LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X576_LEIDO
TriTrypDb:
LdBPK_320250.1 , LdCL_320007400 , LDHU3_32.0330
Length:
1085

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 6
GO:0042995 cell projection 2 6
GO:0043226 organelle 2 6
GO:0043227 membrane-bounded organelle 3 6
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 6
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1

Expansion

Sequence features

A0A3S7X576
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X576

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 141 145 PF00656 0.627
CLV_C14_Caspase3-7 192 196 PF00656 0.529
CLV_C14_Caspase3-7 850 854 PF00656 0.740
CLV_C14_Caspase3-7 887 891 PF00656 0.608
CLV_C14_Caspase3-7 953 957 PF00656 0.839
CLV_NRD_NRD_1 1042 1044 PF00675 0.753
CLV_NRD_NRD_1 696 698 PF00675 0.581
CLV_NRD_NRD_1 723 725 PF00675 0.630
CLV_NRD_NRD_1 737 739 PF00675 0.613
CLV_NRD_NRD_1 767 769 PF00675 0.755
CLV_NRD_NRD_1 845 847 PF00675 0.746
CLV_PCSK_KEX2_1 1042 1044 PF00082 0.753
CLV_PCSK_KEX2_1 659 661 PF00082 0.567
CLV_PCSK_KEX2_1 696 698 PF00082 0.581
CLV_PCSK_KEX2_1 739 741 PF00082 0.623
CLV_PCSK_KEX2_1 767 769 PF00082 0.755
CLV_PCSK_KEX2_1 845 847 PF00082 0.754
CLV_PCSK_PC1ET2_1 659 661 PF00082 0.567
CLV_PCSK_PC1ET2_1 739 741 PF00082 0.623
CLV_PCSK_PC7_1 763 769 PF00082 0.765
CLV_PCSK_SKI1_1 1081 1085 PF00082 0.721
CLV_PCSK_SKI1_1 174 178 PF00082 0.360
CLV_PCSK_SKI1_1 424 428 PF00082 0.606
CLV_PCSK_SKI1_1 662 666 PF00082 0.579
CLV_Separin_Metazoa 730 734 PF03568 0.599
DEG_Nend_UBRbox_2 1 3 PF02207 0.513
DOC_CDC14_PxL_1 937 945 PF14671 0.606
DOC_CKS1_1 67 72 PF01111 0.597
DOC_CKS1_1 960 965 PF01111 0.690
DOC_CYCLIN_RxL_1 169 179 PF00134 0.451
DOC_CYCLIN_RxL_1 421 429 PF00134 0.632
DOC_CYCLIN_yClb5_NLxxxL_5 108 117 PF00134 0.472
DOC_MAPK_gen_1 151 159 PF00069 0.562
DOC_MAPK_gen_1 410 419 PF00069 0.596
DOC_MAPK_gen_1 6 15 PF00069 0.501
DOC_MAPK_gen_1 704 713 PF00069 0.610
DOC_MAPK_HePTP_8 153 165 PF00069 0.453
DOC_MAPK_MEF2A_6 156 165 PF00069 0.451
DOC_PP1_RVXF_1 10 16 PF00149 0.602
DOC_PP2B_LxvP_1 236 239 PF13499 0.499
DOC_PP2B_LxvP_1 457 460 PF13499 0.686
DOC_PP2B_LxvP_1 822 825 PF13499 0.748
DOC_PP2B_LxvP_1 913 916 PF13499 0.700
DOC_PP4_FxxP_1 159 162 PF00568 0.444
DOC_PP4_FxxP_1 980 983 PF00568 0.800
DOC_USP7_MATH_1 140 144 PF00917 0.643
DOC_USP7_MATH_1 145 149 PF00917 0.480
