Nuclear segregation protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear segregation protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X525_LEIDO

TriTrypDb:

LdBPK_320020.1 , LdCL_320005100 , LDHU3_32.0030

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	1
GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7X525

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X525

Function

Biological processes
Term	Name	Level	Count
GO:0006403	RNA localization	3	1
GO:0008298	intracellular mRNA localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	237	243	PF00089	0.580
CLV_NRD_NRD_1	103	105	PF00675	0.468
CLV_NRD_NRD_1	138	140	PF00675	0.509
CLV_NRD_NRD_1	152	154	PF00675	0.637
CLV_NRD_NRD_1	269	271	PF00675	0.520
CLV_NRD_NRD_1	284	286	PF00675	0.382
CLV_NRD_NRD_1	291	293	PF00675	0.534
CLV_NRD_NRD_1	338	340	PF00675	0.542
CLV_NRD_NRD_1	341	343	PF00675	0.554
CLV_NRD_NRD_1	45	47	PF00675	0.539
CLV_NRD_NRD_1	85	87	PF00675	0.473
CLV_NRD_NRD_1	92	94	PF00675	0.452
CLV_PCSK_FUR_1	281	285	PF00082	0.494
CLV_PCSK_FUR_1	339	343	PF00082	0.600
CLV_PCSK_FUR_1	90	94	PF00082	0.579
CLV_PCSK_KEX2_1	152	154	PF00082	0.503
CLV_PCSK_KEX2_1	213	215	PF00082	0.594
CLV_PCSK_KEX2_1	283	285	PF00082	0.513
CLV_PCSK_KEX2_1	291	293	PF00082	0.480
CLV_PCSK_KEX2_1	300	302	PF00082	0.435
CLV_PCSK_KEX2_1	306	308	PF00082	0.501
CLV_PCSK_KEX2_1	340	342	PF00082	0.577
CLV_PCSK_KEX2_1	45	47	PF00082	0.489
CLV_PCSK_KEX2_1	85	87	PF00082	0.481
CLV_PCSK_KEX2_1	92	94	PF00082	0.536
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.594
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.639
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.462
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.515
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.557
CLV_PCSK_SKI1_1	179	183	PF00082	0.528
CLV_PCSK_SKI1_1	213	217	PF00082	0.553
CLV_PCSK_SKI1_1	303	307	PF00082	0.578
CLV_PCSK_SKI1_1	374	378	PF00082	0.729
CLV_PCSK_SKI1_1	72	76	PF00082	0.601
DEG_APCC_KENBOX_2	386	390	PF00400	0.658
DOC_MAPK_gen_1	326	334	PF00069	0.569
DOC_MAPK_gen_1	413	422	PF00069	0.546
DOC_MAPK_MEF2A_6	326	334	PF00069	0.520
DOC_USP7_MATH_1	18	22	PF00917	0.628
DOC_USP7_MATH_1	393	397	PF00917	0.768
DOC_USP7_MATH_1	467	471	PF00917	0.580
DOC_USP7_UBL2_3	209	213	PF12436	0.592
DOC_USP7_UBL2_3	267	271	PF12436	0.480
DOC_USP7_UBL2_3	296	300	PF12436	0.519
DOC_USP7_UBL2_3	370	374	PF12436	0.711
DOC_USP7_UBL2_3	377	381	PF12436	0.711
DOC_WW_Pin1_4	470	475	PF00397	0.697
DOC_WW_Pin1_4	5	10	PF00397	0.650
LIG_14-3-3_CanoR_1	238	248	PF00244	0.581
LIG_14-3-3_CanoR_1	45	49	PF00244	0.534
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_deltaCOP1_diTrp_1	261	265	PF00928	0.469
LIG_FHA_1	164	170	PF00498	0.578
LIG_FHA_1	449	455	PF00498	0.582
LIG_FHA_1	482	488	PF00498	0.741
LIG_FHA_2	180	186	PF00498	0.519
LIG_FHA_2	395	401	PF00498	0.759
LIG_FHA_2	428	434	PF00498	0.563
LIG_FHA_2	45	51	PF00498	0.369
LIG_IBAR_NPY_1	309	311	PF08397	0.504
LIG_LIR_Gen_1	191	199	PF02991	0.450
LIG_LIR_Nem_3	191	195	PF02991	0.426
LIG_PDZ_Class_3	489	494	PF00595	0.799
LIG_PTB_Apo_2	200	207	PF02174	0.548
LIG_PTB_Phospho_1	200	206	PF10480	0.546
LIG_SH2_CRK	192	196	PF00017	0.558
LIG_SH2_STAP1	206	210	PF00017	0.495
LIG_SH2_STAP1	445	449	PF00017	0.493
LIG_SH2_STAT3	273	276	PF00017	0.568
LIG_SH2_STAT3	324	327	PF00017	0.558
LIG_SH2_STAT5	273	276	PF00017	0.515
LIG_SH2_STAT5	311	314	PF00017	0.471
LIG_SH2_STAT5	324	327	PF00017	0.449
LIG_SH3_2	23	28	PF14604	0.613
LIG_SH3_3	20	26	PF00018	0.532
LIG_SH3_3	473	479	PF00018	0.607
LIG_SH3_3	6	12	PF00018	0.740
LIG_SUMO_SIM_par_1	418	423	PF11976	0.537
LIG_TRAF2_1	182	185	PF00917	0.531
LIG_TRAF2_1	2	5	PF00917	0.793
LIG_TRAF2_1	489	492	PF00917	0.743
LIG_UBA3_1	321	329	PF00899	0.491
LIG_UBA3_1	48	54	PF00899	0.536
MOD_CDK_SPxK_1	5	11	PF00069	0.564
MOD_CDK_SPxxK_3	470	477	PF00069	0.698
MOD_CK1_1	242	248	PF00069	0.481
MOD_CK1_1	316	322	PF00069	0.467
MOD_CK1_1	364	370	PF00069	0.646
MOD_CK1_1	427	433	PF00069	0.582
MOD_CK1_1	470	476	PF00069	0.674
MOD_CK2_1	179	185	PF00069	0.551
MOD_CK2_1	440	446	PF00069	0.581
MOD_CMANNOS	262	265	PF00535	0.458
MOD_GlcNHglycan	1	4	PF01048	0.700
MOD_GlcNHglycan	142	146	PF01048	0.525
MOD_GlcNHglycan	314	318	PF01048	0.472
MOD_GlcNHglycan	390	393	PF01048	0.703
MOD_GlcNHglycan	457	460	PF01048	0.763
MOD_GlcNHglycan	468	472	PF01048	0.774
MOD_GSK3_1	313	320	PF00069	0.396
MOD_GSK3_1	364	371	PF00069	0.701
MOD_GSK3_1	440	447	PF00069	0.488
MOD_N-GLC_1	368	373	PF02516	0.776
MOD_N-GLC_1	388	393	PF02516	0.484
MOD_NEK2_1	141	146	PF00069	0.514
MOD_NEK2_1	372	377	PF00069	0.652
MOD_NEK2_1	454	459	PF00069	0.715
MOD_NEK2_1	55	60	PF00069	0.509
MOD_NEK2_2	247	252	PF00069	0.467
MOD_PIKK_1	242	248	PF00454	0.481
MOD_PIKK_1	348	354	PF00454	0.677
MOD_PIKK_1	440	446	PF00454	0.522
MOD_PIKK_1	62	68	PF00454	0.651
MOD_PKA_2	239	245	PF00069	0.553
MOD_PKA_2	44	50	PF00069	0.367
MOD_Plk_1	368	374	PF00069	0.543
MOD_Plk_4	317	323	PF00069	0.438
MOD_ProDKin_1	470	476	PF00069	0.697
MOD_ProDKin_1	5	11	PF00069	0.650
MOD_SUMO_rev_2	162	166	PF00179	0.559
MOD_SUMO_rev_2	205	210	PF00179	0.570
MOD_SUMO_rev_2	362	372	PF00179	0.747
MOD_SUMO_rev_2	427	435	PF00179	0.601
TRG_ENDOCYTIC_2	192	195	PF00928	0.529
TRG_ER_diArg_1	237	240	PF00400	0.580
TRG_ER_diArg_1	339	342	PF00400	0.621
TRG_NLS_Bipartite_1	283	304	PF00514	0.616
TRG_NLS_Bipartite_1	86	108	PF00514	0.591
TRG_NLS_MonoExtC_3	103	109	PF00514	0.571
TRG_NLS_MonoExtC_3	211	216	PF00514	0.581
TRG_NLS_MonoExtC_3	269	275	PF00514	0.411
TRG_NLS_MonoExtN_4	102	108	PF00514	0.575
TRG_NLS_MonoExtN_4	209	216	PF00514	0.511
TRG_NLS_MonoExtN_4	267	274	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD36	Leptomonas seymouri	56%	98%
A0A0S4J925	Bodo saltans	39%	100%
A0A1X0P6U5	Trypanosomatidae	41%	100%
A0A3R7KQ83	Trypanosoma rangeli	40%	98%
A4HJX8	Leishmania braziliensis	76%	99%
A4HJY1	Leishmania braziliensis	76%	99%
A4I7G5	Leishmania infantum	100%	100%
C9ZZZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B2C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5T4	Leishmania major	91%	100%
V5BS50	Trypanosoma cruzi	41%	98%