Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X519_LEIDO

TriTrypDb:

LdBPK_320060.1 , LdCL_320005500 , LDHU3_32.0100

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X519

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X519

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.529
CLV_NRD_NRD_1	188	190	PF00675	0.291
CLV_NRD_NRD_1	276	278	PF00675	0.469
CLV_NRD_NRD_1	328	330	PF00675	0.563
CLV_NRD_NRD_1	379	381	PF00675	0.503
CLV_NRD_NRD_1	9	11	PF00675	0.415
CLV_PCSK_KEX2_1	168	170	PF00082	0.527
CLV_PCSK_KEX2_1	188	190	PF00082	0.291
CLV_PCSK_KEX2_1	276	278	PF00082	0.382
CLV_PCSK_KEX2_1	327	329	PF00082	0.542
CLV_PCSK_KEX2_1	340	342	PF00082	0.547
CLV_PCSK_KEX2_1	379	381	PF00082	0.503
CLV_PCSK_KEX2_1	9	11	PF00082	0.415
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.547
CLV_PCSK_PC7_1	375	381	PF00082	0.421
CLV_PCSK_SKI1_1	189	193	PF00082	0.506
CLV_PCSK_SKI1_1	247	251	PF00082	0.440
CLV_PCSK_SKI1_1	253	257	PF00082	0.405
CLV_PCSK_SKI1_1	375	379	PF00082	0.498
DOC_ANK_TNKS_1	398	405	PF00023	0.504
DOC_CDC14_PxL_1	284	292	PF14671	0.661
DOC_CYCLIN_yCln2_LP_2	91	97	PF00134	0.513
DOC_MAPK_gen_1	168	174	PF00069	0.615
DOC_MAPK_gen_1	188	194	PF00069	0.317
DOC_MAPK_gen_1	316	324	PF00069	0.617
DOC_PP4_FxxP_1	8	11	PF00568	0.415
DOC_USP7_MATH_1	129	133	PF00917	0.570
DOC_USP7_MATH_1	348	352	PF00917	0.687
DOC_USP7_MATH_1	46	50	PF00917	0.420
DOC_USP7_MATH_1	86	90	PF00917	0.615
DOC_WW_Pin1_4	117	122	PF00397	0.644
DOC_WW_Pin1_4	15	20	PF00397	0.416
DOC_WW_Pin1_4	328	333	PF00397	0.554
DOC_WW_Pin1_4	344	349	PF00397	0.664
DOC_WW_Pin1_4	81	86	PF00397	0.591
DOC_WW_Pin1_4	93	98	PF00397	0.471
DOC_WW_Pin1_4	99	104	PF00397	0.506
LIG_14-3-3_CanoR_1	291	295	PF00244	0.489
LIG_14-3-3_CanoR_1	384	393	PF00244	0.564
LIG_Actin_WH2_2	262	278	PF00022	0.431
LIG_Actin_WH2_2	383	401	PF00022	0.509
LIG_BIR_II_1	1	5	PF00653	0.406
LIG_BIR_III_3	1	5	PF00653	0.406
LIG_BRCT_BRCA1_1	17	21	PF00533	0.419
LIG_BRCT_BRCA1_1	56	60	PF00533	0.431
LIG_Clathr_ClatBox_1	148	152	PF01394	0.469
LIG_FHA_1	221	227	PF00498	0.379
LIG_FHA_1	278	284	PF00498	0.538
LIG_FHA_1	381	387	PF00498	0.576
LIG_FHA_1	85	91	PF00498	0.599
LIG_FHA_2	229	235	PF00498	0.356
LIG_FHA_2	291	297	PF00498	0.633
LIG_FHA_2	389	395	PF00498	0.507
LIG_Integrin_RGD_1	195	197	PF01839	0.460
LIG_LIR_Apic_2	319	323	PF02991	0.640
LIG_LIR_Apic_2	5	11	PF02991	0.416
LIG_LIR_Gen_1	227	237	PF02991	0.401
LIG_LIR_Nem_3	227	233	PF02991	0.429
LIG_LIR_Nem_3	271	275	PF02991	0.477
LIG_LIR_Nem_3	319	324	PF02991	0.640
LIG_MLH1_MIPbox_1	56	60	PF16413	0.431
LIG_MYND_1	65	69	PF01753	0.552
LIG_NRBOX	424	430	PF00104	0.427
LIG_SH2_CRK	251	255	PF00017	0.448
LIG_SH2_NCK_1	251	255	PF00017	0.571
LIG_SH2_NCK_1	393	397	PF00017	0.468
LIG_SH2_PTP2	321	324	PF00017	0.645
LIG_SH2_SRC	321	324	PF00017	0.645
LIG_SH2_STAP1	162	166	PF00017	0.503
LIG_SH2_STAP1	366	370	PF00017	0.515
LIG_SH2_STAT5	12	15	PF00017	0.417
LIG_SH2_STAT5	162	165	PF00017	0.645
LIG_SH2_STAT5	176	179	PF00017	0.371
LIG_SH2_STAT5	28	31	PF00017	0.400
LIG_SH2_STAT5	321	324	PF00017	0.628
LIG_SH3_3	112	118	PF00018	0.603
LIG_SH3_3	152	158	PF00018	0.484
LIG_SH3_3	238	244	PF00018	0.406
LIG_SH3_3	282	288	PF00018	0.461
LIG_SH3_3	42	48	PF00018	0.419
LIG_SH3_3	91	97	PF00018	0.555
LIG_SUMO_SIM_par_1	145	152	PF11976	0.505
LIG_TRAF2_1	69	72	PF00917	0.510