DOC_USP7_MATH_1 252 256 PF00917 0.699
DOC_USP7_MATH_1 261 265 PF00917 0.445
DOC_USP7_MATH_1 306 310 PF00917 0.587
DOC_USP7_MATH_1 373 377 PF00917 0.744
DOC_USP7_MATH_1 435 439 PF00917 0.806
DOC_USP7_MATH_1 499 503 PF00917 0.647
DOC_USP7_MATH_1 523 527 PF00917 0.788
DOC_USP7_MATH_1 566 570 PF00917 0.657
DOC_USP7_MATH_1 670 674 PF00917 0.567
DOC_USP7_MATH_1 705 709 PF00917 0.721
DOC_USP7_MATH_1 83 87 PF00917 0.651
DOC_USP7_MATH_1 840 844 PF00917 0.780
DOC_USP7_MATH_1 984 988 PF00917 0.748
DOC_WW_Pin1_4 1041 1046 PF00397 0.812
DOC_WW_Pin1_4 257 262 PF00397 0.614
DOC_WW_Pin1_4 294 299 PF00397 0.522
DOC_WW_Pin1_4 577 582 PF00397 0.636
DOC_WW_Pin1_4 66 71 PF00397 0.495
DOC_WW_Pin1_4 750 755 PF00397 0.697
DOC_WW_Pin1_4 762 767 PF00397 0.739
DOC_WW_Pin1_4 792 797 PF00397 0.692
DOC_WW_Pin1_4 838 843 PF00397 0.779
DOC_WW_Pin1_4 845 850 PF00397 0.733
DOC_WW_Pin1_4 870 875 PF00397 0.824
DOC_WW_Pin1_4 916 921 PF00397 0.712
DOC_WW_Pin1_4 959 964 PF00397 0.819
DOC_WW_Pin1_4 975 980 PF00397 0.727
LIG_14-3-3_CanoR_1 1006 1014 PF00244 0.660
LIG_14-3-3_CanoR_1 1027 1035 PF00244 0.722
LIG_14-3-3_CanoR_1 434 443 PF00244 0.804
LIG_14-3-3_CanoR_1 522 532 PF00244 0.752
LIG_14-3-3_CanoR_1 58 64 PF00244 0.450
LIG_14-3-3_CanoR_1 66 70 PF00244 0.500
LIG_14-3-3_CanoR_1 818 823 PF00244 0.570
LIG_14-3-3_CanoR_1 972 980 PF00244 0.731
LIG_Actin_WH2_2 382 398 PF00022 0.597
LIG_Actin_WH2_2 43 60 PF00022 0.443
LIG_Actin_WH2_2 802 820 PF00022 0.599
LIG_APCC_ABBA_1 787 792 PF00400 0.649
LIG_BIR_III_2 563 567 PF00653 0.653
LIG_BIR_III_4 1047 1051 PF00653 0.857
LIG_BIR_III_4 1071 1075 PF00653 0.731
LIG_BIR_III_4 16 20 PF00653 0.536
LIG_BRCT_BRCA1_1 826 830 PF00533 0.747
LIG_FHA_1 100 106 PF00498 0.449
LIG_FHA_1 1026 1032 PF00498 0.736
LIG_FHA_1 1055 1061 PF00498 0.843
LIG_FHA_1 144 150 PF00498 0.626
LIG_FHA_1 313 319 PF00498 0.681
LIG_FHA_1 343 349 PF00498 0.694
LIG_FHA_1 456 462 PF00498 0.611
LIG_FHA_1 613 619 PF00498 0.575
LIG_FHA_1 663 669 PF00498 0.663
LIG_FHA_1 708 714 PF00498 0.550
LIG_FHA_1 793 799 PF00498 0.685
LIG_FHA_2 1054 1060 PF00498 0.743
LIG_FHA_2 268 274 PF00498 0.518
LIG_FHA_2 578 584 PF00498 0.632
LIG_FHA_2 776 782 PF00498 0.738
LIG_FHA_2 848 854 PF00498 0.852
LIG_FHA_2 933 939 PF00498 0.746
LIG_HCF-1_HBM_1 783 786 PF13415 0.708
LIG_LIR_Apic_2 571 576 PF02991 0.670
LIG_LIR_Apic_2 978 983 PF02991 0.792
LIG_LIR_Gen_1 107 117 PF02991 0.425
