C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X500_LEIDO

TriTrypDb:

LdBPK_320030.1 , LdCL_320005200 , LDHU3_32.0050

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X500

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X500

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.392
CLV_C14_Caspase3-7	345	349	PF00656	0.527
CLV_NRD_NRD_1	117	119	PF00675	0.505
CLV_NRD_NRD_1	151	153	PF00675	0.372
CLV_NRD_NRD_1	189	191	PF00675	0.542
CLV_PCSK_KEX2_1	110	112	PF00082	0.432
CLV_PCSK_KEX2_1	150	152	PF00082	0.470
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.468
CLV_PCSK_SKI1_1	111	115	PF00082	0.396
CLV_PCSK_SKI1_1	131	135	PF00082	0.418
CLV_PCSK_SKI1_1	152	156	PF00082	0.421
CLV_PCSK_SKI1_1	235	239	PF00082	0.440
CLV_PCSK_SKI1_1	241	245	PF00082	0.443
CLV_PCSK_SKI1_1	352	356	PF00082	0.546
DEG_APCC_DBOX_1	110	118	PF00400	0.392
DEG_APCC_DBOX_1	151	159	PF00400	0.422
DEG_Nend_UBRbox_3	1	3	PF02207	0.617
DOC_MAPK_gen_1	99	109	PF00069	0.480
DOC_MAPK_HePTP_8	73	85	PF00069	0.508
DOC_MAPK_MEF2A_6	76	85	PF00069	0.491
DOC_PP2B_LxvP_1	284	287	PF13499	0.575
DOC_PP4_FxxP_1	282	285	PF00568	0.716
DOC_USP7_MATH_1	274	278	PF00917	0.626
DOC_USP7_MATH_1	39	43	PF00917	0.497
DOC_USP7_UBL2_3	191	195	PF12436	0.500
DOC_USP7_UBL2_3	235	239	PF12436	0.443
DOC_USP7_UBL2_3	91	95	PF12436	0.518
DOC_WW_Pin1_4	265	270	PF00397	0.669
DOC_WW_Pin1_4	296	301	PF00397	0.540
DOC_WW_Pin1_4	317	322	PF00397	0.749
LIG_14-3-3_CanoR_1	222	227	PF00244	0.330
LIG_14-3-3_CanoR_1	352	359	PF00244	0.550
LIG_14-3-3_CanoR_1	76	82	PF00244	0.479
LIG_BRCT_BRCA1_1	55	59	PF00533	0.481
LIG_CtBP_PxDLS_1	329	333	PF00389	0.529
LIG_eIF4E_1	22	28	PF01652	0.491
LIG_EVH1_1	282	286	PF00568	0.555
LIG_EVH1_2	303	307	PF00568	0.547
LIG_FHA_1	160	166	PF00498	0.392
LIG_FHA_1	22	28	PF00498	0.459
LIG_FHA_1	266	272	PF00498	0.620
LIG_FHA_1	56	62	PF00498	0.512
LIG_FHA_2	170	176	PF00498	0.409
LIG_FHA_2	31	37	PF00498	0.403
LIG_LIR_Gen_1	138	149	PF02991	0.404
LIG_LIR_Gen_1	357	366	PF02991	0.621
LIG_LIR_Nem_3	138	144	PF02991	0.415
LIG_LIR_Nem_3	348	354	PF02991	0.557
LIG_LIR_Nem_3	357	362	PF02991	0.581
LIG_Pex14_2	85	89	PF04695	0.436
LIG_SH2_CRK	121	125	PF00017	0.502
LIG_SH2_CRK	93	97	PF00017	0.512
LIG_SH2_GRB2like	121	124	PF00017	0.502
LIG_SH2_NCK_1	121	125	PF00017	0.491
LIG_SH2_STAP1	174	178	PF00017	0.392
LIG_SH2_STAP1	23	27	PF00017	0.456
LIG_SH2_STAT3	174	177	PF00017	0.400
LIG_SH2_STAT5	121	124	PF00017	0.504
LIG_SH2_STAT5	128	131	PF00017	0.481
LIG_SH2_STAT5	157	160	PF00017	0.373
LIG_SH2_STAT5	23	26	PF00017	0.441
LIG_SH2_STAT5	305	308	PF00017	0.626
LIG_SH3_3	268	274	PF00018	0.626
LIG_SH3_3	280	286	PF00018	0.643
LIG_SH3_3	294	300	PF00018	0.549
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.434
LIG_SxIP_EBH_1	8	17	PF03271	0.473
LIG_TRFH_1	282	286	PF08558	0.494
LIG_WRC_WIRS_1	359	364	PF05994	0.541
LIG_WRC_WIRS_1	86	91	PF05994	0.468
LIG_WW_1	302	305	PF00397	0.486
MOD_CDK_SPK_2	265	270	PF00069	0.631
MOD_CDK_SPK_2	296	301	PF00069	0.479
MOD_CK1_1	259	265	PF00069	0.567
MOD_CK1_1	314	320	PF00069	0.596
MOD_CK2_1	169	175	PF00069	0.465
MOD_CK2_1	181	187	PF00069	0.579
MOD_CK2_1	30	36	PF00069	0.414
MOD_CK2_1	354	360	PF00069	0.449
MOD_Cter_Amidation	250	253	PF01082	0.449
MOD_GlcNHglycan	274	277	PF01048	0.578
MOD_GlcNHglycan	315	319	PF01048	0.660
MOD_GlcNHglycan	8	11	PF01048	0.673
MOD_GSK3_1	165	172	PF00069	0.435
MOD_GSK3_1	252	259	PF00069	0.521
MOD_GSK3_1	26	33	PF00069	0.446
MOD_GSK3_1	317	324	PF00069	0.679
MOD_GSK3_1	354	361	PF00069	0.536
MOD_GSK3_1	55	62	PF00069	0.508
MOD_N-GLC_1	135	140	PF02516	0.401
MOD_N-GLC_1	77	82	PF02516	0.530
MOD_N-GLC_2	209	211	PF02516	0.376
MOD_NEK2_1	129	134	PF00069	0.445
MOD_NEK2_1	204	209	PF00069	0.415
MOD_NEK2_1	214	219	PF00069	0.375
MOD_NEK2_1	295	300	PF00069	0.579
MOD_NEK2_1	316	321	PF00069	0.724
MOD_NEK2_1	330	335	PF00069	0.486
MOD_NEK2_1	6	11	PF00069	0.646
MOD_NEK2_1	85	90	PF00069	0.475
MOD_OFUCOSY	220	226	PF10250	0.395
MOD_PIKK_1	260	266	PF00454	0.605
MOD_PIKK_1	354	360	PF00454	0.591
MOD_PIKK_1	44	50	PF00454	0.488
MOD_PKA_1	252	258	PF00069	0.540
MOD_PKA_2	189	195	PF00069	0.536
MOD_Plk_1	330	336	PF00069	0.731
MOD_Plk_1	77	83	PF00069	0.560
MOD_Plk_2-3	159	165	PF00069	0.409
MOD_Plk_2-3	30	36	PF00069	0.366
MOD_Plk_4	143	149	PF00069	0.394
MOD_Plk_4	252	258	PF00069	0.540
MOD_Plk_4	30	36	PF00069	0.420
MOD_ProDKin_1	265	271	PF00069	0.670
MOD_ProDKin_1	296	302	PF00069	0.537
MOD_ProDKin_1	317	323	PF00069	0.749
MOD_SUMO_for_1	109	112	PF00179	0.407
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.531
TRG_ENDOCYTIC_2	157	160	PF00928	0.393
TRG_ENDOCYTIC_2	93	96	PF00928	0.510
TRG_ER_diArg_1	150	152	PF00400	0.473
TRG_NLS_MonoExtN_4	188	194	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	25	30	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H1	Leptomonas seymouri	60%	100%
A0A0S4JCY0	Bodo saltans	35%	94%
A0A3S7X526	Leishmania donovani	36%	100%
A4HJY2	Leishmania braziliensis	74%	100%
A4I7G6	Leishmania infantum	99%	100%
E9B2C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5T3	Leishmania major	93%	100%