Kinesin motor domain/MORN repeat, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin motor domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X544_LEIDO

TriTrypDb:

LdBPK_320430.1 , LdCL_320009200 , LDHU3_32.0530

Length:

719

Annotations

Annotations by Jardim et al.

Structural Proteins, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X544

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X544

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	13
GO:0007018	microtubule-based movement	3	13
GO:0009987	cellular process	1	13

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003774	cytoskeletal motor activity	1	13
GO:0003777	microtubule motor activity	2	13
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0005524	ATP binding	5	13
GO:0008017	microtubule binding	5	13
GO:0008092	cytoskeletal protein binding	3	13
GO:0015631	tubulin binding	4	13
GO:0017076	purine nucleotide binding	4	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.274
CLV_C14_Caspase3-7	2	6	PF00656	0.579
CLV_NRD_NRD_1	127	129	PF00675	0.409
CLV_NRD_NRD_1	213	215	PF00675	0.385
CLV_NRD_NRD_1	216	218	PF00675	0.374
CLV_NRD_NRD_1	247	249	PF00675	0.440
CLV_NRD_NRD_1	457	459	PF00675	0.584
CLV_NRD_NRD_1	501	503	PF00675	0.431
CLV_NRD_NRD_1	519	521	PF00675	0.506
CLV_NRD_NRD_1	659	661	PF00675	0.485

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F2	Leptomonas seymouri	69%	97%
A0A0S4IK37	Bodo saltans	41%	100%
A0A0S4INH0	Bodo saltans	40%	100%
A0A1X0P6P1	Trypanosomatidae	46%	100%
A0A422N1G2	Trypanosoma rangeli	45%	100%
A4HK22	Leishmania braziliensis	86%	100%
A4I7K6	Leishmania infantum	100%	100%
D0A0B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B2G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5P3	Leishmania major	95%	100%

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