LIG_LIR_Gen_1 388 399 PF02991 0.557
LIG_LIR_Gen_1 68 79 PF02991 0.494
LIG_LIR_Nem_3 107 113 PF02991 0.423
LIG_LIR_Nem_3 388 394 PF02991 0.516
LIG_LIR_Nem_3 631 636 PF02991 0.601
LIG_LIR_Nem_3 68 74 PF02991 0.463
LIG_LIR_Nem_3 783 789 PF02991 0.683
LIG_MYND_1 447 451 PF01753 0.702
LIG_MYND_1 916 920 PF01753 0.667
LIG_NRBOX 148 154 PF00104 0.578
LIG_NRBOX 421 427 PF00104 0.597
LIG_NRBOX 884 890 PF00104 0.614
LIG_OCRL_FandH_1 109 121 PF00620 0.526
LIG_PTAP_UEV_1 450 455 PF05743 0.814
LIG_SH2_CRK 391 395 PF00017 0.551
LIG_SH2_CRK 71 75 PF00017 0.521
LIG_SH2_NCK_1 752 756 PF00017 0.682
LIG_SH2_SRC 574 577 PF00017 0.543
LIG_SH2_STAP1 391 395 PF00017 0.551
LIG_SH2_STAT5 786 789 PF00017 0.683
LIG_SH2_STAT5 805 808 PF00017 0.648
LIG_SH3_3 445 451 PF00018 0.704
LIG_SH3_3 505 511 PF00018 0.626
LIG_SH3_3 526 532 PF00018 0.693
LIG_SH3_3 957 963 PF00018 0.697
LIG_SUMO_SIM_anti_2 29 35 PF11976 0.450
LIG_SUMO_SIM_anti_2 297 303 PF11976 0.553
LIG_SUMO_SIM_par_1 708 714 PF11976 0.573
LIG_TRAF2_1 551 554 PF00917 0.641
LIG_TRAF2_1 742 745 PF00917 0.636
LIG_TRAF2_1 779 782 PF00917 0.685
LIG_TYR_ITIM 389 394 PF00017 0.559
LIG_WRC_WIRS_1 113 118 PF05994 0.447
MOD_CDC14_SPxK_1 765 768 PF00782 0.704
MOD_CDK_SPK_2 762 767 PF00069 0.744
MOD_CDK_SPxK_1 762 768 PF00069 0.706
MOD_CDK_SPxxK_3 66 73 PF00069 0.533
MOD_CDK_SPxxK_3 766 773 PF00069 0.711
MOD_CDK_SPxxK_3 792 799 PF00069 0.690
MOD_CDK_SPxxK_3 838 845 PF00069 0.742
MOD_CK1_1 1008 1014 PF00069 0.598
MOD_CK1_1 143 149 PF00069 0.561
MOD_CK1_1 255 261 PF00069 0.707
MOD_CK1_1 297 303 PF00069 0.510
MOD_CK1_1 401 407 PF00069 0.543
MOD_CK1_1 540 546 PF00069 0.771
MOD_CK1_1 548 554 PF00069 0.716
MOD_CK1_1 559 565 PF00069 0.725
MOD_CK1_1 577 583 PF00069 0.491
MOD_CK1_1 718 724 PF00069 0.684
MOD_CK1_1 775 781 PF00069 0.723
MOD_CK1_1 848 854 PF00069 0.787
MOD_CK1_1 881 887 PF00069 0.637
MOD_CK1_1 942 948 PF00069 0.677
MOD_CK1_1 975 981 PF00069 0.755
MOD_CK1_1 987 993 PF00069 0.687
MOD_CK2_1 1053 1059 PF00069 0.767
MOD_CK2_1 112 118 PF00069 0.455
MOD_CK2_1 183 189 PF00069 0.497
MOD_CK2_1 267 273 PF00069 0.612
MOD_CK2_1 548 554 PF00069 0.649
MOD_CK2_1 577 583 PF00069 0.648
MOD_CK2_1 775 781 PF00069 0.738
MOD_CK2_1 826 832 PF00069 0.827
MOD_CK2_1 881 887 PF00069 0.637
MOD_CK2_1 932 938 PF00069 0.823
MOD_DYRK1A_RPxSP_1 870 874 PF00069 0.624
MOD_GlcNHglycan 1007 1010 PF01048 0.514
