Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X509_LEIDO

TriTrypDb:

LdBPK_320010.1 , LdCL_320005000 , LDHU3_32.0020

Length:

134

Annotations

LeishMANIAdb annotations

A protein with unclear topology, conserved but entirely restricted to Kinetoplastida.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7X509

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X509

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.648
CLV_NRD_NRD_1	36	38	PF00675	0.455
CLV_NRD_NRD_1	8	10	PF00675	0.480
CLV_PCSK_KEX2_1	36	38	PF00082	0.464
CLV_PCSK_KEX2_1	8	10	PF00082	0.480
DEG_Nend_Nbox_1	1	3	PF02207	0.664
DOC_USP7_MATH_1	126	130	PF00917	0.387
DOC_USP7_MATH_1	19	23	PF00917	0.701
DOC_USP7_UBL2_3	121	125	PF12436	0.441
DOC_USP7_UBL2_3	23	27	PF12436	0.580
DOC_WW_Pin1_4	9	14	PF00397	0.679
LIG_14-3-3_CanoR_1	3	10	PF00244	0.639
LIG_14-3-3_CanoR_1	71	76	PF00244	0.411
LIG_BRCT_BRCA1_1	128	132	PF00533	0.375
LIG_FHA_2	110	116	PF00498	0.396
LIG_LIR_Apic_2	17	21	PF02991	0.671
LIG_LIR_Gen_1	44	55	PF02991	0.491
LIG_LIR_Gen_1	93	104	PF02991	0.415
LIG_LIR_Nem_3	29	34	PF02991	0.664
LIG_LIR_Nem_3	44	50	PF02991	0.394
LIG_LIR_Nem_3	52	56	PF02991	0.376
LIG_LIR_Nem_3	60	64	PF02991	0.339
LIG_Pex14_2	53	57	PF04695	0.362
LIG_SH2_CRK	47	51	PF00017	0.401
LIG_SH2_STAT5	67	70	PF00017	0.362
LIG_SH3_3	80	86	PF00018	0.489
LIG_WRC_WIRS_1	58	63	PF05994	0.346
MOD_CK1_1	74	80	PF00069	0.536
MOD_CK2_1	109	115	PF00069	0.556
MOD_CK2_1	32	38	PF00069	0.515
MOD_GlcNHglycan	122	125	PF01048	0.554
MOD_GlcNHglycan	98	102	PF01048	0.628
MOD_GSK3_1	116	123	PF00069	0.543
MOD_GSK3_1	32	39	PF00069	0.533
MOD_N-GLC_1	69	74	PF02516	0.578
MOD_NEK2_1	2	7	PF00069	0.525
MOD_NEK2_1	57	62	PF00069	0.392
MOD_NEK2_1	69	74	PF00069	0.562
MOD_PK_1	36	42	PF00069	0.502
MOD_PKA_1	36	42	PF00069	0.580
MOD_PKA_2	2	8	PF00069	0.586
MOD_PKA_2	32	38	PF00069	0.589
MOD_Plk_2-3	109	115	PF00069	0.541
MOD_Plk_4	126	132	PF00069	0.461
MOD_ProDKin_1	9	15	PF00069	0.611
MOD_SUMO_rev_2	100	110	PF00179	0.544
TRG_ENDOCYTIC_2	31	34	PF00928	0.595
TRG_ENDOCYTIC_2	47	50	PF00928	0.309
TRG_ER_diArg_1	7	9	PF00400	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P8	Leptomonas seymouri	75%	100%
A0A0S4J967	Bodo saltans	44%	100%
A0A1X0PA05	Trypanosomatidae	61%	99%
A4HJY0	Leishmania braziliensis	79%	100%
A4I7G4	Leishmania infantum	97%	100%
D0A202	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9B2C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5T5	Leishmania major	96%	100%