Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X529_LEIDO

TriTrypDb:

LdBPK_320210.1 , LdCL_320007000 , LDHU3_32.0290

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X529

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X529

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.558
CLV_NRD_NRD_1	142	144	PF00675	0.473
CLV_NRD_NRD_1	175	177	PF00675	0.485
CLV_NRD_NRD_1	272	274	PF00675	0.433
CLV_NRD_NRD_1	57	59	PF00675	0.394
CLV_PCSK_KEX2_1	142	144	PF00082	0.487
CLV_PCSK_KEX2_1	149	151	PF00082	0.485
CLV_PCSK_KEX2_1	175	177	PF00082	0.487
CLV_PCSK_KEX2_1	272	274	PF00082	0.433
CLV_PCSK_KEX2_1	57	59	PF00082	0.394
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.471
CLV_PCSK_SKI1_1	142	146	PF00082	0.482
CLV_PCSK_SKI1_1	175	179	PF00082	0.436
CLV_PCSK_SKI1_1	222	226	PF00082	0.497
CLV_PCSK_SKI1_1	85	89	PF00082	0.449
DEG_APCC_DBOX_1	271	279	PF00400	0.443
DEG_APCC_KENBOX_2	242	246	PF00400	0.471
DOC_CKS1_1	218	223	PF01111	0.527
DOC_CYCLIN_RxL_1	261	270	PF00134	0.530
DOC_MAPK_gen_1	149	155	PF00069	0.444
DOC_USP7_MATH_1	133	137	PF00917	0.572
DOC_USP7_MATH_1	2	6	PF00917	0.477
DOC_USP7_MATH_1	200	204	PF00917	0.580
DOC_USP7_MATH_1	253	257	PF00917	0.560
DOC_USP7_MATH_1	333	337	PF00917	0.562
DOC_USP7_MATH_1	34	38	PF00917	0.488
DOC_WW_Pin1_4	202	207	PF00397	0.586
DOC_WW_Pin1_4	217	222	PF00397	0.586
DOC_WW_Pin1_4	249	254	PF00397	0.551
DOC_WW_Pin1_4	296	301	PF00397	0.640
DOC_WW_Pin1_4	315	320	PF00397	0.745
LIG_14-3-3_CanoR_1	212	221	PF00244	0.572
LIG_14-3-3_CanoR_1	272	276	PF00244	0.434
LIG_14-3-3_CanoR_1	331	340	PF00244	0.513
LIG_14-3-3_CanoR_1	66	71	PF00244	0.434
LIG_Actin_WH2_2	70	87	PF00022	0.431
LIG_deltaCOP1_diTrp_1	119	126	PF00928	0.513
LIG_DLG_GKlike_1	66	73	PF00625	0.439
LIG_EH1_1	17	25	PF00400	0.435
LIG_eIF4E_1	242	248	PF01652	0.472
LIG_FHA_1	157	163	PF00498	0.452
LIG_FHA_1	272	278	PF00498	0.480
LIG_FHA_1	297	303	PF00498	0.618
LIG_FHA_1	342	348	PF00498	0.524
LIG_FHA_1	349	355	PF00498	0.431
LIG_FHA_1	47	53	PF00498	0.614
LIG_FHA_2	260	266	PF00498	0.538
LIG_GBD_Chelix_1	169	177	PF00786	0.436
LIG_LIR_Gen_1	182	191	PF02991	0.433
LIG_LIR_Nem_3	182	188	PF02991	0.433
LIG_SH2_CRK	185	189	PF00017	0.431
LIG_SH2_NCK_1	185	189	PF00017	0.431
LIG_SH2_STAP1	185	189	PF00017	0.431
LIG_SH3_3	247	253	PF00018	0.582
LIG_SH3_3	299	305	PF00018	0.714
LIG_SH3_3	313	319	PF00018	0.647
LIG_SH3_3	322	328	PF00018	0.575
LIG_SUMO_SIM_anti_2	274	281	PF11976	0.497
LIG_SUMO_SIM_par_1	12	17	PF11976	0.434
