40S_ribosomal_protein_S2/GeneDB:LmjF.32.0450

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S2

Species:

Leishmania donovani

UniProt:

A0A3S7X558_LEIDO

TriTrypDb:

LdBPK_320460.1 , LdCL_320009500 , LDHU3_32.0560

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0015935	small ribosomal subunit	4	16
GO:0032991	protein-containing complex	1	16
GO:0044391	ribosomal subunit	3	16
GO:1990904	ribonucleoprotein complex	2	16
GO:0022627	cytosolic small ribosomal subunit	5	2
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7X558

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X558

PDB structure(s): 6az1_F

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	16
GO:0006518	peptide metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009058	biosynthetic process	2	16
GO:0009059	macromolecule biosynthetic process	4	16
GO:0009987	cellular process	1	16
GO:0019538	protein metabolic process	3	16
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	16
GO:0043043	peptide biosynthetic process	5	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043603	amide metabolic process	3	16
GO:0043604	amide biosynthetic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044260	obsolete cellular macromolecule metabolic process	3	16
GO:0044271	cellular nitrogen compound biosynthetic process	4	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:1901566	organonitrogen compound biosynthetic process	4	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	16
GO:0003723	RNA binding	4	16
GO:0003735	structural constituent of ribosome	2	16
GO:0005198	structural molecule activity	1	16
GO:0005488	binding	1	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	124	130	PF00089	0.291
CLV_NRD_NRD_1	151	153	PF00675	0.345
CLV_NRD_NRD_1	229	231	PF00675	0.291
CLV_PCSK_KEX2_1	151	153	PF00082	0.345
CLV_PCSK_SKI1_1	196	200	PF00082	0.311
CLV_PCSK_SKI1_1	52	56	PF00082	0.407
DEG_SPOP_SBC_1	207	211	PF00917	0.291
DOC_CKS1_1	235	240	PF01111	0.291
DOC_CYCLIN_RxL_1	194	205	PF00134	0.291
DOC_MAPK_gen_1	127	136	PF00069	0.291
DOC_MAPK_HePTP_8	124	136	PF00069	0.291
DOC_MAPK_MEF2A_6	127	136	PF00069	0.291
DOC_MAPK_MEF2A_6	172	180	PF00069	0.312
DOC_PP1_RVXF_1	195	202	PF00149	0.289
DOC_PP4_FxxP_1	235	238	PF00568	0.291
DOC_PP4_FxxP_1	68	71	PF00568	0.423
DOC_USP7_UBL2_3	168	172	PF12436	0.381
DOC_WW_Pin1_4	234	239	PF00397	0.291
LIG_14-3-3_CanoR_1	137	141	PF00244	0.299
LIG_14-3-3_CanoR_1	230	234	PF00244	0.307
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BIR_III_2	3	7	PF00653	0.556
LIG_BIR_III_3	1	5	PF00653	0.614
LIG_FHA_1	185	191	PF00498	0.311
LIG_FHA_1	235	241	PF00498	0.299
LIG_FHA_2	58	64	PF00498	0.419
LIG_LIR_Apic_2	232	238	PF02991	0.291
LIG_LIR_Nem_3	107	112	PF02991	0.314
LIG_LIR_Nem_3	200	204	PF02991	0.308
LIG_LIR_Nem_3	225	229	PF02991	0.306
LIG_LIR_Nem_3	232	236	PF02991	0.315
LIG_PCNA_yPIPBox_3	214	227	PF02747	0.291
LIG_PDZ_Class_1	259	264	PF00595	0.589
LIG_SH2_CRK	233	237	PF00017	0.304
LIG_SH2_STAT3	95	98	PF00017	0.395
LIG_SH2_STAT5	208	211	PF00017	0.291
LIG_SH3_3	178	184	PF00018	0.314
LIG_SH3_3	187	193	PF00018	0.293
LIG_SH3_3	9	15	PF00018	0.701
LIG_TRAF2_1	38	41	PF00917	0.696
LIG_TRAF2_1	61	64	PF00917	0.404
LIG_UBA3_1	67	73	PF00899	0.446
LIG_UBA3_1	91	99	PF00899	0.311
LIG_WRC_WIRS_1	223	228	PF05994	0.291
MOD_CK2_1	57	63	PF00069	0.427
MOD_GlcNHglycan	101	104	PF01048	0.314
MOD_GSK3_1	208	215	PF00069	0.309
MOD_GSK3_1	244	251	PF00069	0.463
MOD_NEK2_1	167	172	PF00069	0.446
MOD_NEK2_1	229	234	PF00069	0.291
MOD_NEK2_1	66	71	PF00069	0.437
MOD_PK_1	172	178	PF00069	0.291
MOD_PKA_2	136	142	PF00069	0.291
MOD_PKA_2	184	190	PF00069	0.311
MOD_PKA_2	229	235	PF00069	0.304
MOD_Plk_1	130	136	PF00069	0.294
MOD_Plk_4	136	142	PF00069	0.308
MOD_Plk_4	222	228	PF00069	0.311
MOD_Plk_4	77	83	PF00069	0.512
MOD_ProDKin_1	234	240	PF00069	0.291
TRG_DiLeu_BaEn_1	253	258	PF01217	0.538
TRG_ENDOCYTIC_2	233	236	PF00928	0.307
TRG_ER_diArg_1	106	109	PF00400	0.300
TRG_ER_diArg_1	150	152	PF00400	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8J1	Leptomonas seymouri	92%	100%
A0A0S4IWW3	Bodo saltans	78%	99%
A0A1X0P6Q2	Trypanosomatidae	91%	100%
A0A3Q8IED5	Leishmania donovani	97%	100%
A0A422N1E2	Trypanosoma rangeli	89%	100%
A0B9V0	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	46%	100%
A0RUE7	Cenarchaeum symbiosum (strain A)	40%	100%
A1RU37	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	47%	100%
A1RWR6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	45%	100%
A2BMD9	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	46%	100%
A2SPM2	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	45%	100%
A3CT17	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	44%	100%
A3DNC7	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	46%	100%
A3MU88	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	46%	100%
A4FWA1	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	41%	100%
A4H9W3	Leishmania braziliensis	92%	100%
A4HK25	Leishmania braziliensis	93%	100%
A4I7K9	Leishmania infantum	100%	100%
A4WHQ8	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	45%	100%
A4YCY6	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	45%	100%
A5UL68	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	43%	100%
A6UQ64	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	41%	100%
A6UWV8	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	40%	100%
A6VH05	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	41%	100%
A7I5Q9	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	42%	100%
A8AC00	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	47%	100%
A9A9P4	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	41%	100%
B8ISA2	Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)	34%	100%
C3NH89	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	44%	100%
D0A0B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	89%	99%
E9AGQ8	Leishmania infantum	97%	100%
E9ARV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B2G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O05641	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	43%	100%
O18789	Bos taurus	62%	90%
O26131	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	43%	100%
O28374	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	44%	100%
O43992	Leishmania amazonensis	97%	100%
O59439	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	43%	100%
O74892	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	62%	100%
P14036	Methanococcus vannielii	41%	100%
P15880	Homo sapiens	62%	90%
P25443	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	62%	100%
P25444	Mus musculus	62%	90%
P26815	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	40%	100%
P27685	Dictyostelium discoideum	60%	100%
P27952	Rattus norvegicus	62%	90%
P31009	Drosophila melanogaster	61%	99%
P46791	Cricetulus griseus	66%	100%
P49154	Urechis caupo	62%	95%
P49688	Arabidopsis thaliana	65%	93%
P51403	Caenorhabditis elegans	62%	97%
P54045	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	44%	100%
Q0W1W8	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	44%	100%
Q12ZT1	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	44%	100%
Q18GG9	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	40%	100%
Q2FSG3	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	46%	100%
Q2NFX7	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	38%	100%
Q3IMW8	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	41%	100%
Q46GB5	Methanosarcina barkeri (strain Fusaro / DSM 804)	45%	100%
Q4Q5P0	Leishmania major	99%	100%
Q4QDL5	Leishmania major	97%	100%
Q5A900	Candida albicans (strain SC5314 / ATCC MYA-2876)	59%	100%
Q5JJG8	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	45%	100%
Q6L1A7	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	42%	100%
Q6LXD3	Methanococcus maripaludis (strain S2 / LL)	41%	100%
Q74MD4	Nanoarchaeum equitans (strain Kin4-M)	43%	100%
Q8L8Y0	Arabidopsis thaliana	65%	93%
Q8PV30	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	43%	100%
Q8TRS7	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	43%	100%
Q8TZA6	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	46%	100%
Q8U017	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	44%	100%
Q8ZXN9	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	46%	100%
Q90YS3	Ictalurus punctatus	61%	95%
Q93VB8	Arabidopsis thaliana	65%	93%
Q975K0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	46%	100%
Q97BV6	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	41%	100%
Q9HIS7	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	41%	100%
Q9HPB4	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	43%	100%
Q9RSL1	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	29%	100%
Q9SCM3	Arabidopsis thaliana	65%	96%
Q9UX87	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	43%	100%
Q9V1V5	Pyrococcus abyssi (strain GE5 / Orsay)	42%	100%
Q9YF95	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	47%	100%