Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X546_LEIDO

TriTrypDb:

LdBPK_320190.1 , LdCL_320006800 , LDHU3_32.0270

Length:

116

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7X546

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X546

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.615
CLV_NRD_NRD_1	16	18	PF00675	0.487
CLV_PCSK_KEX2_1	106	108	PF00082	0.632
CLV_PCSK_KEX2_1	16	18	PF00082	0.487
DOC_MAPK_gen_1	27	35	PF00069	0.576
DOC_PP4_FxxP_1	52	55	PF00568	0.326
DOC_USP7_MATH_1	15	19	PF00917	0.689
DOC_WW_Pin1_4	78	83	PF00397	0.415
LIG_14-3-3_CanoR_1	16	20	PF00244	0.682
LIG_14-3-3_CanoR_1	37	45	PF00244	0.606
LIG_CSK_EPIYA_1	93	97	PF00017	0.350
LIG_eIF4E_1	65	71	PF01652	0.452
LIG_FHA_1	51	57	PF00498	0.414
LIG_FHA_1	58	64	PF00498	0.225
LIG_FHA_1	75	81	PF00498	0.468
LIG_IBAR_NPY_1	29	31	PF08397	0.578
LIG_LIR_Apic_2	49	55	PF02991	0.326
LIG_MYND_1	68	72	PF01753	0.377
LIG_SH2_CRK	105	109	PF00017	0.381
LIG_SH2_NCK_1	22	26	PF00017	0.668
LIG_SH2_STAP1	39	43	PF00017	0.606
LIG_SH2_STAT5	22	25	PF00017	0.656
LIG_SH2_STAT5	31	34	PF00017	0.576
LIG_SH2_STAT5	65	68	PF00017	0.333
LIG_SH2_STAT5	90	93	PF00017	0.391
LIG_SH3_CIN85_PxpxPR_1	11	16	PF14604	0.600
LIG_SUMO_SIM_par_1	53	60	PF11976	0.293
LIG_SxIP_EBH_1	36	48	PF03271	0.555
LIG_TRAF2_1	113	116	PF00917	0.478
LIG_TRFH_1	90	94	PF08558	0.355
LIG_WRC_WIRS_1	58	63	PF05994	0.291
MOD_CDK_SPxK_1	78	84	PF00069	0.483
MOD_CK1_1	9	15	PF00069	0.733
MOD_CK2_1	110	116	PF00069	0.529
MOD_GlcNHglycan	112	115	PF01048	0.652
MOD_GlcNHglycan	8	11	PF01048	0.447
MOD_GSK3_1	33	40	PF00069	0.567
MOD_GSK3_1	74	81	PF00069	0.426
MOD_N-GLC_1	20	25	PF02516	0.438
MOD_NEK2_1	38	43	PF00069	0.584
MOD_NEK2_1	50	55	PF00069	0.334
MOD_NEK2_1	57	62	PF00069	0.187
MOD_PIKK_1	74	80	PF00454	0.407
MOD_PKA_2	15	21	PF00069	0.688
MOD_Plk_1	88	94	PF00069	0.399
MOD_Plk_4	66	72	PF00069	0.546
MOD_ProDKin_1	78	84	PF00069	0.416
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.289
TRG_ENDOCYTIC_2	105	108	PF00928	0.364
TRG_ER_diArg_1	105	107	PF00400	0.430
TRG_ER_diArg_1	15	17	PF00400	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I957	Leptomonas seymouri	76%	94%
A0A0S4IP38	Bodo saltans	45%	96%
A0A1X0P6V0	Trypanosomatidae	62%	87%
A0A3R7NTE7	Trypanosoma rangeli	62%	91%
A4HJZ9	Leishmania braziliensis	78%	100%
A4I7I2	Leishmania infantum	100%	100%
D0A085	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	97%
E9B2D9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q5R7	Leishmania major	92%	100%