U2 small nuclear ribonucleoprotein 40K, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U2 small nuclear ribonucleoprotein 40K, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X552_LEIDO

TriTrypDb:

LdBPK_320180.1 , LdCL_320006700 , LDHU3_32.0260

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A0A3S7X552

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X552

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0017069	snRNA binding	5	11
GO:0030620	U2 snRNA binding	6	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.741
CLV_C14_Caspase3-7	236	240	PF00656	0.674
CLV_NRD_NRD_1	216	218	PF00675	0.626
CLV_NRD_NRD_1	302	304	PF00675	0.555
CLV_PCSK_KEX2_1	218	220	PF00082	0.625
CLV_PCSK_KEX2_1	273	275	PF00082	0.403
CLV_PCSK_KEX2_1	304	306	PF00082	0.564
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.621
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.403
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.600
CLV_PCSK_SKI1_1	153	157	PF00082	0.268
CLV_PCSK_SKI1_1	188	192	PF00082	0.440
CLV_PCSK_SKI1_1	273	277	PF00082	0.404
DEG_APCC_DBOX_1	110	118	PF00400	0.561
DEG_APCC_DBOX_1	152	160	PF00400	0.468
DEG_MDM2_SWIB_1	122	129	PF02201	0.472
DEG_Nend_UBRbox_1	1	4	PF02207	0.311
DOC_CYCLIN_RxL_1	267	279	PF00134	0.400
DOC_MAPK_gen_1	124	134	PF00069	0.495
DOC_MAPK_gen_1	151	159	PF00069	0.449
DOC_MIT_MIM_1	261	271	PF04212	0.564
DOC_PP1_RVXF_1	116	123	PF00149	0.488
DOC_PP4_FxxP_1	158	161	PF00568	0.488
DOC_USP7_MATH_1	229	233	PF00917	0.663
DOC_USP7_MATH_1	67	71	PF00917	0.518
DOC_USP7_UBL2_3	124	128	PF12436	0.538
DOC_USP7_UBL2_3	183	187	PF12436	0.527
DOC_USP7_UBL2_3	214	218	PF12436	0.666
DOC_WW_Pin1_4	247	252	PF00397	0.752
LIG_14-3-3_CanoR_1	2	6	PF00244	0.461
LIG_14-3-3_CanoR_1	204	211	PF00244	0.757
LIG_14-3-3_CanoR_1	29	34	PF00244	0.513
LIG_14-3-3_CanoR_1	78	83	PF00244	0.470
LIG_14-3-3_CanoR_1	91	101	PF00244	0.438
LIG_Actin_WH2_2	149	166	PF00022	0.450
LIG_Actin_WH2_2	16	31	PF00022	0.538
LIG_BRCT_BRCA1_1	143	147	PF00533	0.561
LIG_Clathr_ClatBox_1	38	42	PF01394	0.483
LIG_FHA_1	2	8	PF00498	0.520
LIG_FHA_1	78	84	PF00498	0.484
LIG_FHA_1	93	99	PF00498	0.428
LIG_FHA_2	170	176	PF00498	0.488
LIG_FHA_2	279	285	PF00498	0.512
LIG_FHA_2	54	60	PF00498	0.510
LIG_IRF3_LxIS_1	25	31	PF10401	0.538
LIG_LIR_Apic_2	192	196	PF02991	0.549
LIG_LIR_Gen_1	42	50	PF02991	0.448
LIG_LIR_Nem_3	184	189	PF02991	0.418
LIG_LIR_Nem_3	42	48	PF02991	0.474
LIG_Pex14_2	122	126	PF04695	0.472
LIG_SH2_CRK	168	172	PF00017	0.472
LIG_SH2_STAT5	121	124	PF00017	0.561
LIG_SH2_STAT5	60	63	PF00017	0.449
LIG_SUMO_SIM_anti_2	34	42	PF11976	0.513
