BTB/POZ domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X510_LEIDO

TriTrypDb:

LdBPK_313200.1 , LdCL_310040300 , LDHU3_31.5460

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X510

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X510

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043933	protein-containing complex organization	4	2
GO:0051259	protein complex oligomerization	6	2
GO:0051260	protein homooligomerization	7	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.671
CLV_C14_Caspase3-7	186	190	PF00656	0.529
CLV_NRD_NRD_1	142	144	PF00675	0.749
CLV_NRD_NRD_1	63	65	PF00675	0.695
CLV_NRD_NRD_1	78	80	PF00675	0.559
CLV_PCSK_KEX2_1	144	146	PF00082	0.756
CLV_PCSK_KEX2_1	63	65	PF00082	0.652
CLV_PCSK_KEX2_1	77	79	PF00082	0.560
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.747
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.576
CLV_PCSK_SKI1_1	107	111	PF00082	0.416
CLV_PCSK_SKI1_1	313	317	PF00082	0.477
CLV_PCSK_SKI1_1	53	57	PF00082	0.584
DOC_CKS1_1	271	276	PF01111	0.583
DOC_CYCLIN_RxL_1	101	113	PF00134	0.481
DOC_CYCLIN_RxL_1	50	58	PF00134	0.582
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.490
DOC_MAPK_gen_1	164	173	PF00069	0.526
DOC_MAPK_MEF2A_6	167	175	PF00069	0.459
DOC_PP1_RVXF_1	121	127	PF00149	0.378
DOC_PP1_RVXF_1	287	293	PF00149	0.463
DOC_PP1_RVXF_1	311	317	PF00149	0.481
DOC_PP1_RVXF_1	319	326	PF00149	0.494
DOC_PP4_FxxP_1	217	220	PF00568	0.580
DOC_SPAK_OSR1_1	207	211	PF12202	0.569
DOC_USP7_MATH_1	136	140	PF00917	0.715
DOC_USP7_MATH_1	157	161	PF00917	0.508
DOC_USP7_MATH_1	345	349	PF00917	0.411
DOC_USP7_MATH_1	350	354	PF00917	0.444
DOC_WW_Pin1_4	270	275	PF00397	0.579
LIG_14-3-3_CanoR_1	207	217	PF00244	0.560
LIG_14-3-3_CanoR_1	352	360	PF00244	0.443
LIG_14-3-3_CanoR_1	44	54	PF00244	0.702
LIG_BRCT_BRCA1_1	115	119	PF00533	0.385
LIG_BRCT_BRCA1_1	235	239	PF00533	0.479
LIG_FHA_1	153	159	PF00498	0.638
LIG_FHA_2	151	157	PF00498	0.671
LIG_LIR_Nem_3	194	200	PF02991	0.364
LIG_MLH1_MIPbox_1	235	239	PF16413	0.479
LIG_NRBOX	171	177	PF00104	0.397
LIG_PCNA_yPIPBox_3	164	172	PF02747	0.424
LIG_Pex14_1	204	208	PF04695	0.429
LIG_PTB_Apo_2	202	209	PF02174	0.437
LIG_PTB_Apo_2	325	332	PF02174	0.529
LIG_PTB_Phospho_1	325	331	PF10480	0.529
LIG_SH2_GRB2like	284	287	PF00017	0.391
LIG_SH2_STAT5	216	219	PF00017	0.589
LIG_SH2_STAT5	293	296	PF00017	0.546
LIG_SH2_STAT5	331	334	PF00017	0.520
LIG_SH3_3	156	162	PF00018	0.561
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.535
LIG_SUMO_SIM_anti_2	353	361	PF11976	0.554
LIG_SUMO_SIM_par_1	155	163	PF11976	0.572
LIG_TRAF2_1	26	29	PF00917	0.582
LIG_TRAF2_1	267	270	PF00917	0.606
LIG_UBA3_1	171	180	PF00899	0.448
LIG_WRC_WIRS_1	93	98	PF05994	0.359
MOD_CK1_1	128	134	PF00069	0.624
MOD_CK1_1	354	360	PF00069	0.557
MOD_CK1_1	49	55	PF00069	0.723
MOD_CK1_1	92	98	PF00069	0.514
MOD_CK2_1	157	163	PF00069	0.592
MOD_CK2_1	187	193	PF00069	0.511
MOD_CK2_1	23	29	PF00069	0.547
MOD_CK2_1	264	270	PF00069	0.509
MOD_CK2_1	65	71	PF00069	0.609
MOD_Cter_Amidation	141	144	PF01082	0.624
MOD_GlcNHglycan	130	133	PF01048	0.552
MOD_GlcNHglycan	137	141	PF01048	0.611
MOD_GlcNHglycan	200	203	PF01048	0.567
MOD_GlcNHglycan	266	269	PF01048	0.536
MOD_GlcNHglycan	57	60	PF01048	0.713
MOD_GSK3_1	113	120	PF00069	0.514
MOD_GSK3_1	221	228	PF00069	0.574
MOD_GSK3_1	233	240	PF00069	0.386
MOD_GSK3_1	260	267	PF00069	0.476
MOD_GSK3_1	34	41	PF00069	0.668
MOD_GSK3_1	350	357	PF00069	0.548
MOD_GSK3_1	45	52	PF00069	0.567
MOD_GSK3_1	81	88	PF00069	0.508
MOD_NEK2_1	1	6	PF00069	0.555
MOD_NEK2_1	103	108	PF00069	0.503
MOD_NEK2_1	117	122	PF00069	0.314
MOD_NEK2_1	126	131	PF00069	0.435
MOD_NEK2_1	203	208	PF00069	0.483
MOD_NEK2_1	221	226	PF00069	0.583
MOD_NEK2_1	238	243	PF00069	0.336
MOD_NEK2_1	248	253	PF00069	0.391
MOD_NEK2_1	260	265	PF00069	0.462
MOD_NEK2_1	38	43	PF00069	0.651
MOD_NEK2_1	55	60	PF00069	0.652
MOD_NEK2_2	187	192	PF00069	0.507
MOD_NEK2_2	288	293	PF00069	0.485
MOD_PIKK_1	210	216	PF00454	0.488
MOD_PIKK_1	248	254	PF00454	0.484
MOD_PIKK_1	351	357	PF00454	0.534
MOD_PKA_1	143	149	PF00069	0.731
MOD_PKA_1	63	69	PF00069	0.532
MOD_PKA_2	351	357	PF00069	0.463
MOD_PKA_2	63	69	PF00069	0.619
MOD_PKB_1	141	149	PF00069	0.588
MOD_Plk_1	150	156	PF00069	0.572
MOD_Plk_1	246	252	PF00069	0.497
MOD_Plk_2-3	65	71	PF00069	0.637
MOD_Plk_4	113	119	PF00069	0.389
MOD_Plk_4	288	294	PF00069	0.489
MOD_Plk_4	354	360	PF00069	0.537
MOD_Plk_4	46	52	PF00069	0.705
MOD_Plk_4	7	13	PF00069	0.601
MOD_Plk_4	89	95	PF00069	0.519
MOD_ProDKin_1	270	276	PF00069	0.580
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.540
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.696
TRG_ENDOCYTIC_2	197	200	PF00928	0.424
TRG_ENDOCYTIC_2	80	83	PF00928	0.588
TRG_ER_diArg_1	62	64	PF00400	0.553
TRG_ER_diArg_1	78	80	PF00400	0.399
TRG_NLS_MonoExtC_3	142	147	PF00514	0.622
TRG_NLS_MonoExtN_4	141	147	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N2	Leptomonas seymouri	62%	100%
A0A1X0NIJ4	Trypanosomatidae	37%	100%
A0A3R7K9T3	Trypanosoma rangeli	35%	100%
A0A422P2R6	Trypanosoma rangeli	24%	70%
A4HJU7	Leishmania braziliensis	81%	100%
A4HJV2	Leishmania braziliensis	81%	100%
A4I7B4	Leishmania infantum	99%	100%
C9ZWJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B2A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q5U9	Leishmania major	95%	100%
V5B9A8	Trypanosoma cruzi	36%	100%
V5DUU9	Trypanosoma cruzi	26%	71%