LIG_TRFH_1	154	158	PF08558	0.482
LIG_WRC_WIRS_1	80	85	PF05994	0.646
LIG_WW_2	45	48	PF00397	0.410
MOD_CK1_1	102	108	PF00069	0.637
MOD_CK1_1	113	119	PF00069	0.546
MOD_CK1_1	160	166	PF00069	0.547
MOD_CK1_1	219	225	PF00069	0.454
MOD_CK1_1	352	358	PF00069	0.523
MOD_CK1_1	397	403	PF00069	0.582
MOD_CK1_1	419	425	PF00069	0.562
MOD_CK1_1	79	85	PF00069	0.601
MOD_CK2_1	221	227	PF00069	0.358
MOD_CK2_1	228	234	PF00069	0.341
MOD_CK2_1	290	296	PF00069	0.638
MOD_CK2_1	388	394	PF00069	0.466
MOD_CK2_1	397	403	PF00069	0.477
MOD_GlcNHglycan	112	115	PF01048	0.582
MOD_GlcNHglycan	201	204	PF01048	0.708
MOD_GlcNHglycan	277	280	PF01048	0.467
MOD_GlcNHglycan	32	35	PF01048	0.422
MOD_GlcNHglycan	337	340	PF01048	0.618
MOD_GlcNHglycan	418	421	PF01048	0.578
MOD_GlcNHglycan	48	51	PF01048	0.398
MOD_GSK3_1	113	120	PF00069	0.559
MOD_GSK3_1	15	22	PF00069	0.418
MOD_GSK3_1	157	164	PF00069	0.508
MOD_GSK3_1	216	223	PF00069	0.453
MOD_GSK3_1	344	351	PF00069	0.714
MOD_GSK3_1	412	419	PF00069	0.605
MOD_GSK3_1	54	61	PF00069	0.537
MOD_N-GLC_1	122	127	PF02516	0.576
MOD_N-GLC_2	106	108	PF02516	0.532
MOD_NEK2_1	122	127	PF00069	0.714
MOD_NEK2_1	13	18	PF00069	0.415
MOD_NEK2_1	161	166	PF00069	0.546
MOD_NEK2_1	21	26	PF00069	0.407
MOD_NEK2_1	221	226	PF00069	0.503
MOD_NEK2_1	275	280	PF00069	0.460
MOD_NEK2_1	290	295	PF00069	0.524
MOD_NEK2_1	30	35	PF00069	0.396
MOD_NEK2_2	54	59	PF00069	0.429
MOD_OFUCOSY	52	58	PF10250	0.431
MOD_PIKK_1	385	391	PF00454	0.434
MOD_PIKK_1	67	73	PF00454	0.527
MOD_PKA_2	275	281	PF00069	0.597
MOD_PKA_2	290	296	PF00069	0.523
MOD_PKA_2	429	435	PF00069	0.439
MOD_Plk_1	123	129	PF00069	0.711
MOD_Plk_1	144	150	PF00069	0.468
MOD_Plk_1	226	232	PF00069	0.488
MOD_Plk_4	129	135	PF00069	0.616
MOD_Plk_4	144	150	PF00069	0.656
MOD_Plk_4	157	163	PF00069	0.429
MOD_Plk_4	2	8	PF00069	0.422
MOD_Plk_4	221	227	PF00069	0.401
MOD_Plk_4	268	274	PF00069	0.376
MOD_Plk_4	303	309	PF00069	0.469
MOD_Plk_4	388	394	PF00069	0.486
MOD_Plk_4	86	92	PF00069	0.646
MOD_ProDKin_1	117	123	PF00069	0.671
MOD_ProDKin_1	15	21	PF00069	0.417
MOD_ProDKin_1	328	334	PF00069	0.557
MOD_ProDKin_1	344	350	PF00069	0.662
MOD_ProDKin_1	81	87	PF00069	0.592
MOD_ProDKin_1	93	99	PF00069	0.470
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.508
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.624
TRG_ENDOCYTIC_2	12	15	PF00928	0.417
TRG_ENDOCYTIC_2	272	275	PF00928	0.508
TRG_ENDOCYTIC_2	28	31	PF00928	0.400
TRG_ENDOCYTIC_2	321	324	PF00928	0.628
TRG_ER_diArg_1	138	141	PF00400	0.461
TRG_ER_diArg_1	188	190	PF00400	0.616
TRG_ER_diArg_1	275	277	PF00400	0.462
TRG_ER_diArg_1	327	329	PF00400	0.559
TRG_ER_diArg_1	378	380	PF00400	0.474
TRG_ER_diArg_1	8	10	PF00400	0.419
TRG_NLS_Bipartite_1	327	344	PF00514	0.575
TRG_NLS_MonoExtC_3	339	345	PF00514	0.591
TRG_NLS_MonoExtN_4	337	344	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	354	359	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P875	Leptomonas seymouri	60%	100%
A0A1X0P6X1	Trypanosomatidae	35%	100%
A0A3R7M1V0	Trypanosoma rangeli	32%	96%
A4HJY6	Leishmania braziliensis	78%	100%
A4I7G9	Leishmania infantum	99%	100%
C9ZZZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	96%
E9B2C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q5T0	Leishmania major	92%	100%
V5DTD7	Trypanosoma cruzi	31%	95%