C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X526_LEIDO

TriTrypDb:

LdBPK_320040.1 , LdCL_320005300 , LDHU3_32.0070

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X526

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X526

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.563
CLV_MEL_PAP_1	100	106	PF00089	0.392
CLV_NRD_NRD_1	121	123	PF00675	0.480
CLV_NRD_NRD_1	253	255	PF00675	0.583
CLV_NRD_NRD_1	59	61	PF00675	0.471
CLV_NRD_NRD_1	68	70	PF00675	0.563
CLV_NRD_NRD_1	84	86	PF00675	0.483
CLV_PCSK_KEX2_1	121	123	PF00082	0.499
CLV_PCSK_KEX2_1	253	255	PF00082	0.583
CLV_PCSK_KEX2_1	68	70	PF00082	0.604
CLV_PCSK_KEX2_1	84	86	PF00082	0.485
CLV_PCSK_SKI1_1	122	126	PF00082	0.484
CLV_PCSK_SKI1_1	21	25	PF00082	0.520
CLV_PCSK_SKI1_1	233	237	PF00082	0.584
CLV_PCSK_SKI1_1	68	72	PF00082	0.586
CLV_PCSK_SKI1_1	73	77	PF00082	0.389
CLV_PCSK_SKI1_1	84	88	PF00082	0.387
CLV_PCSK_SKI1_1	93	97	PF00082	0.267
DEG_Nend_Nbox_1	1	3	PF02207	0.492
DOC_CYCLIN_RxL_1	119	129	PF00134	0.486
DOC_MAPK_gen_1	18	28	PF00069	0.505
DOC_MAPK_MEF2A_6	18	26	PF00069	0.500
DOC_WW_Pin1_4	77	82	PF00397	0.401
LIG_14-3-3_CanoR_1	103	109	PF00244	0.421
LIG_APCC_ABBAyCdc20_2	121	127	PF00400	0.475
LIG_BRCT_BRCA1_1	104	108	PF00533	0.378
LIG_FHA_1	109	115	PF00498	0.408
LIG_FHA_1	134	140	PF00498	0.437
LIG_FHA_1	183	189	PF00498	0.553
LIG_FHA_1	274	280	PF00498	0.766
LIG_FHA_1	70	76	PF00498	0.435
LIG_FHA_2	127	133	PF00498	0.540
LIG_FHA_2	214	220	PF00498	0.561
LIG_FHA_2	242	248	PF00498	0.601
LIG_LIR_Gen_1	211	221	PF02991	0.597
LIG_LIR_Gen_1	234	243	PF02991	0.617
LIG_LIR_Nem_3	211	217	PF02991	0.582
LIG_LIR_Nem_3	234	238	PF02991	0.653
LIG_MYND_1	196	200	PF01753	0.570
LIG_NRBOX	82	88	PF00104	0.448
LIG_Pex14_2	28	32	PF04695	0.472
LIG_REV1ctd_RIR_1	68	77	PF16727	0.492
LIG_SH2_CRK	214	218	PF00017	0.608
LIG_SH2_CRK	63	67	PF00017	0.488
LIG_SH2_GRB2like	63	66	PF00017	0.598
LIG_SH2_NCK_1	116	120	PF00017	0.422
LIG_SH2_NCK_1	63	67	PF00017	0.495
LIG_SH2_SRC	159	162	PF00017	0.361
LIG_SH2_STAP1	116	120	PF00017	0.411
LIG_SH2_STAT5	159	162	PF00017	0.372
LIG_SH2_STAT5	63	66	PF00017	0.517
LIG_SH2_STAT5	99	102	PF00017	0.398
LIG_SH3_2	189	194	PF14604	0.497
LIG_SH3_3	186	192	PF00018	0.623
LIG_SUMO_SIM_anti_2	136	141	PF11976	0.419
LIG_UBA3_1	86	93	PF00899	0.392
LIG_WRC_WIRS_1	29	34	PF05994	0.484
MOD_CDK_SPxxK_3	77	84	PF00069	0.398
MOD_CK1_1	126	132	PF00069	0.530
MOD_CK1_1	150	156	PF00069	0.461
MOD_CK1_1	182	188	PF00069	0.518
MOD_CK1_1	264	270	PF00069	0.838
MOD_CK1_1	280	286	PF00069	0.542
MOD_CK1_1	303	309	PF00069	0.682
MOD_CK1_1	327	333	PF00069	0.643
MOD_CK2_1	126	132	PF00069	0.535
MOD_CK2_1	241	247	PF00069	0.553
MOD_CK2_1	310	316	PF00069	0.612
MOD_CK2_1	327	333	PF00069	0.627
MOD_Cter_Amidation	251	254	PF01082	0.578
MOD_GlcNHglycan	224	227	PF01048	0.597
MOD_GlcNHglycan	249	252	PF01048	0.693
MOD_GlcNHglycan	267	270	PF01048	0.540
MOD_GlcNHglycan	302	305	PF01048	0.620
MOD_GlcNHglycan	307	310	PF01048	0.599
MOD_GlcNHglycan	329	332	PF01048	0.620
MOD_GSK3_1	143	150	PF00069	0.433
MOD_GSK3_1	222	229	PF00069	0.663
MOD_GSK3_1	261	268	PF00069	0.711
MOD_GSK3_1	273	280	PF00069	0.661
MOD_GSK3_1	296	303	PF00069	0.674
MOD_GSK3_1	318	325	PF00069	0.582
MOD_GSK3_1	38	45	PF00069	0.514
MOD_LATS_1	260	266	PF00433	0.615
MOD_N-GLC_1	273	278	PF02516	0.765
MOD_N-GLC_1	311	316	PF02516	0.816
MOD_N-GLC_1	322	327	PF02516	0.550
MOD_NEK2_1	143	148	PF00069	0.401
MOD_NEK2_1	241	246	PF00069	0.767
MOD_NEK2_1	28	33	PF00069	0.503
MOD_NEK2_1	318	323	PF00069	0.559
MOD_NEK2_1	71	76	PF00069	0.451
MOD_PIKK_1	182	188	PF00454	0.520
MOD_PKA_2	102	108	PF00069	0.410
MOD_PKA_2	261	267	PF00069	0.828
MOD_PKA_2	37	43	PF00069	0.468
MOD_Plk_1	210	216	PF00069	0.576
MOD_Plk_1	239	245	PF00069	0.549
MOD_Plk_4	280	286	PF00069	0.623
MOD_ProDKin_1	77	83	PF00069	0.396
TRG_DiLeu_BaEn_1	82	87	PF01217	0.393
TRG_DiLeu_LyEn_5	19	24	PF01217	0.526
TRG_DiLeu_LyEn_5	82	87	PF01217	0.359
TRG_ENDOCYTIC_2	214	217	PF00928	0.624
TRG_ER_diArg_1	120	122	PF00400	0.489
TRG_ER_diArg_1	253	255	PF00400	0.825
TRG_ER_diArg_1	68	70	PF00400	0.585
TRG_ER_diArg_1	83	85	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H1	Leptomonas seymouri	35%	93%
A0A0N1I963	Leptomonas seymouri	60%	87%
A0A3S7X500	Leishmania donovani	36%	91%
A4HJY4	Leishmania braziliensis	70%	100%
A4I7G6	Leishmania infantum	36%	91%
A4I7G7	Leishmania infantum	97%	100%
E9B2C4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q5T2	Leishmania major	90%	100%