MOD_GlcNHglycan 1018 1021 PF01048 0.664
MOD_GlcNHglycan 1035 1038 PF01048 0.542
MOD_GlcNHglycan 165 168 PF01048 0.591
MOD_GlcNHglycan 244 247 PF01048 0.681
MOD_GlcNHglycan 28 31 PF01048 0.556
MOD_GlcNHglycan 308 311 PF01048 0.604
MOD_GlcNHglycan 345 348 PF01048 0.667
MOD_GlcNHglycan 44 47 PF01048 0.457
MOD_GlcNHglycan 451 454 PF01048 0.815
MOD_GlcNHglycan 500 504 PF01048 0.778
MOD_GlcNHglycan 545 548 PF01048 0.818
MOD_GlcNHglycan 550 553 PF01048 0.721
MOD_GlcNHglycan 558 561 PF01048 0.786
MOD_GlcNHglycan 568 571 PF01048 0.649
MOD_GlcNHglycan 576 579 PF01048 0.440
MOD_GlcNHglycan 707 710 PF01048 0.704
MOD_GlcNHglycan 717 720 PF01048 0.635
MOD_GlcNHglycan 826 829 PF01048 0.721
MOD_GlcNHglycan 850 853 PF01048 0.798
MOD_GlcNHglycan 956 960 PF01048 0.766
MOD_GlcNHglycan 993 996 PF01048 0.740
MOD_GSK3_1 1054 1061 PF00069 0.742
MOD_GSK3_1 183 190 PF00069 0.513
MOD_GSK3_1 205 212 PF00069 0.626
MOD_GSK3_1 216 223 PF00069 0.497
MOD_GSK3_1 255 262 PF00069 0.617
MOD_GSK3_1 263 270 PF00069 0.479
MOD_GSK3_1 381 388 PF00069 0.706
MOD_GSK3_1 521 528 PF00069 0.668
MOD_GSK3_1 532 539 PF00069 0.702
MOD_GSK3_1 541 548 PF00069 0.506
MOD_GSK3_1 662 669 PF00069 0.580
MOD_GSK3_1 714 721 PF00069 0.658
MOD_GSK3_1 762 769 PF00069 0.745
MOD_GSK3_1 826 833 PF00069 0.719
MOD_GSK3_1 834 841 PF00069 0.743
MOD_GSK3_1 879 886 PF00069 0.754
MOD_GSK3_1 928 935 PF00069 0.758
MOD_GSK3_1 955 962 PF00069 0.717
MOD_GSK3_1 971 978 PF00069 0.605
MOD_GSK3_1 987 994 PF00069 0.678
MOD_N-GLC_1 1016 1021 PF02516 0.656
MOD_NEK2_1 163 168 PF00069 0.453
MOD_NEK2_1 176 181 PF00069 0.395
MOD_NEK2_1 183 188 PF00069 0.292
MOD_NEK2_1 205 210 PF00069 0.516
MOD_NEK2_1 234 239 PF00069 0.557
MOD_NEK2_1 267 272 PF00069 0.520
MOD_NEK2_1 312 317 PF00069 0.661
MOD_NEK2_1 417 422 PF00069 0.531
MOD_NEK2_1 545 550 PF00069 0.815
MOD_NEK2_1 57 62 PF00069 0.430
MOD_NEK2_1 586 591 PF00069 0.634
MOD_NEK2_1 646 651 PF00069 0.678
MOD_NEK2_1 74 79 PF00069 0.536
MOD_NEK2_1 830 835 PF00069 0.839
MOD_NEK2_1 971 976 PF00069 0.753
MOD_PIKK_1 252 258 PF00454 0.716
MOD_PIKK_1 840 846 PF00454 0.782
MOD_PKA_2 1005 1011 PF00069 0.675
MOD_PKA_2 1026 1032 PF00069 0.714
MOD_PKA_2 187 193 PF00069 0.503
MOD_PKA_2 433 439 PF00069 0.803
MOD_PKA_2 521 527 PF00069 0.671
MOD_PKA_2 57 63 PF00069 0.460
MOD_PKA_2 65 71 PF00069 0.492
MOD_PKA_2 74 80 PF00069 0.569
MOD_PKA_2 772 778 PF00069 0.776
MOD_PKA_2 945 951 PF00069 0.660
MOD_PKA_2 971 977 PF00069 0.752
MOD_Plk_1 143 149 PF00069 0.639
MOD_Plk_1 183 189 PF00069 0.543
MOD_Plk_1 205 211 PF00069 0.524
MOD_Plk_1 220 226 PF00069 0.492
MOD_Plk_1 23 29 PF00069 0.518
MOD_Plk_1 624 630 PF00069 0.571
MOD_Plk_1 646 652 PF00069 0.609
MOD_Plk_1 662 668 PF00069 0.463
MOD_Plk_1 878 884 PF00069 0.670
MOD_Plk_1 955 961 PF00069 0.661
MOD_Plk_4 112 118 PF00069 0.431
MOD_Plk_4 297 303 PF00069 0.565
MOD_Plk_4 381 387 PF00069 0.565
MOD_Plk_4 91 97 PF00069 0.411
MOD_Plk_4 928 934 PF00069 0.754
MOD_ProDKin_1 1041 1047 PF00069 0.816
MOD_ProDKin_1 257 263 PF00069 0.596
MOD_ProDKin_1 294 300 PF00069 0.519
MOD_ProDKin_1 577 583 PF00069 0.633
MOD_ProDKin_1 66 72 PF00069 0.502
MOD_ProDKin_1 750 756 PF00069 0.697
MOD_ProDKin_1 762 768 PF00069 0.741
MOD_ProDKin_1 792 798 PF00069 0.689
MOD_ProDKin_1 838 844 PF00069 0.779
MOD_ProDKin_1 845 851 PF00069 0.733
MOD_ProDKin_1 870 876 PF00069 0.819
MOD_ProDKin_1 916 922 PF00069 0.714
MOD_ProDKin_1 959 965 PF00069 0.815
MOD_ProDKin_1 975 981 PF00069 0.729
MOD_SUMO_for_1 757 760 PF00179 0.823
MOD_SUMO_rev_2 134 141 PF00179 0.593
MOD_SUMO_rev_2 588 597 PF00179 0.611
MOD_SUMO_rev_2 743 749 PF00179 0.663
TRG_DiLeu_BaLyEn_6 148 153 PF01217 0.579
TRG_DiLeu_BaLyEn_6 421 426 PF01217 0.680
TRG_ENDOCYTIC_2 391 394 PF00928 0.547
TRG_ENDOCYTIC_2 587 590 PF00928 0.575
TRG_ENDOCYTIC_2 71 74 PF00928 0.514
TRG_ENDOCYTIC_2 786 789 PF00928 0.683
TRG_ER_diArg_1 153 156 PF00400 0.564
TRG_ER_diArg_1 701 704 PF00400 0.604
TRG_ER_diArg_1 737 740 PF00400 0.618
TRG_ER_diArg_1 766 768 PF00400 0.786
TRG_NES_CRM1_1 313 326 PF08389 0.639
TRG_NES_CRM1_1 416 429 PF08389 0.615
TRG_NES_CRM1_1 42 56 PF08389 0.494
TRG_NLS_Bipartite_1 724 742 PF00514 0.618
TRG_NLS_MonoExtC_3 723 728 PF00514 0.650
TRG_NLS_MonoExtC_3 737 743 PF00514 0.618
TRG_NLS_MonoExtN_4 724 729 PF00514 0.637
TRG_Pf-PMV_PEXEL_1 1001 1005 PF00026 0.719
TRG_Pf-PMV_PEXEL_1 424 429 PF00026 0.656
TRG_Pf-PMV_PEXEL_1 595 599 PF00026 0.599
TRG_Pf-PMV_PEXEL_1 626 631 PF00026 0.571
TRG_Pf-PMV_PEXEL_1 699 703 PF00026 0.570

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P868 Leptomonas seymouri 48% 100%
A4HK05 Leishmania braziliensis 75% 100%
A4I7I8 Leishmania infantum 100% 100%
E9B2E5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q5R1 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS