ZIP Zinc transporter family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

iron/zinc transporter protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X501_LEIDO

TriTrypDb:

LdBPK_313190.1 , LdCL_310040100 , LdCL_310040200 , LDHU3_31.5420

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 28
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	29
GO:0110165	cellular anatomical entity	1	29
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	3

Expansion

Sequence features

A0A3S7X501

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X501

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	3
GO:0006810	transport	3	3
GO:0006811	monoatomic ion transport	4	3
GO:0006812	monoatomic cation transport	5	3
GO:0006829	zinc ion transport	8	3
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0009987	cellular process	1	3
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	3
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	3
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071577	zinc ion transmembrane transport	6	3
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098655	monoatomic cation transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098662	inorganic cation transmembrane transport	5	3
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	29
GO:0008324	monoatomic cation transmembrane transporter activity	4	29
GO:0015075	monoatomic ion transmembrane transporter activity	3	29
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	29
GO:0022857	transmembrane transporter activity	2	29
GO:0022890	inorganic cation transmembrane transporter activity	4	29
GO:0046873	metal ion transmembrane transporter activity	5	29
GO:0005385	zinc ion transmembrane transporter activity	7	3
GO:0046915	transition metal ion transmembrane transporter activity	6	3
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.508
CLV_MEL_PAP_1	18	24	PF00089	0.526
CLV_NRD_NRD_1	205	207	PF00675	0.340
CLV_PCSK_KEX2_1	164	166	PF00082	0.302
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.302
CLV_PCSK_SKI1_1	157	161	PF00082	0.329
CLV_PCSK_SKI1_1	300	304	PF00082	0.405
CLV_PCSK_SKI1_1	407	411	PF00082	0.291
CLV_PCSK_SKI1_1	45	49	PF00082	0.455
DEG_Nend_UBRbox_2	1	3	PF02207	0.509
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.303
DOC_MAPK_DCC_7	294	304	PF00069	0.217
DOC_MAPK_gen_1	407	416	PF00069	0.446
DOC_MAPK_HePTP_8	322	334	PF00069	0.542
DOC_MAPK_MEF2A_6	300	308	PF00069	0.240
DOC_MAPK_MEF2A_6	325	334	PF00069	0.537
DOC_MAPK_MEF2A_6	407	416	PF00069	0.472
DOC_MAPK_RevD_3	280	295	PF00069	0.219
DOC_PP2B_LxvP_1	340	343	PF13499	0.367
DOC_USP7_MATH_1	28	32	PF00917	0.392
DOC_USP7_MATH_1	316	320	PF00917	0.328
DOC_USP7_UBL2_3	160	164	PF12436	0.545
DOC_USP7_UBL2_3	171	175	PF12436	0.402
DOC_WW_Pin1_4	181	186	PF00397	0.561
DOC_WW_Pin1_4	232	237	PF00397	0.550
DOC_WW_Pin1_4	353	358	PF00397	0.244
LIG_14-3-3_CanoR_1	206	212	PF00244	0.431
LIG_14-3-3_CanoR_1	21	25	PF00244	0.433
LIG_14-3-3_CanoR_1	268	278	PF00244	0.453
LIG_eIF4E_1	133	139	PF01652	0.312
LIG_eIF4E_1	382	388	PF01652	0.297
LIG_FHA_1	1	7	PF00498	0.361
LIG_FHA_1	10	16	PF00498	0.431
LIG_FHA_1	104	110	PF00498	0.346
LIG_FHA_1	190	196	PF00498	0.541
LIG_FHA_1	216	222	PF00498	0.567
LIG_FHA_1	31	37	PF00498	0.448
LIG_FHA_1	327	333	PF00498	0.556
LIG_FHA_1	384	390	PF00498	0.331
LIG_FHA_1	96	102	PF00498	0.343
LIG_GBD_Chelix_1	139	147	PF00786	0.312
LIG_GBD_Chelix_1	332	340	PF00786	0.293
LIG_HP1_1	230	234	PF01393	0.370
LIG_LIR_Gen_1	363	372	PF02991	0.301
LIG_LIR_Nem_3	128	132	PF02991	0.242
LIG_LIR_Nem_3	284	289	PF02991	0.324
LIG_LIR_Nem_3	363	368	PF02991	0.334
LIG_LYPXL_yS_3	86	89	PF13949	0.417
LIG_PDZ_Wminus1_1	430	432	PF00595	0.458
LIG_Pex14_2	308	312	PF04695	0.357
LIG_Pex14_2	415	419	PF04695	0.263
LIG_Pex14_2	61	65	PF04695	0.351
LIG_SH2_CRK	129	133	PF00017	0.258
LIG_SH2_STAT5	133	136	PF00017	0.440
LIG_SH2_STAT5	14	17	PF00017	0.435
LIG_SH2_STAT5	266	269	PF00017	0.546
LIG_SH2_STAT5	382	385	PF00017	0.278
LIG_SH2_STAT5	399	402	PF00017	0.451
LIG_SH2_STAT5	88	91	PF00017	0.474
LIG_SH3_3	19	25	PF00018	0.477
LIG_SH3_3	233	239	PF00018	0.446
LIG_SH3_3	255	261	PF00018	0.502
LIG_SH3_3	81	87	PF00018	0.402
LIG_SUMO_SIM_anti_2	329	334	PF11976	0.534
LIG_SUMO_SIM_anti_2	367	374	PF11976	0.244
LIG_SUMO_SIM_par_1	100	106	PF11976	0.280
LIG_SUMO_SIM_par_1	230	235	PF11976	0.415
LIG_SUMO_SIM_par_1	367	374	PF11976	0.358
LIG_SUMO_SIM_par_1	385	391	PF11976	0.178
LIG_SxIP_EBH_1	66	78	PF03271	0.330
LIG_TYR_ITIM	84	89	PF00017	0.383
LIG_WW_3	259	263	PF00397	0.383
MOD_CK1_1	103	109	PF00069	0.283
MOD_CK1_1	210	216	PF00069	0.548
MOD_CK1_1	358	364	PF00069	0.283
MOD_CK1_1	95	101	PF00069	0.375
MOD_GlcNHglycan	192	195	PF01048	0.357
MOD_GlcNHglycan	212	215	PF01048	0.353
MOD_GlcNHglycan	22	25	PF01048	0.692
MOD_GlcNHglycan	271	274	PF01048	0.313
MOD_GlcNHglycan	326	329	PF01048	0.302
MOD_GlcNHglycan	340	343	PF01048	0.350
MOD_GlcNHglycan	357	360	PF01048	0.476
MOD_GlcNHglycan	362	365	PF01048	0.497
MOD_GlcNHglycan	94	97	PF01048	0.398
MOD_GSK3_1	206	213	PF00069	0.538
MOD_GSK3_1	351	358	PF00069	0.306
MOD_GSK3_1	360	367	PF00069	0.236
MOD_GSK3_1	4	11	PF00069	0.448
MOD_GSK3_1	45	52	PF00069	0.323
MOD_GSK3_1	64	71	PF00069	0.281
MOD_GSK3_1	88	95	PF00069	0.518
MOD_NEK2_1	102	107	PF00069	0.273
MOD_NEK2_1	278	283	PF00069	0.327
MOD_NEK2_1	336	341	PF00069	0.306
MOD_NEK2_1	360	365	PF00069	0.263
MOD_NEK2_1	383	388	PF00069	0.342
MOD_NEK2_1	414	419	PF00069	0.234
MOD_NEK2_1	64	69	PF00069	0.290
MOD_NEK2_2	405	410	PF00069	0.368
MOD_PKA_1	206	212	PF00069	0.417
MOD_PKA_1	294	300	PF00069	0.194
MOD_PKA_2	20	26	PF00069	0.443
MOD_PKA_2	205	211	PF00069	0.431
MOD_Plk_1	39	45	PF00069	0.424
MOD_Plk_2-3	115	121	PF00069	0.225
MOD_Plk_4	281	287	PF00069	0.305
MOD_Plk_4	364	370	PF00069	0.289
MOD_Plk_4	414	420	PF00069	0.397
MOD_Plk_4	64	70	PF00069	0.304
MOD_Plk_4	79	85	PF00069	0.463
MOD_ProDKin_1	181	187	PF00069	0.561
MOD_ProDKin_1	232	238	PF00069	0.550
MOD_ProDKin_1	353	359	PF00069	0.244
MOD_SUMO_for_1	163	166	PF00179	0.431
MOD_SUMO_for_1	170	173	PF00179	0.406
MOD_SUMO_rev_2	199	209	PF00179	0.417
MOD_SUMO_rev_2	296	302	PF00179	0.263
MOD_SUMO_rev_2	319	327	PF00179	0.288
TRG_DiLeu_LyEn_5	298	303	PF01217	0.244
TRG_ENDOCYTIC_2	129	132	PF00928	0.229
TRG_ENDOCYTIC_2	133	136	PF00928	0.244
TRG_ENDOCYTIC_2	382	385	PF00928	0.282
TRG_ENDOCYTIC_2	86	89	PF00928	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU5	Leptomonas seymouri	57%	100%
A0A1X0NSB9	Trypanosomatidae	35%	100%
A0A1X0NSI7	Trypanosomatidae	36%	100%
A0A3R7LZX6	Trypanosoma rangeli	32%	100%
A0A3S7X1N7	Leishmania donovani	40%	100%
A0A422MUI2	Trypanosoma rangeli	35%	100%
A4HGP7	Leishmania braziliensis	42%	92%
A4HJU9	Leishmania braziliensis	75%	99%
A4HJV0	Leishmania braziliensis	75%	99%
A4HJV1	Leishmania braziliensis	59%	100%
A4HM27	Leishmania braziliensis	32%	86%
A4I3R9	Leishmania infantum	40%	100%
A4I7B1	Leishmania infantum	100%	100%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	87%
O04089	Arabidopsis thaliana	28%	100%
O82643	Arabidopsis thaliana	26%	100%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q12436	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q4Q5V0	Leishmania major	90%	100%
Q4Q5V1	Leishmania major	90%	100%
Q4Q873	Leishmania major	41%	100%
Q6L8F9	Oryza sativa subsp. japonica	23%	100%
Q6L8G0	Oryza sativa subsp. japonica	28%	100%
Q6L8G1	Oryza sativa subsp. japonica	24%	100%
Q75HB1	Oryza sativa subsp. japonica	25%	100%
Q8LE59	Arabidopsis thaliana	26%	100%
Q8W246	Arabidopsis thaliana	23%	100%
V5AWN3	Trypanosoma cruzi	34%	100%
V5BC34	Trypanosoma cruzi	36%	100%
V5DCU2	Trypanosoma cruzi	40%	100%