LIG_SUMO_SIM_par_1	130	136	PF11976	0.472
LIG_SUMO_SIM_par_1	194	201	PF11976	0.446
LIG_SUMO_SIM_par_1	34	42	PF11976	0.513
LIG_TRAF2_1	281	284	PF00917	0.505
LIG_TYR_ITIM	166	171	PF00017	0.472
MOD_CK1_1	200	206	PF00069	0.715
MOD_CK1_1	207	213	PF00069	0.674
MOD_CK1_1	244	250	PF00069	0.629
MOD_CK1_1	77	83	PF00069	0.527
MOD_CK1_1	93	99	PF00069	0.418
MOD_CK2_1	278	284	PF00069	0.507
MOD_CK2_1	29	35	PF00069	0.511
MOD_CK2_1	53	59	PF00069	0.510
MOD_GlcNHglycan	243	246	PF01048	0.681
MOD_GlcNHglycan	247	250	PF01048	0.672
MOD_GlcNHglycan	98	101	PF01048	0.338
MOD_GSK3_1	198	205	PF00069	0.670
MOD_GSK3_1	230	237	PF00069	0.674
MOD_GSK3_1	241	248	PF00069	0.697
MOD_GSK3_1	274	281	PF00069	0.591
MOD_GSK3_1	49	56	PF00069	0.524
MOD_GSK3_1	74	81	PF00069	0.561
MOD_GSK3_1	92	99	PF00069	0.349
MOD_N-GLC_1	48	53	PF02516	0.289
MOD_NEK2_1	14	19	PF00069	0.488
MOD_NEK2_1	197	202	PF00069	0.558
MOD_NEK2_1	28	33	PF00069	0.472
MOD_PIKK_1	169	175	PF00454	0.473
MOD_PIKK_1	202	208	PF00454	0.572
MOD_PKA_2	1	7	PF00069	0.317
MOD_PKA_2	169	175	PF00069	0.466
MOD_PKA_2	28	34	PF00069	0.538
MOD_PKA_2	74	80	PF00069	0.516
MOD_PKA_2	90	96	PF00069	0.393
MOD_Plk_2-3	130	136	PF00069	0.472
MOD_Plk_4	14	20	PF00069	0.510
MOD_Plk_4	78	84	PF00069	0.458
MOD_ProDKin_1	247	253	PF00069	0.751
MOD_SUMO_for_1	182	185	PF00179	0.567
MOD_SUMO_rev_2	184	189	PF00179	0.543
MOD_SUMO_rev_2	207	216	PF00179	0.688
TRG_DiLeu_BaEn_1	185	190	PF01217	0.447
TRG_DiLeu_BaEn_4	283	289	PF01217	0.532
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.575
TRG_ENDOCYTIC_2	168	171	PF00928	0.482
TRG_ER_diArg_1	111	114	PF00400	0.538
TRG_ER_diLys_1	304	308	PF00400	0.700
TRG_NLS_MonoCore_2	302	307	PF00514	0.637
TRG_NLS_MonoExtC_3	213	218	PF00514	0.632
TRG_NLS_MonoExtC_3	302	307	PF00514	0.637
TRG_NLS_MonoExtN_4	214	221	PF00514	0.622
TRG_NLS_MonoExtN_4	303	308	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P873	Leptomonas seymouri	67%	100%
A0A0S4IPQ0	Bodo saltans	33%	100%
A0A1X0P6L0	Trypanosomatidae	44%	89%
A0A3R7N1N5	Trypanosoma rangeli	43%	90%
A4HJZ8	Leishmania braziliensis	86%	100%
A4I7I1	Leishmania infantum	99%	100%
D0A084	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	94%
E9B2D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q5R8	Leishmania major	92%	100%
Q4WV66	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q6BT60	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	100%
Q6C417	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	100%
Q7S9P4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	100%
Q9V4Q8	Drosophila melanogaster	27%	100%