LeishMANIAdb
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Serine/threonine-protein kinase Nek1-related, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein kinase Nek1-related, putative
Gene product:
Serine/threonine-protein kinase Nek1-related, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X553_LEIDO
TriTrypDb:
LdBPK_320270.1 * , LdCL_320007600 , LDHU3_32.0350
Length:
1360

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0097542 ciliary tip 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A3S7X553
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
TermNameLevelCount
GO:0006468 protein phosphorylation 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016310 phosphorylation 5 7
GO:0019538 protein metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0004672 protein kinase activity 3 7
GO:0004674 protein serine/threonine kinase activity 4 6
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0016301 kinase activity 4 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 7
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1239 1243 PF00656 0.484
CLV_C14_Caspase3-7 1297 1301 PF00656 0.594
CLV_NRD_NRD_1 1002 1004 PF00675 0.499
CLV_NRD_NRD_1 1097 1099 PF00675 0.627
CLV_NRD_NRD_1 1177 1179 PF00675 0.574
CLV_NRD_NRD_1 22 24 PF00675 0.304
CLV_NRD_NRD_1 231 233 PF00675 0.304
CLV_NRD_NRD_1 259 261 PF00675 0.527
CLV_NRD_NRD_1 293 295 PF00675 0.705
CLV_NRD_NRD_1 444 446 PF00675 0.559
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P8J6 Leptomonas seymouri 53% 100%
A4HK07 Leishmania braziliensis 73% 100%
A4I7J0 Leishmania infantum 100% 100%
E9B2E7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q5Q9 Leishmania major 92% 99%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS