GSK3_1 297 304 PF00069 0.526
MOD_GSK3_1 47 54 PF00069 0.432
MOD_N-GLC_1 301 306 PF02516 0.613
MOD_NEK2_1 129 134 PF00069 0.590
MOD_NEK2_1 152 157 PF00069 0.620
MOD_NEK2_1 193 198 PF00069 0.556
MOD_NEK2_1 209 214 PF00069 0.561
MOD_NEK2_1 248 253 PF00069 0.558
MOD_NEK2_1 282 287 PF00069 0.363
MOD_NEK2_1 301 306 PF00069 0.340
MOD_NEK2_1 45 50 PF00069 0.477
MOD_NEK2_2 105 110 PF00069 0.635
MOD_PIKK_1 249 255 PF00454 0.540
MOD_PIKK_1 261 267 PF00454 0.503
MOD_PKA_1 137 143 PF00069 0.614
MOD_PKA_1 230 236 PF00069 0.606
MOD_PKA_2 121 127 PF00069 0.620
MOD_PKA_2 137 143 PF00069 0.641
MOD_PKA_2 152 158 PF00069 0.587
MOD_PKA_2 193 199 PF00069 0.537
MOD_PKA_2 209 215 PF00069 0.493
MOD_PKA_2 230 236 PF00069 0.673
MOD_PKA_2 261 267 PF00069 0.526
MOD_PKA_2 50 56 PF00069 0.431
MOD_Plk_1 105 111 PF00069 0.611
MOD_Plk_1 200 206 PF00069 0.512
MOD_Plk_1 301 307 PF00069 0.449
MOD_Plk_1 45 51 PF00069 0.477
MOD_Plk_4 282 288 PF00069 0.376
MOD_ProDKin_1 32 38 PF00069 0.561
TRG_DiLeu_BaEn_2 276 282 PF01217 0.498
TRG_ENDOCYTIC_2 42 45 PF00928 0.434
TRG_ENDOCYTIC_2 88 91 PF00928 0.474
TRG_ER_diArg_1 152 154 PF00400 0.678
TRG_ER_diArg_1 229 231 PF00400 0.550
TRG_ER_diArg_1 4 6 PF00400 0.702
TRG_ER_diArg_1 99 101 PF00400 0.576
TRG_Pf-PMV_PEXEL_1 156 160 PF00026 0.374
TRG_Pf-PMV_PEXEL_1 254 258 PF00026 0.304
TRG_Pf-PMV_PEXEL_1 273 277 PF00026 0.299

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I888 Leptomonas seymouri 82% 100%
A0A0S4KIH6 Bodo saltans 60% 98%
A0A1X0NV04 Trypanosomatidae 64% 100%
A0A3R7NF81 Trypanosoma rangeli 61% 100%
A4HK40 Leishmania braziliensis 91% 100%
A4I7M3 Leishmania infantum 100% 100%
D0A9S5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9B2I2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q5M4 Leishmania major 96% 100%
V5AQU3 Trypanosoma cruzi 62% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS