TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X563_LEIDO

TriTrypDb:

LdBPK_320420.1 , LdCL_320009100 , LDHU3_32.0520

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X563

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X563

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.390
CLV_C14_Caspase3-7	730	734	PF00656	0.392
CLV_NRD_NRD_1	182	184	PF00675	0.394
CLV_NRD_NRD_1	372	374	PF00675	0.462
CLV_NRD_NRD_1	397	399	PF00675	0.354
CLV_NRD_NRD_1	459	461	PF00675	0.341
CLV_NRD_NRD_1	51	53	PF00675	0.521
CLV_NRD_NRD_1	517	519	PF00675	0.443
CLV_NRD_NRD_1	673	675	PF00675	0.646
CLV_NRD_NRD_1	756	758	PF00675	0.603
CLV_NRD_NRD_1	94	96	PF00675	0.576
CLV_PCSK_KEX2_1	182	184	PF00082	0.411
CLV_PCSK_KEX2_1	372	374	PF00082	0.462
CLV_PCSK_KEX2_1	397	399	PF00082	0.354
CLV_PCSK_KEX2_1	459	461	PF00082	0.341
CLV_PCSK_KEX2_1	517	519	PF00082	0.443
CLV_PCSK_KEX2_1	53	55	PF00082	0.507
CLV_PCSK_KEX2_1	57	59	PF00082	0.455
CLV_PCSK_KEX2_1	673	675	PF00082	0.675
CLV_PCSK_KEX2_1	756	758	PF00082	0.540
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.673
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.603
CLV_PCSK_SKI1_1	152	156	PF00082	0.437
CLV_PCSK_SKI1_1	198	202	PF00082	0.425
CLV_PCSK_SKI1_1	237	241	PF00082	0.396
CLV_PCSK_SKI1_1	409	413	PF00082	0.421
CLV_PCSK_SKI1_1	482	486	PF00082	0.342
CLV_PCSK_SKI1_1	54	58	PF00082	0.637
CLV_PCSK_SKI1_1	655	659	PF00082	0.570
CLV_PCSK_SKI1_1	674	678	PF00082	0.566
CLV_Separin_Metazoa	179	183	PF03568	0.449
CLV_Separin_Metazoa	332	336	PF03568	0.374
DEG_APCC_DBOX_1	265	273	PF00400	0.468
DEG_APCC_DBOX_1	408	416	PF00400	0.411
DEG_COP1_1	560	571	PF00400	0.470
DEG_Nend_UBRbox_2	1	3	PF02207	0.702
DEG_SPOP_SBC_1	357	361	PF00917	0.398
DOC_CDC14_PxL_1	303	311	PF14671	0.496
DOC_CKS1_1	509	514	PF01111	0.535
DOC_CYCLIN_RxL_1	266	278	PF00134	0.437
DOC_MAPK_gen_1	135	144	PF00069	0.301
DOC_MAPK_gen_1	182	189	PF00069	0.439
DOC_MAPK_gen_1	479	488	PF00069	0.400
DOC_MAPK_MEF2A_6	482	490	PF00069	0.371
DOC_PP4_FxxP_1	33	36	PF00568	0.584
DOC_PP4_FxxP_1	648	651	PF00568	0.574
DOC_PP4_FxxP_1	699	702	PF00568	0.611
DOC_USP7_MATH_1	103	107	PF00917	0.522
DOC_USP7_MATH_1	171	175	PF00917	0.390
DOC_USP7_MATH_1	308	312	PF00917	0.615
DOC_USP7_MATH_1	315	319	PF00917	0.639
DOC_USP7_MATH_1	366	370	PF00917	0.460
DOC_USP7_MATH_1	489	493	PF00917	0.396
DOC_USP7_MATH_1	521	525	PF00917	0.333
DOC_USP7_MATH_1	611	615	PF00917	0.466
DOC_USP7_MATH_1	675	679	PF00917	0.737
DOC_USP7_MATH_1	91	95	PF00917	0.566
DOC_USP7_UBL2_3	53	57	PF12436	0.472
DOC_WW_Pin1_4	31	36	PF00397	0.741
DOC_WW_Pin1_4	361	366	PF00397	0.459
DOC_WW_Pin1_4	508	513	PF00397	0.545
DOC_WW_Pin1_4	9	14	PF00397	0.729
LIG_14-3-3_CanoR_1	152	158	PF00244	0.391
LIG_14-3-3_CanoR_1	218	225	PF00244	0.392
LIG_14-3-3_CanoR_1	301	307	PF00244	0.536
LIG_14-3-3_CanoR_1	335	342	PF00244	0.268
LIG_14-3-3_CanoR_1	372	381	PF00244	0.373
LIG_14-3-3_CanoR_1	397	401	PF00244	0.352
LIG_14-3-3_CanoR_1	459	464	PF00244	0.325
LIG_14-3-3_CanoR_1	531	535	PF00244	0.447
LIG_14-3-3_CanoR_1	655	661	PF00244	0.563
LIG_APCC_ABBAyCdc20_2	466	472	PF00400	0.440
LIG_BIR_III_4	17	21	PF00653	0.588
LIG_BRCT_BRCA1_1	336	340	PF00533	0.290
LIG_BRCT_BRCA1_1	460	464	PF00533	0.343
LIG_deltaCOP1_diTrp_1	476	484	PF00928	0.334
LIG_deltaCOP1_diTrp_1	61	68	PF00928	0.610
LIG_EH1_1	575	583	PF00400	0.318
LIG_FHA_1	184	190	PF00498	0.417
LIG_FHA_1	297	303	PF00498	0.515
LIG_FHA_1	358	364	PF00498	0.551
LIG_FHA_1	483	489	PF00498	0.356
LIG_FHA_1	563	569	PF00498	0.634
LIG_FHA_1	620	626	PF00498	0.515
LIG_FHA_1	657	663	PF00498	0.473
LIG_FHA_2	118	124	PF00498	0.394
LIG_FHA_2	362	368	PF00498	0.472
LIG_FHA_2	453	459	PF00498	0.489
LIG_FHA_2	559	565	PF00498	0.646
LIG_FHA_2	666	672	PF00498	0.455
LIG_FHA_2	77	83	PF00498	0.552
LIG_GBD_Chelix_1	407	415	PF00786	0.442
LIG_GBD_Chelix_1	625	633	PF00786	0.489
LIG_LIR_Apic_2	508	512	PF02991	0.460
LIG_LIR_Apic_2	645	651	PF02991	0.571
LIG_LIR_Apic_2	697	702	PF02991	0.516
LIG_LIR_Gen_1	236	246	PF02991	0.483
LIG_LIR_Gen_1	483	491	PF02991	0.440
LIG_LIR_Gen_1	545	555	PF02991	0.315
LIG_LIR_Gen_1	627	638	PF02991	0.400
LIG_LIR_Gen_1	710	721	PF02991	0.428
LIG_LIR_Gen_1	722	732	PF02991	0.410
LIG_LIR_Nem_3	230	235	PF02991	0.316
LIG_LIR_Nem_3	343	349	PF02991	0.323
LIG_LIR_Nem_3	376	381	PF02991	0.377
LIG_LIR_Nem_3	483	487	PF02991	0.418
LIG_LIR_Nem_3	508	513	PF02991	0.308
LIG_LIR_Nem_3	545	550	PF02991	0.310
LIG_LIR_Nem_3	61	67	PF02991	0.487
LIG_LIR_Nem_3	710	716	PF02991	0.455
LIG_LIR_Nem_3	722	727	PF02991	0.476
LIG_LIR_Nem_3	733	738	PF02991	0.459
LIG_NRBOX	268	274	PF00104	0.336
LIG_NRP_CendR_1	757	760	PF00754	0.558
LIG_PALB2_WD40_1	505	513	PF16756	0.375
LIG_PCNA_APIM_2	407	413	PF02747	0.250
LIG_Pex14_2	731	735	PF04695	0.464
LIG_PTB_Apo_2	382	389	PF02174	0.382
LIG_PTB_Apo_2	583	590	PF02174	0.314
LIG_PTB_Phospho_1	382	388	PF10480	0.386
LIG_PTB_Phospho_1	583	589	PF10480	0.333
LIG_SH2_CRK	713	717	PF00017	0.416
LIG_SH2_GRB2like	594	597	PF00017	0.327
LIG_SH2_SRC	388	391	PF00017	0.412
LIG_SH2_SRC	392	395	PF00017	0.431
LIG_SH2_STAP1	111	115	PF00017	0.392
LIG_SH2_STAP1	235	239	PF00017	0.388
LIG_SH2_STAP1	379	383	PF00017	0.349
LIG_SH2_STAP1	392	396	PF00017	0.304
LIG_SH2_STAP1	470	474	PF00017	0.306
LIG_SH2_STAP1	547	551	PF00017	0.355
LIG_SH2_STAP1	594	598	PF00017	0.347
LIG_SH2_STAP1	630	634	PF00017	0.384
LIG_SH2_STAP1	80	84	PF00017	0.604
LIG_SH2_STAT3	470	473	PF00017	0.435
LIG_SH2_STAT5	215	218	PF00017	0.368
LIG_SH2_STAT5	341	344	PF00017	0.322
LIG_SH2_STAT5	346	349	PF00017	0.285
LIG_SH2_STAT5	351	354	PF00017	0.288
LIG_SH2_STAT5	388	391	PF00017	0.339
LIG_SH2_STAT5	410	413	PF00017	0.392
LIG_SH2_STAT5	414	417	PF00017	0.376
LIG_SH2_STAT5	425	428	PF00017	0.337
LIG_SH2_STAT5	600	603	PF00017	0.424
LIG_SH2_STAT5	630	633	PF00017	0.378
LIG_SH2_STAT5	706	709	PF00017	0.507
LIG_SH3_3	490	496	PF00018	0.542
LIG_SH3_3	637	643	PF00018	0.536
LIG_SH3_3	8	14	PF00018	0.722
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.376
LIG_SUMO_SIM_anti_2	329	337	PF11976	0.522
LIG_SUMO_SIM_anti_2	511	517	PF11976	0.436
LIG_SUMO_SIM_par_1	271	278	PF11976	0.378
LIG_SUMO_SIM_par_1	485	492	PF11976	0.361
LIG_SUMO_SIM_par_1	658	665	PF11976	0.477
LIG_TYR_ITIM	704	709	PF00017	0.396
LIG_UBA3_1	411	419	PF00899	0.335
LIG_WW_1	74	77	PF00397	0.546
MOD_CK1_1	102	108	PF00069	0.506
MOD_CK1_1	295	301	PF00069	0.652
MOD_CK1_1	34	40	PF00069	0.652
MOD_CK1_1	359	365	PF00069	0.468
MOD_CK1_1	377	383	PF00069	0.407
MOD_CK1_1	529	535	PF00069	0.542
MOD_CK1_1	661	667	PF00069	0.546
MOD_CK1_1	691	697	PF00069	0.562
MOD_CK2_1	217	223	PF00069	0.377
MOD_CK2_1	326	332	PF00069	0.481
MOD_CK2_1	361	367	PF00069	0.455
MOD_CK2_1	452	458	PF00069	0.487
MOD_CK2_1	558	564	PF00069	0.473
MOD_CK2_1	617	623	PF00069	0.408
MOD_CK2_1	665	671	PF00069	0.450
MOD_CK2_1	67	73	PF00069	0.578
MOD_Cter_Amidation	27	30	PF01082	0.605
MOD_Cter_Amidation	754	757	PF01082	0.511
MOD_GlcNHglycan	101	104	PF01048	0.607
MOD_GlcNHglycan	105	108	PF01048	0.511
MOD_GlcNHglycan	111	114	PF01048	0.303
MOD_GlcNHglycan	251	254	PF01048	0.412
MOD_GlcNHglycan	310	313	PF01048	0.614
MOD_GlcNHglycan	367	371	PF01048	0.408
MOD_GlcNHglycan	37	40	PF01048	0.736
MOD_GlcNHglycan	446	449	PF01048	0.450
MOD_GlcNHglycan	619	622	PF01048	0.509
MOD_GlcNHglycan	668	671	PF01048	0.603
MOD_GlcNHglycan	690	693	PF01048	0.689
MOD_GlcNHglycan	695	699	PF01048	0.671
MOD_GSK3_1	158	165	PF00069	0.491
MOD_GSK3_1	279	286	PF00069	0.413
MOD_GSK3_1	292	299	PF00069	0.587
MOD_GSK3_1	31	38	PF00069	0.671
MOD_GSK3_1	357	364	PF00069	0.452
MOD_GSK3_1	373	380	PF00069	0.437
MOD_GSK3_1	388	395	PF00069	0.375
MOD_GSK3_1	454	461	PF00069	0.458
MOD_GSK3_1	526	533	PF00069	0.611
MOD_GSK3_1	558	565	PF00069	0.616
MOD_GSK3_1	63	70	PF00069	0.548
MOD_GSK3_1	656	663	PF00069	0.614
MOD_GSK3_1	9	16	PF00069	0.822
MOD_GSK3_1	99	106	PF00069	0.521
MOD_N-GLC_1	201	206	PF02516	0.346
MOD_NEK2_1	201	206	PF00069	0.349
MOD_NEK2_1	217	222	PF00069	0.305
MOD_NEK2_1	249	254	PF00069	0.423
MOD_NEK2_1	280	285	PF00069	0.450
MOD_NEK2_1	333	338	PF00069	0.453
MOD_NEK2_1	340	345	PF00069	0.327
MOD_NEK2_1	629	634	PF00069	0.411
MOD_NEK2_1	660	665	PF00069	0.551
MOD_NEK2_1	76	81	PF00069	0.667
MOD_NEK2_2	392	397	PF00069	0.342
MOD_PIKK_1	158	164	PF00454	0.484
MOD_PIKK_1	283	289	PF00454	0.446
MOD_PIKK_1	317	323	PF00454	0.542
MOD_PKA_1	373	379	PF00069	0.335
MOD_PKA_1	459	465	PF00069	0.335
MOD_PKA_2	217	223	PF00069	0.383
MOD_PKA_2	24	30	PF00069	0.725
MOD_PKA_2	334	340	PF00069	0.281
MOD_PKA_2	396	402	PF00069	0.349
MOD_PKA_2	458	464	PF00069	0.331
MOD_PKA_2	530	536	PF00069	0.532
MOD_Plk_1	366	372	PF00069	0.511
MOD_Plk_1	392	398	PF00069	0.495
MOD_Plk_1	482	488	PF00069	0.299
MOD_Plk_1	611	617	PF00069	0.497
MOD_Plk_4	140	146	PF00069	0.471
MOD_Plk_4	211	217	PF00069	0.447
MOD_Plk_4	374	380	PF00069	0.498
MOD_Plk_4	459	465	PF00069	0.315
MOD_Plk_4	530	536	PF00069	0.569
MOD_Plk_4	63	69	PF00069	0.560
MOD_Plk_4	636	642	PF00069	0.466
MOD_Plk_4	662	668	PF00069	0.621
MOD_Plk_4	719	725	PF00069	0.496
MOD_ProDKin_1	31	37	PF00069	0.740
MOD_ProDKin_1	361	367	PF00069	0.455
MOD_ProDKin_1	508	514	PF00069	0.540
MOD_ProDKin_1	9	15	PF00069	0.731
MOD_SUMO_for_1	745	748	PF00179	0.442
MOD_SUMO_rev_2	127	136	PF00179	0.513
TRG_DiLeu_BaEn_1	150	155	PF01217	0.443
TRG_DiLeu_BaEn_1	55	60	PF01217	0.526
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.465
TRG_DiLeu_BaLyEn_6	700	705	PF01217	0.554
TRG_ENDOCYTIC_2	238	241	PF00928	0.353
TRG_ENDOCYTIC_2	346	349	PF00928	0.290
TRG_ENDOCYTIC_2	378	381	PF00928	0.446
TRG_ENDOCYTIC_2	547	550	PF00928	0.303
TRG_ENDOCYTIC_2	630	633	PF00928	0.365
TRG_ENDOCYTIC_2	706	709	PF00928	0.382
TRG_ENDOCYTIC_2	713	716	PF00928	0.383
TRG_ER_diArg_1	181	183	PF00400	0.408
TRG_ER_diArg_1	371	373	PF00400	0.458
TRG_ER_diArg_1	396	398	PF00400	0.354
TRG_ER_diArg_1	516	518	PF00400	0.401
TRG_ER_diArg_1	522	525	PF00400	0.402
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEY9	Leptomonas seymouri	60%	97%
A0A0S4IK45	Bodo saltans	25%	100%
A0A1X0P7J0	Trypanosomatidae	32%	100%
A0A422N1G1	Trypanosoma rangeli	34%	100%
A4HK21	Leishmania braziliensis	81%	100%
A4I7K5	Leishmania infantum	100%	100%
D0A0B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B2G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5P4	Leishmania major	95%	100%
V5BWW5	Trypanosoma cruzi	34%	100%