LIG_SUMO_SIM_par_1	28	33	PF11976	0.552
LIG_SUMO_SIM_par_1	280	288	PF11976	0.555
LIG_TRAF2_1	285	288	PF00917	0.652
MOD_CDC14_SPxK_1	205	208	PF00782	0.583
MOD_CDK_SPK_2	217	222	PF00069	0.542
MOD_CDK_SPK_2	315	320	PF00069	0.693
MOD_CDK_SPxK_1	202	208	PF00069	0.587
MOD_CK1_1	199	205	PF00069	0.651
MOD_CK1_1	46	52	PF00069	0.430
MOD_CK1_1	69	75	PF00069	0.424
MOD_CK2_1	122	128	PF00069	0.668
MOD_CK2_1	133	139	PF00069	0.395
MOD_CK2_1	158	164	PF00069	0.513
MOD_CK2_1	259	265	PF00069	0.543
MOD_CK2_1	282	288	PF00069	0.616
MOD_CK2_1	333	339	PF00069	0.507
MOD_CK2_1	73	79	PF00069	0.578
MOD_GlcNHglycan	198	201	PF01048	0.560
MOD_GlcNHglycan	202	205	PF01048	0.601
MOD_GlcNHglycan	335	338	PF01048	0.704
MOD_GlcNHglycan	36	39	PF01048	0.509
MOD_GSK3_1	122	129	PF00069	0.572
MOD_GSK3_1	156	163	PF00069	0.432
MOD_GSK3_1	196	203	PF00069	0.635
MOD_GSK3_1	207	214	PF00069	0.618
MOD_GSK3_1	249	256	PF00069	0.563
MOD_GSK3_1	278	285	PF00069	0.567
MOD_GSK3_1	30	37	PF00069	0.515
MOD_GSK3_1	69	76	PF00069	0.524
MOD_N-GLC_1	348	353	PF02516	0.427
MOD_N-GLC_1	73	78	PF02516	0.427
MOD_NEK2_1	16	21	PF00069	0.426
MOD_NEK2_1	277	282	PF00069	0.519
MOD_NEK2_1	30	35	PF00069	0.541
MOD_NEK2_1	73	78	PF00069	0.481
MOD_NEK2_2	2	7	PF00069	0.473
MOD_PIKK_1	156	162	PF00454	0.452
MOD_PIKK_1	232	238	PF00454	0.456
MOD_PIKK_1	46	52	PF00454	0.460
MOD_PIKK_1	87	93	PF00454	0.656
MOD_PK_1	282	288	PF00069	0.560
MOD_PKA_2	106	112	PF00069	0.502
MOD_PKA_2	207	213	PF00069	0.612
MOD_PKA_2	271	277	PF00069	0.450
MOD_PKA_2	278	284	PF00069	0.538
MOD_Plk_1	341	347	PF00069	0.437
MOD_Plk_1	43	49	PF00069	0.459
MOD_Plk_1	73	79	PF00069	0.425
MOD_Plk_2-3	122	128	PF00069	0.558
MOD_Plk_2-3	353	359	PF00069	0.467
MOD_ProDKin_1	202	208	PF00069	0.587
MOD_ProDKin_1	217	223	PF00069	0.580
MOD_ProDKin_1	249	255	PF00069	0.546
MOD_ProDKin_1	296	302	PF00069	0.641
MOD_ProDKin_1	315	321	PF00069	0.747
MOD_SUMO_rev_2	109	118	PF00179	0.533
TRG_DiLeu_BaEn_2	341	347	PF01217	0.437
TRG_DiLeu_BaEn_4	79	85	PF01217	0.453
TRG_ENDOCYTIC_2	185	188	PF00928	0.485
TRG_ER_diArg_1	141	143	PF00400	0.443
TRG_ER_diArg_1	150	153	PF00400	0.438
TRG_ER_diArg_1	175	177	PF00400	0.487
TRG_ER_diArg_1	271	273	PF00400	0.433
TRG_ER_diArg_1	56	58	PF00400	0.405
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME2	Leptomonas seymouri	63%	83%
A4HK01	Leishmania braziliensis	69%	100%
A4I7I4	Leishmania infantum	99%	100%
E9B2E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5R5	Leishmania major	93%	100%