LeishMANIAdb
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FAD_binding_3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
FAD_binding_3 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X516_LEIDO
TriTrypDb:
LdBPK_313270.1 , LdCL_310041000 , LDHU3_31.5530
Length:
427

Annotations

LeishMANIAdb annotations

Consists of a conserved FAD-binding domain. No TM segments are present.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A0A3S7X516
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X516

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 287 291 PF00656 0.641
CLV_C14_Caspase3-7 399 403 PF00656 0.508
CLV_MEL_PAP_1 329 335 PF00089 0.291
CLV_NRD_NRD_1 111 113 PF00675 0.304
CLV_NRD_NRD_1 194 196 PF00675 0.352
CLV_NRD_NRD_1 423 425 PF00675 0.530
CLV_NRD_NRD_1 81 83 PF00675 0.353
CLV_NRD_NRD_1 92 94 PF00675 0.257
CLV_PCSK_KEX2_1 194 196 PF00082 0.292
CLV_PCSK_KEX2_1 391 393 PF00082 0.292
CLV_PCSK_KEX2_1 423 425 PF00082 0.491
CLV_PCSK_KEX2_1 80 82 PF00082 0.346
CLV_PCSK_KEX2_1 92 94 PF00082 0.270
CLV_PCSK_PC1ET2_1 391 393 PF00082 0.303
CLV_PCSK_PC7_1 88 94 PF00082 0.342
CLV_PCSK_SKI1_1 102 106 PF00082 0.323
CLV_PCSK_SKI1_1 112 116 PF00082 0.260
CLV_PCSK_SKI1_1 281 285 PF00082 0.447
CLV_PCSK_SKI1_1 93 97 PF00082 0.346
DEG_APCC_DBOX_1 111 119 PF00400 0.597
DEG_SCF_FBW7_2 129 136 PF00400 0.465
DEG_SPOP_SBC_1 4 8 PF00917 0.562
DOC_MAPK_gen_1 159 168 PF00069 0.465
DOC_MAPK_gen_1 69 77 PF00069 0.488
DOC_MAPK_HePTP_8 219 231 PF00069 0.548
DOC_MAPK_MEF2A_6 222 231 PF00069 0.555
DOC_PP2B_LxvP_1 32 35 PF13499 0.232
DOC_PP4_FxxP_1 126 129 PF00568 0.482
DOC_SPAK_OSR1_1 330 334 PF12202 0.490
DOC_USP7_MATH_1 12 16 PF00917 0.612
DOC_USP7_MATH_1 35 39 PF00917 0.407
DOC_USP7_MATH_1 5 9 PF00917 0.595
DOC_WW_Pin1_4 125 130 PF00397 0.554
DOC_WW_Pin1_4 210 215 PF00397 0.542
DOC_WW_Pin1_4 318 323 PF00397 0.517
DOC_WW_Pin1_4 80 85 PF00397 0.565
LIG_14-3-3_CanoR_1 11 17 PF00244 0.617
LIG_14-3-3_CanoR_1 112 118 PF00244 0.621
LIG_14-3-3_CanoR_1 159 168 PF00244 0.476
LIG_14-3-3_CanoR_1 19 27 PF00244 0.569
LIG_14-3-3_CanoR_1 281 289 PF00244 0.674
LIG_14-3-3_CanoR_1 310 315 PF00244 0.589
LIG_14-3-3_CanoR_1 93 103 PF00244 0.533
LIG_Actin_WH2_2 154 169 PF00022 0.489
LIG_Actin_WH2_2 286 303 PF00022 0.542
LIG_AP2alpha_2 344 346 PF02296 0.472
LIG_BRCT_BRCA1_1 245 249 PF00533 0.612
LIG_Clathr_ClatBox_1 230 234 PF01394 0.567
LIG_Clathr_ClatBox_1 340 344 PF01394 0.466
LIG_FHA_1 151 157 PF00498 0.523
LIG_FHA_1 161 167 PF00498 0.449
LIG_FHA_1 188 194 PF00498 0.540
LIG_FHA_1 24 30 PF00498 0.200
LIG_FHA_1 243 249 PF00498 0.522
LIG_FHA_1 319 325 PF00498 0.515
LIG_FHA_1 98 104 PF00498 0.502
LIG_FHA_2 199 205 PF00498 0.491
LIG_FHA_2 74 80 PF00498 0.589
LIG_Integrin_RGD_1 349 351 PF01839 0.274
LIG_Integrin_RGD_1 374 376 PF01839 0.427
LIG_LIR_Gen_1 163 172 PF02991 0.478
LIG_LIR_Gen_1 213 221 PF02991 0.597
LIG_LIR_Nem_3 163 168 PF02991 0.489
LIG_LIR_Nem_3 274 280 PF02991 0.501
LIG_MYND_1 129 133 PF01753 0.488
LIG_Rb_LxCxE_1 105 116 PF01857 0.528
LIG_Rb_pABgroove_1 225 233 PF01858 0.516
LIG_SH2_NCK_1 86 90 PF00017 0.563
LIG_SH3_3 114 120 PF00018 0.528
LIG_SH3_3 339 345 PF00018 0.500
LIG_SH3_3 414 420 PF00018 0.588
LIG_SUMO_SIM_anti_2 225 232 PF11976 0.555
LIG_SUMO_SIM_anti_2 253 259 PF11976 0.467
LIG_SUMO_SIM_anti_2 38 44 PF11976 0.232
LIG_SUMO_SIM_anti_2 72 79 PF11976 0.549
LIG_SUMO_SIM_par_1 20 28 PF11976 0.489
LIG_UBA3_1 206 211 PF00899 0.538
MOD_CDK_SPxK_1 129 135 PF00069 0.607
MOD_CDK_SPxxK_3 318 325 PF00069 0.510
MOD_CK1_1 14 20 PF00069 0.589
MOD_CK1_1 242 248 PF00069 0.515
MOD_CK1_1 253 259 PF00069 0.451
MOD_CK1_1 282 288 PF00069 0.563
MOD_CK1_1 30 36 PF00069 0.186
MOD_CK1_1 415 421 PF00069 0.630
MOD_CK1_1 73 79 PF00069 0.551
MOD_CK2_1 198 204 PF00069 0.496
MOD_CK2_1 73 79 PF00069 0.548
MOD_Cter_Amidation 368 371 PF01082 0.339
MOD_GlcNHglycan 147 150 PF01048 0.274
MOD_GlcNHglycan 179 182 PF01048 0.377
MOD_GlcNHglycan 269 272 PF01048 0.330
MOD_GlcNHglycan 281 284 PF01048 0.346
MOD_GlcNHglycan 29 32 PF01048 0.232
MOD_GlcNHglycan 358 363 PF01048 0.189
MOD_GlcNHglycan 7 10 PF01048 0.418
MOD_GSK3_1 125 132 PF00069 0.566
MOD_GSK3_1 14 21 PF00069 0.732
MOD_GSK3_1 173 180 PF00069 0.541
MOD_GSK3_1 23 30 PF00069 0.376
MOD_GSK3_1 239 246 PF00069 0.529
MOD_GSK3_1 281 288 PF00069 0.579
MOD_GSK3_1 3 10 PF00069 0.607
MOD_N-GLC_1 73 78 PF02516 0.380
MOD_NEK2_1 157 162 PF00069 0.509
MOD_NEK2_1 27 32 PF00069 0.270
MOD_NEK2_1 279 284 PF00069 0.627
MOD_NEK2_1 36 41 PF00069 0.213
MOD_PIKK_1 304 310 PF00454 0.609
MOD_PK_1 113 119 PF00069 0.546
MOD_PK_1 135 141 PF00069 0.537
MOD_PK_1 243 249 PF00069 0.532
MOD_PK_1 310 316 PF00069 0.560
MOD_PKA_2 10 16 PF00069 0.620
MOD_PKA_2 18 24 PF00069 0.573
MOD_PKA_2 242 248 PF00069 0.549
MOD_PKA_2 70 76 PF00069 0.521
MOD_PKB_1 80 88 PF00069 0.619
MOD_Plk_1 243 249 PF00069 0.568
MOD_Plk_1 253 259 PF00069 0.514
MOD_Plk_1 289 295 PF00069 0.614
MOD_Plk_1 358 364 PF00069 0.442
MOD_Plk_1 73 79 PF00069 0.546
MOD_Plk_1 97 103 PF00069 0.516
MOD_Plk_4 113 119 PF00069 0.553
MOD_Plk_4 135 141 PF00069 0.514
MOD_Plk_4 243 249 PF00069 0.596
MOD_Plk_4 253 259 PF00069 0.571
MOD_Plk_4 299 305 PF00069 0.494
MOD_Plk_4 376 382 PF00069 0.522
MOD_Plk_4 73 79 PF00069 0.580
MOD_ProDKin_1 125 131 PF00069 0.553
MOD_ProDKin_1 210 216 PF00069 0.542
MOD_ProDKin_1 318 324 PF00069 0.512
MOD_ProDKin_1 80 86 PF00069 0.561
MOD_SUMO_for_1 324 327 PF00179 0.548
MOD_SUMO_rev_2 106 115 PF00179 0.526
TRG_DiLeu_BaLyEn_6 362 367 PF01217 0.583
TRG_DiLeu_BaLyEn_6 408 413 PF01217 0.639
TRG_ER_diArg_1 193 195 PF00400 0.483
TRG_ER_diArg_1 422 424 PF00400 0.730
TRG_ER_diArg_1 80 82 PF00400 0.579
TRG_ER_diArg_1 91 93 PF00400 0.461
TRG_Pf-PMV_PEXEL_1 125 130 PF00026 0.376
TRG_Pf-PMV_PEXEL_1 159 164 PF00026 0.269
TRG_Pf-PMV_PEXEL_1 398 402 PF00026 0.342

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBQ2 Leptomonas seymouri 71% 100%
A0A0S4IXP3 Bodo saltans 46% 100%
A0A1X0NIV3 Trypanosomatidae 56% 100%
A4HJV9 Leishmania braziliensis 88% 100%
A4I7C1 Leishmania infantum 100% 100%
C9ZMI3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
C9ZWI4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9B2B4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q5U2 Leishmania major 96% 100%
V5B4U1 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS