Huntingtin interacting protein 1 related

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X505_LEIDO

TriTrypDb:

LdBPK_313120.1 , LdCL_310039500 , LDHU3_31.5330

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X505

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X505

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.593
CLV_NRD_NRD_1	109	111	PF00675	0.652
CLV_NRD_NRD_1	125	127	PF00675	0.399
CLV_NRD_NRD_1	207	209	PF00675	0.600
CLV_NRD_NRD_1	262	264	PF00675	0.683
CLV_NRD_NRD_1	489	491	PF00675	0.748
CLV_NRD_NRD_1	519	521	PF00675	0.505
CLV_NRD_NRD_1	81	83	PF00675	0.763
CLV_PCSK_FUR_1	169	173	PF00082	0.573
CLV_PCSK_KEX2_1	109	111	PF00082	0.577
CLV_PCSK_KEX2_1	171	173	PF00082	0.580
CLV_PCSK_KEX2_1	207	209	PF00082	0.616
CLV_PCSK_KEX2_1	228	230	PF00082	0.646
CLV_PCSK_KEX2_1	264	266	PF00082	0.678
CLV_PCSK_KEX2_1	276	278	PF00082	0.489
CLV_PCSK_KEX2_1	389	391	PF00082	0.750
CLV_PCSK_KEX2_1	489	491	PF00082	0.744
CLV_PCSK_KEX2_1	81	83	PF00082	0.802
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.580
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.646
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.678
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.489
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.750
CLV_PCSK_PC7_1	224	230	PF00082	0.611
CLV_PCSK_SKI1_1	416	420	PF00082	0.567
CLV_PCSK_SKI1_1	87	91	PF00082	0.682
CLV_Separin_Metazoa	221	225	PF03568	0.623
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DOC_CKS1_1	475	480	PF01111	0.631
DOC_CKS1_1	516	521	PF01111	0.796
DOC_MAPK_gen_1	109	117	PF00069	0.439
DOC_MAPK_gen_1	489	497	PF00069	0.630
DOC_MAPK_MEF2A_6	109	117	PF00069	0.439
DOC_MAPK_MEF2A_6	406	415	PF00069	0.672
DOC_PP1_RVXF_1	242	248	PF00149	0.549
DOC_PP1_RVXF_1	30	37	PF00149	0.453
DOC_PP2B_LxvP_1	48	51	PF13499	0.561
DOC_PP2B_LxvP_1	8	11	PF13499	0.565
DOC_PP4_FxxP_1	36	39	PF00568	0.446
DOC_USP7_MATH_1	137	141	PF00917	0.606
DOC_USP7_MATH_1	252	256	PF00917	0.652
DOC_USP7_MATH_1	285	289	PF00917	0.725
DOC_USP7_MATH_1	376	380	PF00917	0.688
DOC_USP7_MATH_1	399	403	PF00917	0.695
DOC_USP7_MATH_1	425	429	PF00917	0.730
DOC_USP7_MATH_1	457	461	PF00917	0.693
DOC_USP7_MATH_1	485	489	PF00917	0.770
DOC_USP7_MATH_1	9	13	PF00917	0.562
DOC_WW_Pin1_4	34	39	PF00397	0.544
DOC_WW_Pin1_4	429	434	PF00397	0.775
DOC_WW_Pin1_4	441	446	PF00397	0.604
DOC_WW_Pin1_4	474	479	PF00397	0.734
DOC_WW_Pin1_4	515	520	PF00397	0.792
DOC_WW_Pin1_4	55	60	PF00397	0.546
DOC_WW_Pin1_4	71	76	PF00397	0.792
DOC_WW_Pin1_4	91	96	PF00397	0.659
LIG_14-3-3_CanoR_1	360	368	PF00244	0.532
LIG_14-3-3_CanoR_1	489	498	PF00244	0.793
LIG_BRCT_BRCA1_1	25	29	PF00533	0.552
LIG_BRCT_BRCA1_1	32	36	PF00533	0.507
LIG_BRCT_BRCA1_1	493	497	PF00533	0.738
LIG_EVH1_1	474	478	PF00568	0.629
LIG_FHA_1	149	155	PF00498	0.448
LIG_FHA_1	240	246	PF00498	0.623
LIG_FHA_1	403	409	PF00498	0.695
LIG_FHA_1	91	97	PF00498	0.617
LIG_FHA_2	100	106	PF00498	0.671
LIG_FHA_2	181	187	PF00498	0.614
LIG_FHA_2	257	263	PF00498	0.548
LIG_FHA_2	494	500	PF00498	0.644
LIG_LIR_Apic_2	33	39	PF02991	0.446
LIG_LIR_Gen_1	288	297	PF02991	0.678
LIG_LIR_Gen_1	510	519	PF02991	0.783
LIG_LIR_Nem_3	101	106	PF02991	0.572
LIG_LIR_Nem_3	288	293	PF02991	0.746
LIG_LIR_Nem_3	37	43	PF02991	0.526
LIG_LIR_Nem_3	510	516	PF02991	0.779
LIG_Pex14_2	36	40	PF04695	0.443
LIG_Pex14_2	513	517	PF04695	0.787
LIG_SH2_CRK	31	35	PF00017	0.453
LIG_SH2_NCK_1	231	235	PF00017	0.639
LIG_SH2_STAT5	156	159	PF00017	0.644
LIG_SH2_STAT5	237	240	PF00017	0.555
LIG_SH3_1	472	478	PF00018	0.672
LIG_SH3_3	35	41	PF00018	0.540
LIG_SH3_3	47	53	PF00018	0.468
LIG_SH3_3	472	478	PF00018	0.668
LIG_SH3_3	479	485	PF00018	0.640
LIG_SH3_3	492	498	PF00018	0.596
LIG_SH3_3	89	95	PF00018	0.678
LIG_SH3_4	308	315	PF00018	0.749
LIG_SUMO_SIM_par_1	112	119	PF11976	0.439
LIG_SUMO_SIM_par_1	40	46	PF11976	0.447
LIG_SUMO_SIM_par_1	409	414	PF11976	0.626
LIG_TRAF2_1	202	205	PF00917	0.608
LIG_TRAF2_1	213	216	PF00917	0.532
LIG_TRAF2_1	259	262	PF00917	0.662
LIG_WRC_WIRS_1	100	105	PF05994	0.596
MOD_CDK_SPK_2	515	520	PF00069	0.792
MOD_CDK_SPxK_1	515	521	PF00069	0.793
MOD_CDK_SPxxK_3	429	436	PF00069	0.712
MOD_CK1_1	12	18	PF00069	0.684
MOD_CK1_1	140	146	PF00069	0.436
MOD_CK1_1	288	294	PF00069	0.635
MOD_CK1_1	402	408	PF00069	0.700
MOD_CK1_1	428	434	PF00069	0.771
MOD_CK1_1	460	466	PF00069	0.816
MOD_CK1_1	507	513	PF00069	0.704
MOD_CK1_1	99	105	PF00069	0.561
MOD_CK2_1	180	186	PF00069	0.610
MOD_CK2_1	256	262	PF00069	0.622
MOD_CK2_1	345	351	PF00069	0.660
MOD_CK2_1	376	382	PF00069	0.710
MOD_CK2_1	493	499	PF00069	0.678
MOD_CK2_1	99	105	PF00069	0.677
MOD_GlcNHglycan	139	142	PF01048	0.653
MOD_GlcNHglycan	17	20	PF01048	0.491
MOD_GlcNHglycan	2	5	PF01048	0.457
MOD_GlcNHglycan	289	293	PF01048	0.675
MOD_GlcNHglycan	347	350	PF01048	0.683
MOD_GlcNHglycan	427	430	PF01048	0.651
MOD_GlcNHglycan	433	436	PF01048	0.707
MOD_GlcNHglycan	459	462	PF01048	0.787
MOD_GlcNHglycan	463	466	PF01048	0.786
MOD_GlcNHglycan	468	471	PF01048	0.724
MOD_GlcNHglycan	69	72	PF01048	0.721
MOD_GSK3_1	181	188	PF00069	0.497
MOD_GSK3_1	252	259	PF00069	0.495
MOD_GSK3_1	30	37	PF00069	0.613
MOD_GSK3_1	368	375	PF00069	0.629
MOD_GSK3_1	407	414	PF00069	0.692
MOD_GSK3_1	425	432	PF00069	0.558
MOD_GSK3_1	457	464	PF00069	0.819
MOD_GSK3_1	480	487	PF00069	0.810
MOD_GSK3_1	489	496	PF00069	0.646
MOD_GSK3_1	67	74	PF00069	0.697
MOD_GSK3_1	9	16	PF00069	0.629
MOD_N-GLC_1	457	462	PF02516	0.755
MOD_N-GLC_1	90	95	PF02516	0.673
MOD_NEK2_1	17	22	PF00069	0.682
MOD_NEK2_1	256	261	PF00069	0.619
MOD_NEK2_1	332	337	PF00069	0.705
MOD_NEK2_1	368	373	PF00069	0.660
MOD_NEK2_1	411	416	PF00069	0.656
MOD_NEK2_1	67	72	PF00069	0.659
MOD_NEK2_1	90	95	PF00069	0.575
MOD_NEK2_2	512	517	PF00069	0.782
MOD_PKA_1	489	495	PF00069	0.708
MOD_PKA_2	295	301	PF00069	0.748
MOD_PKA_2	359	365	PF00069	0.702
MOD_PKA_2	392	398	PF00069	0.742
MOD_PKA_2	489	495	PF00069	0.802
MOD_Plk_1	288	294	PF00069	0.647
MOD_Plk_1	411	417	PF00069	0.655
MOD_Plk_2-3	493	499	PF00069	0.651
MOD_Plk_4	512	518	PF00069	0.783
MOD_ProDKin_1	34	40	PF00069	0.543
MOD_ProDKin_1	429	435	PF00069	0.776
MOD_ProDKin_1	441	447	PF00069	0.604
MOD_ProDKin_1	474	480	PF00069	0.736
MOD_ProDKin_1	515	521	PF00069	0.793
MOD_ProDKin_1	55	61	PF00069	0.544
MOD_ProDKin_1	71	77	PF00069	0.790
MOD_ProDKin_1	91	97	PF00069	0.656
MOD_SUMO_for_1	170	173	PF00179	0.574
MOD_SUMO_for_1	243	246	PF00179	0.622
MOD_SUMO_rev_2	173	181	PF00179	0.581
TRG_DiLeu_BaEn_1	364	369	PF01217	0.512
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.797
TRG_ENDOCYTIC_2	220	223	PF00928	0.663
TRG_ENDOCYTIC_2	231	234	PF00928	0.342
TRG_ENDOCYTIC_2	31	34	PF00928	0.594
TRG_ER_diArg_1	263	266	PF00400	0.682
TRG_ER_diArg_1	80	82	PF00400	0.692
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.776

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJU0	Leishmania braziliensis	62%	100%
A4I7A6	Leishmania infantum	98%	100%
E9B2A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q5V7	Leishmania major	84%	100%